Incidental Mutation 'R0149:Prdm10'
ID 22727
Institutional Source Beutler Lab
Gene Symbol Prdm10
Ensembl Gene ENSMUSG00000042496
Gene Name PR domain containing 10
Synonyms LOC382066, tristanin
MMRRC Submission 038433-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0149 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 31191834-31293019 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 31227455 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074510] [ENSMUST00000117389] [ENSMUST00000215499] [ENSMUST00000215847]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000074510
AA Change: L16R
SMART Domains Protein: ENSMUSP00000074104
Gene: ENSMUSG00000042496
AA Change: L16R

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 111 117 N/A INTRINSIC
PDB:3IHX|D 133 284 1e-104 PDB
Blast:SET 165 277 3e-32 BLAST
ZnF_C2H2 300 322 5.42e-2 SMART
Pfam:Tristanin_u2 325 455 2.4e-49 PFAM
ZnF_C2H2 471 493 7.78e-3 SMART
ZnF_C2H2 501 523 1.95e-3 SMART
ZnF_C2H2 529 551 3.83e-2 SMART
ZnF_C2H2 557 580 8.34e-3 SMART
ZnF_C2H2 585 607 3.21e-4 SMART
ZnF_C2H2 613 636 3.69e-4 SMART
ZnF_C2H2 668 691 8.22e-2 SMART
ZnF_C2H2 801 824 1.25e-1 SMART
low complexity region 904 916 N/A INTRINSIC
low complexity region 956 964 N/A INTRINSIC
low complexity region 988 1007 N/A INTRINSIC
low complexity region 1110 1122 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000117389
SMART Domains Protein: ENSMUSP00000112588
Gene: ENSMUSG00000042496

DomainStartEndE-ValueType
coiled coil region 119 150 N/A INTRINSIC
PDB:3IHX|D 182 317 2e-97 PDB
Blast:SET 214 317 2e-25 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136144
Predicted Effect probably benign
Transcript: ENSMUST00000215499
Predicted Effect probably benign
Transcript: ENSMUST00000215847
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency 97% (84/87)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A230072I06Rik A C 8: 12,330,000 (GRCm39) S152R unknown Het
Acsbg2 A G 17: 57,160,924 (GRCm39) probably benign Het
Adam6a G T 12: 113,509,369 (GRCm39) V581F probably damaging Het
Adgrl3 A T 5: 81,908,544 (GRCm39) I1165F probably damaging Het
Aldh1l1 A G 6: 90,566,396 (GRCm39) K656E possibly damaging Het
Ankhd1 T C 18: 36,780,267 (GRCm39) I1773T probably damaging Het
Api5 A T 2: 94,253,842 (GRCm39) L287* probably null Het
Ascc3 A T 10: 50,484,089 (GRCm39) N55I probably benign Het
Cav1 C A 6: 17,339,352 (GRCm39) R146S possibly damaging Het
Cdhr2 A T 13: 54,881,820 (GRCm39) I1118F probably damaging Het
Cemip A G 7: 83,613,218 (GRCm39) I660T probably benign Het
Clk1 T A 1: 58,453,760 (GRCm39) N305Y probably damaging Het
Cux1 T A 5: 136,308,351 (GRCm39) I1263F probably damaging Het
Cyp2d26 A G 15: 82,676,968 (GRCm39) L152P probably damaging Het
Dmtf1 A G 5: 9,182,571 (GRCm39) S188P probably damaging Het
Dock2 A G 11: 34,388,327 (GRCm39) L202P probably damaging Het
Dscaml1 T G 9: 45,653,978 (GRCm39) Y1418* probably null Het
