Incidental Mutation 'R2129:Kif1b'
| ID |
227821 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif1b
|
| Ensembl Gene |
ENSMUSG00000063077 |
| Gene Name |
kinesin family member 1B |
| Synonyms |
N-3 kinesin, KIF1Bp130, KIF1Bp204, Kif1b beta, Kif1b alpha, D4Mil1e, A530096N05Rik |
| MMRRC Submission |
040132-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2129 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
149260776-149392150 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 149272097 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Leucine
at position 1568
(S1568L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056754
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055647]
[ENSMUST00000060537]
|
| AlphaFold |
Q60575 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055647
AA Change: S1522L
PolyPhen 2
Score 0.282 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000061472
Gene: ENSMUSG00000063077
AA Change: S1522L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
685 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
799 |
846 |
9.7e-13 |
PFAM |
|
internal_repeat_1
|
901 |
933 |
7.01e-7 |
PROSPERO |
|
low complexity region
|
1165 |
1179 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1220 |
1368 |
1.1e-46 |
PFAM |
|
low complexity region
|
1444 |
1461 |
N/A |
INTRINSIC |
|
low complexity region
|
1479 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1591 |
N/A |
INTRINSIC |
|
PH
|
1656 |
1755 |
1.02e-14 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000060537
AA Change: S1568L
PolyPhen 2
Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000056754
Gene: ENSMUSG00000063077
AA Change: S1568L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
362 |
7.61e-175 |
SMART |
|
low complexity region
|
390 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
432 |
450 |
N/A |
INTRINSIC |
|
FHA
|
555 |
612 |
1.61e-4 |
SMART |
|
coiled coil region
|
672 |
731 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
845 |
892 |
7.1e-15 |
PFAM |
|
internal_repeat_1
|
947 |
979 |
4.76e-7 |
PROSPERO |
|
low complexity region
|
1211 |
1225 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1266 |
1413 |
1.1e-40 |
PFAM |
|
low complexity region
|
1490 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1619 |
1637 |
N/A |
INTRINSIC |
|
PH
|
1702 |
1801 |
1.02e-14 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000139123
AA Change: S246L
|
| SMART Domains |
Protein: ENSMUSP00000120076
Gene: ENSMUSG00000063077
AA Change: S246L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3694
|
1 |
92 |
4.4e-23 |
PFAM |
|
low complexity region
|
169 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
204 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
316 |
N/A |
INTRINSIC |
|
PH
|
381 |
480 |
1.02e-14 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150853
|
| Meta Mutation Damage Score |
0.2112 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
99% (91/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
A |
G |
10: 87,066,066 (GRCm39) |
E249G |
possibly damaging |
Het |
| 2610028H24Rik |
A |
G |
10: 76,293,349 (GRCm39) |
M136V |
possibly damaging |
Het |
| 4930523C07Rik |
A |
T |
1: 159,902,945 (GRCm39) |
K72* |
probably null |
Het |
| Abhd14a |
A |
T |
9: 106,318,064 (GRCm39) |
L125Q |
probably null |
Het |
| Abhd17b |
T |
A |
19: 21,658,413 (GRCm39) |
|
probably null |
Het |
| Abo |
G |
A |
2: 26,736,586 (GRCm39) |
T61I |
probably benign |
Het |
| Adamts15 |
T |
C |
9: 30,815,799 (GRCm39) |
T686A |
probably benign |
Het |
| Adgrv1 |
A |
T |
13: 81,705,199 (GRCm39) |
F1537Y |
probably damaging |
Het |
| Anxa2 |
A |
T |
9: 69,383,410 (GRCm39) |
Y75F |
possibly damaging |
Het |
| Aqp3 |
T |
A |
