Incidental Mutation 'R2071:Nap1l1'
ID 227150
Institutional Source Beutler Lab
Gene Symbol Nap1l1
Ensembl Gene ENSMUSG00000058799
Gene Name nucleosome assembly protein 1-like 1
Synonyms D10Ertd68e
MMRRC Submission 040076-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.333) question?
Stock # R2071 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 111309084-111334011 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111328761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 230 (T230I)
Ref Sequence ENSEMBL: ENSMUSP00000151507 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065917] [ENSMUST00000171797] [ENSMUST00000217908] [ENSMUST00000218828] [ENSMUST00000219143] [ENSMUST00000219961]
AlphaFold P28656
Predicted Effect probably benign
Transcript: ENSMUST00000065917
AA Change: T230I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000070068
Gene: ENSMUSG00000058799
AA Change: T230I

DomainStartEndE-ValueType
coiled coil region 6 31 N/A INTRINSIC
Pfam:NAP 75 346 1.5e-96 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171797
AA Change: T257I

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000126850
Gene: ENSMUSG00000058799
AA Change: T257I

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
coiled coil region 33 58 N/A INTRINSIC
Pfam:NAP 103 372 9.6e-110 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217908
AA Change: T230I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000218828
AA Change: T230I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218982
Predicted Effect possibly damaging
Transcript: ENSMUST00000219143
AA Change: T230I

