Incidental Mutation 'R1996:Robo1'
| ID |
225791 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
040006-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1996 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 72767067 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 413
(R413L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023600
AA Change: R413L
PolyPhen 2
Score 0.402 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: R413L
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000232205
AA Change: R422L
|
| Meta Mutation Damage Score |
0.1301 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
99% (84/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
T |
A |
6: 121,646,556 (GRCm39) |
W1069R |
probably damaging |
Het |
| Aaas |
C |
T |
15: 102,248,494 (GRCm39) |
V241I |
probably benign |
Het |
| Abca3 |
A |
G |
17: 24,606,506 (GRCm39) |
E787G |
probably damaging |
Het |
| Abi3bp |
A |
T |
16: 56,491,720 (GRCm39) |
E582D |
possibly damaging |
Het |
| Adam21 |
A |
G |
12: 81,606,376 (GRCm39) |
M462T |
possibly damaging |
Het |
| Alox12e |
T |
C |
11: 70,207,034 (GRCm39) |
T591A |
probably benign |
Het |
| Ankmy2 |
T |
C |
12: 36,243,796 (GRCm39) |
M337T |
probably benign |
Het |
| Antxrl |
A |
G |
14: 33,797,786 (GRCm39) |
N587S |
probably benign |
Het |
| Apol6 |
T |
A |
15: 76,934,956 (GRCm39) |
I75N |
probably benign |
Het |
| Atad2b |
A |
T |
12: 5,040,883 (GRCm39) |
H184L |
probably benign |
Het |
| Atf6b |
A |
T |
17: 34,871,961 (GRCm39) |
|
probably null |
Het |
| B3gnt4 |
G |
A |
5: 123,649,402 (GRCm39) |
V256I |
probably damaging |
Het |
| BC034090 |
C |
T |
1: 155,097,340 (GRCm39) |
|
probably benign |
Het |
| Bend4 |
C |
A |
5: 67,557,527 (GRCm39) |
V430F |
probably damaging |
Het |
| Camkv |
A |
G |
9: 107,824,320 (GRCm39) |
D244G |
probably damaging |
Het |
| Caps2 |
T |
A |
10: 112,039,908 (GRCm39) |
L450Q |
probably damaging |
Het |
| Ccr1 |
T |
A |
9: 123,763,551 (GRCm39) |
K326N |
probably benign |
Het |
| Cep135 |
T |
C |
5: 76,780,113 (GRCm39) |
I815T |
probably benign |
Het |
| Chchd4 |
A |
G |
6: 91,442,116 (GRCm39) |
Y101H |
probably damaging |
Het |
| Copb1 |
G |
C |
7: 113,831,438 (GRCm39) |
A570G |
probably benign |
Het |
| Cpsf2 |
C |
A |
12: 101,964,867 (GRCm39) |
T505K |
probably benign |
Het |
| Cwf19l2 |
A |
G |
9: 3,417,947 (GRCm39) |
R136G |
probably benign |
Het |
| Daxx |
A |
G |
17: 34,132,585 (GRCm39) |
T572A |
possibly damaging |
Het |
| Etaa1 |
C |
A |
11: 17,902,671 (GRCm39) |
D89Y |
probably damaging |
Het |
| Ezhip |
GTCATCATCATCATC |
GTCATCATCATCATCATC |
X: 5,994,645 (GRCm39) |
|
probably benign |
Het |
| Fchsd2 |
T |
C |
7: 100,927,660 (GRCm39) |
F701L |
probably benign |
Het |
| Fstl5 |
A |
T |
3: 76,615,141 (GRCm39) |
H734L |
probably benign |
Het |
| Gabbr1 |
T |
A |
17: 37,380,112 (GRCm39) |
W584R |
probably damaging |
Het |
| Galc |
T |
C |
12: 98,218,285 (GRCm39) |
D189G |
probably damaging |
Het |
| Gm9979 |
T |
C |
13: 40,859,228 (GRCm39) |
|
noncoding transcript |
Het |
| Grin2b |
T |
C |
6: 136,021,209 (GRCm39) |
S31G |
possibly damaging |
Het |
| Gtf2ird1 |
T |
C |
5: 134,405,740 (GRCm39) |
|
probably benign |
Het |
| Hoxc4 |
T |
C |
15: 102,944,183 (GRCm39) |
I187T |
probably damaging |
Het |
| Hsd3b6 |
A |
T |
3: 98,713,597 (GRCm39) |
I234N |
probably damaging |
Het |
| Ifit3b |
T |
C |
19: 34,588,877 (GRCm39) |
C18R |
probably damaging |
Het |
| Igdcc4 |
T |
A |
9: 65,029,101 (GRCm39) |
V246E |
probably damaging |
Het |
| Il1rap |
A |
T |
16: 26,541,243 (GRCm39) |
T495S |
probably benign |
Het |
| Kctd19 |
T |
C |
8: 106,121,932 (GRCm39) |
E205G |
probably null |
Het |
| Kif21a |
A |
T |
15: 90,878,574 (GRCm39) |
C235* |
probably null |
Het |
| Krt16 |
A |
T |
11: 100,139,614 (GRCm39) |
S35T |
unknown |
Het |
| Lamc2 |
T |
C |
1: 153,030,216 (GRCm39) |
