Incidental Mutation 'R2035:Or7a38'
ID 224493
Institutional Source Beutler Lab
Gene Symbol Or7a38
Ensembl Gene ENSMUSG00000094673
Gene Name olfactory receptor family 7 subfamily A member 38
Synonyms GA_x6K02T03FR9-4826-3919, Olfr1354, Olfr233-ps1, MOR185-8, EG257869, MOR139-7, MOR139-5, GA_x6K02T2QGN0-2895081-2894349
MMRRC Submission 040042-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.170) question?
Stock # R2035 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78752676-78753770 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78753421 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 249 (V249A)
Ref Sequence ENSEMBL: ENSMUSP00000150374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075859] [ENSMUST00000204587] [ENSMUST00000217073]
AlphaFold E9Q5G9
Predicted Effect possibly damaging
Transcript: ENSMUST00000075859
AA Change: V249A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000093126
Gene: ENSMUSG00000094673
AA Change: V249A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.4e-49 PFAM
Pfam:7tm_1 42 291 3.8e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203132
AA Change: V249A
SMART Domains Protein: ENSMUSP00000144897
Gene: ENSMUSG00000094673
AA Change: V249A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.4e-49 PFAM
Pfam:7tm_1 42 291 3.8e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204587
AA Change: V249A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205040
SMART Domains Protein: ENSMUSP00000144994
Gene: ENSMUSG00000094673

DomainStartEndE-ValueType
Pfam:7tm_4 32 146 9.6e-24 PFAM
Pfam:7TM_GPCR_Srsx 36 147 1.8e-6 PFAM
Pfam:7tm_1 42 147 4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217073
AA Change: V249A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,760,761 (GRCm39) *1273Q probably null Het
Aars2 A G 17: 45,825,727 (GRCm39) I348V possibly damaging Het
Abca8b G A 11: 109,847,932 (GRCm39) R788C possibly damaging Het
Abhd15 T C 11: 77,406,536 (GRCm39) L171P probably damaging Het
Abi3bp A T 16: 56,480,581 (GRCm39) H686L probably benign Het
Acsl1 A G 8: 46,981,621 (GRCm39) Y456C probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Ash1l T A 3: 88,973,624 (GRCm39) V2561D probably benign Het
B3galnt2 T A 13: 14,140,909 (GRCm39) F44I probably benign Het
Bicra A T 7: 15,730,338 (GRCm39) H24Q possibly damaging Het
Ccdc163 T C 4: 116,568,530 (GRCm39) S195P probably damaging Het
Cd163 A T 6: 124,297,588 (GRCm39) K911N probably damaging Het
Clcn3 A T 8: 61,387,632 (GRCm39) S179T probably damaging Het
Dctn4 T A 18: 60,671,489 (GRCm39) D120E possibly damaging Het
Dnali1 C T 4: 124,952,903 (GRCm39) V207M probably damaging Het
Dnhd1 A G 7: 105,354,128 (GRCm39) Q3036R probably damaging Het
Dst G A 1: 34,310,494 (GRCm39) R4098H probably damaging Het
Eml5 A T 12: 98,760,525 (GRCm39) N1741K probably benign Het
Enah G A 1: 181,749,537 (GRCm39) P415L probably damaging Het
Entr1 T A 2: 26,273,639 (GRCm39) S374C probably damaging Het
Ess2 A G 16: 17,727,950 (GRCm39) probably null Het
F8 ATCTCTCTC ATCTCTC X: 74,366,604 (GRCm39) probably null Het
Gm4841 T G 18: 60,402,929 (GRCm39) Y388S probably benign Het
Grin3a T C 4: 49,771,336 (GRCm39) T479A probably damaging Het
Gucy2e C A 11: 69,118,358 (GRCm39) V743L probably benign Het
Il33 T A 19: 29,932,037 (GRCm39) N143K probably damaging Het
Ism1 T A 2: 139,599,075 (GRCm39) S349R probably damaging Het
Itgb2 T A 10: 77,383,033 (GRCm39) D134E probably damaging Het
Kcnk1 A C 8: 126,752,108 (GRCm39) N238T possibly damaging Het
Kcnu1 G T 8: 26,386,721 (GRCm39) V535L probably benign Het
Muc19 T A 15: 91,776,599 (GRCm39) noncoding transcript Het
Mycbp2 A T 14: 103,497,675 (GRCm39) Y966N probably damaging Het
Myo19 A T 11: 84,788,434 (GRCm39) M349L probably benign Het
Narf G A 11: 121,129,326 (GRCm39) A37T probably benign Het
Ncapd2 T C 6: 125,161,491 (GRCm39) N208D probably benign Het
