Incidental Mutation 'R0142:Or10q1'
ID 22410
Institutional Source Beutler Lab
Gene Symbol Or10q1
Ensembl Gene ENSMUSG00000050865
Gene Name olfactory receptor family 10 subfamily Q member 1
Synonyms MOR266-1, Olfr1494, GA_x6K02T2RE5P-4082427-4083374
MMRRC Submission 038427-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0142 (G1)
Quality Score 183
Status Validated (trace)
Chromosome 19
Chromosomal Location 13726472-13727419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13726619 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 50 (I50F)
Ref Sequence ENSEMBL: ENSMUSP00000146563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051768] [ENSMUST00000207836]
AlphaFold Q8VGP8
Predicted Effect probably benign
Transcript: ENSMUST00000051768
AA Change: I50F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000056291
Gene: ENSMUSG00000050865
AA Change: I50F

DomainStartEndE-ValueType
low complexity region 13 27 N/A INTRINSIC
Pfam:7tm_4 35 313 3.2e-53 PFAM
Pfam:7tm_1 45 295 7.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207836
AA Change: I50F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214479
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214697
Meta Mutation Damage Score 0.1603 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 87.6%
Validation Efficiency 92% (61/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T G 11: 110,079,467 (GRCm39) D1229A probably damaging Het
Abhd8 A C 8: 71,914,506 (GRCm39) F41V probably damaging Het
Ago4 T G 4: 126,410,725 (GRCm39) E222A probably benign Het
Ap3b2 T C 7: 81,122,828 (GRCm39) I470V probably damaging Het
Bcl9l C T 9: 44,418,409 (GRCm39) T749M probably benign Het
Bicc1 T C 10: 70,761,200 (GRCm39) K937E probably damaging Het
Bmi1 G A 2: 18,688,095 (GRCm39) probably null Het
Boc A C 16: 44,310,604 (GRCm39) I772S probably damaging Het
Brd10 A G 19: 29,695,654 (GRCm39) S1347P possibly damaging Het
C2 T A 17: 35,092,504 (GRCm39) I178F possibly damaging Het
Cacna1c G T 6: 118,580,843 (GRCm39) A1416E probably damaging Het
Chst10 A G 1: 38,910,810 (GRCm39) L118P probably damaging Het
Crybg1 G A 10: 43,875,059 (GRCm39) T683I possibly damaging Het
Cul5 C T 9: 53,546,350 (GRCm39) V314I probably damaging Het
Dnajc17 C A 2: 119,010,415 (GRCm39) R211I probably benign Het
Emilin1 A G 5: 31,071,264 (GRCm39) T16A probably benign Het
Ercc6l2 A C 13: 64,020,320 (GRCm39) probably benign Het
Fsd2 T A 7: 81,209,683 (GRCm39) D53V probably damaging Het
Galnt13 A G 2: 54,988,615 (GRCm39) D479G probably damaging Het
Grk3 A T 5: 113,062,919 (GRCm39) W643R probably damaging Het
Hdgf G A 3: 87,820,416 (GRCm39) A4T possibly damaging Het
Hnrnpr T A 4: 136,054,593 (GRCm39) V182E probably damaging Het
Ipo13 A C 4: 117,762,766 (GRCm39) L279R probably damaging Het
Itga9 C A 9: 118,465,654 (GRCm39) N169K probably damaging Het
Jph3 A G 8: 122,480,110 (GRCm39) T263A possibly damaging Het
Jph4 G T 14: 55,345,783 (GRCm39) Q625K probably benign Het
Kctd3 A C 1: 188,728,595 (GRCm39) probably null Het
Kif26b A T 1: 178,742,954 (GRCm39) S570C probably damaging Het
Klhl5 G A 5: 65,300,693 (GRCm39) W164* probably null Het
Lacc1 A T 14: 77,268,239 (GRCm39) H357Q probably benign Het
Lama2 A G 10: 27,063,841 (GRCm39) I1316T probably benign Het
Lcp2 C T 11: 34,032,418 (GRCm39) P332L probably damaging Het
Map3k6 A T 4: 132,978,257 (GRCm39) H1033L probably benign Het
Mfsd2b A G 12: 4,916,234 (GRCm39) V252A probably benign Het
Myo16 T A 8: 10,619,790 (GRCm39) I1447N probably benign Het
