Incidental Mutation 'R2001:Gria2'
| ID |
225906 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gria2
|
| Ensembl Gene |
ENSMUSG00000033981 |
| Gene Name |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
| Synonyms |
Glur-2, GluA2, GluR2, GluR-B, Glur2 |
| MMRRC Submission |
040011-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.274)
|
| Stock # |
R2001 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
80588757-80710142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 80618112 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 308
(T308A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075316]
[ENSMUST00000107745]
[ENSMUST00000192463]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075316
AA Change: T308A
PolyPhen 2
Score 0.230 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000074787
Gene: ENSMUSG00000033981
AA Change: T308A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
49 |
379 |
2.7e-58 |
PFAM |
|
PBPe
|
415 |
790 |
3.75e-132 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107745
AA Change: T308A
PolyPhen 2
Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000103374
Gene: ENSMUSG00000033981
AA Change: T308A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
47 |
379 |
4.8e-53 |
PFAM |
|
PBPe
|
415 |
790 |
8.16e-133 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192463
AA Change: T308A
PolyPhen 2
Score 0.275 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000141447
Gene: ENSMUSG00000033981
AA Change: T308A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
47 |
379 |
1.7e-51 |
PFAM |
|
PBPe
|
415 |
770 |
1.2e-105 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.2e-35 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193645
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194383
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194523
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195062
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932414N04Rik |
T |
C |
2: 68,571,800 (GRCm39) |
S559P |
probably benign |
Het |
| A430005L14Rik |
T |
A |
4: 154,044,314 (GRCm39) |
C42S |
probably damaging |
Het |
| Abca13 |
A |
T |
11: 9,223,967 (GRCm39) |
T449S |
probably benign |
Het |
| Acvr1c |
T |
A |
2: 58,205,987 (GRCm39) |
Q41L |
probably benign |
Het |
| Adamts13 |
C |
T |
2: 26,864,002 (GRCm39) |
P60L |
probably benign |
Het |
| Adamts20 |
T |
C |
15: 94,245,599 (GRCm39) |
T568A |
possibly damaging |
Het |
| Ago1 |
T |
C |
4: 126,348,187 (GRCm39) |
I44V |
probably null |
Het |
| Agtpbp1 |
TGAAGATGCATCTTGAGAAGA |
TGAAGA |
13: 59,623,617 (GRCm39) |
|
probably null |
Het |
| Ankrd28 |
A |
T |
14: 31,467,293 (GRCm39) |
V39E |
possibly damaging |
Het |
| Apaf1 |
A |
G |
10: 90,897,676 (GRCm39) |
V269A |
possibly damaging |
Het |
| Astn1 |
A |
G |
1: 158,348,091 (GRCm39) |
N506D |
probably damaging |
Het |
| BC051019 |
G |
A |
7: 109,319,758 (GRCm39) |
Q102* |
probably null |
Het |
| Bpifb5 |
A |
G |
2: 154,075,199 (GRCm39) |
T376A |
possibly damaging |
Het |
| Ccdc121rt1 |
G |
T |
1: 181,338,551 (GRCm39) |
Q134K |
probably benign |
Het |
| Ccl20 |
ATT |
ATTT |
1: 83,095,576 (GRCm39) |
|
probably null |
Het |
| Ccl6 |
G |
T |
11: 83,480,163 (GRCm39) |
P68T |
possibly damaging |
Het |
| Cd300ld |
A |
T |
11: 114,878,156 (GRCm39) |
F119I |
probably benign |
Het |
| Cdk2ap2 |
A |
G |
19: 4,147,903 (GRCm39) |
M57V |
possibly damaging |
Het |
| Cemip2 |
A |
G |
19: 21,779,351 (GRCm39) |
D387G |
probably benign |
Het |
| Chkb |
C |
T |
15: 89,312,969 (GRCm39) |
G36E |
probably damaging |
Het |
| Col11a1 |
A |
G |
3: 113,958,942 (GRCm39) |
|
probably null |
Het |
| Ctla2b |
T |
C |
13: 61,043,881 (GRCm39) |
Y120C |
probably damaging |
Het |
| Ctnnd1 |
T |
C |
