Incidental Mutation 'R1995:Or5d35'
ID 225658
Institutional Source Beutler Lab
Gene Symbol Or5d35
Ensembl Gene ENSMUSG00000045150
Gene Name olfactory receptor family 5 subfamily D member 35
Synonyms MOR174-2, GA_x6K02T2Q125-49516664-49517629, Olfr1161
MMRRC Submission 040005-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R1995 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87855046-87856057 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87856016 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 317 (S317T)
Ref Sequence ENSEMBL: ENSMUSP00000150220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054845] [ENSMUST00000214438] [ENSMUST00000217006]
AlphaFold Q7TR29
Predicted Effect probably benign
Transcript: ENSMUST00000054845
AA Change: S317T

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000060977
Gene: ENSMUSG00000045150
AA Change: S317T

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 8.8e-52 PFAM
Pfam:7tm_1 42 291 9e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214438
AA Change: S317T

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000217006
AA Change: S317T

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtpbp1 T G 13: 59,678,872 (GRCm39) K145N probably damaging Het
AY358078 T A 14: 52,063,519 (GRCm39) D388E probably damaging Het
Btbd9 A G 17: 30,493,904 (GRCm39) Y496H possibly damaging Het
Catsperb T A 12: 101,569,026 (GRCm39) N899K possibly damaging Het
Cenpl T C 1: 160,905,994 (GRCm39) S123P probably damaging Het
Cep120 G A 18: 53,873,208 (GRCm39) T41I probably damaging Het
Cep295 C T 9: 15,252,179 (GRCm39) E397K probably damaging Het
Cnbd1 G A 4: 19,055,112 (GRCm39) P105S possibly damaging Het
Col6a1 T C 10: 76,557,790 (GRCm39) N149D probably damaging Het
Ctnna3 T A 10: 63,656,143 (GRCm39) V241D probably damaging Het
Dcbld2 A C 16: 58,276,695 (GRCm39) E495D probably benign Het
Dmp1 T G 5: 104,357,779 (GRCm39) S40A possibly damaging Het
Dpysl4 A G 7: 138,676,686 (GRCm39) I379V probably benign Het
Eral1 C T 11: 77,965,315 (GRCm39) G367S probably benign Het
Fah C T 7: 84,251,389 (GRCm39) R31Q probably damaging Het
Fbn1 T A 2: 125,192,293 (GRCm39) probably null Het
Fbxo40 T C 16: 36,790,231 (GRCm39) D293G probably damaging Het
Gemin6 A C 17: 80,535,414 (GRCm39) T125P probably damaging Het
Gpbar1 G A 1: 74,318,603 (GRCm39) G282D possibly damaging Het
Gria2 G A 3: 80,709,664 (GRCm39) L10F probably benign Het
Gucy1b1 A G 3: 81,942,160 (GRCm39) I533T probably damaging Het
H2-M9 A T 17: 36,952,678 (GRCm39) Y123N probably damaging Het
Hipk2 C A 6: 38,692,909 (GRCm39) D868Y probably damaging Het
Itprid1 T C 6: 55,945,694 (GRCm39) I805T probably benign Het
Jarid2 T C 13: 45,027,917 (GRCm39) L123P probably damaging Het
Kcnb2 C A 1: 15,779,990 (GRCm39) N287K possibly damaging Het
Kdm8 G A 7: 125,051,511 (GRCm39) G35S probably benign Het
Kirrel1 G T 3: 87,003,093 (GRCm39) A100D possibly damaging Het
Ltbp2 T G 12: 84,855,220 (GRCm39) probably null Het
Mfsd12 C A 10: 81,193,515 (GRCm39) H28Q probably damaging Het
Neb C T 2: 52,188,744 (GRCm39) V837M probably damaging Het
