Incidental Mutation 'R1997:Plxnb2'
| ID |
224443 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb2
|
| Ensembl Gene |
ENSMUSG00000036606 |
| Gene Name |
plexin B2 |
| Synonyms |
1110007H23Rik, Debt |
| MMRRC Submission |
040007-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.938)
|
| Stock # |
R1997 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
89039752-89064960 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 89042971 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 1473
(V1473I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060808]
[ENSMUST00000109331]
|
| AlphaFold |
B2RXS4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060808
AA Change: V1473I
PolyPhen 2
Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: V1473I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109331
AA Change: V1473I
PolyPhen 2
Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: V1473I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139372
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143014
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151418
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197760
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229966
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230393
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,382,005 (GRCm39) |
F1320S |
possibly damaging |
Het |
| Aaas |
C |
T |
15: 102,248,494 (GRCm39) |
V241I |
probably benign |
Het |
| Abca17 |
A |
G |
17: 24,504,700 (GRCm39) |
I1233T |
probably benign |
Het |
| Acin1 |
T |
C |
14: 54,884,156 (GRCm39) |
|
probably null |
Het |
| Acly |
A |
T |
11: 100,409,977 (GRCm39) |
I185N |
probably damaging |
Het |
| Adamts16 |
T |
C |
13: 70,901,386 (GRCm39) |
D897G |
probably benign |
Het |
| Allc |
A |
C |
12: 28,613,482 (GRCm39) |
D153E |
probably benign |
Het |
| Ankrd12 |
A |
G |
17: 66,291,879 (GRCm39) |
S1185P |
probably damaging |
Het |
| Aoc1l2 |
A |
T |
6: 48,909,363 (GRCm39) |
Q536L |
probably damaging |
Het |
| Ap1g2 |
T |
C |
14: 55,339,835 (GRCm39) |
E448G |
probably benign |
Het |
| Atg9a |
A |
T |
1: 75,166,270 (GRCm39) |
V50D |
probably benign |
Het |
| Bace2 |
A |
T |
16: 97,216,289 (GRCm39) |
D294V |
possibly damaging |
Het |
| Camsap2 |
T |
C |
1: 136,199,283 (GRCm39) |
K708E |
probably damaging |
Het |
| Card10 |
G |
A |
15: 78,678,175 (GRCm39) |
R358C |
probably damaging |
Het |
| Ccdc81 |
A |
T |
7: 89,547,271 (GRCm39) |
V39E |
probably damaging |
Het |
| Cdh20 |
A |
T |
1: 109,976,668 (GRCm39) |
D111V |
probably damaging |
Het |
| Cercam |
C |
A |
2: 29,762,935 (GRCm39) |
T223K |
probably benign |
Het |
| Cimip2a |
T |
G |
2: 25,110,217 (GRCm39) |
L43R |
probably damaging |
Het |
| Cog5 |
A |
G |
12: 31,710,848 (GRCm39) |
H76R |
possibly damaging |
Het |
| Col28a1 |
A |
T |
6: 7,999,644 (GRCm39) |
N1024K |
probably benign |
Het |
| Csrnp3 |
A |
T |
2: 65,779,446 (GRCm39) |
N41Y |
probably damaging |
Het |
| Cyp2t4 |
G |
A |
7: 26,857,038 (GRCm39) |
|
probably null |
Het |
| Dbn1 |
T |
C |
13: 55,630,254 (GRCm39) |
H38R |
probably damaging |
Het |
| Dclre1b |
A |
G |
3: 103,710,672 (GRCm39) |
V287A |
probably benign |
Het |
| Dennd4c |
A |
G |
4: 86,755,634 (GRCm39) |
T1609A |
probably benign |
Het |
| Depdc5 |
T |
