Incidental Mutation 'R2037:Or10u4'
ID 224802
Institutional Source Beutler Lab
Gene Symbol Or10u4
Ensembl Gene ENSMUSG00000094295
Gene Name olfactory receptor family 10 subfamily U member 4
Synonyms MOR265-2_p, Olfr819, GA_x6K02T2PULF-11644164-11643823
MMRRC Submission 040044-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R2037 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129801605-129802567 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129802009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 187 (I187V)
Ref Sequence ENSEMBL: ENSMUSP00000131761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167974] [ENSMUST00000216322]
AlphaFold K7N727
Predicted Effect probably benign
Transcript: ENSMUST00000167974
AA Change: I187V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000131761
Gene: ENSMUSG00000094295
AA Change: I187V

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.1e-55 PFAM
Pfam:7tm_1 47 296 3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216322
AA Change: I181V

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A T 11: 109,980,810 (GRCm39) probably null Het
AI987944 T C 7: 41,023,815 (GRCm39) Y391C probably benign Het
Ankfn1 A T 11: 89,346,946 (GRCm39) S296T probably benign Het
Apob A G 12: 8,057,488 (GRCm39) D1957G probably benign Het
Baz1a G T 12: 54,976,431 (GRCm39) P415Q probably damaging Het
Brca2 T A 5: 150,464,134 (GRCm39) H1299Q probably benign Het
C7 G T 15: 5,063,720 (GRCm39) S227* probably null Het
Catsperb A T 12: 101,474,221 (GRCm39) R306S probably damaging Het
Cbx3 T A 6: 51,448,793 (GRCm39) probably null Het
Ccnt2 A G 1: 127,731,136 (GRCm39) Y671C probably damaging Het
Crocc A G 4: 140,774,253 (GRCm39) probably null Het
Ctr9 G A 7: 110,646,014 (GRCm39) V669I probably benign Het
Dck T G 5: 88,920,576 (GRCm39) Y99D probably damaging Het
Ddx52 T A 11: 83,835,432 (GRCm39) D119E probably benign Het
Dnah10 A T 5: 124,823,768 (GRCm39) K596N probably benign Het
Dnah7a A T 1: 53,621,741 (GRCm39) V1128E probably benign Het
Dph1 A T 11: 75,076,679 (GRCm39) probably null Het
Enah G A 1: 181,749,537 (GRCm39) P415L probably damaging Het
Enthd1 A G 15: 80,444,550 (GRCm39) S2P possibly damaging Het
Erc1 A C 6: 119,699,216 (GRCm39) V802G possibly damaging Het
F8 ATCTCTCTC ATCTCTC X: 74,366,604 (GRCm39) probably null Het
Fam169a C A 13: 97,243,600 (GRCm39) A210E probably benign Het
Fcmr A G 1: 130,806,070 (GRCm39) D342G possibly damaging Het
Fgfr4 T G 13: 55,315,702 (GRCm39) V743G possibly damaging Het
Fsip2 A G 2: 82,808,856 (GRCm39) D1725G probably damaging Het
Heatr5b A T 17: 79,136,934 (GRCm39) C195* probably null Het
Herc2 G A 7: 55,855,709 (GRCm39) A3882T probably damaging Het
Il20 T A 1: 130,836,115 (GRCm39) N143Y probably damaging Het
Inpp5b A G 4: 124,692,092 (GRCm39) S892G probably damaging Het
Ipo13 A T 4: 117,761,858 (GRCm39) Y447* probably null Het
Itprid1 A G 6: 55,874,860 (GRCm39) N270S probably benign Het
Kbtbd12 A T 6: 88,594,779 (GRCm39) N350K probably benign Het
Kiz T C 2: 146,811,880 (GRCm39) F663S probably damaging Het
Matn2 A G 15: 34,433,263 (GRCm39) D870G probably benign Het