4: 41,098,061 (GRCm39) |
I17F |
probably benign |
Het |
| Aspm |
T |
C |
1: 139,385,373 (GRCm39) |
V339A |
probably benign |
Het |
| Bri3bp |
T |
A |
5: 125,528,735 (GRCm39) |
L48* |
probably null |
Het |
| Car7 |
T |
A |
8: 105,275,605 (GRCm39) |
C185S |
possibly damaging |
Het |
| Casp8ap2 |
T |
C |
4: 32,640,142 (GRCm39) |
Y399H |
probably benign |
Het |
| Ces4a |
G |
A |
8: 105,864,729 (GRCm39) |
G69S |
probably damaging |
Het |
| Chst10 |
A |
G |
1: 38,904,776 (GRCm39) |
Y203H |
probably benign |
Het |
| Clca3a1 |
T |
C |
3: 144,722,526 (GRCm39) |
D282G |
probably damaging |
Het |
| Coq3 |
T |
G |
4: 21,900,342 (GRCm39) |
S190A |
probably benign |
Het |
| Crocc |
G |
A |
4: 140,744,407 (GRCm39) |
R1830C |
probably damaging |
Het |
| Cygb |
A |
G |
11: 116,540,668 (GRCm39) |
L106P |
probably damaging |
Het |
| Dab2 |
G |
T |
15: 6,365,864 (GRCm39) |
E87* |
probably null |
Het |
| Dcst1 |
T |
A |
3: 89,264,852 (GRCm39) |
I299F |
probably damaging |
Het |
| Dennd4a |
T |
G |
9: 64,813,256 (GRCm39) |
|
probably null |
Het |
| Depdc7 |
A |
G |
2: 104,558,518 (GRCm39) |
S168P |
probably benign |
Het |
| Dicer1 |
G |
A |
12: 104,688,290 (GRCm39) |
T429I |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,408,467 (GRCm39) |
Q3484R |
probably benign |
Het |
| Dock2 |
T |
C |
11: 34,618,242 (GRCm39) |
M125V |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,175,289 (GRCm39) |
S107P |
possibly damaging |
Het |
| Emb |
T |
C |
13: 117,404,082 (GRCm39) |
V278A |
probably damaging |
Het |
| Firrm |
T |
C |
1: 163,794,026 (GRCm39) |
Y518C |
probably damaging |
Het |
| Foxk1 |
C |
A |
5: 142,420,943 (GRCm39) |
S189* |
probably null |
Het |
| Galm |
T |
C |
17: 80,490,647 (GRCm39) |
I268T |
probably benign |
Het |
| Gm5581 |
A |
C |
6: 131,145,247 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr6 |
G |
A |
10: 40,947,168 (GRCm39) |
S138L |
possibly damaging |
Het |
| Hesx1 |
C |
A |
14: 26,722,802 (GRCm39) |
H42Q |
possibly damaging |
Het |
| Hsp90b1 |
T |
C |
10: 86,531,570 (GRCm39) |
D421G |
probably damaging |
Het |
| Kctd19 |
T |
C |
8: 106,111,804 (GRCm39) |
T31A |
probably damaging |
Het |
| Krtap19-3 |
T |
C |
16: 88,674,863 (GRCm39) |
|
probably benign |
Het |
| Lin28a |
T |
A |
4: 133,745,465 (GRCm39) |
I43F |
probably benign |
Het |
| Lrriq1 |
G |
A |
10: 103,050,718 (GRCm39) |
T678I |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,262,608 (GRCm39) |
|
probably benign |
Het |
| Madcam1 |
A |
G |
10: 79,501,406 (GRCm39) |
E157G |
possibly damaging |
Het |
| Mctp1 |
A |
G |
13: 76,972,941 (GRCm39) |
D648G |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,030,140 (GRCm39) |
L425P |
probably damaging |
Het |
| Mospd4 |
A |
G |
18: 46,598,731 (GRCm39) |
|
noncoding transcript |
Het |
| Mybpc1 |
T |
G |
10: 88,387,314 (GRCm39) |
T466P |
probably damaging |
Het |
| Myo10 |
T |
C |
15: 25,781,885 (GRCm39) |
Y1127H |
probably benign |
Het |
| Myo18b |
A |
T |
5: 112,978,944 (GRCm39) |
L1223Q |
probably damaging |
Het |
| Myo9b |
T |
C |
8: 71,786,343 (GRCm39) |
Y670H |
probably damaging |
Het |
| Ndufaf4 |
G |
T |
4: 24,898,608 (GRCm39) |
D55Y |
probably damaging |
Het |
| Neurod2 |
G |
T |
11: 98,218,414 (GRCm39) |
A250E |
possibly damaging |
Het |
| Nherf1 |
A |
T |
11: 115,067,270 (GRCm39) |
I174F |
probably damaging |
Het |
| Nipsnap1 |
C |
A |
11: 4,838,932 (GRCm39) |
N119K |
probably benign |
Het |
| Npffr2 |
A |
T |
5: 89,715,924 (GRCm39) |
I84F |
probably damaging |
Het |
| Or10ab4 |
T |
A |
7: 107,655,111 (GRCm39) |
N307K |
probably benign |
Het |
| Or11h23 |
A |
G |
14: 50,948,093 (GRCm39) |
Y102C |
probably damaging |
Het |
| Or2t48 |
T |
C |
11: 58,420,437 (GRCm39) |
D125G |
probably damaging |
Het |
| Pald1 |
A |
G |
10: 61,184,085 (GRCm39) |
|
probably null |
Het |
| Palld |
T |
C |
8: 62,330,395 (GRCm39) |
S161G |
probably benign |
Het |
| Paqr9 |
T |
A |
9: 95,443,122 (GRCm39) |
F371I |
probably benign |
Het |
| Pear1 |
A |
T |
3: 87,665,666 (GRCm39) |
C120* |
probably null |
Het |
| Pla2g4e |
A |
T |
2: 120,013,292 (GRCm39) |
F343I |
probably damaging |
Het |
| Plxdc2 |
A |
T |
2: 16,516,902 (GRCm39) |
Y61F |
probably benign |
Het |
| Polh |
G |
A |
17: 46,499,014 (GRCm39) |
Q234* |
probably null |
Het |
| Prkce |
T |
A |
17: 86,803,463 (GRCm39) |
M454K |
possibly damaging |
Het |
| Proser1 |
C |
A |
3: 53,385,366 (GRCm39) |
T416K |
probably benign |
Het |
| Prr14l |
G |
T |
5: 32,989,172 (GRCm39) |
|
probably benign |
Het |
| Rabgap1l |
A |
T |
1: 160,566,527 (GRCm39) |
D90E |
probably benign |
Het |
| Rp1l1 |
T |
A |
14: 64,266,415 (GRCm39) |
V667D |
possibly damaging |
Het |
| Rpp40 |
A |
T |
13: 36,082,604 (GRCm39) |
C256* |
probably null |
Het |
| Rps6ka5 |
A |
G |
12: 100,644,797 (GRCm39) |
L51P |
probably damaging |
Het |
| Rtp2 |
C |
T |
16: 23,746,457 (GRCm39) |
C78Y |
probably damaging |
Het |
| Ryr3 |
A |
G |
2: 112,508,715 (GRCm39) |
|
probably benign |
Het |
| Slc10a6 |
A |
G |
5: 103,756,922 (GRCm39) |
Y281H |
probably benign |
Het |
| Slc6a21 |
T |
G |
7: 44,932,197 (GRCm39) |
|
probably null |
Het |
| Smo |
A |
G |
6: 29,757,313 (GRCm39) |
Y476C |
probably damaging |
Het |
| Tacr3 |
A |
T |
3: 134,560,621 (GRCm39) |
T187S |
probably damaging |
Het |
| Tas1r3 |
G |
A |
4: 155,944,927 (GRCm39) |
R765C |
probably damaging |
Het |
| Tasp1 |
T |
C |
2: 139,890,164 (GRCm39) |
K71E |
possibly damaging |
Het |
| Tg |
A |
G |
15: 66,566,743 (GRCm39) |
I1264V |
probably benign |
Het |
| Tmem41a |
T |
C |
16: 21,764,911 (GRCm39) |
|
probably null |
Het |
| Tmem63a |
A |
G |
1: 180,793,105 (GRCm39) |
N459D |
probably benign |
Het |
| Ube2k |
A |
G |
5: 65,752,269 (GRCm39) |
T151A |
probably damaging |
Het |
| Ubr1 |
T |
C |
2: 120,773,034 (GRCm39) |
E402G |
probably benign |
Het |
| Ulk4 |
T |
A |
9: 120,981,248 (GRCm39) |
I897F |
probably benign |
Het |
| Usp30 |
A |
G |
5: 114,249,224 (GRCm39) |
E176G |
probably damaging |
Het |
| Utp20 |
A |
G |
10: 88,649,917 (GRCm39) |
F431S |
probably damaging |
Het |
| Vmn1r206 |
T |
C |
13: 22,804,782 (GRCm39) |
S142G |
probably benign |
Het |
| Wdr17 |
C |
T |
8: 55,085,416 (GRCm39) |
V1236M |
probably damaging |
Het |
| Zbtb32 |
T |
C |
7: 30,290,918 (GRCm39) |
K126E |
possibly damaging |
Het |
| Zeb1 |
A |
T |
18: 5,767,681 (GRCm39) |
S731C |
possibly damaging |
Het |
|
| Other mutations in Kif1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Kif1b
|
APN |
4 |
149,305,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01943:Kif1b
|
APN |
4 |
149,299,362 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02240:Kif1b
|
APN |
4 |
149,330,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02414:Kif1b
|
APN |
4 |
149,283,771 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02490:Kif1b
|
APN |
4 |
149,288,665 (GRCm39) |
missense |
probably benign |
|
|
IGL02501:Kif1b
|
APN |
4 |
149,299,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02833:Kif1b
|
APN |
4 |
149,330,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Kif1b
|
APN |
4 |
149,375,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02900:Kif1b
|
APN |
4 |
149,265,266 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03287:Kif1b
|
APN |
4 |
149,299,438 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL03412:Kif1b
|
APN |
4 |
149,359,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4305001:Kif1b
|
UTSW |
4 |
149,305,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0005:Kif1b
|
UTSW |
4 |
149,266,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0129:Kif1b