A |
5: 33,059,250 (GRCm39) |
|
probably null |
Het |
| Dhcr7 |
T |
G |
7: 143,401,167 (GRCm39) |
D446E |
probably damaging |
Het |
| Dlx5 |
A |
T |
6: 6,879,680 (GRCm39) |
M129K |
possibly damaging |
Het |
| Dnah11 |
C |
G |
12: 118,046,203 (GRCm39) |
G1745A |
possibly damaging |
Het |
| Dnm3 |
T |
C |
1: 162,181,281 (GRCm39) |
T133A |
possibly damaging |
Het |
| Eif3e |
A |
G |
15: 43,129,005 (GRCm39) |
L205P |
probably damaging |
Het |
| Fam91a1 |
A |
G |
15: 58,296,044 (GRCm39) |
|
probably null |
Het |
| Fank1 |
C |
T |
7: 133,463,954 (GRCm39) |
T50I |
probably damaging |
Het |
| Fhod3 |
A |
G |
18: 25,223,473 (GRCm39) |
T940A |
possibly damaging |
Het |
| Fkbp10 |
T |
C |
11: 100,306,841 (GRCm39) |
F78L |
probably damaging |
Het |
| Gabbr2 |
A |
C |
4: 46,787,502 (GRCm39) |
F387C |
probably damaging |
Het |
| Ggnbp2 |
A |
T |
11: 84,751,387 (GRCm39) |
L138I |
probably damaging |
Het |
| Gm2832 |
T |
A |
14: 41,002,943 (GRCm39) |
|
probably null |
Het |
| Gm5084 |
T |
A |
13: 60,360,344 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9979 |
T |
C |
13: 40,859,228 (GRCm39) |
|
noncoding transcript |
Het |
| Hepacam2 |
A |
G |
6: 3,487,241 (GRCm39) |
S39P |
probably damaging |
Het |
| Hesx1 |
A |
T |
14: 26,723,340 (GRCm39) |
N57Y |
probably damaging |
Het |
| Kcnh1 |
G |
A |
1: 191,959,243 (GRCm39) |
V266I |
probably damaging |
Het |
| Kif24 |
T |
C |
4: 41,392,904 (GRCm39) |
T1168A |
possibly damaging |
Het |
| Kng2 |
A |
T |
16: 22,843,626 (GRCm39) |
F118I |
possibly damaging |
Het |
| Lig3 |
C |
T |
11: 82,678,492 (GRCm39) |
P245S |
probably benign |
Het |
| Loxhd1 |
G |
T |
18: 77,383,465 (GRCm39) |
W121C |
probably damaging |
Het |
| Ltn1 |
A |
G |
16: 87,178,525 (GRCm39) |
V1568A |
probably damaging |
Het |
| Map3k4 |
A |
T |
17: 12,473,882 (GRCm39) |
|
probably null |
Het |
| Mcm10 |
C |
T |
2: 4,998,571 (GRCm39) |
V790M |
probably damaging |
Het |
| Mia3 |
A |
T |
1: 183,125,707 (GRCm39) |
F1223I |
possibly damaging |
Het |
| Mlec |
C |
A |
5: 115,288,405 (GRCm39) |
K150N |
probably damaging |
Het |
| Morn4 |
T |
C |
19: 42,064,977 (GRCm39) |
K70R |
possibly damaging |
Het |
| Mphosph10 |
A |
C |
7: 64,037,195 (GRCm39) |
|
probably null |
Het |
| Myocd |
G |
A |
11: 65,095,147 (GRCm39) |
Q47* |
probably null |
Het |
| Nav2 |
T |
A |
7: 49,198,219 (GRCm39) |
S1283T |
probably benign |
Het |
| Nbeal2 |
T |
C |
9: 110,461,266 (GRCm39) |
H1599R |
probably damaging |
Het |
| Nek10 |
G |
T |
14: 14,827,003 (GRCm38) |
G67V |
probably benign |
Het |
| Nlgn2 |
A |
C |
11: 69,718,876 (GRCm39) |
V271G |
probably damaging |
Het |
| Or1o2 |
A |
G |
17: 37,542,523 (GRCm39) |
V246A |
probably damaging |
Het |
| Or2l5 |
A |
C |
16: 19,333,792 (GRCm39) |
V198G |
probably damaging |
Het |
| Pcolce2 |
A |
T |
9: 95,576,793 (GRCm39) |
M355L |
probably benign |
Het |
| Per2 |
T |
C |
1: 91,368,581 (GRCm39) |
E264G |
probably damaging |
Het |
| Phf2 |
A |
G |
13: 48,982,384 (GRCm39) |
L113P |
unknown |
Het |
| Piwil2 |
A |
G |
14: 70,664,107 (GRCm39) |
V14A |
possibly damaging |
Het |
| Plekha6 |
G |
A |
1: 133,191,556 (GRCm39) |
A146T |
probably benign |
Het |
| Pms2 |
T |
C |
5: 143,850,518 (GRCm39) |
L111P |
probably damaging |
Het |
| Polg |
A |
G |
7: 79,108,979 (GRCm39) |
L533P |
