Incidental Mutation 'R2049:Ipo9'
ID 226182
Institutional Source Beutler Lab
Gene Symbol Ipo9
Ensembl Gene ENSMUSG00000041879
Gene Name importin 9
Synonyms 0710008K06Rik, Imp9
MMRRC Submission 040056-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2049 (G1)
Quality Score 217
Status Validated
Chromosome 1
Chromosomal Location 135310050-135358237 bp(-) (GRCm39)
Type of Mutation small insertion (1 aa in frame mutation)
DNA Base Change (assembly) ATCCTCCTCCTCCTCCTC to ATCCTCCTCCTCCTCCTCCTC at 135314006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000041023] [ENSMUST00000161032] [ENSMUST00000161189]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000041023
SMART Domains Protein: ENSMUSP00000036093
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
low complexity region 911 922 N/A INTRINSIC
low complexity region 978 990 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159089
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159487
Predicted Effect probably benign
Transcript: ENSMUST00000161032
SMART Domains Protein: ENSMUSP00000124779
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161189
SMART Domains Protein: ENSMUSP00000124492
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
SCOP:d1i6la_ 21 52 4e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161258
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161750
Predicted Effect probably benign
Transcript: ENSMUST00000161934
SMART Domains Protein: ENSMUSP00000124210
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 81 92 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162858
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 97% (118/122)
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 117 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik G A 14: 54,822,444 (GRCm39) R8* probably null Het
Abhd17a A G 10: 80,421,440 (GRCm39) probably null Het
Acsm1 A G 7: 119,255,262 (GRCm39) R415G probably damaging Het
Acta1 G T 8: 124,618,803 (GRCm39) T360N probably benign Het
Adam6a T A 12: 113,508,049 (GRCm39) S141T probably benign Het
Adgrd1 G T 5: 129,192,159 (GRCm39) K76N probably benign Het
Afdn A G 17: 14,030,695 (GRCm39) E202G probably damaging Het
Agps T A 2: 75,689,270 (GRCm39) M156K probably benign Het
Agxt A G 1: 93,065,037 (GRCm39) I149V probably benign Het
Aoc1l1 T A 6: 48,954,689 (GRCm39) L609* probably null Het
Aqp2 A G 15: 99,477,247 (GRCm39) T72A probably damaging Het
Arhgap18 T A 10: 26,725,938 (GRCm39) D54E probably benign Het
Asb8 C A 15: 98,033,950 (GRCm39) E202* probably null Het
Bmp5 A G 9: 75,801,072 (GRCm39) I401V probably damaging Het
Bscl2 T C 19: 8,822,684 (GRCm39) probably null Het
Capn9 G A 8: 125,332,450 (GRCm39) G430R possibly damaging Het
Cd55 C T 1: 130,377,160 (GRCm39) V333I probably benign Het
Cep112 A G 11: 108,497,151 (GRCm39) E697G probably damaging Het
Cerk G A 15: 86,027,009 (GRCm39) S167L probably benign Het
Chrm3 T A 13: 9,928,371 (GRCm39) I222F probably damaging Het
Clcn6 A G 4: 148,108,594 (GRCm39) F145S possibly damaging Het
Cnksr1 A G 4: 133,956,939 (GRCm39) Y488H probably damaging Het
Cntrl CAGAG CAG 2: 35,012,818 (GRCm39) probably null Het
Commd10 A T 18: 47,096,814 (GRCm39) T74S probably benign Het
Cyp4f39 T C 17: 32,701,112 (GRCm39) F201L probably benign Het
Dennd4a A G 9: 64,796,887 (GRCm39) T860A possibly damaging Het
Dlg5 A T 14: 24,204,715 (GRCm39) I1253N probably damaging Het
Dnah7b T A 1: 46,307,830 (GRCm39) M3048K probably damaging Het
Dnah9 A G 11: 65,935,509 (GRCm39) M1970T probably damaging Het
Dsc3 A T 18: 20,122,737 (GRCm39) D62E possibly damaging Het
