Incidental Mutation 'R2057:Grin1'
| ID |
228237 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Grin1
|
| Ensembl Gene |
ENSMUSG00000026959 |
| Gene Name |
glutamate receptor, ionotropic, NMDA1 (zeta 1) |
| Synonyms |
NR1, GluRzeta1, NMDAR1, M100174, Nmdar, Rgsc174 |
| MMRRC Submission |
040062-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2057 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
25181193-25209199 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 25206832 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 110
(T110S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109949
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028335]
[ENSMUST00000114307]
[ENSMUST00000114308]
[ENSMUST00000114310]
[ENSMUST00000114312]
[ENSMUST00000114314]
[ENSMUST00000114317]
[ENSMUST00000114318]
|
| AlphaFold |
P35438 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000028335
AA Change: T110S
PolyPhen 2
Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000028335
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
357 |
6.6e-35 |
PFAM |
|
PBPe
|
433 |
795 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
439 |
507 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
835 |
863 |
1.5e-18 |
PFAM |
|
PDB:3BYA|B
|
875 |
898 |
4e-6 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114307
AA Change: T110S
PolyPhen 2
Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000109946
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
357 |
1e-34 |
PFAM |
|
PBPe
|
433 |
795 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
439 |
507 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
835 |
863 |
3.2e-19 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114308
AA Change: T110S
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000109947
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
378 |
8e-31 |
PFAM |
|
PBPe
|
454 |
816 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
460 |
528 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
856 |
884 |
3.3e-19 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114310
AA Change: T110S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000109949
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
39 |
299 |
3.6e-24 |
PFAM |
|
Blast:PBPe
|
352 |
420 |
9e-37 |
BLAST |
|
PBPe
|
454 |
816 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
460 |
528 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
856 |
884 |
8.4e-17 |
PFAM |
|
PDB:3BYA|B
|
896 |
919 |
4e-6 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114312
AA Change: T110S
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000109951
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
357 |
5.9e-35 |
PFAM |
|
PBPe
|
433 |
795 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
439 |
507 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
835 |
863 |
1.4e-18 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114314
AA Change: T110S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000109953
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
357 |
1.1e-34 |
PFAM |
|
PBPe
|
433 |
795 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
439 |
507 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
835 |
863 |
3.3e-19 |
PFAM |
|
PDB:3BYA|B
|
875 |
898 |
4e-6 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114317
AA Change: T110S
PolyPhen 2
Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000109956
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
378 |
7.7e-31 |
PFAM |
|
PBPe
|
454 |
816 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
460 |
528 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
856 |
884 |
3.3e-19 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114318
AA Change: T110S
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000109957
Gene: ENSMUSG00000026959