D142G |
possibly damaging |
Het |
| Larp4 |
G |
T |
15: 99,882,844 (GRCm39) |
W22L |
probably damaging |
Het |
| Ldlrad1 |
C |
T |
4: 107,072,158 (GRCm39) |
R127* |
probably null |
Het |
| Mamdc2 |
G |
A |
19: 23,341,289 (GRCm39) |
Q229* |
probably null |
Het |
| Mbtd1 |
CT |
CTT |
11: 93,823,222 (GRCm39) |
|
probably null |
Het |
| Msln |
T |
A |
17: 25,973,193 (GRCm39) |
M1L |
possibly damaging |
Het |
| Mtch2 |
T |
C |
2: 90,677,665 (GRCm39) |
V8A |
possibly damaging |
Het |
| Nav3 |
A |
T |
10: 109,689,262 (GRCm39) |
N338K |
probably damaging |
Het |
| Or10x4 |
T |
C |
1: 174,218,983 (GRCm39) |
M116T |
probably damaging |
Het |
| Or51a39 |
A |
G |
7: 102,362,999 (GRCm39) |
L207P |
probably damaging |
Het |
| Or6c5 |
C |
A |
10: 129,074,298 (GRCm39) |
N93K |
possibly damaging |
Het |
| Otof |
A |
G |
5: 30,578,381 (GRCm39) |
V89A |
probably benign |
Het |
| Phka2 |
T |
C |
X: 159,324,411 (GRCm39) |
I255T |
probably benign |
Het |
| Pias2 |
T |
C |
18: 77,216,759 (GRCm39) |
|
probably null |
Het |
| Pja2 |
T |
A |
17: 64,594,639 (GRCm39) |
|
probably null |
Het |
| Plxnb2 |
C |
T |
15: 89,042,971 (GRCm39) |
V1473I |
probably benign |
Het |
| Pnpt1 |
T |
A |
11: 29,091,679 (GRCm39) |
D363E |
probably benign |
Het |
| Prdm5 |
A |
G |
6: 65,913,072 (GRCm39) |
Y207C |
probably damaging |
Het |
| Rexo5 |
T |
A |
7: 119,423,080 (GRCm39) |
V304E |
probably damaging |
Het |
| Rsf1 |
G |
A |
7: 97,313,839 (GRCm39) |
E864K |
probably damaging |
Het |
| Scap |
C |
T |
9: 110,202,039 (GRCm39) |
|
probably benign |
Het |
| Scn8a |
T |
A |
15: 100,922,260 (GRCm39) |
M1311K |
probably damaging |
Het |
| Slc28a2 |
A |
T |
2: 122,286,043 (GRCm39) |
I460F |
probably damaging |
Het |
| Smco1 |
A |
G |
16: 32,092,730 (GRCm39) |
R134G |
probably benign |
Het |
| Spopfm1 |
A |
T |
3: 94,173,018 (GRCm39) |
M9L |
probably benign |
Het |
| Sspo |
A |
G |
6: 48,452,424 (GRCm39) |
E2651G |
possibly damaging |
Het |
| Stab2 |
T |
C |
10: 86,838,895 (GRCm39) |
N57S |
probably damaging |
Het |
| Tenm3 |
C |
A |
8: 48,681,703 (GRCm39) |
Q2642H |
probably damaging |
Het |
| Thsd7b |
G |
T |
1: 129,686,188 (GRCm39) |
E577* |
probably null |
Het |
| Tlr3 |
A |
G |
8: 45,850,734 (GRCm39) |
V721A |
probably benign |
Het |
| Tnik |
A |
G |
3: 28,719,829 (GRCm39) |
I1226V |
probably damaging |
Het |
| Traf3 |
A |
G |
12: 111,227,095 (GRCm39) |
K328E |
probably benign |
Het |
| Tyw1 |
T |
A |
5: 130,291,652 (GRCm39) |
|
probably benign |
Het |
| Vmn1r213 |
T |
G |
13: 23,196,473 (GRCm39) |
V352G |
probably benign |
Het |
| Vmn2r111 |
T |
C |
17: 22,767,062 (GRCm39) |
I812V |
probably benign |
Het |
| Vmn2r26 |
A |
G |
6: 124,038,144 (GRCm39) |
N573S |
probably damaging |
Het |
| Vmn2r45 |
G |
A |
7: 8,475,024 (GRCm39) |
T668I |
probably damaging |
Het |
| Zbtb20 |
T |
A |
16: 43,430,443 (GRCm39) |
V318E |
probably damaging |
Het |
| Zc2hc1c |
A |
G |
12: 85,343,434 (GRCm39) |
R524G |
probably benign |
Het |
| Zc3h18 |
C |
G |
8: 123,134,126 (GRCm39) |
|
probably benign |
Het |
| Zfp618 |
T |
C |
4: 63,049,452 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1773:Robo1
|
UTSW |
16 |
72,801,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1777:Robo1
|
UTSW |
16 |
72,801,555 (GRCm39) |
missense |
probably benign |
|
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6191:Robo1
|
UTSW |
16 |
72,730,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9246:Robo1
|
UTSW |
16 |
72,769,178 (GRCm39) |
missense |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9509:Robo1
|
UTSW |
16 |
72,759,167 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGGTCATTTGAAAGGCGTAC -3'
(R):5'- CGTCTTTGCAAGTTACCTTAGCG -3'
Sequencing Primer
(F):5'- GTCATTTGAAAGGCGTACATTGTATC -3'
(R):5'- TAGCGGATCTGCAGCACG -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation