Incidental Mutation 'R2036:Cdc25c'
ID 224693
Institutional Source Beutler Lab
Gene Symbol Cdc25c
Ensembl Gene ENSMUSG00000044201
Gene Name cell division cycle 25C
Synonyms Cdc25
MMRRC Submission 040043-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2036 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 34866046-34884586 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 34871292 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Valine at position 275 (L275V)
Ref Sequence ENSEMBL: ENSMUSP00000055427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060710] [ENSMUST00000105038]
AlphaFold P48967
Predicted Effect probably damaging
Transcript: ENSMUST00000060710
AA Change: L275V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000055427
Gene: ENSMUSG00000044201
AA Change: L275V

DomainStartEndE-ValueType
low complexity region 246 257 N/A INTRINSIC
RHOD 284 398 3.71e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105038
SMART Domains Protein: ENSMUSP00000100655
Gene: ENSMUSG00000078240

DomainStartEndE-ValueType
Pfam:Ribosomal_L29e 3 42 1.4e-31 PFAM
low complexity region 124 160 N/A INTRINSIC
Meta Mutation Damage Score 0.2663 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930415H17Rik C T 11: 99,576,358 (GRCm39) C3Y unknown Het
Abr G T 11: 76,343,176 (GRCm39) T547K probably benign Het
Akr1c21 T C 13: 4,626,305 (GRCm39) Y110H probably damaging Het
Ankar T A 1: 72,705,689 (GRCm39) K556* probably null Het
Anks1b T C 10: 90,805,715 (GRCm39) V431A probably damaging Het
Ap5b1 T C 19: 5,618,897 (GRCm39) S106P possibly damaging Het
Arhgap17 T C 7: 122,917,717 (GRCm39) N156D possibly damaging Het
Arhgap35 T C 7: 16,297,058 (GRCm39) E669G probably damaging Het
Arhgap44 T C 11: 64,932,318 (GRCm39) M201V possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atg4c C T 4: 99,106,376 (GRCm39) T112M possibly damaging Het
Bcl11a A T 11: 24,114,087 (GRCm39) N477Y possibly damaging Het
Brinp3 A T 1: 146,577,579 (GRCm39) I205F possibly damaging Het
Capza2 T C 6: 17,660,777 (GRCm39) F159S probably damaging Het
Cd40 T C 2: 164,904,221 (GRCm39) C61R probably benign Het
Cdh23 A G 10: 60,301,822 (GRCm39) I415T possibly damaging Het
Clnk A T 5: 38,910,143 (GRCm39) probably null Het
Ctcfl C T 2: 172,943,778 (GRCm39) R524Q possibly damaging Het
Cyb5r4 T G 9: 86,924,932 (GRCm39) probably benign Het
Ddb1 T A 19: 10,588,186 (GRCm39) probably benign Het
Ddx51 C A 5: 110,804,491 (GRCm39) Q526K probably benign Het
Dennd6a A T 14: 26,329,274 (GRCm39) Q56L probably damaging Het
Dhdds T C 4: 133,698,410 (GRCm39) E142G probably damaging Het
Dnai1 A G 4: 41,632,225 (GRCm39) H553R probably damaging Het
Fryl T C 5: 73,179,887 (GRCm39) N2908S probably benign Het
Fryl C A 5: 73,265,305 (GRCm39) probably null Het
Fut9 A G 4: 25,620,322 (GRCm39) I164T probably damaging Het
Gba2 G A 4: 43,568,118 (GRCm39) probably benign Het
Gm11627 C T 11: 102,467,580 (GRCm39) V33I unknown Het
Helz2 T A 2: 180,879,272 (GRCm39) H782L probably benign Het
Kcnmb3 A G 3: 32,526,531 (GRCm39) V220A probably damaging Het
