Mutagenetix > Incidental Mutation

Incidental Mutation 'R2041:Morn1'

224903

Institutional Source

Beutler Lab

Gene Symbol

Morn1

Ensembl Gene

ENSMUSG00000029049

Gene Name

MORN repeat containing 1

Synonyms

4930417P05Rik, 2900057D20Rik

MMRRC Submission

040048-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2041 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

155171034-155229962 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 155175399 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 103 (Y103H)

Ref Sequence

ENSEMBL: ENSMUSP00000116794 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030914] [ENSMUST00000030915] [ENSMUST00000127457] [ENSMUST00000132367] [ENSMUST00000155775]

AlphaFold

A2RTS7

Predicted Effect

probably benign
Transcript: ENSMUST00000030914

SMART Domains

Protein: ENSMUSP00000030914
Gene: ENSMUSG00000029048

Domain	Start	End	E-Value	Type
Pfam:Rer1	20	185	4.1e-82	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000030915
AA Change: Y103H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	1.4e-3	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125357

Predicted Effect

probably damaging
Transcript: ENSMUST00000127457
AA Change: Y103H

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	5.5e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129180

Predicted Effect

probably damaging
Transcript: ENSMUST00000132367
AA Change: Y103H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	6.8e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149796

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155375

Predicted Effect

probably benign
Transcript: ENSMUST00000155775

SMART Domains

Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	2.7e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	93	114	2.06e-6	SMART

Meta Mutation Damage Score

0.3978

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

100% (61/61)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	T	A	5: 144,982,211 (GRCm39)	D265E	probably damaging	Het
2610021A01Rik	A	G	7: 41,275,403 (GRCm39)	R369G	possibly damaging	Het
Actr3b	T	C	5: 25,965,128 (GRCm39)		probably null	Het
Adamts12	A	T	15: 11,215,821 (GRCm39)	M281L	probably damaging	Het
Aipl1	T	A	11: 71,922,332 (GRCm39)	M126L	possibly damaging	Het
Akap12	C	T	10: 4,306,489 (GRCm39)	P1100S	probably benign	Het
Alox8	T	A	11: 69,088,517 (GRCm39)	H40L	possibly damaging	Het
Anks1	T	A	17: 28,227,388 (GRCm39)	F659L	probably damaging	Het
Asxl3	G	T	18: 22,656,508 (GRCm39)	R1506L	probably benign	Het
Bicd2	A	G	13: 49,495,252 (GRCm39)	T36A	probably benign	Het
Ccar1	A	T	10: 62,601,827 (GRCm39)	L448Q	probably damaging	Het
Ccdc17	T	G	4: 116,456,789 (GRCm39)	N497K	probably damaging	Het
Chek2	T	C	5: 110,996,530 (GRCm39)	I164T	probably damaging	Het
Cntnap5c	T	C	17: 58,411,765 (GRCm39)		probably null	Het
Cntnap5c	T	A	17: 58,505,984 (GRCm39)	D669E	probably benign	Het
Cpsf6	A	G	10: 117,195,033 (GRCm39)	I482T	probably damaging	Het
Csf3	C	T	11: 98,592,483 (GRCm39)	S65L	possibly damaging	Het
Dlc1	A	G	8: 37,049,922 (GRCm39)	Y1049H	probably damaging	Het
Dnah6	T	C	6: 73,050,422 (GRCm39)	D3048G	probably damaging	Het
Eif4g3	T	A	4: 137,832,617 (GRCm39)		probably benign	Het
Epb41l4b	T	C	4: 57,084,070 (GRCm39)	K195R	probably damaging	Het
Epn1	T	C	7: 5,086,874 (GRCm39)	S41P	probably damaging	Het
Fam120a	C	A	13: 49,051,243 (GRCm39)	V721L	probably benign	Het
Fchsd1	T	A	18: 38,100,729 (GRCm39)		probably null	Het
Fer1l6	G	A	15: 58,430,155 (GRCm39)	G194D	probably damaging	Het
Fpr-rs4	CAGGAA	CA	17: 18,242,596 (GRCm39)		probably null	Het
Fyb1	A	C	15: 6,674,268 (GRCm39)	T635P	possibly damaging	Het
Gpr153	A	G	4: 152,367,810 (GRCm39)	S554G	probably benign	Het
Grm1	A	G	10: 10,622,347 (GRCm39)	F459L	probably damaging	Het
H60c	C	T	10: 3,209,972 (GRCm39)	G105D	probably damaging	Het
Ifnlr1	T	A	4: 135,433,148 (GRCm39)	M528K	possibly damaging	Het
Lama4	A	T	10: 38,945,987 (GRCm39)	D790V	probably damaging	Het
Mfsd13b	T	C	7: 120,591,139 (GRCm39)		probably benign	Het
Mis12	T	A	11: 70,916,132 (GRCm39)	I55N	probably damaging	Het
Mrgpra2b	C	T	7: 47,113,908 (GRCm39)	V249I	probably benign	Het
Ndst3	C	A	3: 123,465,864 (GRCm39)	G36V	probably benign	Het
Nlrp4a	T	A	7: 26,149,611 (GRCm39)	M406K	probably damaging	Het
Or4p18	T	C	2: 88,232,568 (GRCm39)	T237A	probably damaging	Het
Or51t4	T	A	7: 102,598,170 (GRCm39)	V156E	probably damaging	Het
Or5b106	A	T	19: 13,124,041 (GRCm39)		probably benign	Het
Or7g32	A	T	9: 19,408,131 (GRCm39)	D29V	probably benign	Het
Or9m1	T	C	2: 87,733,141 (GRCm39)	N293S	probably damaging	Het
Pars2	A	G	4: 106,510,814 (GRCm39)	T199A	probably damaging	Het
Plcb4	C	T	2: 135,780,191 (GRCm39)	T172I	probably damaging	Het
Pomgnt2	A	T	9: 121,811,354 (GRCm39)	W476R	probably benign	Het
Psg23	T	A	7: 18,348,703 (GRCm39)	S35C	possibly damaging	Het
Pycr3	T	A	15: 75,791,144 (GRCm39)		probably null	Het
Rab3gap1	T	C	1: 127,865,727 (GRCm39)	V764A	possibly damaging	Het
Rgs2	A	G	1: 143,877,960 (GRCm39)	F80S	probably damaging	Het
Sall1	A	G	8: 89,759,429 (GRCm39)	L225P	probably benign	Het
Setd3	A	G	12: 108,079,651 (GRCm39)	I284T	possibly damaging	Het
Slc4a9	C	T	18: 36,663,846 (GRCm39)	T290I	possibly damaging	Het
Tmem87b	T	C	2: 128,673,509 (GRCm39)	V251A	probably damaging	Het
Ube3b	T	C	5: 114,525,294 (GRCm39)	L39P	probably damaging	Het
Ubr2	C	A	17: 47,296,973 (GRCm39)	R269L	probably damaging	Het
Vrk2	A	T	11: 26,497,914 (GRCm39)	I90K	probably benign	Het
Zer1	G	A	2: 29,998,286 (GRCm39)	L342F	probably damaging	Het
Zfp984	A	T	4: 147,839,796 (GRCm39)	C352S	probably damaging	Het