AA Change: T110S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
38 |
378 |
8.4e-31 |
PFAM |
|
PBPe
|
454 |
816 |
2.71e-97 |
SMART |
|
Lig_chan-Glu_bd
|
460 |
528 |
2.99e-18 |
SMART |
|
Pfam:CaM_bdg_C0
|
856 |
884 |
3.4e-19 |
PFAM |
|
PDB:3BYA|B
|
896 |
919 |
4e-6 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144402
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155627
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Null mutants lack whisker patterns in brain cortex, are ataxic and die neonatally of respiratory failure. Hypomorph mutants exhibit hyperactivity, stereotypy, and impaired social/sexual interactions. Mice homozygous for an ENU-induced allele exhibit abnormal behavior and neuron physiology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
A |
G |
19: 43,806,477 (GRCm39) |
K764E |
probably damaging |
Het |
| Abcg2 |
T |
C |
6: 58,667,525 (GRCm39) |
V129A |
probably benign |
Het |
| Adgrf5 |
A |
G |
17: 43,739,477 (GRCm39) |
Y72C |
possibly damaging |
Het |
| Ago1 |
C |
T |
4: 126,337,021 (GRCm39) |
R228H |
probably damaging |
Het |
| Ano1 |
A |
G |
7: 144,201,789 (GRCm39) |
V334A |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,052,164 (GRCm39) |
R1202* |
probably null |
Het |
| Arfgap3 |
G |
T |
15: 83,194,501 (GRCm39) |
D389E |
probably benign |
Het |
| Atf6b |
A |
T |
17: 34,867,549 (GRCm39) |
|
probably null |
Het |
| Atoh8 |
T |
C |
6: 72,212,112 (GRCm39) |
K13E |
probably damaging |
Het |
| Bicral |
G |
T |
17: 47,135,814 (GRCm39) |
N465K |
possibly damaging |
Het |
| Bves |
T |
A |
10: 45,219,231 (GRCm39) |
Y110N |
probably damaging |
Het |
| C4b |
A |
G |
17: 34,947,594 (GRCm39) |
Y1695H |
probably damaging |
Het |
| Cage1 |
A |
G |
13: 38,207,356 (GRCm39) |
V163A |
probably benign |
Het |
| Canx |
T |
C |
11: 50,195,252 (GRCm39) |
N272S |
probably damaging |
Het |
| Caskin1 |
G |
T |
17: 24,715,433 (GRCm39) |
G93V |
probably damaging |
Het |
| Cd34 |
T |
C |
1: 194,641,450 (GRCm39) |
V292A |
probably damaging |
Het |
| Cd84 |
A |
G |
1: 171,700,317 (GRCm39) |
T145A |
possibly damaging |
Het |
| Cdh16 |
C |
A |
8: 105,348,597 (GRCm39) |
G144* |
probably null |
Het |
| Chaf1b |
T |
A |
16: 93,691,795 (GRCm39) |
H280Q |
probably damaging |
Het |
| Chpf2 |
G |
A |
5: 24,796,220 (GRCm39) |
G389R |
probably damaging |
Het |
| Crb1 |
T |
C |
1: 139,242,488 (GRCm39) |
Y330C |
probably damaging |
Het |
| Cux2 |
A |
T |
5: 122,007,567 (GRCm39) |
V698E |
probably benign |
Het |
| Dhtkd1 |
A |
G |
2: 5,947,430 (GRCm39) |
V18A |
unknown |
Het |
| Dmbt1 |
G |
A |
7: 130,707,900 (GRCm39) |
A1381T |
possibly damaging |
Het |
| Enpp1 |
C |
G |
10: 24,536,090 (GRCm39) |
A437P |
probably damaging |
Het |
| Fat2 |
C |
T |
11: 55,172,686 (GRCm39) |
V2676I |
possibly damaging |
Het |
| Fzd2 |
A |
G |
11: 102,496,759 (GRCm39) |
D401G |
probably damaging |
Het |
| Gcm2 |
T |
C |
13: 41,263,430 (GRCm39) |
M1V |
probably null |
Het |
| Gnai3 |
C |
T |
3: 108,019,812 (GRCm39) |
V233I |
probably benign |
Het |
| Golim4 |
T |
A |
3: 75,802,194 (GRCm39) |
D366V |
possibly damaging |
Het |
| Grin2a |
A |
G |
16: 9,487,608 (GRCm39) |
V430A |
probably benign |
Het |
| Gstp3 |
G |
A |
19: 4,109,282 (GRCm39) |
T5I |
probably damaging |
Het |
| Il17rb |
T |
A |
14: 29,719,111 (GRCm39) |
M324L |
probably benign |
Het |
| Jmy |
A |
G |
13: 93,596,211 (GRCm39) |
Y473H |
probably damaging |
Het |
| Khdc1b |
A |
G |
1: 21,454,534 (GRCm39) |
D79G |
probably benign |
Het |
| Kremen2 |
T |
C |
17: 23,961,691 (GRCm39) |
E272G |
possibly damaging |
Het |
| Lmo7 |
G |
C |
14: 102,124,614 (GRCm39) |
A358P |
probably damaging |
Het |
| Mdh1b |
T |
C |
1: 63,760,741 (GRCm39) |
I107V |
probably benign |
Het |
| Mlkl |
T |
C |
8: 112,060,242 (GRCm39) |
Q48R |
probably benign |
Het |
| Myh2 |
G |
A |
11: 67,079,665 (GRCm39) |
|
probably null |
Het |
| Naip1 |
T |
A |
13: 100,562,081 (GRCm39) |
Q1028L |
probably damaging |
Het |