Nkain2 A G 10: 32,278,347 (GRCm39) I26T possibly damaging Het
Nuggc A G 14: 65,848,623 (GRCm39) R175G probably benign Het
Or10ag57 T G 2: 87,218,175 (GRCm39) I42R probably damaging Het
Or5ac23 A G 16: 59,149,654 (GRCm39) S73P probably damaging Het
Or8g52 T C 9: 39,630,709 (GRCm39) F62S probably damaging Het
Pcnt G A 10: 76,228,633 (GRCm39) Q1511* probably null Het
Piezo2 G T 18: 63,211,852 (GRCm39) T1311K probably damaging Het
Pik3c2a T C 7: 115,953,241 (GRCm39) Y1218C probably damaging Het
Pik3r4 T A 9: 105,546,364 (GRCm39) S905T probably benign Het
Pikfyve T A 1: 65,285,867 (GRCm39) D1035E probably damaging Het
Pkn3 G C 2: 29,979,989 (GRCm39) G744A probably damaging Het
Pms1 A G 1: 53,234,174 (GRCm39) S781P probably benign Het
Pogz C T 3: 94,785,255 (GRCm39) R793W probably damaging Het
Prrc2a A T 17: 35,376,405 (GRCm39) V795D probably damaging Het
Rock1 G A 18: 10,101,026 (GRCm39) R630* probably null Het
Scd4 T A 19: 44,322,617 (GRCm39) I70N possibly damaging Het
Serpine2 A G 1: 79,799,159 (GRCm39) S32P probably damaging Het
Slc9c1 A C 16: 45,374,618 (GRCm39) T328P probably damaging Het
Spata31d1b G C 13: 59,864,194 (GRCm39) L447F probably benign Het
Speer2 A G 16: 69,654,965 (GRCm39) S167P probably benign Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Tbcel C A 9: 42,362,957 (GRCm39) G29W probably damaging Het
Tmcc3 T C 10: 94,414,468 (GRCm39) S57P possibly damaging Het
Tmem240 T A 4: 155,824,304 (GRCm39) D125E possibly damaging Het
Ttll7 G A 3: 146,667,510 (GRCm39) C792Y possibly damaging Het
Vmn1r177 T A 7: 23,565,112 (GRCm39) I255F probably damaging Het
Zp2 T A 7: 119,734,388 (GRCm39) I554F probably damaging Het
Other mutations in Or5d35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Or5d35 APN 2 87,855,347 (GRCm39) missense probably benign 0.23
IGL01564:Or5d35 APN 2 87,855,648 (GRCm39) missense probably benign 0.00
IGL01588:Or5d35 APN 2 87,855,417 (GRCm39) missense probably benign
R0268:Or5d35 UTSW 2 87,855,812 (GRCm39) missense probably damaging 0.99
R1587:Or5d35 UTSW 2 87,855,477 (GRCm39) missense probably damaging 1.00
R2249:Or5d35 UTSW 2 87,855,707 (GRCm39) missense probably damaging 0.98
R3813:Or5d35 UTSW 2 87,855,105 (GRCm39) missense probably damaging 1.00
R4473:Or5d35 UTSW 2 87,855,464 (GRCm39) missense probably damaging 1.00
R4772:Or5d35 UTSW 2 87,855,207 (GRCm39) missense probably damaging 0.99
R4787:Or5d35 UTSW 2 87,855,204 (GRCm39) missense possibly damaging 0.79
R4870:Or5d35 UTSW 2 87,855,804 (GRCm39) missense probably damaging 1.00
R5260:Or5d35 UTSW 2 87,855,818 (GRCm39) missense probably benign 0.02
R5896:Or5d35 UTSW 2 87,855,465 (GRCm39) missense probably damaging 0.98
R6262:Or5d35 UTSW 2 87,855,738 (GRCm39) missense probably benign 0.00
R7330:Or5d35 UTSW 2 87,855,265 (GRCm39) missense possibly damaging 0.59
R8702:Or5d35 UTSW 2 87,855,839 (GRCm39) missense possibly damaging 0.69
R9100:Or5d35 UTSW 2 87,855,330 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTCTACTCTGTACCCAACTCAAAG -3'
(R):5'- TCCTTGGGGTGTCATAAAGAAGG -3'

Sequencing Primer
(F):5'- GAACTCCCAGCTCACATTCAAAGTG -3'
(R):5'- AGGGGTATGGTAGAAATGCTATTATG -3'
Posted On 2014-08-25