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000219961
AA Change: T230I

PolyPhen 2 Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219718
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700066M21Rik T A 1: 57,422,474 (GRCm39) H283Q probably damaging Het
2810021J22Rik A G 11: 58,767,595 (GRCm39) K31E probably damaging Het
Abcc10 G C 17: 46,614,491 (GRCm39) N1477K probably benign Het
Adam33 T C 2: 130,897,266 (GRCm39) T310A probably benign Het
Afm A G 5: 90,671,594 (GRCm39) D92G probably benign Het
Arg1 C T 10: 24,798,561 (GRCm39) A30T probably benign Het
Ash1l C G 3: 88,873,510 (GRCm39) P98A probably damaging Het
Atad5 A T 11: 79,988,878 (GRCm39) probably null Het
Atg2a T C 19: 6,307,488 (GRCm39) V1474A probably benign Het
Atp12a A G 14: 56,603,466 (GRCm39) K24E probably benign Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
B3gnt4 A T 5: 123,649,433 (GRCm39) H266L probably benign Het
Bora T C 14: 99,299,714 (GRCm39) S229P probably damaging Het
Ccn1 C T 3: 145,354,428 (GRCm39) W161* probably null Het
Cdsn A T 17: 35,865,591 (GRCm39) D40V probably damaging Het
Cep295 T C 9: 15,252,860 (GRCm39) R323G probably damaging Het
Chek2 T C 5: 110,989,112 (GRCm39) probably benign Het
Chga A T 12: 102,529,122 (GRCm39) K366N probably damaging Het
Chrm5 T C 2: 112,309,572 (GRCm39) K515E probably null Het
Cmtr1 A G 17: 29,913,757 (GRCm39) probably null Het
Dsg3 T C 18: 20,669,882 (GRCm39) L632S probably damaging Het
Eif1ad8 T A 12: 87,563,822 (GRCm39) F52L probably benign Het
Fzd3 A G 14: 65,473,012 (GRCm39) F252S probably damaging Het
Gas2l2 T C 11: 83,312,775 (GRCm39) K846E probably benign Het
Gpatch11 T C 17: 79,148,514 (GRCm39) probably null Het
Gucy2g T A 19: 55,210,772 (GRCm39) Y661F possibly damaging Het
Hhip A G 8: 80,783,931 (GRCm39) F72L probably benign Het
Kat14 T C 2: 144,231,136 (GRCm39) L181P probably damaging Het
Kifc3 A T 8: 95,834,981 (GRCm39) probably null Het
Kntc1 G T 5: 123,932,340 (GRCm39) probably null Het
Man2b1 G T 8: 85,812,013 (GRCm39) V156L possibly damaging Het
Mast1 T C 8: 85,647,823 (GRCm39) D517G probably damaging Het
Mc1r T C 8: 124,135,108 (GRCm39) L287P possibly damaging Het
Mctp1 A T 13: 76,907,843 (GRCm39) E238V probably damaging Het
Mmp12 T A 9: 7,349,725 (GRCm39) I52N probably damaging Het
Morc1 C T 16: 48,412,974 (GRCm39) T705I probably benign Het
Mrpl24 T C 3: 87,830,374 (GRCm39) probably null Het
Niban1 T C 1: 151,512,181 (GRCm39) F28L probably damaging Het
Nmral1 T A 16: 4,534,211 (GRCm39) I77F probably damaging Het
Nudt13 T A 14: 20,354,045 (GRCm39) D36E probably damaging Het
Oxsm A G 14: 16,241,983 (GRCm38) L262P probably benign Het
Pde10a A T 17: 9,180,827 (GRCm39) I754F probably benign Het
Pdzph1 T C 17: 59,281,092 (GRCm39) R397G probably benign Het
Pgap6 T C 17: 26,341,017 (GRCm39) Y176H probably damaging Het
Polr1a T A 6: 71,953,058 (GRCm39) V567E possibly damaging Het
Pou3f2 A G 4: 22,488,076 (GRCm39) V19A probably benign Het
Pramel34 T G 5: 93,784,375 (GRCm39) Q363P probably damaging Het
Pth1r A G 9: 110,556,081 (GRCm39) I264T probably benign Het
Ptprn C A 1: 75,231,788 (GRCm39) G504C probably damaging Het
Rbak A G 5: 143,162,339 (GRCm39) L8P probably damaging Het
Rev3l T A 10: 39,700,349 (GRCm39) D1615E probably benign Het
Rhob A G 12: 8,549,232 (GRCm39) M134T probably benign Het
Slc10a4 T C 5: 73,164,840 (GRCm39) L144P probably damaging Het
Slc45a3 T C 1: 131,905,370 (GRCm39) L131P probably damaging Het
Slf1 T A 13: 77,252,743 (GRCm39) E259D probably benign Het
Slitrk5 A G 14: 111,917,621 (GRCm39) Y415C probably damaging Het
Sohlh2 A G 3: 55,115,043 (GRCm39) I343V probably benign Het
Sorl1 T C 9: 41,890,753 (GRCm39) D1922G possibly damaging Het
Spats2l T A 1: 57,979,623 (GRCm39) I243N possibly damaging Het
Specc1 A C 11: 62,008,701 (GRCm39) K152N probably damaging Het
Sv2a G A 3: 96,101,191 (GRCm39) A730T possibly damaging Het
Tars2 C A 3: 95,654,950 (GRCm39) G113C probably damaging Het
Tcstv2b A T 13: 120,373,836 (GRCm39) D151E probably benign Het
Tep1 T C 14: 51,091,739 (GRCm39) K601E probably benign Het
Trp53 A G 11: 69,480,458 (GRCm39) D278G probably damaging Het
Ttc39d G A 17: 80,524,030 (GRCm39) G230R probably damaging Het
Tubb2b T A 13: 34,312,244 (GRCm39) Y183F probably damaging Het
Ubxn7 T A 16: 32,191,287 (GRCm39) C160S possibly damaging Het
Vcp A G 4: 42,995,894 (GRCm39) probably null Het
Vmn1r201 T C 13: 22,658,995 (GRCm39) F70L probably benign Het
Vmn1r49 C T 6: 90,049,184 (GRCm39) V273I probably benign Het
Vmn2r103 A T 17: 20,014,056 (GRCm39) I283L probably benign Het
Xpr1 T C 1: 155,166,026 (GRCm39) T574A probably benign Het
Zfp408 A G 2: 91,476,363 (GRCm39) F364L probably damaging Het
Zfyve26 A G 12: 79,334,220 (GRCm39) L266P possibly damaging Het
Other mutations in Nap1l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Nap1l1 APN 10 111,322,536 (GRCm39) missense probably damaging 0.98
IGL01453:Nap1l1 APN 10 111,328,839 (GRCm39) missense probably benign 0.09
IGL01734:Nap1l1 APN 10 111,328,760 (GRCm39) missense probably benign 0.26
IGL01843:Nap1l1 APN 10 111,328,772 (GRCm39) missense possibly damaging 0.93
PIT1430001:Nap1l1 UTSW 10 111,322,597 (GRCm39) missense probably damaging 1.00
PIT4131001:Nap1l1 UTSW 10 111,322,583 (GRCm39) missense probably null
R0020:Nap1l1 UTSW 10 111,326,884 (GRCm39) missense probably benign 0.01
R0020:Nap1l1 UTSW 10 111,326,884 (GRCm39) missense probably benign 0.01
R0131:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0131:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0132:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0601:Nap1l1 UTSW 10 111,326,224 (GRCm39) splice site probably benign
R1576:Nap1l1 UTSW 10 111,330,681 (GRCm39) missense probably damaging 1.00
R1619:Nap1l1 UTSW 10 111,329,240 (GRCm39) missense possibly damaging 0.77
R1969:Nap1l1 UTSW 10 111,326,914 (GRCm39) missense probably benign 0.03
R2383:Nap1l1 UTSW 10 111,329,272 (GRCm39) missense probably damaging 1.00
R3836:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R3837:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R3838:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R3839:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R4084:Nap1l1 UTSW 10 111,325,938 (GRCm39) missense possibly damaging 0.92
R4609:Nap1l1 UTSW 10 111,328,741 (GRCm39) nonsense probably null
R4985:Nap1l1 UTSW 10 111,325,944 (GRCm39) missense probably benign 0.01
R5906:Nap1l1 UTSW 10 111,326,891 (GRCm39) nonsense probably null
R5982:Nap1l1 UTSW 10 111,331,229 (GRCm39) missense possibly damaging 0.71
R6522:Nap1l1 UTSW 10 111,330,084 (GRCm39) missense probably damaging 0.99
R6868:Nap1l1 UTSW 10 111,330,669 (GRCm39) missense probably damaging 1.00
R7134:Nap1l1 UTSW 10 111,330,655 (GRCm39) critical splice acceptor site probably null
R7202:Nap1l1 UTSW 10 111,326,964 (GRCm39) missense probably damaging 1.00
R7789:Nap1l1 UTSW 10 111,326,317 (GRCm39) missense probably benign 0.01
R7950:Nap1l1 UTSW 10 111,328,769 (GRCm39) missense probably damaging 1.00
R8404:Nap1l1 UTSW 10 111,317,162 (GRCm39) start codon destroyed probably null 0.53
R8502:Nap1l1 UTSW 10 111,317,162 (GRCm39) start codon destroyed probably null 0.53
R8933:Nap1l1 UTSW 10 111,328,710 (GRCm39) missense probably benign 0.04
R9680:Nap1l1 UTSW 10 111,330,657 (GRCm39) missense probably damaging 0.99
R9772:Nap1l1 UTSW 10 111,325,911 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACTAAGAGTCTCCCCTGCATC -3'
(R):5'- TACATGATAGTCAGACCCAGAGG -3'

Sequencing Primer
(F):5'- GCATCCCTGTTAGCATTGTAGTAAG -3'
(R):5'- GGAGACCAAAGCGTCTGACTAC -3'
Posted On 2014-09-17