Efemp2 A T 19: 5,527,988 (GRCm39) H107L probably damaging Het
Eng T C 2: 32,562,397 (GRCm39) probably null Het
Erc1 A T 6: 119,801,791 (GRCm39) S75R probably damaging Het
Fgl2 A T 5: 21,580,783 (GRCm39) D375V probably damaging Het
Fpr-rs6 T C 17: 20,402,475 (GRCm39) I295M probably benign Het
Fsip2 T C 2: 82,805,849 (GRCm39) S723P possibly damaging Het
Gdpd5 A G 7: 99,107,997 (GRCm39) I530V possibly damaging Het
Gm15217 T A 14: 46,617,841 (GRCm39) probably benign Het
Gm4922 T C 10: 18,659,289 (GRCm39) T478A probably benign Het
Gmcl1 A T 6: 86,709,891 (GRCm39) probably null Het
Has1 T C 17: 18,070,433 (GRCm39) T163A probably damaging Het
Hmcn1 A T 1: 150,553,075 (GRCm39) N2538K probably benign Het
Itga2 A G 13: 114,973,115 (GRCm39) probably benign Het
Kcnip1 A T 11: 33,793,177 (GRCm39) M5K probably benign Het
Kcnk4 T C 19: 6,903,562 (GRCm39) E329G probably benign Het
Kcnt1 T C 2: 25,788,276 (GRCm39) probably benign Het
Klkb1 A G 8: 45,729,100 (GRCm39) C375R probably damaging Het
Loxl2 C A 14: 69,930,527 (GRCm39) H764N probably benign Het
Lrrc55 A T 2: 85,026,589 (GRCm39) M145K probably damaging Het
Lrrtm2 A G 18: 35,345,985 (GRCm39) I439T probably benign Het
Magi1 A T 6: 93,724,226 (GRCm39) I263N probably damaging Het
Map4 C T 9: 109,896,692 (GRCm39) P641L probably damaging Het
Mars1 A T 10: 127,135,903 (GRCm39) N558K probably damaging Het
Mfap2 A G 4: 140,742,294 (GRCm39) D98G probably damaging Het
Mgat5b A G 11: 116,875,965 (GRCm39) probably benign Het
Mki67 A T 7: 135,300,153 (GRCm39) V1627D probably benign Het
Mtnr1a A T 8: 45,522,352 (GRCm39) I36F probably benign Het
Myh15 A T 16: 48,934,368 (GRCm39) N645I probably benign Het
Myo7b T A 18: 32,147,262 (GRCm39) I94F probably damaging Het
Nefh A T 11: 4,890,799 (GRCm39) S607T probably benign Het
Ngf T A 3: 102,427,762 (GRCm39) H174Q probably benign Het
Noa1 G A 5: 77,445,020 (GRCm39) Q600* probably null Het
Nr2f2 A G 7: 70,007,810 (GRCm39) V71A possibly damaging Het
Oas2 A T 5: 120,876,466 (GRCm39) F492L probably damaging Het
Or2y17 A T 11: 49,231,641 (GRCm39) Y94F probably benign Het
Or8g21 T A 9: 38,905,880 (GRCm39) M284L probably benign Het
Osmr A G 15: 6,871,432 (GRCm39) probably null Het
P4ha1 A G 10: 59,184,221 (GRCm39) T228A probably damaging Het
Pip5kl1 T C 2: 32,468,966 (GRCm39) V195A possibly damaging Het
Plagl2 A T 2: 153,073,523 (GRCm39) D459E probably benign Het
Plxna1 T C 6: 89,297,595 (GRCm39) E1863G probably null Het
Prr14l A C 5: 32,950,985 (GRCm39) L1936R probably damaging Het
Rgs1 T C 1: 144,124,825 (GRCm39) probably benign Het
Rgsl1 A G 1: 153,669,510 (GRCm39) F292S probably damaging Het
Rhobtb2 T C 14: 70,033,357 (GRCm39) T538A probably benign Het
Rictor A G 15: 6,813,588 (GRCm39) N1025D possibly damaging Het
Rsph10b T A 5: 143,875,727 (GRCm39) probably benign Het
Rwdd4a A G 8: 47,997,255 (GRCm39) D158G probably null Het
Sdk1 T C 5: 141,842,809 (GRCm39) probably benign Het
