Incidental Mutation 'R2077:Vmn2r24'
ID 229211
Institutional Source Beutler Lab
Gene Symbol Vmn2r24
Ensembl Gene ENSMUSG00000072780
Gene Name vomeronasal 2, receptor 24
Synonyms EG243628
MMRRC Submission 040082-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R2077 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 123755930-123793239 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 123792358 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 562 (C562S)
Ref Sequence ENSEMBL: ENSMUSP00000074602 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075095]
AlphaFold D3YUI0
Predicted Effect probably damaging
Transcript: ENSMUST00000075095
AA Change: C562S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: C562S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 469 1.6e-32 PFAM
Pfam:NCD3G 518 571 1.1e-22 PFAM
Pfam:7tm_3 602 839 1.1e-54 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 T A 4: 144,183,604 (GRCm39) probably benign Het
Abhd16b A C 2: 181,135,209 (GRCm39) D37A probably benign Het
Acp7 T C 7: 28,328,907 (GRCm39) E91G probably damaging Het
Alms1 T A 6: 85,599,291 (GRCm39) N1841K possibly damaging Het
Arhgap25 T A 6: 87,436,990 (GRCm39) D620V probably damaging Het
Caps2 C T 10: 112,035,632 (GRCm39) T371I possibly damaging Het
Ccdc175 A G 12: 72,186,794 (GRCm39) I350T possibly damaging Het
Cdc25c G C 18: 34,871,292 (GRCm39) L275V probably damaging Het
Cdc42bpb A G 12: 111,265,630 (GRCm39) L1434P probably damaging Het
Cdkl3 A T 11: 51,917,666 (GRCm39) E321V probably damaging Het
Clec2d G T 6: 129,160,153 (GRCm39) V56L possibly damaging Het
Cops3 A T 11: 59,715,136 (GRCm39) S301T possibly damaging Het
Crygd T C 1: 65,102,405 (GRCm39) D19G probably damaging Het
Dnah2 T C 11: 69,387,432 (GRCm39) I931M possibly damaging Het
Dst A T 1: 34,250,251 (GRCm39) R4068S probably damaging Het
Fas C T 19: 34,297,953 (GRCm39) probably benign Het
G6pd2 T A 5: 61,967,594 (GRCm39) D456E probably damaging Het
Galnt18 G A 7: 111,153,809 (GRCm39) R272W probably damaging Het
Grb2 C A 11: 115,536,651 (GRCm39) G200W probably damaging Het
Herc4 A G 10: 63,099,832 (GRCm39) N85S probably benign Het
Ighv7-2 T C 12: 113,875,727 (GRCm39) D92G probably damaging Het
Itih3 A G 14: 30,631,792 (GRCm39) V765A possibly damaging Het
Itm2b T C 14: 73,600,560 (GRCm39) N247D probably benign Het
Kcnd3 T C 3: 105,574,315 (GRCm39) V500A probably benign Het
Lrp2 C T 2: 69,338,187 (GRCm39) G1198R probably damaging Het
Ltb4r2 A G 14: 55,999,444 (GRCm39) T22A probably damaging Het
Mdga2 A G 12: 66,702,136 (GRCm39) V355A probably damaging Het
Megf8 T A 7: 25,053,163 (GRCm39) V1778E probably benign Het
Mroh2b G A 15: 4,974,448 (GRCm39) E1143K probably damaging Het
Nbn A T 4: 15,979,389 (GRCm39) Y458F probably damaging Het
Nlrc3 A G 16: 3,781,856 (GRCm39) C534R probably benign Het
Nup155 A G 15: 8,172,510 (GRCm39) E832G probably damaging Het
Or5w11 A G 2: 87,459,173 (GRCm39) Y122C probably damaging Het
Plcl2 A G 17: 50,913,857 (GRCm39) T289A probably benign Het
Ptprs C T 17: 56,741,990 (GRCm39) R7Q probably null Het
