Incidental Mutation 'R2056:Krt9'
ID 228206
Institutional Source Beutler Lab
Gene Symbol Krt9
Ensembl Gene ENSMUSG00000051617
Gene Name keratin 9
Synonyms K9, Krt1-9
MMRRC Submission 040061-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2056 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 100077607-100084072 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 100082321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 201 (N201K)
Ref Sequence ENSEMBL: ENSMUSP00000055255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059707]
AlphaFold Q6RHW0
Predicted Effect probably damaging
Transcript: ENSMUST00000059707
AA Change: N201K

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055255
Gene: ENSMUSG00000051617
AA Change: N201K

DomainStartEndE-ValueType
low complexity region 6 125 N/A INTRINSIC
Filament 130 442 2.96e-124 SMART
low complexity region 462 716 N/A INTRINSIC
low complexity region 721 737 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg2 T C 6: 58,667,525 (GRCm39) V129A probably benign Het
Adh1 A G 3: 137,992,676 (GRCm39) D264G probably damaging Het
Ahnak2 T A 12: 112,748,626 (GRCm39) D407V probably benign Het
Alas1 T C 9: 106,118,489 (GRCm39) E211G probably damaging Het
Alkbh1 C T 12: 87,490,520 (GRCm39) probably benign Het
Ankmy1 T C 1: 92,809,553 (GRCm39) I662V possibly damaging Het
Ano1 A G 7: 144,201,789 (GRCm39) V334A probably damaging Het
Apc A G 18: 34,449,481 (GRCm39) R2092G probably damaging Het
Arhgap18 C T 10: 26,730,904 (GRCm39) T122I probably benign Het
Atp2b4 G T 1: 133,654,275 (GRCm39) Q777K probably benign Het
Brap G A 5: 121,801,529 (GRCm39) G95S probably damaging Het
Cbfa2t2 G A 2: 154,377,077 (GRCm39) A587T probably damaging Het
Ccdc180 A G 4: 45,932,477 (GRCm39) I1308V probably benign Het
Ccser1 T A 6: 61,399,936 (GRCm39) probably null Het
Cd84 A G 1: 171,700,317 (GRCm39) T145A possibly damaging Het
Cmtm4 A C 8: 105,081,920 (GRCm39) F156V probably damaging Het
Cntln G A 4: 84,967,911 (GRCm39) R710K probably benign Het
Csn1s1 A T 5: 87,819,387 (GRCm39) T15S possibly damaging Het
Cul9 T C 17: 46,854,298 (GRCm39) T135A probably benign Het
Cyp2d10 T A 15: 82,288,015 (GRCm39) I363F probably damaging Het
Dhx38 G T 8: 110,289,352 (GRCm39) probably benign Het
Dis3 A T 14: 99,336,251 (GRCm39) I85N possibly damaging Het
Dmbt1 G A 7: 130,707,900 (GRCm39) A1381T possibly damaging Het
Dscaml1 A G 9: 45,661,430 (GRCm39) D1776G probably damaging Het
Erbin A G 13: 103,966,824 (GRCm39) S1209P probably benign Het
Fat4 T A 3: 38,945,319 (GRCm39) M1404K possibly damaging Het
Fbxo45 G T 16: 32,057,346 (GRCm39) Q183K possibly damaging Het
Frmd4b C T 6: 97,389,448 (GRCm39) probably null Het
Fzd7 A G 1: 59,523,361 (GRCm39) S415G probably benign Het
Gpd2 T A 2: 57,229,025 (GRCm39) probably null Het
Gsk3b T A 16: 38,008,271 (GRCm39) D192E probably benign Het
Gstcd T C 3: 132,787,814 (GRCm39) I295V probably benign Het
Gucy1a1 A G 3: 82,016,592 (GRCm39) L132P possibly damaging Het
Il12b A C 11: 44,298,727 (GRCm39) T61P probably damaging Het
Il7 A T 3: 7,638,975 (GRCm39) N130K probably damaging Het
Itih3 A C 14: 30,631,481 (GRCm39) probably null Het
Kdm5b T A 1: 134,540,952 (GRCm39) D681E probably benign Het
