Incidental Mutation 'R2074:Cnot1'
ID |
227434 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cnot1
|
Ensembl Gene |
ENSMUSG00000036550 |
Gene Name |
CCR4-NOT transcription complex, subunit 1 |
Synonyms |
6030411K04Rik |
MMRRC Submission |
040079-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R2074 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
8 |
Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 96466461 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Lysine
at position 1592
(T1592K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148735
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000068452
AA Change: T1587K
PolyPhen 2
Score 0.526 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000063565 Gene: ENSMUSG00000036550 AA Change: T1587K
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000098473
AA Change: T1592K
PolyPhen 2
Score 0.175 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000096073 Gene: ENSMUSG00000036550 AA Change: T1592K
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211887
AA Change: T1585K
PolyPhen 2
Score 0.677 (Sensitivity: 0.86; Specificity: 0.92)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000211973
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212195
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212340
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000213006
AA Change: T1592K
PolyPhen 2
Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212712
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212415
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 90 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ace |
C |
T |
11: 105,867,449 (GRCm39) |
Q484* |
probably null |
Het |
Ackr3 |
T |
C |
1: 90,141,703 (GRCm39) |
I54T |
probably damaging |
Het |
Aco1 |
G |
A |
4: 40,183,605 (GRCm39) |
G508S |
probably damaging |
Het |
Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
Ankef1 |
T |
C |
2: 136,387,658 (GRCm39) |
S192P |
possibly damaging |
Het |
Ankrd16 |
T |
G |
2: 11,794,559 (GRCm39) |
C315G |
possibly damaging |
Het |
Ankzf1 |
T |
C |
1: 75,172,887 (GRCm39) |
S328P |
probably damaging |
Het |
Aqp2 |
A |
G |
15: 99,480,981 (GRCm39) |
I176V |
probably benign |
Het |
Arhgap45 |
A |
G |
10: 79,863,014 (GRCm39) |
Y730C |
probably damaging |
Het |
Armh3 |
A |
T |
19: 45,953,820 (GRCm39) |
I188K |
probably damaging |
Het |
Asxl2 |
A |
G |
12: 3,543,779 (GRCm39) |
E316G |
probably damaging |
Het |
Btbd17 |
A |
T |
11: 114,682,778 (GRCm39) |
|
probably null |
Het |
Calu |
A |
G |
6: 29,372,614 (GRCm39) |
Y263C |
probably damaging |
Het |
Ccdc122 |
T |
C |
14: 77,306,391 (GRCm39) |
|
probably null |
Het |
Cenpf |
T |
C |
1: 189,389,098 (GRCm39) |
K1578R |
probably damaging |
Het |
Cep120 |
A |
G |
18: 53,852,384 (GRCm39) |
V498A |
possibly damaging |
Het |
Ces1a |
T |
A |
8: 93,774,703 (GRCm39) |
N12Y |
probably benign |
Het |
Chmp1a |
A |
T |
8: 123,934,761 (GRCm39) |
M65K |
probably damaging |
Het |
Cps1 |
T |
A |
1: 67,243,797 (GRCm39) |
I1091N |
probably benign |
Het |
Dhx32 |
T |
C |
7: 133,323,021 (GRCm39) |
N731S |
probably benign |
Het |
Dhx33 |
G |
A |
11: 70,890,669 (GRCm39) |
R177W |
probably damaging |
Het |
Dmd |
G |
C |
X: 83,356,089 (GRCm39) |
A2257P |
probably benign |
Het |
Dnah10 |
T |
C |
5: 124,891,738 (GRCm39) |
S3259P |
probably damaging |
Het |
Dnah7a |
T |
C |
1: 53,496,855 (GRCm39) |
I3134V |
probably benign |
Het |
Dock3 |
A |
G |
9: 106,870,662 (GRCm39) |
F584S |
possibly damaging |
Het |
Dtnb |
A |
G |
12: 3,831,273 (GRCm39) |
T658A |
probably benign |
Het |
Duox2 |
T |
A |
2: 122,125,639 (GRCm39) |
S323C |
probably damaging |
Het |
Elovl3 |
A |
T |
19: 46,120,606 (GRCm39) |
E33V |
probably damaging |
Het |
Enpp5 |
T |
C |
17: 44,396,264 (GRCm39) |
F392S |
probably benign |
Het |
Eogt |
T |
C |
6: 97,108,337 (GRCm39) |
T235A |
probably benign |
Het |
Etv3 |
T |
C |
3: 87,443,526 (GRCm39) |
V370A |
probably benign |
Het |
Ewsr1 |
C |
T |
11: 5,021,555 (GRCm39) |
R466H |
unknown |
Het |
Fcgbp |
G |
A |
7: 27,819,814 (GRCm39) |
G2514S |
probably damaging |
Het |
Flt1 |
A |
T |
5: 147,536,416 (GRCm39) |
D808E |
possibly damaging |
Het |
Glg1 |
C |
T |
8: 111,895,303 (GRCm39) |
G836E |
probably damaging |
Het |
Gm17334 |
A |
G |
11: 53,663,654 (GRCm39) |
|
probably benign |
Het |
Gpbp1 |
A |
T |
13: 111,589,941 (GRCm39) |
D51E |
probably benign |
Het |
Il12rb2 |
C |
G |
6: 67,337,536 (GRCm39) |
C115S |
probably damaging |
Het |
Il1rl1 |
T |
C |
1: 40,501,204 (GRCm39) |
S527P |
probably damaging |
Het |
Ireb2 |
A |
G |
9: 54,788,733 (GRCm39) |
D69G |
probably benign |
Het |
Kif5a |
T |
C |
10: 127,081,238 (GRCm39) |
D232G |
probably damaging |
Het |
M1ap |
A |
G |
6: 82,958,863 (GRCm39) |
I165V |
probably benign |
Het |
Mff |
T |
A |
1: 82,729,421 (GRCm39) |
L287H |
probably damaging |
Het |
Mmp27 |
A |
G |
9: 7,577,740 (GRCm39) |
M311V |
possibly damaging |
Het |
Mpped2 |
T |
A |
2: 106,575,147 (GRCm39) |
Y77* |
probably null |
Het |
Mybbp1a |
G |
A |
11: 72,332,271 (GRCm39) |
S21N |
probably benign |
Het |
Obscn |
G |
C |
11: 58,960,107 (GRCm39) |
I3253M |
probably damaging |
Het |
Obscn |
T |
C |
11: 59,023,478 (GRCm39) |
D633G |
probably damaging |
Het |
Olr1 |
C |
T |
6: 129,479,057 (GRCm39) |
V54I |
probably benign |
Het |
Or10j3b |
A |
T |
1: 173,043,377 (GRCm39) |
D53V |
probably damaging |
Het |
Or4a74 |
A |
G |
2: 89,439,822 (GRCm39) |
V208A |
probably benign |
Het |
Phlpp2 |
T |
C |
8: 110,655,124 (GRCm39) |
S605P |
possibly damaging |
Het |
Plekhg4 |
TAGTCGATGCCCGAGTC |
TAGTC |
8: 106,103,084 (GRCm39) |
|
probably benign |
Het |
Potefam1 |
T |
C |
2: 111,030,763 (GRCm39) |
E382G |
probably damaging |
Het |
Prss8 |
C |
A |
7: 127,526,266 (GRCm39) |
R148L |
possibly damaging |
Het |
Psg27 |
T |
C |
7: 18,294,342 (GRCm39) |
D355G |
probably damaging |
Het |
Rabgef1 |
C |
A |
5: 130,216,402 (GRCm39) |
Q52K |
probably benign |
Het |
Rnf6 |
C |
T |
5: 146,147,716 (GRCm39) |
R434H |
probably damaging |
Het |
Rpl26 |
A |
G |
11: 68,794,099 (GRCm39) |
E88G |
probably benign |
Het |
Rpn1 |
T |
A |
6: 88,077,944 (GRCm39) |
L460Q |
probably damaging |
Het |
Sap130 |
T |
A |
18: 31,781,332 (GRCm39) |
I165N |
probably damaging |
Het |
Sash1 |
A |
G |
10: 8,632,461 (GRCm39) |
V258A |
probably damaging |
Het |
Scarb1 |
G |
T |
5: 125,371,207 (GRCm39) |
N288K |
probably benign |
Het |
Sec16a |
A |
G |
2: 26,330,251 (GRCm39) |
I588T |
probably damaging |
Het |
Shank2 |
C |
A |
7: 143,963,277 (GRCm39) |
S295Y |
probably damaging |
Het |
Slc15a3 |
T |
C |
19: 10,834,663 (GRCm39) |
S515P |
probably damaging |
Het |
Slc25a13 |
A |
T |
6: 6,114,017 (GRCm39) |
M285K |
probably benign |
Het |
Slc39a11 |
A |
G |
11: 113,354,800 (GRCm39) |
I143T |
probably null |
Het |
Smarcd2 |
A |
T |
11: 106,156,133 (GRCm39) |
L42* |
probably null |
Het |
Smc3 |
A |
G |
19: 53,619,964 (GRCm39) |
D620G |
probably benign |
Het |
Spata31g1 |
A |
T |
4: 42,974,171 (GRCm39) |
D1168V |
probably benign |
Het |
Syt10 |
C |
T |
15: 89,674,979 (GRCm39) |
D456N |
probably damaging |
Het |
Taar4 |
A |
C |
10: 23,837,071 (GRCm39) |
Q227P |
probably benign |
Het |
Tasor |
T |
A |
14: 27,183,170 (GRCm39) |
I543K |
probably benign |
Het |
Tecta |
G |
T |
9: 42,248,575 (GRCm39) |
Y1937* |
probably null |
Het |
Tex10 |
C |
T |
4: 48,456,800 (GRCm39) |
R637Q |
probably benign |
Het |
Tmem130 |
T |
A |
5: 144,692,084 (GRCm39) |
T107S |
possibly damaging |
Het |
Tmem132d |
T |
C |
5: 128,346,195 (GRCm39) |
D109G |
probably damaging |
Het |
Tmem81 |
A |
G |
1: 132,435,644 (GRCm39) |
Y150C |
probably damaging |
Het |
Tnrc18 |
C |
T |
5: 142,745,461 (GRCm39) |
|
probably null |
Het |
Trim43a |
A |
G |
9: 88,468,147 (GRCm39) |
K256R |
possibly damaging |
Het |
Trpm6 |
A |
G |
19: 18,855,103 (GRCm39) |
T1921A |
probably damaging |
Het |
Tubb3 |
C |
T |
8: 124,148,009 (GRCm39) |
A314V |
probably damaging |
Het |
Ube3b |
A |
C |
5: 114,553,316 (GRCm39) |
N896T |
probably benign |
Het |
Unc80 |
G |
A |
1: 66,718,903 (GRCm39) |
|
probably null |
Het |
Upb1 |
A |
G |
10: 75,260,347 (GRCm39) |
T134A |
probably damaging |
Het |
Vmn2r15 |
A |
T |
5: 109,434,619 (GRCm39) |
M695K |
possibly damaging |
Het |
Wwc1 |
G |
T |
11: 35,780,180 (GRCm39) |
D258E |
possibly damaging |
Het |
Zfp619 |
T |
A |
7: 39,184,185 (GRCm39) |
Y72N |
probably benign |
Het |
Zfp672 |
G |
T |
11: 58,207,462 (GRCm39) |
H286Q |
possibly damaging |
Het |
|
Other mutations in Cnot1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
Predicted Primers |
PCR Primer
(F):5'- ACTGCTTGACATGCTGATCTAAC -3'
(R):5'- AGCTGGGCATTTTAGCAGG -3'
Sequencing Primer
(F):5'- CAAAGATCAGTTGTAACCAATGGC -3'
(R):5'- AGTTTGAGACCAGCCTGATC -3'
|
Posted On |
2014-09-17 |