Dsel T C 1: 111,787,187 (GRCm39) N1116S probably benign Het
Dusp7 C T 9: 106,251,096 (GRCm39) T407M probably damaging Het
Efnb1 A G X: 98,191,123 (GRCm39) Y343C probably damaging Het
Eif1ad8 A G 12: 87,564,046 (GRCm39) D127G unknown Het
Entpd5 A G 12: 84,443,632 (GRCm39) I12T probably benign Het
Espn T C 4: 152,205,714 (GRCm39) E408G probably damaging Het
Fhip1b A T 7: 105,039,046 (GRCm39) D64E probably damaging Het
Gdpd3 A G 7: 126,367,766 (GRCm39) T200A probably damaging Het
Gli1 A G 10: 127,172,596 (GRCm39) L182P probably damaging Het
Gm5134 G A 10: 75,840,718 (GRCm39) A521T possibly damaging Het
Gprasp1 G A X: 134,702,791 (GRCm39) E995K possibly damaging Het
H2-M10.1 T C 17: 36,636,108 (GRCm39) D153G possibly damaging Het
Helb A T 10: 119,941,926 (GRCm39) M254K possibly damaging Het
I0C0044D17Rik A G 4: 98,708,533 (GRCm39) probably benign Het
Igfn1 AGGG AGG 1: 135,902,590 (GRCm39) probably benign Het
Igfn1 T A 1: 135,898,376 (GRCm39) Q730L probably benign Het
Jmjd1c T A 10: 66,993,777 (GRCm39) L86* probably null Het
Kat5 T A 19: 5,655,713 (GRCm39) probably null Het
Kif14 A G 1: 136,414,818 (GRCm39) N768S probably benign Het
Kif14 A G 1: 136,437,905 (GRCm39) E1199G possibly damaging Het
Klhl29 A G 12: 5,187,876 (GRCm39) S163P probably damaging Het
Kmt2c C A 5: 25,490,077 (GRCm39) Q4287H probably damaging Het
Krt82 T A 15: 101,453,591 (GRCm39) Q265L probably damaging Het
Macf1 C T 4: 123,248,895 (GRCm39) C7210Y probably damaging Het
Mx2 G A 16: 97,339,903 (GRCm39) E20K probably benign Het
Myom2 T G 8: 15,156,379 (GRCm39) I742S probably damaging Het
Narf A T 11: 121,141,195 (GRCm39) R310* probably null Het
Nktr T A 9: 121,570,760 (GRCm39) D167E probably damaging Het
Nle1 A G 11: 82,796,192 (GRCm39) W183R probably damaging Het
Npas3 A G 12: 54,108,871 (GRCm39) N425S probably damaging Het
Obsl1 G A 1: 75,486,756 (GRCm38) T1764M probably benign Het
Optc A T 1: 133,831,534 (GRCm39) probably null Het
Or4a27 A T 2: 88,559,089 (GRCm39) Y285N probably damaging Het
Or4a68 C T 2: 89,269,927 (GRCm39) R232H probably benign Het
Or4d5 T A 9: 40,012,415 (GRCm39) I124L probably benign Het
Or6c69 A G 10: 129,748,036 (GRCm39) V37A probably benign Het
Or8g52 A T 9: 39,631,411 (GRCm39) D296V probably damaging Het
Or8s2 G A 15: 98,276,277 (GRCm39) T238I possibly damaging Het
Otol1 T A 3: 69,926,169 (GRCm39) F115I probably benign Het
Parp8 T A 13: 117,031,422 (GRCm39) D430V probably benign Het
Pex7 T A 10: 19,770,061 (GRCm39) H123L probably damaging Het
Pkhd1l1 T A 15: 44,410,909 (GRCm39) probably benign Het
Pkhd1l1 G A 15: 44,445,137 (GRCm39) D3670N probably damaging Het
Plec T C 15: 76,067,374 (GRCm39) T1331A probably benign Het
Plekha4 A G 7: 45,203,222 (GRCm39) D704G probably benign Het
Plxnb2 T A 15: 89,043,205 (GRCm39) N1453I probably damaging Het
Pms1 T A 1: 53,321,147 (GRCm39) I29F probably damaging Het
Ppp1r1a G A 15: 103,439,833 (GRCm39) T153I probably damaging Het
Pramel12 T A 4: 143,143,441 (GRCm39) L69Q probably damaging Het
Prelp C T 1: 133,842,869 (GRCm39) R92K probably benign Het
Ptpre A G 7: 135,272,424 (GRCm39) probably benign Het
Ptprt A T 2: 161,376,465 (GRCm39) I1312N probably damaging Het
Ren1 C G 1: 133,278,516 (GRCm39) probably null Het
Rims1 C T 1: 22,635,516 (GRCm39) C155Y probably damaging Het
Ro60 T C 1: 143,635,772 (GRCm39) D458G probably benign Het
Slitrk6 T G 14: 110,988,226 (GRCm39) T494P probably benign Het
Sltm G A 9: 70,488,583 (GRCm39) G578S probably benign Het
Smyd5 A G 6: 85,421,300 (GRCm39) E338G probably benign Het
Snx2 G A 18: 53,327,516 (GRCm39) V81M probably damaging Het
Sp2 G T 11: 96,852,191 (GRCm39) N244K probably benign Het