Kif11 A G 19: 37,390,660 (GRCm39) N408D probably benign Het
Kng2 TATGACCATGACCATGACCATGACCATGACCATGACCAT TATGACCATGACCATGACCATGACCATGACCAT 16: 22,806,703 (GRCm39) probably benign Het
Kremen2 T C 17: 23,961,691 (GRCm39) E272G possibly damaging Het
Lmbr1 G A 5: 29,438,092 (GRCm39) P304L probably benign Het
Lrrfip1 A G 1: 91,043,539 (GRCm39) N648S probably benign Het
Mab21l3 C A 3: 101,722,469 (GRCm39) V386L possibly damaging Het
Mamdc4 T C 2: 25,454,180 (GRCm39) Q1149R probably benign Het
Mast1 A G 8: 85,646,995 (GRCm39) F677L possibly damaging Het
Mcoln3 A G 3: 145,833,979 (GRCm39) D173G probably benign Het
Mmrn1 C T 6: 60,921,789 (GRCm39) T82I probably benign Het
Mtcl2 C T 2: 156,864,747 (GRCm39) G1154S probably benign Het
Muc5ac A G 7: 141,345,772 (GRCm39) T203A probably benign Het
Myo9b T C 8: 71,812,334 (GRCm39) I2035T possibly damaging Het
Ndst3 T C 3: 123,465,534 (GRCm39) N146S probably damaging Het
Neu4 A G 1: 93,950,172 (GRCm39) T21A possibly damaging Het
Nos1ap G A 1: 170,155,215 (GRCm39) L267F probably damaging Het
Or14c40 A T 7: 86,313,591 (GRCm39) K240N probably damaging Het
Or3a4 A T 11: 73,944,819 (GRCm39) Y255* probably null Het
Or4p8 A G 2: 88,727,105 (GRCm39) F279L probably damaging Het
Phc1 T C 6: 122,310,299 (GRCm39) N136S probably damaging Het
Prkdc A G 16: 15,545,469 (GRCm39) T1862A probably benign Het
Psd2 A G 18: 36,139,744 (GRCm39) D596G possibly damaging Het
Psmc3 T C 2: 90,888,433 (GRCm39) F315L probably benign Het
Rerg G A 6: 137,034,878 (GRCm39) T42I probably benign Het
Rif1 T A 2: 51,983,588 (GRCm39) M577K probably damaging Het
Sap30 T C 8: 57,940,282 (GRCm39) probably null Het
Scn2b T C 9: 45,036,815 (GRCm39) Y108H probably damaging Het
Senp2 C T 16: 21,832,949 (GRCm39) T79I probably damaging Het
Serpinb2 T C 1: 107,451,543 (GRCm39) V232A probably damaging Het
Sgpp2 T A 1: 78,393,588 (GRCm39) L197Q probably damaging Het
Slc27a4 T C 2: 29,700,953 (GRCm39) W320R probably damaging Het
Spmip4 T C 6: 50,550,725 (GRCm39) R575G possibly damaging Het
Tgm4 T C 9: 122,890,835 (GRCm39) I54T probably damaging Het
Thbs4 T A 13: 92,927,387 (GRCm39) D34V probably benign Het
Tlcd4 T G 3: 121,001,070 (GRCm39) I188L probably benign Het
Tmem176b G A 6: 48,813,267 (GRCm39) T64I probably damaging Het
Tmod2 T C 9: 75,484,524 (GRCm39) E248G probably benign Het
Ttc6 T A 12: 57,784,479 (GRCm39) D1849E probably benign Het
Ttn T C 2: 76,615,882 (GRCm39) D8360G possibly damaging Het
Unc80 A G 1: 66,679,711 (GRCm39) E2094G possibly damaging Het
Vmn2r18 A T 5: 151,508,160 (GRCm39) D321E probably damaging Het
Other mutations in Krt9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00725:Krt9 APN 11 100,080,832 (GRCm39) missense probably damaging 1.00
IGL01695:Krt9 APN 11 100,082,263 (GRCm39) critical splice donor site probably null
IGL02383:Krt9 APN 11 100,082,041 (GRCm39) missense probably damaging 1.00
IGL02529:Krt9 APN 11 100,080,792 (GRCm39) missense probably damaging 0.99
IGL02819:Krt9 APN 11 100,082,346 (GRCm39) missense probably damaging 1.00
droplet UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R5944_Krt9_487 UTSW 11 100,079,265 (GRCm39) missense unknown