Rab3ip A T 10: 116,754,865 (GRCm39) D198E possibly damaging Het
Scaf4 A T 16: 90,049,323 (GRCm39) F255I unknown Het
Senp6 T C 9: 80,033,437 (GRCm39) S475P probably benign Het
Shpk T C 11: 73,094,785 (GRCm39) L67P probably damaging Het
Sik3 T A 9: 46,130,801 (GRCm39) Y1246N probably damaging Het
Slc44a2 A G 9: 21,265,020 (GRCm39) Y686C probably damaging Het
Slc6a19 A G 13: 73,848,685 (GRCm39) V23A probably benign Het
Slit3 A T 11: 35,435,575 (GRCm39) I169F possibly damaging Het
Stxbp5l A G 16: 37,056,637 (GRCm39) V379A possibly damaging Het
Tex2 T C 11: 106,397,690 (GRCm39) probably null Het
Tnpo3 A G 6: 29,586,143 (GRCm39) V149A possibly damaging Het
Vmn1r158 T A 7: 22,489,815 (GRCm39) R131S probably benign Het
Wipi1 T C 11: 109,468,490 (GRCm39) N368S probably benign Het
Zbtb41 T C 1: 139,351,831 (GRCm39) S315P probably damaging Het
Other mutations in Vmn2r24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Vmn2r24 APN 6 123,792,596 (GRCm39) missense probably damaging 1.00
IGL01382:Vmn2r24 APN 6 123,763,938 (GRCm39) missense possibly damaging 0.62
IGL01592:Vmn2r24 APN 6 123,764,445 (GRCm39) missense probably benign 0.30
IGL01754:Vmn2r24 APN 6 123,781,120 (GRCm39) missense probably damaging 1.00
IGL01939:Vmn2r24 APN 6 123,764,404 (GRCm39) missense probably benign
IGL02140:Vmn2r24 APN 6 123,757,631 (GRCm39) missense probably damaging 0.98
IGL02272:Vmn2r24 APN 6 123,763,843 (GRCm39) missense possibly damaging 0.94
IGL02568:Vmn2r24 APN 6 123,792,812 (GRCm39) missense probably benign 0.36
IGL02748:Vmn2r24 APN 6 123,793,057 (GRCm39) missense possibly damaging 0.90
IGL03022:Vmn2r24 APN 6 123,755,967 (GRCm39) missense probably damaging 0.99
IGL03343:Vmn2r24 APN 6 123,793,070 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r24 UTSW 6 123,792,369 (GRCm39) frame shift probably null
R0453:Vmn2r24 UTSW 6 123,757,350 (GRCm39) critical splice acceptor site probably null
R0538:Vmn2r24 UTSW 6 123,793,012 (GRCm39) missense probably benign 0.32
R0607:Vmn2r24 UTSW 6 123,763,893 (GRCm39) missense probably benign
R1381:Vmn2r24 UTSW 6 123,763,692 (GRCm39) missense probably damaging 1.00
R1589:Vmn2r24 UTSW 6 123,783,479 (GRCm39) splice site probably benign
R1848:Vmn2r24 UTSW 6 123,793,183 (GRCm39) missense probably damaging 1.00
R2035:Vmn2r24 UTSW 6 123,793,019 (GRCm39) missense probably damaging 1.00
R2122:Vmn2r24 UTSW 6 123,792,353 (GRCm39) missense possibly damaging 0.81
R2145:Vmn2r24 UTSW 6 123,755,972 (GRCm39) missense probably benign
R2483:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R2512:Vmn2r24 UTSW 6 123,763,985 (GRCm39) missense probably benign 0.01
R3001:Vmn2r24 UTSW 6 123,781,231 (GRCm39) missense probably benign 0.00
R3002:Vmn2r24 UTSW 6 123,781,231 (GRCm39) missense probably benign 0.00
R3236:Vmn2r24 UTSW 6 123,755,984 (GRCm39) nonsense probably null
R3623:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R3624:Vmn2r24 UTSW 6 123,792,997 (GRCm39) missense probably damaging 1.00
R3835:Vmn2r24 UTSW 6 123,764,412 (GRCm39) missense probably benign 0.33
R4074:Vmn2r24 UTSW 6 123,764,374 (GRCm39) missense possibly damaging 0.92
