Incidental Mutation 'R2039:Ugt1a10'
ID 225375
Institutional Source Beutler Lab
Gene Symbol Ugt1a10
Ensembl Gene ENSMUSG00000090165
Gene Name UDP glycosyltransferase 1 family, polypeptide A10
Synonyms A13
MMRRC Submission 040046-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R2039 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 87983110-88146726 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87983703 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 167 (I167S)
Ref Sequence ENSEMBL: ENSMUSP00000108767 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113142] [ENSMUST00000138182] [ENSMUST00000173325]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000113142
AA Change: I167S

PolyPhen 2 Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000108767
Gene: ENSMUSG00000090165
AA Change: I167S

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:UDPGT 26 521 7.3e-231 PFAM
Pfam:Glyco_tran_28_C 360 449 1.3e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138182
SMART Domains Protein: ENSMUSP00000119985
Gene: ENSMUSG00000090165

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:UDPGT 26 62 7e-11 PFAM
Pfam:UDPGT 58 207 1.9e-90 PFAM
Pfam:Glyco_tran_28_C 137 207 4.8e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173165
Predicted Effect probably benign
Transcript: ENSMUST00000173325
SMART Domains Protein: ENSMUSP00000134443
Gene: ENSMUSG00000090165

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:UDPGT 26 61 3.4e-10 PFAM
Pfam:UDPGT 59 210 8.9e-92 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 96% (45/47)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C A 6: 121,636,908 (GRCm39) T757K probably benign Het
Abca14 T C 7: 119,911,487 (GRCm39) V1357A probably damaging Het
Abca5 A G 11: 110,190,755 (GRCm39) F785S probably damaging Het
Bltp1 T A 3: 37,058,027 (GRCm39) F3206I possibly damaging Het
Bmal1 T G 7: 112,884,319 (GRCm39) L119R probably damaging Het
Cacna1h T C 17: 25,610,819 (GRCm39) I554V probably benign Het
Cuzd1 A T 7: 130,916,643 (GRCm39) probably benign Het
Cuzd1 T C 7: 130,911,345 (GRCm39) S545G probably benign Het
Edrf1 T A 7: 133,255,678 (GRCm39) Y574* probably null Het
Eef1d T C 15: 75,767,618 (GRCm39) D252G probably damaging Het
Efna5 T G 17: 63,188,061 (GRCm39) D22A probably benign Het
Esyt1 C T 10: 128,347,820 (GRCm39) V957I probably benign Het
Etl4 T C 2: 20,790,039 (GRCm39) S881P probably damaging Het
Exoc3 A G 13: 74,341,096 (GRCm39) I236T probably benign Het
Far2 T C 6: 148,067,075 (GRCm39) L320S probably benign Het
Fsd1l T A 4: 53,679,972 (GRCm39) D223E probably benign Het
Fut1 C T 7: 45,268,415 (GRCm39) A123V possibly damaging Het
Gap43 A T 16: 42,112,715 (GRCm39) D15E possibly damaging Het
Gm12789 T C 4: 101,846,183 (GRCm39) probably benign Het
Gm5114 T A 7: 39,058,612 (GRCm39) T336S probably damaging Het
Hhla1 G A 15: 65,808,226 (GRCm39) T273I possibly damaging Het
Hira A G 16: 18,770,451 (GRCm39) H812R probably benign Het
Hsp90aa1 T C 12: 110,660,216 (GRCm39) N360S probably damaging Het
Kmt2c A G 5: 25,534,038 (GRCm39) L1463S possibly damaging Het
Lman2l A G 1: 36,467,535 (GRCm39) F171S probably damaging Het
Lrfn5 T C 12: 61,887,109 (GRCm39) L299S possibly damaging Het
Msr1 A T 8: 40,042,418 (GRCm39) W386R probably damaging Het
Myo1e T C 9: 70,227,415 (GRCm39) V162A possibly damaging Het
Npy6r A G 18: 44,409,070 (GRCm39) T164A probably benign Het
Or52e4 T C 7: 104,705,597 (GRCm39) L48P possibly damaging Het
Rbak C A 5: 143,158,930 (GRCm39) V708L probably benign Het
Rev3l A G 10: 39,700,440 (GRCm39) I1646V probably damaging Het
Rsrc1 A G 3: 66,901,951 (GRCm39) T34A unknown Het
Septin9 G A 11: 117,242,443 (GRCm39) V53I probably damaging Het
Snrnp200 G A 2: 127,076,904 (GRCm39) A1646T probably benign Het
Spata31h1 A G 10: 82,120,510 (GRCm39) S4167P probably damaging Het
Sqor G A 2: 122,634,324 (GRCm39) probably null Het
St7 T C 6: 17,886,111 (GRCm39) Y358H probably damaging Het
Tafa1 C A 6: 96,631,725 (GRCm39) probably null Het
Tas2r126 T A 6: 42,411,557 (GRCm39) M30K probably benign Het
Thsd7a G A 6: 12,408,922 (GRCm39) T700I possibly damaging Het
Ttn T G 2: 76,698,810 (GRCm39) probably benign Het
Uhmk1 T C 1: 170,039,836 (GRCm39) D88G probably damaging Het
Washc2 T A 6: 116,201,400 (GRCm39) F332Y probably damaging Het
Wdr48 T A 9: 119,738,453 (GRCm39) W38R probably damaging Het
Zfc3h1 A G 10: 115,242,388 (GRCm39) D622G probably damaging Het