2: 84,450,704 (GRCm39) |
N172S |
probably benign |
Het |
| Cyp2a22 |
G |
A |
7: 26,634,197 (GRCm39) |
P319L |
probably damaging |
Het |
| Dcaf12 |
A |
C |
4: 41,302,804 (GRCm39) |
V117G |
probably damaging |
Het |
| Ddx6 |
A |
G |
9: 44,518,831 (GRCm39) |
T48A |
probably benign |
Het |
| Dgki |
T |
C |
6: 36,842,736 (GRCm39) |
D923G |
possibly damaging |
Het |
| Dhx37 |
G |
T |
5: 125,504,528 (GRCm39) |
T345K |
probably damaging |
Het |
| Dhx9 |
A |
T |
1: 153,331,857 (GRCm39) |
Y1370* |
probably null |
Het |
| Dnah7b |
T |
C |
1: 46,181,247 (GRCm39) |
S1045P |
possibly damaging |
Het |
| Dnmbp |
G |
C |
19: 43,838,612 (GRCm39) |
T1071S |
possibly damaging |
Het |
| Dspp |
T |
A |
5: 104,326,425 (GRCm39) |
S929R |
unknown |
Het |
| Dst |
A |
T |
1: 34,223,144 (GRCm39) |
E1625D |
probably damaging |
Het |
| Egflam |
T |
A |
15: 7,272,048 (GRCm39) |
H630L |
probably benign |
Het |
| Elane |
T |
C |
10: 79,723,593 (GRCm39) |
V186A |
possibly damaging |
Het |
| Fam209 |
C |
A |
2: 172,314,689 (GRCm39) |
N59K |
probably benign |
Het |
| Gbe1 |
A |
G |
16: 70,325,814 (GRCm39) |
E617G |
probably damaging |
Het |
| Get3 |
T |
C |
8: 85,751,789 (GRCm39) |
S36G |
probably damaging |
Het |
| Gfra1 |
A |
G |
19: 58,288,707 (GRCm39) |
L246P |
probably damaging |
Het |
| Grip2 |
A |
T |
6: 91,756,831 (GRCm39) |
V540D |
probably benign |
Het |
| Hhipl1 |
A |
T |
12: 108,288,118 (GRCm39) |
I575F |
possibly damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,614,364 (GRCm39) |
E1347D |
possibly damaging |
Het |
| Itga2b |
C |
A |
11: 102,358,165 (GRCm39) |
A187S |
probably benign |
Het |
| Kalrn |
C |
A |
16: 33,848,415 (GRCm39) |
R469M |
probably damaging |
Het |
| Kif23 |
A |
T |
9: 61,834,666 (GRCm39) |
C426* |
probably null |
Het |
| Lck |
T |
C |
4: 129,442,730 (GRCm39) |
N475S |
probably benign |
Het |
| Leng8 |
A |
G |
7: 4,148,073 (GRCm39) |
N642S |
probably damaging |
Het |
| Lingo4 |
T |
A |
3: 94,310,382 (GRCm39) |
I440N |
probably damaging |
Het |
| Lrrc4 |
A |
G |
6: 28,830,904 (GRCm39) |
F237S |
probably damaging |
Het |
| Magel2 |
G |
A |
7: 62,028,844 (GRCm39) |
V583I |
unknown |
Het |
| Naip2 |
A |
T |
13: 100,281,096 (GRCm39) |
I1316N |
probably damaging |
Het |
| Naip6 |
C |
T |
13: 100,437,237 (GRCm39) |
G429S |
probably benign |
Het |
| Noct |
C |
T |
3: 51,155,465 (GRCm39) |
R78C |
probably damaging |
Het |
| Npbwr1 |
A |
G |
1: 5,987,394 (GRCm39) |
V40A |
possibly damaging |
Het |
| Nsd2 |
A |
G |
5: 34,000,746 (GRCm39) |
N88D |
probably damaging |
Het |
| Or1e29 |
T |
A |
11: 73,667,539 (GRCm39) |
I205F |
probably benign |
Het |
| Or5ap2 |
T |
A |
2: 85,680,744 (GRCm39) |
V316E |
probably benign |
Het |
| Or6c210 |
T |
A |
10: 129,496,290 (GRCm39) |
I205N |
probably benign |
Het |
| Or8k28 |
T |
C |
2: 86,285,817 (GRCm39) |
H266R |
probably benign |
Het |
| Pak5 |
T |
A |
2: 135,958,557 (GRCm39) |
H177L |
probably benign |
Het |
| Pard3 |
C |
T |
8: 127,791,097 (GRCm39) |
|
probably null |
Het |
| Pde4c |
A |
G |
8: 71,200,007 (GRCm39) |
|
probably null |
Het |
| Pde6h |
T |
A |
6: 136,940,203 (GRCm39) |
I63N |
probably damaging |
Het |
| Phldb2 |
T |
C |
16: 45,594,558 (GRCm39) |
K916E |
possibly damaging |
Het |
| Ppig |
T |
C |
2: 69,571,988 (GRCm39) |
S236P |
unknown |
Het |
| Ptprd |
T |
C |
4: 75,872,359 (GRCm39) |
Y1370C |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,493,083 (GRCm39) |
T352A |
probably benign |
Het |
| Rab3gap1 |
A |
G |
1: 127,831,456 (GRCm39) |
Y177C |
possibly damaging |
Het |
| Rasgef1a |
G |
A |
6: 118,066,157 (GRCm39) |
V457M |
probably benign |
Het |
| Scel |
A |
T |
14: 103,848,226 (GRCm39) |
T616S |
possibly damaging |
Het |
| Sel1l |
A |
T |
12: 91,793,324 (GRCm39) |
Y228* |
probably null |
Het |
| Sgms1 |