Myo19 G A 11: 84,785,429 (GRCm39) R224H probably damaging Het
Myo5a C T 9: 75,067,856 (GRCm39) H637Y probably benign Het
Nek10 C T 14: 14,861,560 (GRCm38) R539C possibly damaging Het
Nfix A T 8: 85,448,315 (GRCm39) V404E probably damaging Het
Nr1i2 T C 16: 38,073,368 (GRCm39) R203G probably benign Het
Nup210l G A 3: 90,079,420 (GRCm39) G968D probably damaging Het
Or2ag15 G T 7: 106,340,972 (GRCm39) H56Q probably benign Het
Or8b37 A T 9: 37,959,406 (GRCm39) H296L probably benign Het
Phlpp2 C T 8: 110,634,145 (GRCm39) R242W probably damaging Het
Plcz1 A G 6: 139,953,423 (GRCm39) F398S probably damaging Het
Ppfibp2 C A 7: 107,343,384 (GRCm39) P808T probably damaging Het
Srpk2 T C 5: 23,732,928 (GRCm39) K239E probably damaging Het
Svep1 A G 4: 58,118,232 (GRCm39) V830A probably benign Het
Tesc A T 5: 118,194,635 (GRCm39) I149F possibly damaging Het
Thsd7a A G 6: 12,418,334 (GRCm39) W632R probably damaging Het
Tmprss9 A G 10: 80,730,212 (GRCm39) D704G possibly damaging Het
Tob1 T C 11: 94,105,423 (GRCm39) Y320H probably damaging Het
Trpm3 G T 19: 22,965,280 (GRCm39) D1582Y probably damaging Het
Ttc28 A G 5: 111,425,323 (GRCm39) K1716R probably benign Het
Uqcrfs1 A G 13: 30,724,925 (GRCm39) V205A probably benign Het
Usp29 G A 7: 6,965,334 (GRCm39) M392I probably benign Het
Uspl1 A T 5: 149,125,159 (GRCm39) Y22F possibly damaging Het
Virma C A 4: 11,548,783 (GRCm39) N1780K probably benign Het
Vmn1r56 C T 7: 5,199,372 (GRCm39) A82T probably benign Het
Vmn2r5 A T 3: 64,400,009 (GRCm39) C553S probably damaging Het
Vwce A T 19: 10,641,976 (GRCm39) R901W probably damaging Het
Wdpcp C A 11: 21,807,444 (GRCm39) probably null Het
Zfp423 A T 8: 88,506,968 (GRCm39) C1000* probably null Het
Zscan20 A G 4: 128,479,630 (GRCm39) F954L probably benign Het
Other mutations in Or10q1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or10q1 APN 19 13,727,165 (GRCm39) missense probably benign 0.04
IGL02335:Or10q1 APN 19 13,727,298 (GRCm39) missense probably benign 0.01
IGL02388:Or10q1 APN 19 13,726,994 (GRCm39) missense possibly damaging 0.91
IGL03231:Or10q1 APN 19 13,726,749 (GRCm39) missense probably benign 0.35
R0133:Or10q1 UTSW 19 13,727,352 (GRCm39) missense probably damaging 1.00
R0561:Or10q1 UTSW 19 13,726,662 (GRCm39) missense probably damaging 1.00
R0783:Or10q1 UTSW 19 13,727,040 (GRCm39) missense probably damaging 0.99
R1826:Or10q1 UTSW 19 13,726,711 (GRCm39) missense probably benign 0.05
R1967:Or10q1 UTSW 19 13,727,417 (GRCm39) makesense probably null
R3706:Or10q1 UTSW 19 13,726,476 (GRCm39) missense probably benign 0.42
R5417:Or10q1 UTSW 19 13,727,217 (GRCm39) missense probably benign 0.18
R6508:Or10q1 UTSW 19 13,726,718 (GRCm39) missense probably damaging 1.00
R7126:Or10q1 UTSW 19 13,726,887 (GRCm39) missense possibly damaging 0.90
R7262:Or10q1 UTSW 19 13,726,535 (GRCm39) missense probably benign 0.02
R7395:Or10q1 UTSW 19 13,726,502 (GRCm39) missense probably damaging 0.98
R7740:Or10q1 UTSW 19 13,727,328 (GRCm39) missense probably benign 0.00
R7744:Or10q1 UTSW 19 13,727,419 (GRCm39) makesense probably null
R7864:Or10q1 UTSW 19 13,726,710 (GRCm39) missense probably benign 0.03
R8495:Or10q1 UTSW 19 13,726,593 (GRCm39) missense possibly damaging 0.95
R9372:Or10q1 UTSW 19 13,727,069 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- CACACTAGACATGCTGACTGGGAAG -3'
(R):5'- ATGCCCACTACATAGAGGACTGCC -3'

Sequencing Primer
(F):5'- GGGAAGTCTGTCCTCAATCAGTC -3'
(R):5'- ATACCTGTCATAGGCCATGACTG -3'
Posted On 2013-04-16