Other mutations in Ugt1a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01126:Ugt1a10 APN 1 87,983,709 (GRCm39) missense possibly damaging 0.72
IGL02219:Ugt1a10 APN 1 87,983,780 (GRCm39) missense probably benign 0.00
IGL02511:Ugt1a10 APN 1 87,983,585 (GRCm39) missense probably damaging 1.00
IGL02990:Ugt1a10 APN 1 87,983,601 (GRCm39) missense probably damaging 1.00
PIT4142001:Ugt1a10 UTSW 1 88,143,880 (GRCm39) small deletion probably benign
R0201:Ugt1a10 UTSW 1 88,145,971 (GRCm39) missense probably damaging 1.00
R0201:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R0522:Ugt1a10 UTSW 1 88,145,971 (GRCm39) missense probably damaging 1.00
R0525:Ugt1a10 UTSW 1 88,145,971 (GRCm39) missense probably damaging 1.00
R0554:Ugt1a10 UTSW 1 87,983,817 (GRCm39) missense probably damaging 1.00
R0748:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R0811:Ugt1a10 UTSW 1 87,983,904 (GRCm39) missense probably benign 0.33
R0812:Ugt1a10 UTSW 1 87,983,904 (GRCm39) missense probably benign 0.33
R1129:Ugt1a10 UTSW 1 87,983,331 (GRCm39) missense probably benign
R1207:Ugt1a10 UTSW 1 88,143,976 (GRCm39) missense probably damaging 1.00
R1432:Ugt1a10 UTSW 1 88,143,982 (GRCm39) missense probably damaging 1.00
R1457:Ugt1a10 UTSW 1 87,983,433 (GRCm39) missense probably damaging 1.00
R1469:Ugt1a10 UTSW 1 88,143,976 (GRCm39) missense probably damaging 1.00
R1972:Ugt1a10 UTSW 1 87,983,769 (GRCm39) missense probably damaging 1.00
R1973:Ugt1a10 UTSW 1 87,983,769 (GRCm39) missense probably damaging 1.00
R2307:Ugt1a10 UTSW 1 87,983,669 (GRCm39) missense probably benign 0.01
R3952:Ugt1a10 UTSW 1 88,143,862 (GRCm39) missense probably damaging 1.00
R3973:Ugt1a10 UTSW 1 88,143,862 (GRCm39) missense probably damaging 1.00
R4232:Ugt1a10 UTSW 1 87,983,932 (GRCm39) missense probably benign 0.39
R4392:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R4393:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R4402:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R4417:Ugt1a10 UTSW 1 87,983,717 (GRCm39) missense probably benign
R4474:Ugt1a10 UTSW 1 88,143,650 (GRCm39) intron probably benign
R4476:Ugt1a10 UTSW 1 88,143,650 (GRCm39) intron probably benign
R4515:Ugt1a10 UTSW 1 87,983,919 (GRCm39) missense probably damaging 1.00
R4579:Ugt1a10 UTSW 1 87,983,838 (GRCm39) missense probably benign
R4582:Ugt1a10 UTSW 1 87,983,463 (GRCm39) missense possibly damaging 0.90
R4609:Ugt1a10 UTSW 1 87,983,204 (GRCm39) start codon destroyed possibly damaging 0.92
R4627:Ugt1a10 UTSW 1 88,146,112 (GRCm39) missense probably damaging 1.00
R4790:Ugt1a10 UTSW 1 87,984,009 (GRCm39) missense probably damaging 0.98
R4799:Ugt1a10 UTSW 1 88,143,650 (GRCm39) intron probably benign
R4910:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R4915:Ugt1a10 UTSW 1 87,983,646 (GRCm39) missense probably damaging 1.00
R5110:Ugt1a10 UTSW 1 87,983,974 (GRCm39) splice site probably null
R5168:Ugt1a10 UTSW 1 87,983,531 (GRCm39) missense probably benign 0.01
R5329:Ugt1a10 UTSW 1 88,143,976 (GRCm39) missense probably damaging 1.00
R5373:Ugt1a10 UTSW 1 87,983,632 (GRCm39) missense probably damaging 0.98
R5374:Ugt1a10 UTSW 1 87,983,632 (GRCm39) missense probably damaging 0.98
R5615:Ugt1a10 UTSW 1 88,143,880 (GRCm39) small deletion probably benign
R6498:Ugt1a10 UTSW 1 88,143,862 (GRCm39) missense probably damaging 1.00
R6727:Ugt1a10 UTSW 1 87,983,979 (GRCm39) splice site probably null
R6809:Ugt1a10 UTSW 1 87,983,647 (GRCm39) missense probably damaging 0.98
R6924:Ugt1a10 UTSW 1 87,983,379 (GRCm39) missense probably damaging 0.99
R6967:Ugt1a10 UTSW 1 88,142,845 (GRCm39) missense probably damaging 1.00
R7913:Ugt1a10 UTSW 1 87,983,477 (GRCm39) missense probably benign 0.00
R9165:Ugt1a10 UTSW 1 87,983,509 (GRCm39) missense probably benign 0.00
R9264:Ugt1a10 UTSW 1 87,983,393 (GRCm39) missense possibly damaging 0.62
R9475:Ugt1a10 UTSW 1 88,143,982 (GRCm39) missense probably damaging 1.00
S24628:Ugt1a10 UTSW 1 88,143,880 (GRCm39) small deletion probably benign
X0013:Ugt1a10 UTSW 1 88,143,976 (GRCm39) missense probably damaging 1.00
Z1088:Ugt1a10 UTSW 1 87,983,564 (GRCm39) missense probably benign 0.20
Z1190:Ugt1a10 UTSW 1 88,143,880 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- ATGACAGGCTCAGCTAGAGG -3'
(R):5'- TCATAGTCACTGGGGTCTGC -3'

Sequencing Primer
(F):5'- CTCAGCTAGAGGTTTCTTTGAAC -3'
(R):5'- TCTGCAGAACTTCAGAGGC -3'
Posted On 2014-08-25