probably damaging |
Het |
| Ppp1r12b |
A |
G |
1: 134,774,093 (GRCm39) |
|
probably benign |
Het |
| Ppp2r1b |
T |
A |
9: 50,778,671 (GRCm39) |
M208K |
possibly damaging |
Het |
| Prdm5 |
A |
G |
6: 65,913,072 (GRCm39) |
Y207C |
probably damaging |
Het |
| Prkar2b |
A |
G |
12: 32,013,934 (GRCm39) |
V314A |
probably damaging |
Het |
| Proser1 |
T |
A |
3: 53,386,292 (GRCm39) |
S725T |
probably benign |
Het |
| Psg20 |
A |
G |
7: 18,416,535 (GRCm39) |
F194L |
probably benign |
Het |
| Ptprz1 |
A |
G |
6: 23,050,496 (GRCm39) |
I2255V |
probably damaging |
Het |
| Sardh |
T |
G |
2: 27,134,409 (GRCm39) |
T36P |
probably damaging |
Het |
| Sec23a |
T |
A |
12: 59,048,793 (GRCm39) |
I110L |
probably benign |
Het |
| Slc22a29 |
T |
A |
19: 8,195,162 (GRCm39) |
I158L |
probably benign |
Het |
| Slc35c1 |
T |
C |
2: 92,284,984 (GRCm39) |
D210G |
probably benign |
Het |
| Syde2 |
A |
G |
3: 145,704,746 (GRCm39) |
N566S |
probably benign |
Het |
| Tcf20 |
G |
A |
15: 82,741,431 (GRCm39) |
Q7* |
probably null |
Het |
| Terb2 |
T |
A |
2: 122,035,338 (GRCm39) |
H186Q |
possibly damaging |
Het |
| Tet2 |
G |
A |
3: 133,192,350 (GRCm39) |
Q695* |
probably null |
Het |
| Tnfaip1 |
T |
C |
11: 78,420,973 (GRCm39) |
Y29C |
probably damaging |
Het |
| Traf3 |
A |
G |
12: 111,227,095 (GRCm39) |
K328E |
probably benign |
Het |
| Uaca |
A |
G |
9: 60,777,623 (GRCm39) |
E668G |
probably damaging |
Het |
| Ube2o |
T |
A |
11: 116,436,163 (GRCm39) |
E326V |
probably damaging |
Het |
| Ubr1 |
C |
T |
2: 120,776,754 (GRCm39) |
|
probably null |
Het |
| Vmn1r19 |
T |
A |
6: 57,382,033 (GRCm39) |
S195R |
probably damaging |
Het |
| Vmn1r213 |
T |
G |
13: 23,196,473 (GRCm39) |
V352G |
probably benign |
Het |
| Vmn2r19 |
T |
A |
6: 123,292,880 (GRCm39) |
D307E |
probably damaging |
Het |
| Wdfy3 |
T |
C |
5: 102,116,812 (GRCm39) |
D76G |
probably damaging |
Het |
| Zan |
A |
T |
5: 137,401,376 (GRCm39) |
C4114* |
probably null |
Het |
| Zbed6 |
A |
G |
1: 133,584,451 (GRCm39) |
L962P |
probably damaging |
Het |
| Zdhhc23 |
A |
T |
16: 43,799,305 (GRCm39) |
C37S |
probably damaging |
Het |
| Zfp628 |
G |
T |
7: 4,921,831 (GRCm39) |
G18W |
probably damaging |
Het |
| Zfp712 |
T |
A |
13: 67,190,114 (GRCm39) |
K138* |
probably null |
Het |
| Zfp867 |
A |
T |
11: 59,354,417 (GRCm39) |
V304D |
probably damaging |
Het |
| Zfp870 |
T |
C |
17: 33,103,027 (GRCm39) |
T102A |
possibly damaging |
Het |
| Zmym5 |
G |
A |
14: 57,035,210 (GRCm39) |
S286L |
possibly damaging |
Het |
|
| Other mutations in Plxnb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00546:Plxnb2
|
APN |
15 |
89,046,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL01574:Plxnb2
|
APN |
15 |
89,046,886 (GRCm39) |
splice site |
probably null |
|
|
IGL01695:Plxnb2
|
APN |
15 |
89,041,417 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01763:Plxnb2
|
APN |
15 |
89,046,184 (GRCm39) |
splice site |
probably null |
|
|
IGL01921:Plxnb2
|
APN |
15 |
89,048,474 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02129:Plxnb2
|
APN |
15 |
89,044,613 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02153:Plxnb2
|
APN |
15 |
89,050,016 (GRCm39) |
nonsense |
probably null |
|
|
IGL02637:Plxnb2
|
APN |
15 |
