Incidental Mutation 'R0656:Ints13'
ID 226145
Institutional Source Beutler Lab
Gene Symbol Ints13
Ensembl Gene ENSMUSG00000040250
Gene Name integrator complex subunit 13
Synonyms 4933424B01Rik, Asun, Spata30
MMRRC Submission 038841-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R0656 (G1)
Quality Score 55
Status Validated
Chromosome 6
Chromosomal Location 146451130-146479333 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 146453959 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 240 (V240A)
Ref Sequence ENSEMBL: ENSMUSP00000145229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032427] [ENSMUST00000203545]
AlphaFold Q8QZV7
Predicted Effect probably benign
Transcript: ENSMUST00000032427
AA Change: V619A

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000032427
Gene: ENSMUSG00000040250
AA Change: V619A

DomainStartEndE-ValueType
Pfam:DUF2151 4 692 8.2e-292 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131662
SMART Domains Protein: ENSMUSP00000118000
Gene: ENSMUSG00000040250

DomainStartEndE-ValueType
Pfam:DUF2151 1 394 7.2e-171 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132963
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135277
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139546
Predicted Effect unknown
Transcript: ENSMUST00000139979
AA Change: V142A
SMART Domains Protein: ENSMUSP00000122279
Gene: ENSMUSG00000040250
AA Change: V142A

DomainStartEndE-ValueType
Pfam:DUF2151 2 216 1.6e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203545
AA Change: V240A

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000145229
Gene: ENSMUSG00000040250
AA Change: V240A