Nr1i2 A G 16: 38,071,488 (GRCm39) probably null Het
Opn5 A G 17: 42,918,052 (GRCm39) I70T probably damaging Het
Or52e19 T A 7: 102,959,463 (GRCm39) H178Q probably damaging Het
Pkn2 G T 3: 142,526,348 (GRCm39) P410T probably damaging Het
Pla2r1 T C 2: 60,253,080 (GRCm39) N1337S probably damaging Het
Prkd3 A T 17: 79,282,802 (GRCm39) probably null Het
Pum2 T A 12: 8,778,638 (GRCm39) Y429* probably null Het
Resf1 G A 6: 149,230,724 (GRCm39) V1257I possibly damaging Het
Rttn T A 18: 89,038,340 (GRCm39) V812E probably damaging Het
Rufy2 T A 10: 62,842,526 (GRCm39) L483H probably damaging Het
Slc35a3 T A 3: 116,480,972 (GRCm39) Q97L probably damaging Het
St18 A T 1: 6,872,552 (GRCm39) M96L probably benign Het
Strc G A 2: 121,205,415 (GRCm39) A905V probably damaging Het
Syne3 T C 12: 104,924,386 (GRCm39) M338V probably benign Het
Syngr2 A G 11: 117,704,186 (GRCm39) D187G probably benign Het
Tas2r109 A C 6: 132,957,423 (GRCm39) I169R probably benign Het
Tbc1d22a T A 15: 86,275,266 (GRCm39) probably null Het
Thbs1 T A 2: 117,948,821 (GRCm39) probably null Het
Them6 C A 15: 74,593,524 (GRCm39) D127E probably damaging Het
Tmem132d T C 5: 127,869,522 (GRCm39) D604G probably damaging Het
Tnni1 A G 1: 135,733,330 (GRCm39) T51A probably benign Het
Topors T C 4: 40,262,879 (GRCm39) N135S probably damaging Het
Unc80 A T 1: 66,645,752 (GRCm39) D1476V probably damaging Het
Vmn1r17 A G 6: 57,337,573 (GRCm39) V264A probably benign Het
Vmn1r193 T A 13: 22,403,732 (GRCm39) T87S probably benign Het
Vmn1r202 C A 13: 22,685,772 (GRCm39) R215L probably damaging Het
Vmn2r24 A T 6: 123,793,019 (GRCm39) N782I probably damaging Het
Vmn2r53 A G 7: 12,332,438 (GRCm39) F404L possibly damaging Het
Xpo4 A T 14: 57,823,383 (GRCm39) C1036S possibly damaging Het
Yae1d1 T C 13: 18,164,306 (GRCm39) N104D probably benign Het
Zan C A 5: 137,442,209 (GRCm39) R1901L unknown Het
Zbtb9 G A 17: 27,193,897 (GRCm39) R434H probably damaging Het
Zdhhc23 A C 16: 43,793,871 (GRCm39) C268G probably damaging Het
Other mutations in Or7a38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02903:Or7a38 APN 10 78,753,250 (GRCm39) missense probably damaging 0.99
IGL02962:Or7a38 APN 10 78,752,773 (GRCm39) missense probably damaging 1.00
IGL03032:Or7a38 APN 10 78,753,471 (GRCm39) missense probably benign 0.21
PIT4495001:Or7a38 UTSW 10 78,752,821 (GRCm39) missense probably benign
R0268:Or7a38 UTSW 10 78,753,439 (GRCm39) missense probably damaging 0.99
R0359:Or7a38 UTSW 10 78,753,177 (GRCm39) missense probably benign 0.00
R0382:Or7a38 UTSW 10 78,752,960 (GRCm39) nonsense probably null
R1895:Or7a38 UTSW 10 78,752,758 (GRCm39) missense probably damaging 1.00
R1946:Or7a38 UTSW 10 78,752,758 (GRCm39) missense probably damaging 1.00
R3853:Or7a38 UTSW 10 78,752,781 (GRCm39) missense probably damaging 1.00
R4756:Or7a38 UTSW 10 78,753,361 (GRCm39) missense probably damaging 0.99
R5326:Or7a38 UTSW 10 78,753,420 (GRCm39) missense possibly damaging 0.86
R5607:Or7a38 UTSW 10 78,752,933 (GRCm39) missense possibly damaging 0.93
R7070:Or7a38 UTSW 10 78,753,102 (GRCm39) missense probably benign
R7088:Or7a38 UTSW 10 78,753,593 (GRCm39) missense probably benign 0.00
R7212:Or7a38 UTSW 10 78,753,339 (GRCm39) missense possibly damaging 0.81
R7348:Or7a38 UTSW 10 78,753,396 (GRCm39) missense probably damaging 1.00
R7386:Or7a38 UTSW 10 78,752,677 (GRCm39) start codon destroyed probably null 0.98
R7847:Or7a38 UTSW 10 78,752,730 (GRCm39) missense probably benign 0.02
R8976:Or7a38 UTSW 10 78,753,418 (GRCm39) missense possibly damaging 0.79
R9267:Or7a38 UTSW 10 78,752,803 (GRCm39) missense probably damaging 1.00
R9502:Or7a38 UTSW 10 78,753,559 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCACATGTTCAGACAGCTTTTC -3'
(R):5'- CAATGGAAACTTCAGCCAGTCC -3'

Sequencing Primer
(F):5'- TCAAGCCAACTCATAATGAATCTTG -3'
(R):5'- CCAACAATACACTTTACAGTTTTCC -3'
Posted On 2014-08-25