Incidental Mutation 'R2038:H2-T10'
ID 225362
Institutional Source Beutler Lab
Gene Symbol H2-T10
Ensembl Gene ENSMUSG00000079491
Gene Name histocompatibility 2, T region locus 10
Synonyms H-2T10
MMRRC Submission 040045-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2038 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 36426763-36432336 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36430317 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 212 (K212E)
Ref Sequence ENSEMBL: ENSMUSP00000133893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046131] [ENSMUST00000166442] [ENSMUST00000173128] [ENSMUST00000174382]
AlphaFold F6T1I5
Predicted Effect probably benign
Transcript: ENSMUST00000046131
SMART Domains Protein: ENSMUSP00000040558
Gene: ENSMUSG00000092243

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:MHC_I 26 204 2.3e-81 PFAM
IGc1 220 285 8.12e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166442
AA Change: E208G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000127602
Gene: ENSMUSG00000079491
AA Change: E208G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:MHC_I 29 191 6.2e-49 PFAM
IGc1 210 281 4.18e-24 SMART
transmembrane domain 294 313 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000173128
SMART Domains Protein: ENSMUSP00000134339
Gene: ENSMUSG00000092277

DomainStartEndE-ValueType
low complexity region 103 115 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174382
AA Change: K212E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000133893
Gene: ENSMUSG00000079491
AA Change: K212E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:MHC_I 29 205 9.5e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174625
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174728
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik T C 8: 125,389,762 (GRCm39) Y54C probably damaging Het
Adgrf4 A T 17: 42,978,754 (GRCm39) H196Q probably damaging Het
Astn1 T G 1: 158,484,690 (GRCm39) S918A probably benign Het
Cd79a A T 7: 24,598,782 (GRCm39) K110N probably benign Het
Cdc34b C T 11: 94,633,114 (GRCm39) Q105* probably null Het
Cdh23 T C 10: 60,148,366 (GRCm39) D2667G probably damaging Het
Clpx G A 9: 65,224,775 (GRCm39) G168R probably damaging Het
Col8a2 T C 4: 126,205,108 (GRCm39) probably benign Het
Ddx27 G A 2: 166,875,675 (GRCm39) E669K probably damaging Het
Dnah8 A T 17: 30,977,255 (GRCm39) I2898F probably damaging Het
Dus2 T C 8: 106,775,294 (GRCm39) Y274H probably damaging Het
Dync2h1 A G 9: 6,967,226 (GRCm39) S4073P probably damaging Het
Dynlrb2 G A 8: 117,241,549 (GRCm39) R31Q possibly damaging Het
Esyt1 C T 10: 128,347,820 (GRCm39) V957I probably benign Het
Fhdc1 A T 3: 84,351,868 (GRCm39) L1119Q probably benign Het
H60b A T 10: 22,162,114 (GRCm39) N113I probably benign Het
Hace1 A C 10: 45,576,721 (GRCm39) K798Q probably benign Het
Hdac7 C T 15: 97,696,151 (GRCm39) R631H probably damaging Het
Kat7 T A 11: 95,190,928 (GRCm39) I153F probably benign Het
Lman1 T C 18: 66,131,681 (GRCm39) T101A probably benign Het
Mapk8 A T 14: 33,110,893 (GRCm39) C245* probably null Het
Mfhas1 T A 8: 36,058,431 (GRCm39) W969R probably damaging Het
Mlxipl A T 5: 135,135,853 (GRCm39) D26V probably damaging Het
Msh5 A G 17: 35,265,016 (GRCm39) V53A probably benign Het
Msl2 C A 9: 100,979,183 (GRCm39) A519D probably damaging Het
Nbeal1 A G 1: 60,245,503 (GRCm39) S176G probably benign Het
Ninl T A 2: 150,817,763 (GRCm39) K134* probably null Het
Or10d1 A G 9: 39,484,283 (GRCm39) S91P probably damaging Het
Or1e25 T A 11: 73,494,239 (GRCm39) Y278N probably damaging Het
Or4a68 C A 2: 89,269,689 (GRCm39) M311I probably benign Het
Pabpn1 T G 14: 55,134,609 (GRCm39) I250S probably damaging Het
Ppp4r4 G A 12: 103,542,539 (GRCm39) probably null Het
Rad51ap2 T C 12: 11,507,025 (GRCm39) S316P possibly damaging Het
Scn7a C A 2: 66,567,780 (GRCm39) W271C probably damaging Het
Set T C 2: 29,960,212 (GRCm39) S182P probably benign Het
Sez6l T C 5: 112,620,618 (GRCm39) T321A possibly damaging Het
Sfpq A T 4: 126,915,295 (GRCm39) H29L unknown Het
Slc33a1 A G 3: 63,855,577 (GRCm39) L356P probably damaging Het
Sptbn1 C G 11: 30,109,293 (GRCm39) probably null Het
Srrd C T 5: 112,486,316 (GRCm39) G179D probably benign Het
Taf4b T C 18: 14,940,456 (GRCm39) S312P probably damaging Het
Tgfbrap1 A T 1: 43,093,794 (GRCm39) L566* probably null Het
Tln2 T A 9: 67,304,935 (GRCm39) M1L probably benign Het
Ttc27 T C 17: 75,163,497 (GRCm39) F702L probably benign Het
Vmn2r54 C T 7: 12,363,637 (GRCm39) G419R possibly damaging Het
Vps13b A G 15: 35,884,887 (GRCm39) S3187G probably damaging Het
Vps13d C A 4: 144,907,685 (GRCm39) probably null Het
Vps35l T C 7: 118,411,097 (GRCm39) F677L probably damaging Het
Zfp568 A T 7: 29,688,507 (GRCm39) E23V probably null Het
Other mutations in H2-T10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:H2-T10 APN 17 36,431,602 (GRCm39) missense probably benign 0.08
IGL01946:H2-T10 APN 17 36,431,608 (GRCm39) missense possibly damaging 0.45
IGL03367:H2-T10 APN 17 36,431,285 (GRCm39) missense possibly damaging 0.81
IGL03381:H2-T10 APN 17 36,430,249 (GRCm39) nonsense probably null
IGL03381:H2-T10 APN 17 36,430,246 (GRCm39) missense probably benign
FR4304:H2-T10 UTSW 17 36,431,173 (GRCm39) frame shift probably null
R0305:H2-T10 UTSW 17 36,430,260 (GRCm39) missense probably damaging 1.00
R1446:H2-T10 UTSW 17 36,430,266 (GRCm39) missense possibly damaging 0.87
R1483:H2-T10 UTSW 17 36,432,038 (GRCm39) missense probably benign 0.44
R2402:H2-T10 UTSW 17 36,428,631 (GRCm39) splice site probably null
R4755:H2-T10 UTSW 17 36,429,837 (GRCm39) nonsense probably null
R4957:H2-T10 UTSW 17 36,428,308 (GRCm39) utr 3 prime probably benign
R5162:H2-T10 UTSW 17 36,429,843 (GRCm39) splice site probably null
R5568:H2-T10 UTSW 17 36,430,079 (GRCm39) critical splice donor site probably null
R6226:H2-T10 UTSW 17 36,431,975 (GRCm39) missense probably damaging 0.99
R6850:H2-T10 UTSW 17 36,430,152 (GRCm39) missense probably damaging 1.00
R7249:H2-T10 UTSW 17 36,430,269 (GRCm39) missense probably damaging 0.99
R7324:H2-T10 UTSW 17 36,430,189 (GRCm39) missense probably damaging 1.00
R7466:H2-T10 UTSW 17 36,431,741 (GRCm39) missense probably benign 0.10
R7679:H2-T10 UTSW 17 36,430,216 (GRCm39) missense not run
R7767:H2-T10 UTSW 17 36,428,622 (GRCm39) missense probably benign 0.02
R7901:H2-T10 UTSW 17 36,431,143 (GRCm39) missense probably benign
R8278:H2-T10 UTSW 17 36,429,832 (GRCm39) missense probably benign 0.00
R8315:H2-T10 UTSW 17 36,429,905 (GRCm39) missense probably benign 0.41
R9646:H2-T10 UTSW 17 36,431,157 (GRCm39) missense probably damaging 0.96
RF032:H2-T10 UTSW 17 36,431,186 (GRCm39) frame shift probably null
RF046:H2-T10 UTSW 17 36,431,186 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ACTCTGCACCTTTCCAAGAGG -3'
(R):5'- GCTCACATCCTAAGGCATCTC -3'

Sequencing Primer
(F):5'- GAGGCACCACCACAGCTG -3'
(R):5'- TCTAAGAACAGATCCTCCCAGGTG -3'
Posted On 2014-08-25