Sspo C A 6: 48,437,697 (GRCm39) probably benign Het
Sspo A C 6: 48,440,465 (GRCm39) D1568A probably benign Het
Ssrp1 T C 2: 84,871,771 (GRCm39) probably benign Het
Syt2 ACTCTCTCT ACTCTCTCTCT 1: 134,674,479 (GRCm39) probably benign Het
Syt7 G A 19: 10,416,577 (GRCm39) R138Q probably benign Het
Taar7f T C 10: 23,926,323 (GRCm39) Y306H possibly damaging Het
Tbccd1 T C 16: 22,637,291 (GRCm39) probably null Het
Tesl1 T A X: 23,773,549 (GRCm39) V350E probably benign Het
Tex261 A G 6: 83,749,241 (GRCm39) Y119H probably damaging Het
Tmem131l T G 3: 83,850,095 (GRCm39) E234D probably damaging Het
Tnnt2 TG TGG 1: 135,774,499 (GRCm39) probably benign Het
Top6bl A G 19: 4,748,633 (GRCm39) probably benign Het
Ttn C T 2: 76,643,683 (GRCm39) G11436R probably damaging Het
Ubap1 C T 4: 41,379,257 (GRCm39) A157V probably damaging Het
Ubr4 C T 4: 139,204,518 (GRCm39) T4810M probably damaging Het
Uso1 G A 5: 92,329,795 (GRCm39) G427R probably damaging Het
Usp15 A T 10: 122,955,042 (GRCm39) V912D probably damaging Het
Vmn1r20 T C 6: 57,408,943 (GRCm39) S90P probably damaging Het
Vmn1r32 T C 6: 66,530,545 (GRCm39) K77R probably damaging Het
Vmn2r100 A G 17: 19,742,312 (GRCm39) K229E probably benign Het
Vmn2r106 A G 17: 20,488,566 (GRCm39) V611A possibly damaging Het
Xrcc6 T A 15: 81,907,178 (GRCm39) F167I probably damaging Het
Zbtb21 G T 16: 97,751,355 (GRCm39) P804H probably damaging Het
Zdhhc3 T C 9: 122,929,602 (GRCm39) D11G probably damaging Het
Zfhx3 A G 8: 109,671,809 (GRCm39) T1324A probably benign Het
Zfp281 GCGGCAGCTCCGGCAGC GCGGCAGCTCCGGCAGCTCCGGCAGC 1: 136,553,091 (GRCm39) probably benign Het
Zfp608 G T 18: 55,028,637 (GRCm39) L1259I probably damaging Het
Other mutations in Ipo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Ipo9 APN 1 135,327,797 (GRCm39) missense probably damaging 1.00
IGL01611:Ipo9 APN 1 135,314,431 (GRCm39) missense possibly damaging 0.76
IGL01941:Ipo9 APN 1 135,335,811 (GRCm39) missense possibly damaging 0.95
IGL01944:Ipo9 APN 1 135,333,624 (GRCm39) missense probably damaging 0.98
IGL01959:Ipo9 APN 1 135,348,093 (GRCm39) critical splice acceptor site probably null
IGL02649:Ipo9 APN 1 135,313,672 (GRCm39) missense possibly damaging 0.92
IGL02697:Ipo9 APN 1 135,318,314 (GRCm39) missense probably benign 0.00
IGL03286:Ipo9 APN 1 135,334,816 (GRCm39) intron probably benign
FR4304:Ipo9 UTSW 1 135,314,017 (GRCm39) nonsense probably null
FR4304:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
FR4548:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,004 (GRCm39) small insertion probably benign
FR4976:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R0111:Ipo9 UTSW 1 135,333,662 (GRCm39) missense probably damaging 0.97
R0238:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0239:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0279:Ipo9 UTSW 1 135,348,101 (GRCm39) intron probably benign
R0704:Ipo9 UTSW 1 135,314,006 (GRCm39) small deletion probably benign
R1070:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1282:Ipo9 UTSW 1 135,330,030 (GRCm39) missense possibly damaging 0.48
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1728:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1728:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