Methig1 C T 15: 100,251,467 (GRCm39) A126V probably benign Het
Mme A G 3: 63,235,681 (GRCm39) D209G probably null Het
Mroh4 A G 15: 74,481,610 (GRCm39) F811L possibly damaging Het
Myo9b G T 8: 71,743,510 (GRCm39) K190N probably damaging Het
Ncf1 T C 5: 134,258,406 (GRCm39) I6V probably damaging Het
Nmt2 T C 2: 3,310,618 (GRCm39) F121L probably damaging Het
Nol10 A G 12: 17,411,152 (GRCm39) D183G probably benign Het
Nsun7 T C 5: 66,418,429 (GRCm39) V53A probably benign Het
Or8j3 T C 2: 86,028,176 (GRCm39) S307G probably benign Het
Or8k22 T C 2: 86,162,774 (GRCm39) N309D probably benign Het
Pappa2 A T 1: 158,784,214 (GRCm39) Y265* probably null Het
Pigg G A 5: 108,486,518 (GRCm39) A724T probably damaging Het
Pik3r4 C T 9: 105,527,534 (GRCm39) R296C probably benign Het
Pkhd1l1 A G 15: 44,431,617 (GRCm39) probably null Het
Pld4 A G 12: 112,734,992 (GRCm39) D483G probably damaging Het
Ppip5k1 C T 2: 121,173,674 (GRCm39) R399H probably damaging Het
Qrfpr A T 3: 36,236,806 (GRCm39) H198Q probably damaging Het
Rasgrf2 A T 13: 92,050,748 (GRCm39) D883E probably damaging Het
Retnlg T C 16: 48,694,615 (GRCm39) C88R probably damaging Het
Sin3a C T 9: 57,004,109 (GRCm39) T287I probably benign Het
Slc44a1 GCC GCCCCC 4: 53,563,243 (GRCm39) probably benign Het
Sppl2c G C 11: 104,077,307 (GRCm39) V36L probably benign Het
Srp72 T A 5: 77,124,338 (GRCm39) I68N probably damaging Het
Srrm3 T A 5: 135,883,231 (GRCm39) S195R probably damaging Het
Srrm4 T A 5: 116,605,887 (GRCm39) probably benign Het
Ssb A G 2: 69,699,163 (GRCm39) S199G probably benign Het
Sult2a6 T A 7: 13,988,634 (GRCm39) Y42F probably damaging Het
Syne2 A G 12: 76,072,343 (GRCm39) T120A probably benign Het
Tas1r1 A G 4: 152,112,627 (GRCm39) F809L probably damaging Het
Tead3 A G 17: 28,555,544 (GRCm39) S117P probably damaging Het
Tefm C T 11: 80,031,056 (GRCm39) R60H probably damaging Het
Tmem104 G A 11: 115,092,221 (GRCm39) R110H possibly damaging Het
Tnxb G A 17: 34,918,179 (GRCm39) G2364D probably damaging Het
Vmn1r211 T A 13: 23,036,134 (GRCm39) I178F probably damaging Het
Vmn1r6 A T 6: 56,980,109 (GRCm39) Y235F probably damaging Het
Xrcc5 C A 1: 72,385,529 (GRCm39) T540K probably benign Het
Other mutations in Or10u4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Or10u4 APN 10 129,801,673 (GRCm39) missense probably damaging 1.00
R2048:Or10u4 UTSW 10 129,801,861 (GRCm39) missense probably damaging 1.00
R3687:Or10u4 UTSW 10 129,802,581 (GRCm39) splice site probably null
R5249:Or10u4 UTSW 10 129,802,078 (GRCm39) missense probably benign 0.06
R5445:Or10u4 UTSW 10 129,802,158 (GRCm39) missense probably benign 0.19
R8007:Or10u4 UTSW 10 129,801,744 (GRCm39) missense possibly damaging 0.69
R8089:Or10u4 UTSW 10 129,802,566 (GRCm39) start codon destroyed probably null 0.66
R8824:Or10u4 UTSW 10 129,801,661 (GRCm39) missense probably damaging 1.00
R9554:Or10u4 UTSW 10 129,802,181 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TGGAGAAAGCTTTGTGTCTGCC -3'
(R):5'- ATCTTGGGGCTGACAGAGTG -3'

Sequencing Primer
(F):5'- AAAGCTTTGTGTCTGCCTGCTG -3'
(R):5'- GCAACTATGGCTTATGATCGC -3'
Posted On 2014-08-25