89,048,260 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02892:Plxnb2
|
APN |
15 |
89,045,425 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03108:Plxnb2
|
APN |
15 |
89,042,234 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03115:Plxnb2
|
APN |
15 |
89,046,641 (GRCm39) |
splice site |
probably benign |
|
|
P0040:Plxnb2
|
UTSW |
15 |
89,047,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Plxnb2
|
UTSW |
15 |
89,047,479 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0095:Plxnb2
|
UTSW |
15 |
89,049,534 (GRCm39) |
missense |
probably benign |
|
|
R0103:Plxnb2
|
UTSW |
15 |
89,045,972 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0544:Plxnb2
|
UTSW |
15 |
89,042,816 (GRCm39) |
splice site |
probably benign |
|
|
R0671:Plxnb2
|
UTSW |
15 |
89,042,184 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1279:Plxnb2
|
UTSW |
15 |
89,046,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1530:Plxnb2
|
UTSW |
15 |
89,051,395 (GRCm39) |
missense |
probably benign |
|
|
R1542:Plxnb2
|
UTSW |
15 |
89,050,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1610:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Plxnb2
|
UTSW |
15 |
89,046,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Plxnb2
|
UTSW |
15 |
89,046,187 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1996:Plxnb2
|
UTSW |
15 |
89,042,971 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2031:Plxnb2
|
UTSW |
15 |
89,047,013 (GRCm39) |
nonsense |
probably null |
|
|
R2049:Plxnb2
|
UTSW |
15 |
89,043,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2072:Plxnb2
|
UTSW |
15 |
89,042,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Plxnb2
|
UTSW |
15 |
89,042,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Plxnb2
|
UTSW |
15 |
89,040,765 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2418:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2419:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R3752:Plxnb2
|
UTSW |
15 |
89,041,458 (GRCm39) |
splice site |
probably benign |
|
|
R3825:Plxnb2
|
UTSW |
15 |
89,050,602 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4154:Plxnb2
|
UTSW |
15 |
89,043,845 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4197:Plxnb2
|
UTSW |
15 |
89,041,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Plxnb2
|
UTSW |
15 |
89,044,826 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4434:Plxnb2
|
UTSW |
15 |
89,047,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4678:Plxnb2
|
UTSW |
15 |
89,045,131 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4717:Plxnb2
|
UTSW |
15 |
89,041,622 (GRCm39) |
nonsense |
probably null |
|
|
R4773:Plxnb2
|
UTSW |
15 |
89,051,150 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4905:Plxnb2
|
UTSW |
15 |
89,041,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5368:Plxnb2
|
UTSW |
15 |
89,043,796 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5418:Plxnb2
|
UTSW |
15 |
89,050,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5484:Plxnb2
|
UTSW |
15 |
89,048,412 (GRCm39) |
splice site |
probably null |
|
|
R5520:Plxnb2
|
UTSW |
15 |
89,051,746 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5566:Plxnb2
|
UTSW |
15 |
89,048,223 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5568:Plxnb2
|
UTSW |