|
UTSW |
4 |
149,345,658 (GRCm39) |
missense |
probably benign |
|
|
R0180:Kif1b
|
UTSW |
4 |
149,298,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0288:Kif1b
|
UTSW |
4 |
149,283,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Kif1b
|
UTSW |
4 |
149,347,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Kif1b
|
UTSW |
4 |
149,286,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0398:Kif1b
|
UTSW |
4 |
149,288,688 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0403:Kif1b
|
UTSW |
4 |
149,266,424 (GRCm39) |
nonsense |
probably null |
|
|
R0445:Kif1b
|
UTSW |
4 |
149,272,466 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Kif1b
|
UTSW |
4 |
149,279,958 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1728:Kif1b
|
UTSW |
4 |
149,272,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1840:Kif1b
|
UTSW |
4 |
149,272,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1874:Kif1b
|
UTSW |
4 |
149,272,089 (GRCm39) |
missense |
probably benign |
|
|
R1915:Kif1b
|
UTSW |
4 |
149,351,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2124:Kif1b
|
UTSW |
4 |
149,306,753 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2126:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2127:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2128:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2146:Kif1b
|
UTSW |
4 |
149,268,766 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2255:Kif1b
|
UTSW |
4 |
149,359,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2392:Kif1b
|
UTSW |
4 |
149,305,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2883:Kif1b
|
UTSW |
4 |
149,322,105 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2981:Kif1b
|
UTSW |
4 |
149,304,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3038:Kif1b
|
UTSW |
4 |
149,297,790 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3616:Kif1b
|
UTSW |
4 |
149,346,740 (GRCm39) |
splice site |
probably benign |
|
|
R3935:Kif1b
|
UTSW |
4 |
149,321,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4347:Kif1b
|
UTSW |
4 |
149,331,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4423:Kif1b
|
UTSW |
4 |
149,298,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4637:Kif1b
|
UTSW |
4 |
149,283,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4745:Kif1b
|
UTSW |
4 |
149,322,339 (GRCm39) |
nonsense |
probably null |
|
|
R4807:Kif1b
|
UTSW |
4 |
149,332,378 (GRCm39) |
intron |
probably benign |
|
|
R5618:Kif1b
|
UTSW |
4 |
149,354,346 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5644:Kif1b
|
UTSW |
4 |
149,322,939 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5683:Kif1b
|
UTSW |
4 |
149,306,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5696:Kif1b
|
UTSW |
4 |
149,358,306 (GRCm39) |
splice site |
probably null |
|
|
R6022:Kif1b
|
UTSW |
4 |
149,282,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6048:Kif1b
|
UTSW |
4 |
149,348,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6137:Kif1b
|
UTSW |
4 |
149,322,883 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6139:Kif1b
|
UTSW |
4 |
149,321,989 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6171:Kif1b
|
UTSW |
4 |
149,342,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6250:Kif1b
|
UTSW |
4 |
149,298,100 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6423:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6424:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6425:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6443:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6460:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6462:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6463:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6469:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6470:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6471:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6472:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6504:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6536:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6537:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6668:Kif1b
