Incidental Mutation 'R2067:Zfp59'
ID 226764
Institutional Source Beutler Lab
Gene Symbol Zfp59
Ensembl Gene ENSMUSG00000078779
Gene Name zinc finger protein 59
Synonyms Mfg2, Mfg-2
MMRRC Submission 040072-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R2067 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 27538032-27555863 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27552935 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 129 (N129S)
Ref Sequence ENSEMBL: ENSMUSP00000145671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108331] [ENSMUST00000205701] [ENSMUST00000205715]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000108331
AA Change: N129S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000103968
Gene: ENSMUSG00000078779
AA Change: N129S

DomainStartEndE-ValueType
KRAB 14 75 1.2e-35 SMART
ZnF_C2H2 172 194 2.91e-2 SMART
ZnF_C2H2 200 222 1.95e-3 SMART
ZnF_C2H2 256 278 2.02e-1 SMART
ZnF_C2H2 284 306 3.21e-4 SMART
ZnF_C2H2 312 334 1.92e-2 SMART
ZnF_C2H2 340 362 1.22e-4 SMART
ZnF_C2H2 368 390 2.53e-2 SMART
ZnF_C2H2 396 418 6.78e-3 SMART
ZnF_C2H2 424 446 3.44e-4 SMART
ZnF_C2H2 452 474 1.38e-3 SMART
ZnF_C2H2 480 502 3.34e-2 SMART
ZnF_C2H2 508 530 2.2e-2 SMART
ZnF_C2H2 536 558 2.71e-2 SMART
ZnF_C2H2 564 586 2.4e-3 SMART
ZnF_C2H2 592 614 1.92e-2 SMART
ZnF_C2H2 620 642 2.57e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205701
AA Change: N129S