R1728:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1729:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1729:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1730:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1730:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1739:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1739:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1783:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1783:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1784:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1784:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1785:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1899:Ipo9 UTSW 1 135,327,884 (GRCm39) missense probably damaging 0.99
R2049:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2130:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2130:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2131:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2131:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2133:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2136:Ipo9 UTSW 1 135,322,023 (GRCm39) missense probably damaging 0.98
R2141:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2141:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,020 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2142:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2356:Ipo9 UTSW 1 135,334,555 (GRCm39) missense probably benign 0.00
R2923:Ipo9 UTSW 1 135,327,867 (GRCm39) missense probably benign 0.25
R3161:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R4086:Ipo9 UTSW 1 135,316,428 (GRCm39) unclassified probably benign
R4679:Ipo9 UTSW 1 135,321,907 (GRCm39) missense probably benign
R4816:Ipo9 UTSW 1 135,334,288 (GRCm39) missense probably benign 0.21
R4956:Ipo9 UTSW 1 135,331,960 (GRCm39) critical splice donor site probably null
R5052:Ipo9 UTSW 1 135,316,349 (GRCm39) splice site probably null
R5055:Ipo9 UTSW 1 135,330,097 (GRCm39) nonsense probably null
R5230:Ipo9 UTSW 1 135,347,808 (GRCm39) missense probably damaging 1.00
R5240:Ipo9 UTSW 1 135,317,344 (GRCm39) unclassified probably benign
R5257:Ipo9 UTSW 1 135,313,173 (GRCm39) missense probably damaging 1.00
R5340:Ipo9 UTSW 1 135,313,170 (GRCm39) missense probably benign 0.00
R5560:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5602:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5604:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5654:Ipo9 UTSW 1 135,313,210 (GRCm39) nonsense probably null
R6018:Ipo9 UTSW 1 135,318,274 (GRCm39) critical splice donor site probably null
R6128:Ipo9 UTSW 1 135,318,311 (GRCm39) missense possibly damaging 0.90
R6841:Ipo9 UTSW 1 135,314,046 (GRCm39) missense probably benign
R7230:Ipo9 UTSW 1 135,334,496 (GRCm39) critical splice donor site probably benign
R7255:Ipo9 UTSW 1 135,313,726 (GRCm39) missense probably benign 0.01
R7383:Ipo9 UTSW 1 135,316,411 (GRCm39) missense probably damaging 1.00
R7844:Ipo9 UTSW 1 135,322,062 (GRCm39) missense probably benign 0.00
R7889:Ipo9 UTSW 1 135,334,591 (GRCm39) missense probably benign 0.22
R8125:Ipo9 UTSW 1 135,331,078 (GRCm39) missense probably benign 0.00
R8823:Ipo9 UTSW 1 135,347,077 (GRCm39) missense probably damaging 0.99
R8889:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8892:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8906:Ipo9 UTSW 1 135,321,951 (GRCm39) missense probably damaging 1.00
R8926:Ipo9 UTSW 1 135,313,952 (GRCm39) splice site probably benign
R9084:Ipo9 UTSW 1 135,334,563 (GRCm39) missense probably benign 0.01
R9215:Ipo9 UTSW 1 135,347,033 (GRCm39) missense probably benign 0.05
R9756:Ipo9 UTSW 1 135,314,057 (GRCm39) missense probably benign 0.00
Y5405:Ipo9 UTSW 1 135,314,022 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- AGATGCGTTTACTGCATGGC -3'
(R):5'- TAGGGCATCCTTGGTGCTATC -3'

Sequencing Primer
(F):5'- TTACTGCATGGCTGAGGC -3'
(R):5'- CATCCTTGGTGCTATCACGTTTGG -3'
Posted On 2014-09-17