Incidental Mutation 'R2038:Adgrf4'
ID 225365
Institutional Source Beutler Lab
Gene Symbol Adgrf4
Ensembl Gene ENSMUSG00000023918
Gene Name adhesion G protein-coupled receptor F4
Synonyms 4632435A09Rik, Gpr115
MMRRC Submission 040045-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2038 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 42967782-43003175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42978754 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 196 (H196Q)
Ref Sequence ENSEMBL: ENSMUSP00000133261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024711] [ENSMUST00000164524] [ENSMUST00000167993] [ENSMUST00000170723]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000024711
AA Change: H196Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000024711
Gene: ENSMUSG00000023918
AA Change: H196Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164524
SMART Domains Protein: ENSMUSP00000129114
Gene: ENSMUSG00000023918

DomainStartEndE-ValueType
SCOP:g1qd6.1 20 44 1e-2 SMART
low complexity region 54 64 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000167993
AA Change: H196Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132890
Gene: ENSMUSG00000023918
AA Change: H196Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000170723
AA Change: H196Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133261
Gene: ENSMUSG00000023918
AA Change: H196Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 9.2e-36 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik T C 8: 125,389,762 (GRCm39) Y54C probably damaging Het
Astn1 T G 1: 158,484,690 (GRCm39) S918A probably benign Het
Cd79a A T 7: 24,598,782 (GRCm39) K110N probably benign Het
Cdc34b C T 11: 94,633,114 (GRCm39) Q105* probably null Het
Cdh23 T C 10: 60,148,366 (GRCm39) D2667G probably damaging Het
Clpx G A 9: 65,224,775 (GRCm39) G168R probably damaging Het
Col8a2 T C 4: 126,205,108 (GRCm39) probably benign Het
Ddx27 G A 2: 166,875,675 (GRCm39) E669K probably damaging Het
Dnah8 A T 17: 30,977,255 (GRCm39) I2898F probably damaging Het
Dus2 T C 8: 106,775,294 (GRCm39) Y274H probably damaging Het
Dync2h1 A G 9: 6,967,226 (GRCm39) S4073P probably damaging Het
Dynlrb2 G A 8: 117,241,549 (GRCm39) R31Q possibly damaging Het
Esyt1 C T 10: 128,347,820 (GRCm39) V957I probably benign Het
Fhdc1 A T 3: 84,351,868 (GRCm39) L1119Q probably benign Het
H2-T10 T C 17: 36,430,317 (GRCm39) K212E probably benign Het
H60b A T 10: 22,162,114 (GRCm39) N113I probably benign Het
Hace1 A C 10: 45,576,721 (GRCm39) K798Q probably benign Het
Hdac7 C T 15: 97,696,151 (GRCm39) R631H probably damaging Het
Kat7 T A 11: 95,190,928 (GRCm39) I153F probably benign Het
Lman1 T C 18: 66,131,681 (GRCm39) T101A probably benign Het
Mapk8 A T 14: 33,110,893 (GRCm39) C245* probably null Het
Mfhas1 T A 8: 36,058,431 (GRCm39) W969R probably damaging Het
Mlxipl A T 5: 135,135,853 (GRCm39) D26V probably damaging Het
Msh5 A G 17: 35,265,016 (GRCm39) V53A probably benign Het
Msl2 C A 9: 100,979,183 (GRCm39) A519D probably damaging Het
Nbeal1 A G 1: 60,245,503 (GRCm39) S176G probably benign Het
Ninl T A 2: 150,817,763 (GRCm39) K134* probably null Het
Or10d1 A G 9: 39,484,283 (GRCm39) S91P probably damaging Het
Or1e25 T A 11: 73,494,239 (GRCm39) Y278N probably damaging Het
Or4a68 C A 2: 89,269,689 (GRCm39) M311I probably benign Het
Pabpn1 T G 14: 55,134,609 (GRCm39) I250S probably damaging Het
Ppp4r4 G A 12: 103,542,539 (GRCm39) probably null Het
Rad51ap2 T C 12: 11,507,025 (GRCm39) S316P possibly damaging Het
Scn7a C A 2: 66,567,780 (GRCm39) W271C probably damaging Het
Set T C 2: 29,960,212 (GRCm39) S182P probably benign Het
Sez6l T C 5: 112,620,618 (GRCm39) T321A possibly damaging Het
Sfpq A T 4: 126,915,295 (GRCm39) H29L unknown Het
Slc33a1 A G 3: 63,855,577 (GRCm39) L356P probably damaging Het
Sptbn1 C G 11: 30,109,293 (GRCm39) probably null Het
Srrd C T 5: 112,486,316 (GRCm39) G179D probably benign Het
Taf4b T C 18: 14,940,456 (GRCm39) S312P probably damaging Het
Tgfbrap1 A T 1: 43,093,794 (GRCm39) L566* probably null Het