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000205715
Meta Mutation Damage Score 0.1377 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 97% (76/78)
MGI Phenotype FUNCTION: The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik T A 4: 122,583,115 (GRCm39) probably benign Het
Abca2 A T 2: 25,327,517 (GRCm39) I669F possibly damaging Het
Acin1 T A 14: 54,902,711 (GRCm39) Q360H probably damaging Het
Aldh3b1 T A 19: 3,971,755 (GRCm39) D72V probably benign Het
Alox12e G A 11: 70,206,828 (GRCm39) R620W probably damaging Het
Alpl T C 4: 137,476,856 (GRCm39) probably benign Het
Amy2a1 T C 3: 113,324,217 (GRCm39) I108V probably benign Het
Ascc2 A T 11: 4,631,496 (GRCm39) M646L probably benign Het
Bod1l G A 5: 41,974,429 (GRCm39) T2295M probably benign Het
Ccdc9 A T 7: 16,012,475 (GRCm39) probably null Het
Clptm1l C T 13: 73,755,842 (GRCm39) Q153* probably null Het
Csmd1 A G 8: 15,950,782 (GRCm39) S3476P probably benign Het
Ddias A T 7: 92,508,907 (GRCm39) M336K possibly damaging Het
Ehd1 T C 19: 6,348,108 (GRCm39) L362P probably benign Het
Epha1 G T 6: 42,342,987 (GRCm39) H187Q probably benign Het
Espl1 T C 15: 102,207,525 (GRCm39) S330P probably damaging Het
Fbln7 G T 2: 128,719,386 (GRCm39) R61L probably damaging Het
Fbxo41 C T 6: 85,455,453 (GRCm39) W577* probably null Het
Fgb C A 3: 82,956,996 (GRCm39) D25Y probably benign Het
Gc T A 5: 89,594,376 (GRCm39) K37N probably damaging Het
Gfpt1 T C 6: 87,034,736 (GRCm39) I178T probably benign Het
Gm12695 T C 4: 96,657,963 (GRCm39) T69A probably benign Het
Gm3944 C A 12: 18,903,895 (GRCm39) S8* probably null Het
Gm9912 T C 3: 148,890,795 (GRCm39) T113A unknown Het
Gpr156 A G 16: 37,799,113 (GRCm39) D109G probably benign Het
Hoxd1 A T 2: 74,593,710 (GRCm39) T89S probably benign Het
Htt C T 5: 34,983,326 (GRCm39) T975I probably benign Het
Itpr3 G A 17: 27,317,050 (GRCm39) M768I probably benign Het
Krt4 C A 15: 101,833,099 (GRCm39) A3S possibly damaging Het
Mrto4 T C 4: 139,076,334 (GRCm39) K86E probably benign Het
Mup4 T A 4: 59,960,622 (GRCm39) probably benign Het
Myh1 G A 11: 67,105,446 (GRCm39) D1079N possibly damaging Het
Myo1a A G 10: 127,541,347 (GRCm39) N43D probably benign Het
Napa A T 7: 15,849,203 (GRCm39) probably benign Het
Ndufa12 A G 10: 94,056,569 (GRCm39) D99G probably damaging Het
Neb A G 2: 52,174,275 (GRCm39) I1528T probably benign Het
Nek1 T C 8: 61,460,196 (GRCm39) S41P probably damaging Het
Nolc1 C T 19: 46,072,046 (GRCm39) T612M probably damaging Het
Nsun5 T G 5: 135,403,926 (GRCm39) Y301D probably damaging Het
Oas1g T C 5: 121,023,946 (GRCm39) E121G probably damaging Het
Or1e1f A G 11: 73,855,740 (GRCm39) Y102C probably damaging Het
Or2ab1 A G 11: 58,488,396 (GRCm39) N58S probably damaging Het
Or5d41 A G 2: 88,054,818 (GRCm39) V186A possibly damaging Het
Or6ae1 T A 7: 139,742,822 (GRCm39) I14F possibly damaging Het
Or8b46 T A 9: 38,450,576 (GRCm39) N128K probably benign Het
Or8k38 G T 2: 86,488,781 (GRCm39) T7K probably damaging Het
Osmr T C 15: 6,844,896 (GRCm39) N957D probably benign Het
Parn G A 16: 13,420,933 (GRCm39) S473L probably damaging Het
Phc2 T C 4: 128,640,929 (GRCm39) F672S probably damaging Het
Pik3c2b T C 1: 133,027,349 (GRCm39) S1283P probably damaging Het
Pole2 G A 12: 69,274,926 (GRCm39) R5W probably benign Het
Prl7a2 T A 13: 27,844,870 (GRCm39) Y172F probably damaging Het
Ptprz1 A G 6: 23,050,388 (GRCm39) probably benign Het
Rapgef3 C A 15: 97,664,842 (GRCm39) G7V probably damaging Het
Ripor1 T A 8: 106,344,340 (GRCm39) S491R probably benign Het
Rnf141 A G 7: 110,420,572 (GRCm39) probably benign Het
Ryr3 C T 2: 112,777,302 (GRCm39) R285Q probably damaging Het
Sall4 T C 2: 168,598,465 (GRCm39) N125S probably benign Het
Schip1 A G 3: 68,525,119 (GRCm39) K360R probably damaging Het
Senp6 T A 9: 79,997,151 (GRCm39) V55E probably benign Het
Skint1 T A 4: 111,882,730 (GRCm39) V258D probably benign Het
Slc25a16 T A 10: 62,768,530 (GRCm39) H130Q probably benign Het
Styx T C 14: 45,611,020 (GRCm39) V217A probably benign Het
Syne2 G A 12: 75,935,116 (GRCm39) probably null Het
Tagap1 A G 17: 7,224,259 (GRCm39) S146P probably benign Het
Tatdn2 A G 6: 113,681,103 (GRCm39) K379E probably benign Het
Thrap3 T C 4: 126,069,189 (GRCm39) Y654C possibly damaging Het
Tle2 T C 10: 81,416,385 (GRCm39) L135P probably damaging Het
Tmc1 A G 19: 20,801,673 (GRCm39) F451S possibly damaging Het
Trpm7 G A 2: 126,639,647 (GRCm39) P1650S probably damaging Het
Ttll4 G A 1: 74,719,541 (GRCm39) R16H possibly damaging Het
Ttn T C 2: 76,544,717 (GRCm39) N32795S probably damaging Het
Tubgcp6 T C 15: 88,988,692 (GRCm39) E803G probably benign Het
Ubr2 A G 17: 47,274,071 (GRCm39) probably null Het
Ugt2b35 A G 5: 87,149,412 (GRCm39) D221G probably damaging Het
Unc45b G A 11: 82,802,515 (GRCm39) A4T probably benign Het
Vmn1r70 A T 7: 10,368,264 (GRCm39) I251F possibly damaging Het
Vmn2r120 T A 17: 57,831,553 (GRCm39) H412L possibly damaging Het
Zgrf1 T C 3: 127,406,999 (GRCm39) C1589R probably damaging Het
Other mutations in Zfp59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02976:Zfp59 APN 7 27,552,821 (GRCm39) missense probably benign 0.00
R0689:Zfp59 UTSW 7 27,553,142 (GRCm39) missense probably benign 0.19
R0726:Zfp59 UTSW 7 27,553,513 (GRCm39) missense probably damaging 0.98
R1570:Zfp59 UTSW 7 27,553,016 (GRCm39) missense probably benign 0.03
R1587:Zfp59 UTSW 7 27,553,559 (GRCm39) missense possibly damaging 0.84
R4880:Zfp59 UTSW 7 27,543,742 (GRCm39) missense probably damaging 0.99
R5677:Zfp59 UTSW 7 27,553,594 (GRCm39) missense probably benign 0.15
R6969:Zfp59 UTSW 7 27,552,922 (GRCm39) missense probably damaging 0.98
R7574:Zfp59 UTSW 7 27,552,863 (GRCm39) missense probably benign 0.04
R7837:Zfp59 UTSW 7 27,554,342 (GRCm39) frame shift probably null
R8332:Zfp59 UTSW 7 27,552,971 (GRCm39) missense probably benign 0.00
R8891:Zfp59 UTSW 7 27,554,313 (GRCm39) missense probably benign 0.00
R9314:Zfp59 UTSW 7 27,554,029 (GRCm39) missense possibly damaging 0.86
R9583:Zfp59 UTSW 7 27,554,483 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GCTCCCATACAGCTTCTCAGAG -3'
(R):5'- ACTTCTGATGCCTTGTGAGCTG -3'

Sequencing Primer
(F):5'- TCCCATACAGCTTCTCAGAGATTAC -3'
(R):5'- CACTCTGATGCTGAGTAAGAGTTGAC -3'
Posted On 2014-09-17