|
UTSW |
4 |
149,297,864 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6698:Kif1b
|
UTSW |
4 |
149,359,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7065:Kif1b
|
UTSW |
4 |
149,286,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7222:Kif1b
|
UTSW |
4 |
149,309,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Kif1b
|
UTSW |
4 |
149,298,547 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7720:Kif1b
|
UTSW |
4 |
149,266,812 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7744:Kif1b
|
UTSW |
4 |
149,321,532 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7797:Kif1b
|
UTSW |
4 |
149,321,844 (GRCm39) |
missense |
probably benign |
|
|
R7829:Kif1b
|
UTSW |
4 |
149,305,447 (GRCm39) |
splice site |
probably null |
|
|
R7869:Kif1b
|
UTSW |
4 |
149,268,833 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7878:Kif1b
|
UTSW |
4 |
149,299,454 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7980:Kif1b
|
UTSW |
4 |
149,354,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8047:Kif1b
|
UTSW |
4 |
149,299,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Kif1b
|
UTSW |
4 |
149,275,642 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8243:Kif1b
|
UTSW |
4 |
149,288,724 (GRCm39) |
missense |
probably benign |
|
|
R8252:Kif1b
|
UTSW |
4 |
149,358,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Kif1b
|
UTSW |
4 |
149,306,805 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8460:Kif1b
|
UTSW |
4 |
149,272,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8462:Kif1b
|
UTSW |
4 |
149,266,797 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8496:Kif1b
|
UTSW |
4 |
149,277,068 (GRCm39) |
nonsense |
probably null |
|
|
R8687:Kif1b
|
UTSW |
4 |
149,345,620 (GRCm39) |
nonsense |
probably null |
|
|
R8694:Kif1b
|
UTSW |
4 |
149,305,024 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8842:Kif1b
|
UTSW |
4 |
149,338,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8883:Kif1b
|
UTSW |
4 |
149,361,342 (GRCm39) |
missense |
probably benign |
|
|
R8971:Kif1b
|
UTSW |
4 |
149,332,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8994:Kif1b
|
UTSW |
4 |
149,279,939 (GRCm39) |
missense |
|
|
|
R9002:Kif1b
|
UTSW |
4 |
149,275,712 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9227:Kif1b
|
UTSW |
4 |
149,322,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Kif1b
|
UTSW |
4 |
149,275,652 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9450:Kif1b
|
UTSW |
4 |
149,322,467 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9478:Kif1b
|
UTSW |
4 |
149,345,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9571:Kif1b
|
UTSW |
4 |
149,305,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Kif1b
|
UTSW |
4 |
149,375,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Kif1b
|
UTSW |
4 |
149,336,195 (GRCm39) |
splice site |
probably null |
|
|
X0009:Kif1b
|
UTSW |
4 |
149,331,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kif1b
|
UTSW |
4 |
149,359,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kif1b
|
UTSW |
4 |
149,350,755 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGTGAAGGTAAGGACTGACC -3'
(R):5'- ACGATGTTCCTCTTGTCAGG -3'
Sequencing Primer
(F):5'- AGGTAAGGACTGACCCTTATTATTTC -3'
(R):5'- AAAAACTCGCCACTTCTTGCTG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation