Incidental Mutation 'R2035:Vmn2r24'
ID |
224459 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r24
|
Ensembl Gene |
ENSMUSG00000072780 |
Gene Name |
vomeronasal 2, receptor 24 |
Synonyms |
EG243628 |
MMRRC Submission |
040042-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.055)
|
Stock # |
R2035 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 123793019 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Isoleucine
at position 782
(N782I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
AlphaFold |
D3YUI0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000075095
AA Change: N782I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000074602 Gene: ENSMUSG00000072780 AA Change: N782I
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 68 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2210408I21Rik |
T |
C |
13: 77,760,761 (GRCm39) |
*1273Q |
probably null |
Het |
Aars2 |
A |
G |
17: 45,825,727 (GRCm39) |
I348V |
possibly damaging |
Het |
Abca8b |
G |
A |
11: 109,847,932 (GRCm39) |
R788C |
possibly damaging |
Het |
Abhd15 |
T |
C |
11: 77,406,536 (GRCm39) |
L171P |
probably damaging |
Het |
Abi3bp |
A |
T |
16: 56,480,581 (GRCm39) |
H686L |
probably benign |
Het |
Acsl1 |
A |
G |
8: 46,981,621 (GRCm39) |
Y456C |
probably damaging |
Het |
Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
Ash1l |
T |
A |
3: 88,973,624 (GRCm39) |
V2561D |
probably benign |
Het |
B3galnt2 |
T |
A |
13: 14,140,909 (GRCm39) |
F44I |
probably benign |
Het |
Bicra |
A |
T |
7: 15,730,338 (GRCm39) |
H24Q |
possibly damaging |
Het |
Ccdc163 |
T |
C |
4: 116,568,530 (GRCm39) |
S195P |
probably damaging |
Het |
Cd163 |
A |
T |
6: 124,297,588 (GRCm39) |
K911N |
probably damaging |
Het |
Clcn3 |
A |
T |
8: 61,387,632 (GRCm39) |
S179T |
probably damaging |
Het |
Dctn4 |
T |
A |
18: 60,671,489 (GRCm39) |
D120E |
possibly damaging |
Het |
Dnali1 |
C |
T |
4: 124,952,903 (GRCm39) |
V207M |
probably damaging |
Het |
Dnhd1 |
A |
G |
7: 105,354,128 (GRCm39) |
Q3036R |
probably damaging |
Het |
Dst |
G |
A |
1: 34,310,494 (GRCm39) |
R4098H |
probably damaging |
Het |
Eml5 |
A |
T |
12: 98,760,525 (GRCm39) |
N1741K |
probably benign |
Het |
Enah |
G |
A |
1: 181,749,537 (GRCm39) |
P415L |
probably damaging |
Het |
Entr1 |
T |
A |
2: 26,273,639 (GRCm39) |
S374C |
probably damaging |
Het |
Ess2 |
A |
G |
16: 17,727,950 (GRCm39) |
|
probably null |
Het |
F8 |
ATCTCTCTC |
ATCTCTC |
X: 74,366,604 (GRCm39) |
|
probably null |
Het |
Gm4841 |
T |
G |
18: 60,402,929 (GRCm39) |
Y388S |
probably benign |
Het |
Grin3a |
T |
C |
4: 49,771,336 (GRCm39) |
T479A |
probably damaging |
Het |
Gucy2e |
C |
A |
11: 69,118,358 (GRCm39) |
V743L |
probably benign |
Het |
Il33 |
T |
A |
19: 29,932,037 (GRCm39) |
N143K |
probably damaging |
Het |
Ism1 |
T |
A |
2: 139,599,075 (GRCm39) |
S349R |
probably damaging |
Het |
Itgb2 |
T |
A |
10: 77,383,033 (GRCm39) |
D134E |
probably damaging |
Het |
Kcnk1 |
A |
C |
8: 126,752,108 (GRCm39) |
N238T |
possibly damaging |
Het |
Kcnu1 |
G |
T |
8: 26,386,721 (GRCm39) |
V535L |
probably benign |
Het |
Muc19 |
T |