Kif20a T C 18: 34,761,515 (GRCm39) S303P possibly damaging Het
Kif22 A T 7: 126,630,126 (GRCm39) V470E possibly damaging Het
Majin C T 19: 6,263,342 (GRCm39) T132M probably benign Het
Mboat7 A G 7: 3,688,671 (GRCm39) probably null Het
Mkrn2 C A 6: 115,588,875 (GRCm39) P206Q probably benign Het
Mphosph9 G A 5: 124,442,274 (GRCm39) T358M probably damaging Het
Nkd1 A G 8: 89,318,305 (GRCm39) D210G probably damaging Het
Or4c110 C T 2: 88,831,976 (GRCm39) V219I probably damaging Het
Or4k41 T A 2: 111,279,971 (GRCm39) L162Q possibly damaging Het
Or5ae2 G T 7: 84,505,566 (GRCm39) probably benign Het
Or5b95 G C 19: 12,658,165 (GRCm39) G231A probably damaging Het
Or5p69 T A 7: 107,966,947 (GRCm39) N83K probably benign Het
Or6c35 G A 10: 129,169,541 (GRCm39) D264N probably benign Het
Or9s15 A T 1: 92,524,328 (GRCm39) E29V probably benign Het
Pi4ka A G 16: 17,120,976 (GRCm39) Y63H probably damaging Het
Plekha1 A G 7: 130,503,922 (GRCm39) R210G probably damaging Het
Ppp2r2c C T 5: 37,109,748 (GRCm39) T369I possibly damaging Het
Relch A G 1: 105,670,979 (GRCm39) D1029G probably damaging Het
Rmnd1 T C 10: 4,357,884 (GRCm39) D12G probably damaging Het
Rtn2 A G 7: 19,027,664 (GRCm39) K120E probably damaging Het
Sh3tc1 A G 5: 35,873,508 (GRCm39) S30P probably benign Het
Tln2 T C 9: 67,179,986 (GRCm39) E795G possibly damaging Het
Tmprss11d T A 5: 86,457,128 (GRCm39) Y177F probably damaging Het
Trrap C A 5: 144,765,372 (GRCm39) D2529E probably benign Het
Vmn2r58 A G 7: 41,513,417 (GRCm39) Y409H probably benign Het
Wdr72 T A 9: 74,058,876 (GRCm39) V323D probably damaging Het
Other mutations in Cdc25c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Cdc25c APN 18 34,880,294 (GRCm39) missense probably benign 0.45
IGL01357:Cdc25c APN 18 34,867,910 (GRCm39) splice site probably null
IGL02122:Cdc25c APN 18 34,877,038 (GRCm39) missense probably benign 0.03
R0053:Cdc25c UTSW 18 34,868,488 (GRCm39) missense probably benign 0.16
R0053:Cdc25c UTSW 18 34,868,488 (GRCm39) missense probably benign 0.16
R1077:Cdc25c UTSW 18 34,882,026 (GRCm39) splice site probably benign
R1679:Cdc25c UTSW 18 34,880,348 (GRCm39) missense probably damaging 1.00
R2051:Cdc25c UTSW 18 34,871,292 (GRCm39) missense probably damaging 1.00
R2077:Cdc25c UTSW 18 34,871,292 (GRCm39) missense probably damaging 1.00
R2511:Cdc25c UTSW 18 34,871,292 (GRCm39) missense probably damaging 1.00
R5304:Cdc25c UTSW 18 34,883,864 (GRCm39) missense possibly damaging 0.71
R5604:Cdc25c UTSW 18 34,866,701 (GRCm39) missense probably damaging 1.00
R7833:Cdc25c UTSW 18 34,880,296 (GRCm39) missense probably benign 0.17
R7919:Cdc25c UTSW 18 34,868,429 (GRCm39) missense probably damaging 0.99
R8193:Cdc25c UTSW 18 34,882,675 (GRCm39) splice site probably null
R8710:Cdc25c UTSW 18 34,882,666 (GRCm39) critical splice acceptor site probably benign
R8960:Cdc25c UTSW 18 34,866,329 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CCTTCAATACAGCTTCAGCCCA -3'
(R):5'- TTCCCTGAATATATGTATGGGCAA -3'

Sequencing Primer
(F):5'- GCTTCAGCCCAGTAAGAGC -3'
(R):5'- GAGCTAGAGATAGTTTTGACCCACC -3'
Posted On 2014-08-25