DomainStartEndE-ValueType
Pfam:DUF2151 1 96 3.8e-48 PFAM
Pfam:DUF2151 94 313 6e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204234
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152994
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.2%
Validation Efficiency 98% (92/94)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930533K18Rik T A 10: 70,704,630 (GRCm39) noncoding transcript Het
Alox5 A G 6: 116,400,291 (GRCm39) probably benign Het
Anxa11 T A 14: 25,874,421 (GRCm39) D203E probably damaging Het
Atp12a A T 14: 56,611,938 (GRCm39) N371Y probably damaging Het
Bloc1s6 A G 2: 122,584,543 (GRCm39) I39M probably benign Het
Celsr3 A C 9: 108,711,854 (GRCm39) I1688L possibly damaging Het
Cgn T C 3: 94,682,204 (GRCm39) probably benign Het
Chd4 A T 6: 125,079,930 (GRCm39) I453F probably damaging Het
Dbnl A G 11: 5,747,321 (GRCm39) T247A probably benign Het
Dpysl3 T C 18: 43,571,136 (GRCm39) E46G possibly damaging Het
Dsg1a T C 18: 20,468,949 (GRCm39) probably benign Het
Fbp1 C T 13: 63,019,099 (GRCm39) E150K probably benign Het
Flnb T A 14: 7,927,352 (GRCm38) L1854Q probably damaging Het
Gcn1 C T 5: 115,727,362 (GRCm39) T714M probably benign Het
Gm12216 A T 11: 53,704,162 (GRCm39) probably benign Het
Gpr82 T C X: 13,531,829 (GRCm39) S126P probably benign Het
Hmbs T A 9: 44,248,657 (GRCm39) H256L probably benign Het
Ibsp A T 5: 104,457,886 (GRCm39) probably null Het
Iqca1l C T 5: 24,754,760 (GRCm39) V337M possibly damaging Het
Kalrn T C 16: 33,852,837 (GRCm39) D343G probably damaging Het
Kin T C 2: 10,090,531 (GRCm39) probably benign Het
Klhdc1 T C 12: 69,304,804 (GRCm39) V192A probably benign Het
Lpar3 T A 3: 145,946,426 (GRCm39) C35S possibly damaging Het
Lrrtm4 A G 6: 79,998,953 (GRCm39) I122V possibly damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mgat4c T C 10: 102,224,452 (GRCm39) M222T probably damaging Het
Muc4 C A 16: 32,570,488 (GRCm39) S516Y possibly damaging Het
Myo1e A T 9: 70,274,956 (GRCm39) Q703L probably damaging Het
Neb A G 2: 52,115,570 (GRCm39) probably benign Het
Necab3 T G 2: 154,388,223 (GRCm39) E239A probably null Het
Npr1 G T 3: 90,368,676 (GRCm39) N461K probably benign Het
Or4k44 T C 2: 111,367,972 (GRCm39) I221V probably damaging Het
Pcdhb2 A G 18: 37,428,543 (GRCm39) Y172C probably damaging Het
Pcdhb7 A G 18: 37,474,954 (GRCm39) D30G probably benign Het
Phf12 A C 11: 77,920,158 (GRCm39) Q898P probably benign Het
Plekhn1 T C 4: 156,309,821 (GRCm39) E132G possibly damaging Het
Ptpn3 A G 4: 57,270,075 (GRCm39) V29A probably benign Het
Rundc3b T A 5: 8,619,529 (GRCm39) I143F probably damaging Het
Ryr3 T G 2: 112,478,651 (GRCm39) probably benign Het
Sash1 A G 10: 8,626,901 (GRCm39) probably null Het
Slc4a2 A G 5: 24,636,257 (GRCm39) D201G probably benign Het
Tecpr1 T A 5: 144,150,871 (GRCm39) probably null Het
Timm21 T C 18: 84,967,326 (GRCm39) H150R probably damaging Het
Tmem79 T C 3: 88,240,241 (GRCm39) T236A probably damaging Het
Usp34 G T 11: 23,422,967 (GRCm39) V3095F probably damaging Het
Vmn1r8 A T 6: 57,013,573 (GRCm39) Q208L probably benign Het
Other mutations in Ints13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Ints13 APN 6 146,467,174 (GRCm39) missense probably damaging 1.00
IGL02085:Ints13 APN 6 146,451,437 (GRCm39) utr 3 prime probably benign
IGL02439:Ints13 APN 6 146,455,721 (GRCm39) splice site probably benign
IGL02512:Ints13 APN 6 146,477,855 (GRCm39) missense probably damaging 1.00
IGL02523:Ints13 APN 6 146,459,109 (GRCm39) missense probably benign 0.09
IGL02988:Ints13 APN 6 146,457,646 (GRCm39) missense possibly damaging 0.49
R0083:Ints13 UTSW 6 146,452,162 (GRCm39) missense probably benign 0.06
R0085:Ints13 UTSW 6 146,476,285 (GRCm39) splice site probably benign
R0184:Ints13 UTSW 6 146,456,542 (GRCm39) missense probably benign 0.26
R1808:Ints13 UTSW 6 146,455,695 (GRCm39) missense probably damaging 1.00
R1838:Ints13 UTSW 6 146,468,109 (GRCm39) missense possibly damaging 0.92
R1906:Ints13 UTSW 6 146,453,868 (GRCm39) critical splice donor site probably null
R2140:Ints13 UTSW 6 146,477,929 (GRCm39) missense probably damaging 1.00
R3082:Ints13 UTSW 6 146,476,205 (GRCm39) missense possibly damaging 0.92
R5568:Ints13 UTSW 6 146,477,855 (GRCm39) missense probably damaging 1.00
R5757:Ints13 UTSW 6 146,451,604 (GRCm39) missense probably benign 0.01
R5770:Ints13 UTSW 6 146,456,571 (GRCm39) missense probably damaging 0.98
R5809:Ints13 UTSW 6 146,477,847 (GRCm39) missense probably benign 0.06
R6273:Ints13 UTSW 6 146,467,179 (GRCm39) missense probably damaging 1.00
R6882:Ints13 UTSW 6 146,464,939 (GRCm39) missense probably null 0.18
R6908:Ints13 UTSW 6 146,456,531 (GRCm39) missense probably damaging 0.99
R7089:Ints13 UTSW 6 146,476,216 (GRCm39) missense probably damaging 1.00
R7425:Ints13 UTSW 6 146,476,198 (GRCm39) critical splice donor site probably null
R7660:Ints13 UTSW 6 146,458,836 (GRCm39) missense probably benign 0.24
R7957:Ints13 UTSW 6 146,452,264 (GRCm39) missense probably damaging 0.99
R8529:Ints13 UTSW 6 146,464,926 (GRCm39) missense probably damaging 0.98
R8847:Ints13 UTSW 6 146,457,631 (GRCm39) missense probably benign 0.01
R9368:Ints13 UTSW 6 146,467,129 (GRCm39) missense probably null 0.99
R9703:Ints13 UTSW 6 146,459,063 (GRCm39) missense probably damaging 1.00
R9777:Ints13 UTSW 6 146,463,326 (GRCm39) missense probably damaging 0.99
RF011:Ints13 UTSW 6 146,457,738 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACACTGCCCAGAAACATGTGCTTAG -3'
(R):5'- GAGAGCATACCTTGTCACACAGACC -3'

Sequencing Primer
(F):5'- ATCCGTTTCAACAAGGGGCT -3'
(R):5'- GGACTAATTCCTGAACTGTTACTAC -3'
Posted On 2014-09-17