| Ncald |
T |
A |
15: 37,397,423 (GRCm39) |
I86F |
possibly damaging |
Het |
| Nid1 |
A |
C |
13: 13,675,058 (GRCm39) |
H926P |
probably benign |
Het |
| Nlrp9a |
T |
A |
7: 26,256,787 (GRCm39) |
I46K |
possibly damaging |
Het |
| Or1p1 |
A |
G |
11: 74,179,652 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or9r3 |
A |
T |
10: 129,947,859 (GRCm39) |
S267T |
probably benign |
Het |
| Pak1 |
T |
A |
7: 97,557,004 (GRCm39) |
|
probably null |
Het |
| Parpbp |
T |
A |
10: 87,960,824 (GRCm39) |
M221L |
probably benign |
Het |
| Pde12 |
T |
C |
14: 26,390,035 (GRCm39) |
I225V |
probably benign |
Het |
| Phf19 |
G |
T |
2: 34,789,620 (GRCm39) |
R367S |
probably benign |
Het |
| Plcl2 |
A |
G |
17: 50,975,139 (GRCm39) |
|
probably null |
Het |
| Plxnb1 |
A |
T |
9: 108,938,294 (GRCm39) |
I1283F |
possibly damaging |
Het |
| Pramel6 |
T |
A |
2: 87,339,059 (GRCm39) |
N86K |
possibly damaging |
Het |
| Prkdc |
A |
G |
16: 15,545,469 (GRCm39) |
T1862A |
probably benign |
Het |
| Prpf40a |
A |
T |
2: 53,034,851 (GRCm39) |
I779K |
probably damaging |
Het |
| Prss3b |
G |
A |
6: 41,009,315 (GRCm39) |
T173I |
probably benign |
Het |
| Ptpn20 |
A |
T |
14: 33,352,942 (GRCm39) |
E227V |
probably damaging |
Het |
| Rad54b |
C |
T |
4: 11,606,088 (GRCm39) |
R499C |
probably benign |
Het |
| Rarg |
C |
A |
15: 102,147,939 (GRCm39) |
A291S |
probably damaging |
Het |
| Rnf169 |
A |
T |
7: 99,574,615 (GRCm39) |
L660Q |
probably damaging |
Het |
| Scn4a |
A |
G |
11: 106,226,550 (GRCm39) |
V670A |
probably damaging |
Het |
| Serpinb9c |
A |
T |
13: 33,340,854 (GRCm39) |
C81* |
probably null |
Het |
| Sik1 |
A |
G |
17: 32,067,771 (GRCm39) |
S435P |
probably benign |
Het |
| Slc35g2 |
G |
A |
9: 100,435,329 (GRCm39) |
A114V |
probably damaging |
Het |
| Slc7a14 |
A |
T |
3: 31,291,645 (GRCm39) |
V211E |
probably damaging |
Het |
| Snrpn |
A |
T |
7: 59,637,204 (GRCm39) |
H37Q |
possibly damaging |
Het |
| Spock3 |
T |
A |
8: 63,698,204 (GRCm39) |
C185* |
probably null |
Het |
| Tbc1d4 |
A |
G |
14: 101,714,591 (GRCm39) |
S627P |
probably damaging |
Het |
| Tgoln1 |
T |
C |
6: 72,592,653 (GRCm39) |
T276A |
probably benign |
Het |
| Tmem176b |
G |
A |
6: 48,813,267 (GRCm39) |
T64I |
probably damaging |
Het |
| Tnpo2 |
T |
C |
8: 85,776,742 (GRCm39) |
L483P |
probably damaging |
Het |
| Tpte |
T |
A |
8: 22,808,355 (GRCm39) |
D163E |
probably benign |
Het |
| Trim36 |
A |
T |
18: 46,329,229 (GRCm39) |
D70E |
probably benign |
Het |
| Umodl1 |
G |
A |
17: 31,227,740 (GRCm39) |
|
probably null |
Het |
| Wdr90 |
T |
C |
17: 26,074,173 (GRCm39) |
T691A |
probably benign |
Het |
| Zdhhc8 |
A |
G |
16: 18,046,210 (GRCm39) |
S118P |
probably damaging |
Het |
| Zfp438 |
T |
C |
18: 5,214,085 (GRCm39) |
E291G |
probably benign |
Het |
| Zfp879 |
C |
T |
11: 50,723,428 (GRCm39) |
E543K |
probably benign |
Het |
|
| Other mutations in Grin1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01383:Grin1
|
APN |
2 |
25,186,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01627:Grin1
|
APN |
2 |
25,208,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02039:Grin1
|
APN |
2 |
25,195,354 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02074:Grin1
|
APN |
2 |
25,188,514 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02083:Grin1
|
APN |
2 |
25,188,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03334:Grin1
|
APN |
2 |
25,188,405 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03349:Grin1
|
APN |
2 |
25,200,448 (GRCm39) |
missense |
probably benign |
|
|
PIT4283001:Grin1
|
UTSW |
2 |
25,187,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Grin1
|
UTSW |
2 |
25,187,471 (GRCm39) |
missense |
probably null |
0.82 |
|
R0829:Grin1
|
UTSW |
2 |
25,188,460 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1454:Grin1
|
UTSW |
2 |
25,182,442 (GRCm39) |
nonsense |
probably null |
|
|
R1550:Grin1
|
UTSW |
2 |