G1citation:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R1356:Krt9 UTSW 11 100,079,640 (GRCm39) small insertion probably benign
R1397:Krt9 UTSW 11 100,083,464 (GRCm39) missense probably damaging 1.00
R1498:Krt9 UTSW 11 100,079,195 (GRCm39) nonsense probably null
R1772:Krt9 UTSW 11 100,082,131 (GRCm39) missense probably damaging 0.99
R1871:Krt9 UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R1883:Krt9 UTSW 11 100,079,523 (GRCm39) missense unknown
R1985:Krt9 UTSW 11 100,080,817 (GRCm39) missense probably benign 0.02
R2253:Krt9 UTSW 11 100,081,685 (GRCm39) missense possibly damaging 0.83
R2305:Krt9 UTSW 11 100,083,942 (GRCm39) missense unknown
R2875:Krt9 UTSW 11 100,080,031 (GRCm39) nonsense probably null
R3813:Krt9 UTSW 11 100,080,503 (GRCm39) missense probably damaging 1.00
R3874:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4157:Krt9 UTSW 11 100,079,475 (GRCm39) missense unknown
R4762:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4873:Krt9 UTSW 11 100,080,863 (GRCm39) missense probably benign 0.06
R4875:Krt9 UTSW 11 100,080,863 (GRCm39) missense probably benign 0.06
R4923:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R4973:Krt9 UTSW 11 100,079,538 (GRCm39) missense unknown
R5153:Krt9 UTSW 11 100,082,068 (GRCm39) missense probably damaging 0.99
R5658:Krt9 UTSW 11 100,081,593 (GRCm39) missense probably damaging 0.98
R5696:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R5944:Krt9 UTSW 11 100,079,265 (GRCm39) missense unknown
R6147:Krt9 UTSW 11 100,079,665 (GRCm39) missense unknown
R6403:Krt9 UTSW 11 100,080,485 (GRCm39) missense probably damaging 0.99
R6476:Krt9 UTSW 11 100,081,640 (GRCm39) missense probably damaging 1.00
R6822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7159:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7174:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7203:Krt9 UTSW 11 100,081,617 (GRCm39) missense probably damaging 1.00
R7805:Krt9 UTSW 11 100,083,522 (GRCm39) missense possibly damaging 0.85
R7817:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7834:Krt9 UTSW 11 100,083,492 (GRCm39) missense probably benign 0.06
R7947:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7977:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R8943:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9092:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9099:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9203:Krt9 UTSW 11 100,079,734 (GRCm39) missense unknown
R9313:Krt9 UTSW 11 100,079,547 (GRCm39) missense unknown
R9361:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9370:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9438:Krt9 UTSW 11 100,079,824 (GRCm39) missense unknown
R9448:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9455:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9620:Krt9 UTSW 11 100,079,186 (GRCm39) missense unknown
R9676:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9719:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- GGCTTTGCTCCATCTCAAGC -3'
(R):5'- GATGACACTGGGCACATCTG -3'

Sequencing Primer
(F):5'- CCTGTAGGCAAGTCATGGGTAC -3'
(R):5'- ACTGGGCACATCTGCTGAAG -3'
Posted On 2014-09-17