A |
15: 91,776,599 (GRCm39) |
|
noncoding transcript |
Het |
Mycbp2 |
A |
T |
14: 103,497,675 (GRCm39) |
Y966N |
probably damaging |
Het |
Myo19 |
A |
T |
11: 84,788,434 (GRCm39) |
M349L |
probably benign |
Het |
Narf |
G |
A |
11: 121,129,326 (GRCm39) |
A37T |
probably benign |
Het |
Ncapd2 |
T |
C |
6: 125,161,491 (GRCm39) |
N208D |
probably benign |
Het |
Nr1i2 |
A |
G |
16: 38,071,488 (GRCm39) |
|
probably null |
Het |
Opn5 |
A |
G |
17: 42,918,052 (GRCm39) |
I70T |
probably damaging |
Het |
Or52e19 |
T |
A |
7: 102,959,463 (GRCm39) |
H178Q |
probably damaging |
Het |
Or7a38 |
T |
C |
10: 78,753,421 (GRCm39) |
V249A |
possibly damaging |
Het |
Pkn2 |
G |
T |
3: 142,526,348 (GRCm39) |
P410T |
probably damaging |
Het |
Pla2r1 |
T |
C |
2: 60,253,080 (GRCm39) |
N1337S |
probably damaging |
Het |
Prkd3 |
A |
T |
17: 79,282,802 (GRCm39) |
|
probably null |
Het |
Pum2 |
T |
A |
12: 8,778,638 (GRCm39) |
Y429* |
probably null |
Het |
Resf1 |
G |
A |
6: 149,230,724 (GRCm39) |
V1257I |
possibly damaging |
Het |
Rttn |
T |
A |
18: 89,038,340 (GRCm39) |
V812E |
probably damaging |
Het |
Rufy2 |
T |
A |
10: 62,842,526 (GRCm39) |
L483H |
probably damaging |
Het |
Slc35a3 |
T |
A |
3: 116,480,972 (GRCm39) |
Q97L |
probably damaging |
Het |
St18 |
A |
T |
1: 6,872,552 (GRCm39) |
M96L |
probably benign |
Het |
Strc |
G |
A |
2: 121,205,415 (GRCm39) |
A905V |
probably damaging |
Het |
Syne3 |
T |
C |
12: 104,924,386 (GRCm39) |
M338V |
probably benign |
Het |
Syngr2 |
A |
G |
11: 117,704,186 (GRCm39) |
D187G |
probably benign |
Het |
Tas2r109 |
A |
C |
6: 132,957,423 (GRCm39) |
I169R |
probably benign |
Het |
Tbc1d22a |
T |
A |
15: 86,275,266 (GRCm39) |
|
probably null |
Het |
Thbs1 |
T |
A |
2: 117,948,821 (GRCm39) |
|
probably null |
Het |
Them6 |
C |
A |
15: 74,593,524 (GRCm39) |
D127E |
probably damaging |
Het |
Tmem132d |
T |
C |
5: 127,869,522 (GRCm39) |
D604G |
probably damaging |
Het |
Tnni1 |
A |
G |
1: 135,733,330 (GRCm39) |
T51A |
probably benign |
Het |
Topors |
T |
C |
4: 40,262,879 (GRCm39) |
N135S |
probably damaging |
Het |
Unc80 |
A |
T |
1: 66,645,752 (GRCm39) |
D1476V |
probably damaging |
Het |
Vmn1r17 |
A |
G |
6: 57,337,573 (GRCm39) |
V264A |
probably benign |
Het |
Vmn1r193 |
T |
A |
13: 22,403,732 (GRCm39) |
T87S |
probably benign |
Het |
Vmn1r202 |
C |
A |
13: 22,685,772 (GRCm39) |
R215L |
probably damaging |
Het |
Vmn2r53 |
A |
G |
7: 12,332,438 (GRCm39) |
F404L |
possibly damaging |
Het |
Xpo4 |
A |
T |
14: 57,823,383 (GRCm39) |
C1036S |
possibly damaging |
Het |
Yae1d1 |
T |
C |
13: 18,164,306 (GRCm39) |
N104D |
probably benign |
Het |
Zan |
C |
A |
5: 137,442,209 (GRCm39) |
R1901L |
unknown |
Het |
Zbtb9 |
G |
A |
17: 27,193,897 (GRCm39) |
R434H |
probably damaging |
Het |
Zdhhc23 |
A |
C |
16: 43,793,871 (GRCm39) |
C268G |
probably damaging |
Het |
|
Other mutations in Vmn2r24 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CATCATTCAAGTGTGCATCTGTG -3'
(R):5'- TCAGCTGACCTCAGTAGAATCAC -3'
Sequencing Primer
(F):5'- TGCAGTCTGGCTGGGAACATAC -3'
(R):5'- CCTCAGTAGAATCACATAGCATTTGG -3'
|
Posted On |
2014-08-25 |