25,195,143 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1969:Grin1
|
UTSW |
2 |
25,187,927 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2424:Grin1
|
UTSW |
2 |
25,208,664 (GRCm39) |
missense |
probably null |
1.00 |
|
R2877:Grin1
|
UTSW |
2 |
25,187,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2878:Grin1
|
UTSW |
2 |
25,187,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3420:Grin1
|
UTSW |
2 |
25,193,926 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3422:Grin1
|
UTSW |
2 |
25,193,926 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3958:Grin1
|
UTSW |
2 |
25,203,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Grin1
|
UTSW |
2 |
25,187,332 (GRCm39) |
intron |
probably benign |
|
|
R4224:Grin1
|
UTSW |
2 |
25,187,332 (GRCm39) |
intron |
probably benign |
|
|
R4225:Grin1
|
UTSW |
2 |
25,187,332 (GRCm39) |
intron |
probably benign |
|
|
R4409:Grin1
|
UTSW |
2 |
25,200,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4723:Grin1
|
UTSW |
2 |
25,184,482 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4775:Grin1
|
UTSW |
2 |
25,182,475 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4783:Grin1
|
UTSW |
2 |
25,182,393 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4784:Grin1
|
UTSW |
2 |
25,182,393 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4785:Grin1
|
UTSW |
2 |
25,182,393 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4829:Grin1
|
UTSW |
2 |
25,208,736 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4915:Grin1
|
UTSW |
2 |
25,188,565 (GRCm39) |
intron |
probably benign |
|
|
R5064:Grin1
|
UTSW |
2 |
25,193,843 (GRCm39) |
intron |
probably benign |
|
|
R5103:Grin1
|
UTSW |
2 |
25,200,433 (GRCm39) |
missense |
probably benign |
|
|
R5125:Grin1
|
UTSW |
2 |
25,186,839 (GRCm39) |
intron |
probably benign |
|
|
R5215:Grin1
|
UTSW |
2 |
25,193,919 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5419:Grin1
|
UTSW |
2 |
25,188,285 (GRCm39) |
splice site |
probably null |
|
|
R6119:Grin1
|
UTSW |
2 |
25,195,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6616:Grin1
|
UTSW |
2 |
25,182,122 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6894:Grin1
|
UTSW |
2 |
25,185,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7101:Grin1
|
UTSW |
2 |
25,186,647 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7137:Grin1
|
UTSW |
2 |
25,203,550 (GRCm39) |
missense |
probably benign |
|
|
R7544:Grin1
|
UTSW |
2 |
25,195,086 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7693:Grin1
|
UTSW |
2 |
25,208,679 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7872:Grin1
|
UTSW |
2 |
25,188,202 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7986:Grin1
|
UTSW |
2 |
25,185,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8350:Grin1
|
UTSW |
2 |
25,188,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Grin1
|
UTSW |
2 |
25,187,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8960:Grin1
|
UTSW |
2 |
25,195,428 (GRCm39) |
splice site |
probably benign |
|
|
R9219:Grin1
|
UTSW |
2 |
25,187,678 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9511:Grin1
|
UTSW |
2 |
25,187,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Grin1
|
UTSW |
2 |
25,187,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9532:Grin1
|
UTSW |
2 |
25,187,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9686:Grin1
|
UTSW |
2 |
25,203,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9729:Grin1
|
UTSW |
2 |
25,187,422 (GRCm39) |
nonsense |
probably null |
|
|
X0026:Grin1
|
UTSW |
2 |
25,195,110 (GRCm39) |
missense |
probably benign |
0.22 |
|
Z1176:Grin1
|
UTSW |
2 |
25,187,919 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCACAGGCCTGAATATTAGTGC -3'
(R):5'- ACAAATGGCATCACCTGGGC -3'
Sequencing Primer
(F):5'- ATACCTGTACCTGTGAGACCTAGTG -3'
(R):5'- CATCACCTGGGCCCCTG -3'
|
| Posted On |
2014-09-17 |
Incidental Mutation