Serpina3n A C 12: 104,377,635 (GRCm39) K296T probably benign Het
Slco1a8 T C 6: 141,938,203 (GRCm39) T239A probably benign Het
Snw1 A G 12: 87,508,687 (GRCm39) V124A possibly damaging Het
Tas2r140 T G 6: 40,468,232 (GRCm39) F21V probably benign Het
Tmc6 G A 11: 117,660,274 (GRCm39) L655F probably damaging Het
Tmem260 A T 14: 48,689,504 (GRCm39) T108S possibly damaging Het
Trim2 T C 3: 84,098,083 (GRCm39) Y406C probably damaging Het
Tsc1 T C 2: 28,560,913 (GRCm39) I257T probably damaging Het
Ttn T C 2: 76,673,746 (GRCm39) probably benign Het
Unc80 T A 1: 66,560,760 (GRCm39) N829K possibly damaging Het
Vmn1r235 A C 17: 21,482,257 (GRCm39) D194A probably damaging Het
Vmn2r100 A T 17: 19,741,509 (GRCm39) probably null Het
Ylpm1 G T 12: 85,075,612 (GRCm39) R321L probably damaging Het
Zan T C 5: 137,395,028 (GRCm39) T4381A unknown Het
Zfp457 A G 13: 67,440,710 (GRCm39) F622L probably damaging Het
Zfy1 T C Y: 726,121 (GRCm39) H548R possibly damaging Het
Zmym4 A T 4: 126,804,938 (GRCm39) S441T probably benign Het
Other mutations in Prdm10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Prdm10 APN 9 31,272,108 (GRCm39) splice site probably benign
IGL00485:Prdm10 APN 9 31,238,842 (GRCm39) missense possibly damaging 0.87
IGL00757:Prdm10 APN 9 31,229,842 (GRCm39) missense possibly damaging 0.69
IGL00836:Prdm10 APN 9 31,241,165 (GRCm39) splice site probably benign
IGL01505:Prdm10 APN 9 31,238,578 (GRCm39) missense probably benign
IGL01594:Prdm10 APN 9 31,258,149 (GRCm39) missense probably damaging 1.00
IGL01894:Prdm10 APN 9 31,227,557 (GRCm39) missense probably damaging 1.00
IGL01927:Prdm10 APN 9 31,246,694 (GRCm39) splice site probably benign
IGL02053:Prdm10 APN 9 31,272,144 (GRCm39) missense probably benign 0.00
IGL02068:Prdm10 APN 9 31,248,646 (GRCm39) missense probably damaging 1.00
IGL02295:Prdm10 APN 9 31,273,664 (GRCm39) missense probably benign
IGL02390:Prdm10 APN 9 31,264,685 (GRCm39) missense possibly damaging 0.68
IGL02574:Prdm10 APN 9 31,268,589 (GRCm39) missense probably damaging 1.00
IGL02636:Prdm10 APN 9 31,240,977 (GRCm39) missense possibly damaging 0.68
IGL02883:Prdm10 APN 9 31,238,644 (GRCm39) missense probably damaging 0.99
IGL03057:Prdm10 APN 9 31,260,481 (GRCm39) missense probably damaging 1.00
PIT4142001:Prdm10 UTSW 9 31,237,063 (GRCm39) missense probably benign 0.00
R0089:Prdm10 UTSW 9 31,227,526 (GRCm39) missense probably damaging 1.00
R0306:Prdm10 UTSW 9 31,227,520 (GRCm39) missense probably damaging 1.00
R0386:Prdm10 UTSW 9 31,227,596 (GRCm39) missense probably damaging 1.00
R0390:Prdm10 UTSW 9 31,260,564 (GRCm39) critical splice donor site probably null
R1512:Prdm10 UTSW 9 31,248,697 (GRCm39) missense probably damaging 1.00
R1528:Prdm10 UTSW 9 31,268,582 (GRCm39) missense probably damaging 1.00
R2409:Prdm10 UTSW 9 31,260,418 (GRCm39) missense possibly damaging 0.81
R3745:Prdm10 UTSW 9 31,251,703 (GRCm39) missense possibly damaging 0.72
R3929:Prdm10 UTSW 9 31,258,432 (GRCm39) missense probably damaging 1.00
R4295:Prdm10 UTSW 9 31,227,590 (GRCm39) missense possibly damaging 0.94
R4629:Prdm10 UTSW 9 31,248,612 (GRCm39) nonsense probably null
R4660:Prdm10 UTSW 9 31,238,624 (GRCm39) missense probably damaging 1.00
R4758:Prdm10 UTSW 9 31,273,708 (GRCm39) missense probably benign 0.00
R4793:Prdm10 UTSW 9 31,264,701 (GRCm39) missense probably damaging 1.00
R4798:Prdm10 UTSW 9 31,252,569 (GRCm39) missense probably damaging 1.00
R4806:Prdm10 UTSW 9 31,241,237 (GRCm39) makesense probably null
R4865:Prdm10 UTSW 9 31,258,376 (GRCm39) missense probably damaging 1.00
R5068:Prdm10 UTSW 9 31,270,343 (GRCm39) missense probably damaging 0.96
R5093:Prdm10 UTSW 9 31,252,779 (GRCm39) missense probably damaging 1.00
R5162:Prdm10 UTSW 9 31,251,714 (GRCm39) missense possibly damaging 0.90
R5656:Prdm10 UTSW 9 31,264,713 (GRCm39) missense probably benign 0.08
R5855:Prdm10 UTSW 9 31,248,619 (GRCm39) missense probably damaging 1.00
R6242:Prdm10 UTSW 9 31,252,548 (GRCm39) missense possibly damaging 0.67
R6396:Prdm10 UTSW 9 31,229,842 (GRCm39) missense possibly damaging 0.69
R6970:Prdm10 UTSW 9 31,241,119 (GRCm39) nonsense probably null
R7165:Prdm10 UTSW 9 31,227,738 (GRCm39) splice site probably null
R7177:Prdm10 UTSW 9 31,279,003 (GRCm39) missense probably benign
R7201:Prdm10 UTSW 9 31,227,602 (GRCm39) missense possibly damaging 0.87
R7313:Prdm10 UTSW 9 31,268,456 (GRCm39) nonsense probably null
R7337:Prdm10 UTSW 9 31,227,537 (GRCm39) missense probably damaging 1.00
R7511:Prdm10 UTSW 9 31,289,777 (GRCm39) missense probably damaging 1.00
R7711:Prdm10 UTSW 9 31,268,528 (GRCm39) missense probably damaging 1.00
R7855:Prdm10 UTSW 9 31,238,770 (GRCm39) missense probably benign 0.04
R7965:Prdm10 UTSW 9 31,258,302 (GRCm39) missense probably damaging 1.00
R7997:Prdm10 UTSW 9 31,264,721 (GRCm39) missense probably damaging 1.00
R8168:Prdm10 UTSW 9 31,258,263 (GRCm39) missense probably benign 0.00
R8717:Prdm10 UTSW 9 31,252,695 (GRCm39) missense probably benign 0.31
R8865:Prdm10 UTSW 9 31,238,693 (GRCm39) missense probably damaging 1.00
R8880:Prdm10 UTSW 9 31,264,742 (GRCm39) missense probably damaging 1.00
R9022:Prdm10 UTSW 9 31,268,424 (GRCm39) missense probably benign 0.01
R9200:Prdm10 UTSW 9 31,268,438 (GRCm39) missense probably damaging 1.00
R9288:Prdm10 UTSW 9 31,252,674 (GRCm39) missense possibly damaging 0.67
R9607:Prdm10 UTSW 9 31,260,486 (GRCm39) missense probably damaging 1.00
RF004:Prdm10 UTSW 9 31,270,422 (GRCm39) missense probably damaging 1.00
X0064:Prdm10 UTSW 9 31,273,747 (GRCm39) missense probably damaging 1.00
Z1176:Prdm10 UTSW 9 31,227,589 (GRCm39) nonsense probably null
Z1176:Prdm10 UTSW 9 31,227,464 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AATTCAAGTCAGCTCTCTGGCATGG -3'
(R):5'- GCTGGTAGTAGGATGCTTTGCTCAC -3'

Sequencing Primer
(F):5'- CTCTCTGGCATGGAGCATC -3'
(R):5'- CAAATGCTTGGTTCTGGATACTC -3'
Posted On 2013-04-16