A |
G |
19: 32,137,083 (GRCm39) |
V161A |
possibly damaging |
Het |
| Slfnl1 |
T |
C |
4: 120,390,424 (GRCm39) |
L25P |
probably benign |
Het |
| Smad5 |
A |
G |
13: 56,885,187 (GRCm39) |
T432A |
probably damaging |
Het |
| Sohlh2 |
T |
C |
3: 55,099,762 (GRCm39) |
|
probably null |
Het |
| Sphkap |
A |
T |
1: 83,254,383 (GRCm39) |
M835K |
probably damaging |
Het |
| Sqor |
A |
C |
2: 122,640,018 (GRCm39) |
T174P |
probably damaging |
Het |
| Stkld1 |
T |
C |
2: 26,842,759 (GRCm39) |
V577A |
probably damaging |
Het |
| Sulf2 |
T |
A |
2: 165,922,773 (GRCm39) |
E652D |
probably benign |
Het |
| Sycp2 |
T |
A |
2: 178,019,848 (GRCm39) |
Q556L |
probably benign |
Het |
| Syk |
A |
G |
13: 52,765,274 (GRCm39) |
T134A |
probably benign |
Het |
| Tas2r122 |
T |
A |
6: 132,688,585 (GRCm39) |
I103F |
possibly damaging |
Het |
| Tex10 |
A |
G |
4: 48,451,940 (GRCm39) |
W729R |
probably damaging |
Het |
| Tex261 |
G |
T |
6: 83,750,713 (GRCm39) |
P95T |
probably damaging |
Het |
| Tm2d2 |
T |
C |
8: 25,507,523 (GRCm39) |
S47P |
probably benign |
Het |
| Tmem95 |
A |
G |
11: 69,767,817 (GRCm39) |
S128P |
probably damaging |
Het |
| Tnxb |
G |
A |
17: 34,911,553 (GRCm39) |
A1619T |
possibly damaging |
Het |
| Trappc9 |
A |
G |
15: 72,929,885 (GRCm39) |
I157T |
probably damaging |
Het |
| Unc13c |
T |
A |
9: 73,390,897 (GRCm39) |
|
probably null |
Het |
| Upb1 |
A |
T |
10: 75,265,803 (GRCm39) |
Y210F |
probably damaging |
Het |
| Urb1 |
T |
C |
16: 90,559,232 (GRCm39) |
M1684V |
probably benign |
Het |
| Wnk2 |
G |
A |
13: 49,232,158 (GRCm39) |
P727S |
possibly damaging |
Het |
| Zfp1004 |
T |
A |
2: 150,034,867 (GRCm39) |
M396K |
probably benign |
Het |
| Zfp551 |
A |
T |
7: 12,150,276 (GRCm39) |
S378T |
probably damaging |
Het |
| Zfp598 |
T |
C |
17: 24,888,898 (GRCm39) |
V56A |
possibly damaging |
Het |
| Zfp945 |
C |
T |
17: 23,076,223 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Gria2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00796:Gria2
|
APN |
3 |
80,618,097 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL00832:Gria2
|
APN |
3 |
80,614,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Gria2
|
APN |
3 |
80,599,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Gria2
|
APN |
3 |
80,615,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01924:Gria2
|
APN |
3 |
80,617,638 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01999:Gria2
|
APN |
3 |
80,639,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02362:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02389:Gria2
|
APN |
3 |
80,616,729 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02444:Gria2
|
APN |
3 |
80,609,860 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02532:Gria2
|
APN |
3 |
80,614,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Gria2
|
UTSW |
3 |
80,615,116 (GRCm39) |
nonsense |
probably null |
|
|
R0015:Gria2
|
UTSW |
3 |
80,615,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Gria2
|
UTSW |
3 |
80,615,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Gria2
|
UTSW |
3 |
80,615,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Gria2
|
UTSW |
3 |
80,618,165 (GRCm39) |
splice site |
probably benign |
|
|
R0551:Gria2
|
UTSW |
3 |
80,639,333 (GRCm39) |
splice site |
probably benign |
|
|
R0655:Gria2
|
UTSW |
3 |
80,639,377 (GRCm39) |
nonsense |
probably null |
|
|
R0866:Gria2
|
UTSW |
3 |
80,629,331 (GRCm39) |
splice site |
probably benign |
|
|
R1393:Gria2
|
UTSW |
3 |
80,614,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Gria2
|
UTSW |
3 |
80,639,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1563:Gria2
|
UTSW |
3 |
80,598,704 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1771:Gria2
|
UTSW |
3 |