Tln2 T A 9: 67,304,935 (GRCm39) M1L probably benign Het
Ttc27 T C 17: 75,163,497 (GRCm39) F702L probably benign Het
Vmn2r54 C T 7: 12,363,637 (GRCm39) G419R possibly damaging Het
Vps13b A G 15: 35,884,887 (GRCm39) S3187G probably damaging Het
Vps13d C A 4: 144,907,685 (GRCm39) probably null Het
Vps35l T C 7: 118,411,097 (GRCm39) F677L probably damaging Het
Zfp568 A T 7: 29,688,507 (GRCm39) E23V probably null Het
Other mutations in Adgrf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00425:Adgrf4 APN 17 42,977,547 (GRCm39) missense probably damaging 1.00
IGL00474:Adgrf4 APN 17 42,986,650 (GRCm39) missense probably damaging 0.97
IGL00913:Adgrf4 APN 17 42,977,793 (GRCm39) missense possibly damaging 0.81
IGL02134:Adgrf4 APN 17 42,980,581 (GRCm39) missense probably damaging 1.00
IGL02225:Adgrf4 APN 17 42,974,269 (GRCm39) critical splice donor site probably null
IGL02423:Adgrf4 APN 17 42,983,467 (GRCm39) missense probably benign 0.06
IGL02945:Adgrf4 APN 17 42,978,257 (GRCm39) missense probably benign
R0329:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R0330:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R1595:Adgrf4 UTSW 17 42,978,764 (GRCm39) missense probably benign 0.09
R1739:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1762:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1783:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1785:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2069:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2140:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2142:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2230:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2232:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2288:Adgrf4 UTSW 17 42,978,402 (GRCm39) missense probably benign
R3107:Adgrf4 UTSW 17 42,977,758 (GRCm39) nonsense probably null
R3732:Adgrf4 UTSW 17 42,983,472 (GRCm39) missense probably damaging 1.00
R4003:Adgrf4 UTSW 17 42,980,650 (GRCm39) missense probably damaging 1.00
R4158:Adgrf4 UTSW 17 42,978,568 (GRCm39) missense probably benign
R4160:Adgrf4 UTSW 17 42,978,568 (GRCm39) missense probably benign
R4163:Adgrf4 UTSW 17 42,978,477 (GRCm39) missense probably benign
R4865:Adgrf4 UTSW 17 42,978,156 (GRCm39) missense probably damaging 1.00
R4940:Adgrf4 UTSW 17 42,977,420 (GRCm39) missense possibly damaging 0.90
R5411:Adgrf4 UTSW 17 42,978,104 (GRCm39) missense probably damaging 1.00
R5512:Adgrf4 UTSW 17 42,978,176 (GRCm39) missense probably benign 0.03
R6421:Adgrf4 UTSW 17 42,983,392 (GRCm39) missense probably damaging 1.00
R7089:Adgrf4 UTSW 17 42,977,424 (GRCm39) missense possibly damaging 0.95
R7261:Adgrf4 UTSW 17 42,978,326 (GRCm39) missense probably benign 0.01
R7359:Adgrf4 UTSW 17 42,978,003 (GRCm39) missense possibly damaging 0.78
R7502:Adgrf4 UTSW 17 42,980,548 (GRCm39) missense possibly damaging 0.53
R7522:Adgrf4 UTSW 17 42,980,675 (GRCm39) missense probably benign 0.04
R7555:Adgrf4 UTSW 17 42,983,494 (GRCm39) missense probably benign 0.16
R7567:Adgrf4 UTSW 17 42,978,333 (GRCm39) missense probably benign
R7743:Adgrf4 UTSW 17 42,983,453 (GRCm39) nonsense probably null
R8002:Adgrf4 UTSW 17 42,978,683 (GRCm39) missense probably benign 0.05
R8210:Adgrf4 UTSW 17 42,978,441 (GRCm39) missense probably damaging 1.00
R8344:Adgrf4 UTSW 17 42,977,799 (GRCm39) missense probably benign 0.00
R8429:Adgrf4 UTSW 17 42,978,340 (GRCm39) missense probably benign
R9131:Adgrf4 UTSW 17 42,978,258 (GRCm39) missense probably benign 0.00
R9159:Adgrf4 UTSW 17 42,973,293 (GRCm39) missense probably benign
R9214:Adgrf4 UTSW 17 42,978,704 (GRCm39) missense possibly damaging 0.89
R9226:Adgrf4 UTSW 17 42,980,606 (GRCm39) missense probably damaging 1.00
R9237:Adgrf4 UTSW 17 42,980,782 (GRCm39) missense probably benign
R9546:Adgrf4 UTSW 17 42,978,283 (GRCm39) nonsense probably null
X0027:Adgrf4 UTSW 17 42,978,419 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCTCTGAGGAACTGTGAGAG -3'
(R):5'- GGTTGACATAAAACTAGCCAGGAC -3'

Sequencing Primer
(F):5'- GAGATACGAGAGCCTTTCGTC -3'
(R):5'- GCCAGGACAACATATTCTTTATAGCC -3'
Posted On 2014-08-25