R4075:Vmn2r24 UTSW 6 123,764,374 (GRCm39) missense possibly damaging 0.92
R4812:Vmn2r24 UTSW 6 123,756,144 (GRCm39) missense probably benign 0.00
R4825:Vmn2r24 UTSW 6 123,792,739 (GRCm39) missense probably benign 0.02
R5351:Vmn2r24 UTSW 6 123,793,223 (GRCm39) missense possibly damaging 0.80
R5665:Vmn2r24 UTSW 6 123,763,938 (GRCm39) missense possibly damaging 0.62
R5790:Vmn2r24 UTSW 6 123,792,499 (GRCm39) missense probably benign
R5808:Vmn2r24 UTSW 6 123,792,597 (GRCm39) nonsense probably null
R5879:Vmn2r24 UTSW 6 123,764,226 (GRCm39) missense possibly damaging 0.89
R5923:Vmn2r24 UTSW 6 123,792,751 (GRCm39) missense probably damaging 0.96
R5969:Vmn2r24 UTSW 6 123,755,981 (GRCm39) missense probably benign 0.00
R6050:Vmn2r24 UTSW 6 123,792,691 (GRCm39) missense probably damaging 1.00
R6171:Vmn2r24 UTSW 6 123,764,205 (GRCm39) missense probably damaging 0.98
R6174:Vmn2r24 UTSW 6 123,793,236 (GRCm39) missense probably benign 0.00
R6356:Vmn2r24 UTSW 6 123,783,368 (GRCm39) missense possibly damaging 0.93
R6562:Vmn2r24 UTSW 6 123,757,386 (GRCm39) missense probably benign 0.01
R6563:Vmn2r24 UTSW 6 123,781,137 (GRCm39) missense possibly damaging 0.86
R6584:Vmn2r24 UTSW 6 123,792,764 (GRCm39) missense possibly damaging 0.53
R6630:Vmn2r24 UTSW 6 123,763,981 (GRCm39) missense probably benign 0.00
R6803:Vmn2r24 UTSW 6 123,755,960 (GRCm39) missense possibly damaging 0.64
R6864:Vmn2r24 UTSW 6 123,756,117 (GRCm39) missense possibly damaging 0.89
R7252:Vmn2r24 UTSW 6 123,764,191 (GRCm39) missense possibly damaging 0.90
R7369:Vmn2r24 UTSW 6 123,792,638 (GRCm39) missense probably damaging 0.99
R7646:Vmn2r24 UTSW 6 123,793,169 (GRCm39) missense probably benign 0.20
R7799:Vmn2r24 UTSW 6 123,757,422 (GRCm39) missense probably benign 0.00
R7803:Vmn2r24 UTSW 6 123,757,438 (GRCm39) missense probably benign 0.00
R7959:Vmn2r24 UTSW 6 123,755,949 (GRCm39) missense possibly damaging 0.86
R8215:Vmn2r24 UTSW 6 123,756,077 (GRCm39) missense probably benign 0.10
R8796:Vmn2r24 UTSW 6 123,757,500 (GRCm39) missense probably benign
R9172:Vmn2r24 UTSW 6 123,783,432 (GRCm39) missense probably damaging 1.00
R9300:Vmn2r24 UTSW 6 123,793,030 (GRCm39) missense possibly damaging 0.46
R9369:Vmn2r24 UTSW 6 123,792,357 (GRCm39) missense probably damaging 1.00
R9375:Vmn2r24 UTSW 6 123,792,542 (GRCm39) missense probably damaging 1.00
R9523:Vmn2r24 UTSW 6 123,763,950 (GRCm39) missense possibly damaging 0.89
R9546:Vmn2r24 UTSW 6 123,764,266 (GRCm39) missense probably damaging 0.98
RF006:Vmn2r24 UTSW 6 123,783,378 (GRCm39) missense probably damaging 1.00
RF016:Vmn2r24 UTSW 6 123,781,174 (GRCm39) missense probably benign 0.04
X0023:Vmn2r24 UTSW 6 123,764,359 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r24 UTSW 6 123,781,155 (GRCm39) missense probably benign 0.00
Z1177:Vmn2r24 UTSW 6 123,763,719 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCACTCACTTCTGAACATATTATGG -3'
(R):5'- GTGTCCCGATAGCAGACAAATAATCC -3'

Sequencing Primer
(F):5'- ACTTCTGAACATATTATGGAAAAGGG -3'
(R):5'- TCCTAAAATCATGGCTGAAAAGGC -3'
Posted On 2014-09-17