80,599,608 (GRCm39) |
nonsense |
probably null |
|
|
R1775:Gria2
|
UTSW |
3 |
80,598,645 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Gria2
|
UTSW |
3 |
80,629,415 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1994:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1995:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R2389:Gria2
|
UTSW |
3 |
80,609,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Gria2
|
UTSW |
3 |
80,614,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Gria2
|
UTSW |
3 |
80,648,260 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3967:Gria2
|
UTSW |
3 |
80,618,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4285:Gria2
|
UTSW |
3 |
80,614,969 (GRCm39) |
intron |
probably benign |
|
|
R4611:Gria2
|
UTSW |
3 |
80,599,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4612:Gria2
|
UTSW |
3 |
80,639,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4616:Gria2
|
UTSW |
3 |
80,614,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4706:Gria2
|
UTSW |
3 |
80,648,297 (GRCm39) |
missense |
probably benign |
|
|
R4996:Gria2
|
UTSW |
3 |
80,614,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5502:Gria2
|
UTSW |
3 |
80,614,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5930:Gria2
|
UTSW |
3 |
80,614,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6142:Gria2
|
UTSW |
3 |
80,709,024 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6233:Gria2
|
UTSW |
3 |
80,614,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6317:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6453:Gria2
|
UTSW |
3 |
80,648,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6526:Gria2
|
UTSW |
3 |
80,599,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Gria2
|
UTSW |
3 |
80,648,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6574:Gria2
|
UTSW |
3 |
80,596,603 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6720:Gria2
|
UTSW |
3 |
80,709,611 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7009:Gria2
|
UTSW |
3 |
80,614,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Gria2
|
UTSW |
3 |
80,596,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7191:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7225:Gria2
|
UTSW |
3 |
80,709,938 (GRCm39) |
unclassified |
probably benign |
|
|
R7374:Gria2
|
UTSW |
3 |
80,648,383 (GRCm39) |
missense |
probably benign |
|
|
R7837:Gria2
|
UTSW |
3 |
80,618,095 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8034:Gria2
|
UTSW |
3 |
80,709,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8125:Gria2
|
UTSW |
3 |
80,614,550 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8189:Gria2
|
UTSW |
3 |
80,629,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8209:Gria2
|
UTSW |
3 |
80,616,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8362:Gria2
|
UTSW |
3 |
80,615,197 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8481:Gria2
|
UTSW |
3 |
80,708,998 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8500:Gria2
|
UTSW |
3 |
80,599,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Gria2
|
UTSW |
3 |
80,614,294 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8918:Gria2
|
UTSW |
3 |
80,599,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Gria2
|
UTSW |
3 |
80,618,170 (GRCm39) |
intron |
probably benign |
|
|
R8971:Gria2
|
UTSW |
3 |
80,615,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Gria2
|
UTSW |
3 |
80,709,689 (GRCm39) |
start codon destroyed |
probably null |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGTGTGAAGTCGCATCAGC -3'
(R):5'- GCATAGTCTCATTGTCCACATAC -3'
Sequencing Primer
(F):5'- GAAGTCGCATCAGCACTCATTCTG -3'
(R):5'- AGGAGCTGTGTTTAACTTCTTAGAGC -3'
|
| Posted On |
2014-08-25 |
Incidental Mutation