Other mutations in Morn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Morn1	APN	4	155,176,785 (GRCm39)	missense	possibly damaging	0.81
IGL01143:Morn1	APN	4	155,176,761 (GRCm39)	missense	probably damaging	1.00
IGL02214:Morn1	APN	4	155,176,776 (GRCm39)	missense	probably damaging	1.00
IGL03112:Morn1	APN	4	155,177,601 (GRCm39)	missense	probably damaging	1.00
R0091:Morn1	UTSW	4	155,229,629 (GRCm39)	missense	probably damaging	1.00
R0573:Morn1	UTSW	4	155,195,473 (GRCm39)	missense	possibly damaging	0.87
R0639:Morn1	UTSW	4	155,173,960 (GRCm39)	missense	possibly damaging	0.92
R0918:Morn1	UTSW	4	155,171,928 (GRCm39)	missense	probably damaging	1.00
R2360:Morn1	UTSW	4	155,176,770 (GRCm39)	missense	probably damaging	0.98
R5831:Morn1	UTSW	4	155,185,733 (GRCm39)	missense	probably benign	0.02
R6897:Morn1	UTSW	4	155,171,112 (GRCm39)	missense	probably benign	0.06
R8178:Morn1	UTSW	4	155,213,160 (GRCm39)	missense	probably benign	0.00
R8505:Morn1	UTSW	4	155,177,792 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TCCTCGCTGTCCATACCAAAG -3'
(R):5'- CTGTATATAGGCTCTGATGGGC -3'

Sequencing Primer
(F):5'- GGTGTAGTAGCGCACACCTCTAATC -3'
(R):5'- AGCTTAGTGGTCTTCCAC -3'

Posted On

2014-08-25