15 |
89,041,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Plxnb2
|
UTSW |
15 |
89,047,012 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5685:Plxnb2
|
UTSW |
15 |
89,051,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5688:Plxnb2
|
UTSW |
15 |
89,042,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5809:Plxnb2
|
UTSW |
15 |
89,051,774 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5813:Plxnb2
|
UTSW |
15 |
89,044,962 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5866:Plxnb2
|
UTSW |
15 |
89,051,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6016:Plxnb2
|
UTSW |
15 |
89,045,225 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6117:Plxnb2
|
UTSW |
15 |
89,042,203 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6187:Plxnb2
|
UTSW |
15 |
89,051,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Plxnb2
|
UTSW |
15 |
89,049,494 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6263:Plxnb2
|
UTSW |
15 |
89,046,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6269:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6351:Plxnb2
|
UTSW |
15 |
89,041,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6522:Plxnb2
|
UTSW |
15 |
89,048,629 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6856:Plxnb2
|
UTSW |
15 |
89,048,523 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6930:Plxnb2
|
UTSW |
15 |
89,044,592 (GRCm39) |
missense |
probably benign |
|
|
R7354:Plxnb2
|
UTSW |
15 |
89,049,928 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7513:Plxnb2
|
UTSW |
15 |
89,042,525 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7522:Plxnb2
|
UTSW |
15 |
89,045,977 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7730:Plxnb2
|
UTSW |
15 |
89,046,533 (GRCm39) |
missense |
probably benign |
|
|
R7766:Plxnb2
|
UTSW |
15 |
89,045,474 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7781:Plxnb2
|
UTSW |
15 |
89,041,225 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8126:Plxnb2
|
UTSW |
15 |
89,047,506 (GRCm39) |
missense |
probably benign |
|
|
R8131:Plxnb2
|
UTSW |
15 |
89,042,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8736:Plxnb2
|
UTSW |
15 |
89,046,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Plxnb2
|
UTSW |
15 |
89,046,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9022:Plxnb2
|
UTSW |
15 |
89,048,471 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9044:Plxnb2
|
UTSW |
15 |
89,044,566 (GRCm39) |
splice site |
probably benign |
|
|
R9253:Plxnb2
|
UTSW |
15 |
89,052,015 (GRCm39) |
missense |
probably benign |
|
|
R9398:Plxnb2
|
UTSW |
15 |
89,045,122 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9562:Plxnb2
|
UTSW |
15 |
89,050,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9568:Plxnb2
|
UTSW |
15 |
89,045,160 (GRCm39) |
nonsense |
probably null |
|
|
R9613:Plxnb2
|
UTSW |
15 |
89,048,496 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0027:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
Z1177:Plxnb2
|
UTSW |
15 |
89,043,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCTCTGCTCATTCCCAGG -3'
(R):5'- AGTATGCGCCTCTGGTAAGTC -3'
Sequencing Primer
(F):5'- TCTGCTCATTCCCAGGCAGAG -3'
(R):5'- TGGTAAGTCCCCCAGAGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation