Incidental Mutation 'R2077:Tex2'
ID 229229
Institutional Source Beutler Lab
Gene Symbol Tex2
Ensembl Gene ENSMUSG00000040548
Gene Name testis expressed gene 2
Synonyms 4930568E07Rik, Taz4, Def-5
MMRRC Submission 040082-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2077 (G1)
Quality Score 215
Status Validated
Chromosome 11
Chromosomal Location 106392973-106504249 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to C at 106397690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000042780]
AlphaFold Q6ZPJ0
Predicted Effect probably null
Transcript: ENSMUST00000042780
SMART Domains Protein: ENSMUSP00000041985
Gene: ENSMUSG00000040548

DomainStartEndE-ValueType
low complexity region 119 186 N/A INTRINSIC
low complexity region 319 341 N/A INTRINSIC
low complexity region 346 360 N/A INTRINSIC
transmembrane domain 473 492 N/A INTRINSIC
transmembrane domain 494 516 N/A INTRINSIC
PH 543 712 5.05e-1 SMART
low complexity region 732 752 N/A INTRINSIC
low complexity region 811 823 N/A INTRINSIC
low complexity region 946 965 N/A INTRINSIC
low complexity region 1003 1016 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000207249
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 T A 4: 144,183,604 (GRCm39) probably benign Het
Abhd16b A C 2: 181,135,209 (GRCm39) D37A probably benign Het
Acp7 T C 7: 28,328,907 (GRCm39) E91G probably damaging Het
Alms1 T A 6: 85,599,291 (GRCm39) N1841K possibly damaging Het
Arhgap25 T A 6: 87,436,990 (GRCm39) D620V probably damaging Het
Caps2 C T 10: 112,035,632 (GRCm39) T371I possibly damaging Het
Ccdc175 A G 12: 72,186,794 (GRCm39) I350T possibly damaging Het
Cdc25c G C 18: 34,871,292 (GRCm39) L275V probably damaging Het
Cdc42bpb A G 12: 111,265,630 (GRCm39) L1434P probably damaging Het
Cdkl3 A T 11: 51,917,666 (GRCm39) E321V probably damaging Het
Clec2d G T 6: 129,160,153 (GRCm39) V56L possibly damaging Het
Cops3 A T 11: 59,715,136 (GRCm39) S301T possibly damaging Het
Crygd T C 1: 65,102,405 (GRCm39) D19G probably damaging Het
Dnah2 T C 11: 69,387,432 (GRCm39) I931M possibly damaging Het
Dst A T 1: 34,250,251 (GRCm39) R4068S probably damaging Het
Fas C T 19: 34,297,953 (GRCm39) probably benign Het
G6pd2 T A 5: 61,967,594 (GRCm39) D456E probably damaging Het
Galnt18 G A 7: 111,153,809 (GRCm39) R272W probably damaging Het
Grb2 C A 11: 115,536,651 (GRCm39) G200W probably damaging Het
Herc4 A G 10: 63,099,832 (GRCm39) N85S probably benign Het
Ighv7-2 T C 12: 113,875,727 (GRCm39) D92G probably damaging Het
Itih3 A G 14: 30,631,792 (GRCm39) V765A possibly damaging Het
Itm2b T C 14: 73,600,560 (GRCm39) N247D probably benign Het
Kcnd3 T C 3: 105,574,315 (GRCm39) V500A probably benign Het
Lrp2 C T 2: 69,338,187 (GRCm39) G1198R probably damaging Het
Ltb4r2 A G 14: 55,999,444 (GRCm39) T22A probably damaging Het
Mdga2 A G 12: 66,702,136 (GRCm39) V355A probably damaging Het
Megf8 T A 7: 25,053,163 (GRCm39) V1778E probably benign Het
Mroh2b G A 15: 4,974,448 (GRCm39) E1143K probably damaging Het
Nbn A T 4: 15,979,389 (GRCm39) Y458F probably damaging Het
Nlrc3 A G 16: 3,781,856 (GRCm39) C534R probably benign Het
Nup155 A G 15: 8,172,510 (GRCm39) E832G probably damaging Het
Or5w11 A G 2: 87,459,173 (GRCm39) Y122C probably damaging Het
Plcl2 A G 17: 50,913,857 (GRCm39) T289A probably benign Het
Ptprs C T 17: 56,741,990 (GRCm39) R7Q probably null Het
Rab3ip A T 10: 116,754,865 (GRCm39) D198E possibly damaging Het
Scaf4 A T 16: 90,049,323 (GRCm39) F255I unknown Het
Senp6 T C 9: 80,033,437 (GRCm39) S475P probably benign Het
Shpk T C 11: 73,094,785 (GRCm39) L67P probably damaging Het
Sik3 T A 9: 46,130,801 (GRCm39) Y1246N probably damaging Het
Slc44a2 A G 9: 21,265,020 (GRCm39) Y686C probably damaging Het
Slc6a19 A G 13: 73,848,685 (GRCm39) V23A probably benign Het
Slit3 A T 11: 35,435,575 (GRCm39) I169F possibly damaging Het
Stxbp5l A G 16: 37,056,637 (GRCm39) V379A possibly damaging Het
Tnpo3 A G 6: 29,586,143 (GRCm39) V149A possibly damaging Het
Vmn1r158 T A 7: 22,489,815 (GRCm39) R131S probably benign Het
Vmn2r24 T A 6: 123,792,358 (GRCm39) C562S probably damaging Het
Wipi1 T C 11: 109,468,490 (GRCm39) N368S probably benign Het
Zbtb41 T C 1: 139,351,831 (GRCm39) S315P probably damaging Het
Other mutations in Tex2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Tex2 APN 11 106,459,361 (GRCm39) missense probably damaging 1.00
IGL01380:Tex2 APN 11 106,435,141 (GRCm39) nonsense probably null
IGL02607:Tex2 APN 11 106,437,573 (GRCm39) missense unknown
IGL02680:Tex2 APN 11 106,459,058 (GRCm39) unclassified probably benign
IGL02699:Tex2 APN 11 106,459,259 (GRCm39) missense possibly damaging 0.53
IGL03187:Tex2 APN 11 106,458,903 (GRCm39) unclassified probably benign
IGL03398:Tex2 APN 11 106,459,098 (GRCm39) missense probably damaging 1.00
R0242:Tex2 UTSW 11 106,410,781 (GRCm39) nonsense probably null
R0242:Tex2 UTSW 11 106,410,781 (GRCm39) nonsense probably null
R1085:Tex2 UTSW 11 106,459,313 (GRCm39) missense probably damaging 0.98
R1491:Tex2 UTSW 11 106,394,466 (GRCm39) missense possibly damaging 0.72
R1664:Tex2 UTSW 11 106,458,608 (GRCm39) unclassified probably benign
R1794:Tex2 UTSW 11 106,458,728 (GRCm39) unclassified probably benign
R1855:Tex2 UTSW 11 106,437,702 (GRCm39) missense possibly damaging 0.87
R2151:Tex2 UTSW 11 106,458,161 (GRCm39) unclassified probably benign
R2175:Tex2 UTSW 11 106,394,513 (GRCm39) missense unknown
R2984:Tex2 UTSW 11 106,437,489 (GRCm39) critical splice donor site probably null
R3156:Tex2 UTSW 11 106,424,695 (GRCm39) critical splice donor site probably null
R3722:Tex2 UTSW 11 106,437,566 (GRCm39) nonsense probably null
R3724:Tex2 UTSW 11 106,420,156 (GRCm39) missense unknown
R3770:Tex2 UTSW 11 106,435,078 (GRCm39) missense unknown
R3771:Tex2 UTSW 11 106,437,720 (GRCm39) missense unknown
R3813:Tex2 UTSW 11 106,402,770 (GRCm39) missense unknown
R3947:Tex2 UTSW 11 106,410,829 (GRCm39) missense unknown
R4206:Tex2 UTSW 11 106,458,398 (GRCm39) unclassified probably benign
R4342:Tex2 UTSW 11 106,457,832 (GRCm39) unclassified probably benign
R4554:Tex2 UTSW 11 106,435,212 (GRCm39) missense unknown
R4896:Tex2 UTSW 11 106,459,230 (GRCm39) missense probably damaging 1.00
R5207:Tex2 UTSW 11 106,437,666 (GRCm39) missense unknown
R5249:Tex2 UTSW 11 106,437,615 (GRCm39) missense unknown
R5257:Tex2 UTSW 11 106,458,585 (GRCm39) unclassified probably benign
R5258:Tex2 UTSW 11 106,458,585 (GRCm39) unclassified probably benign
R5278:Tex2 UTSW 11 106,458,639 (GRCm39) missense probably benign 0.34
R5702:Tex2 UTSW 11 106,435,221 (GRCm39) missense possibly damaging 0.58
R5835:Tex2 UTSW 11 106,410,739 (GRCm39) missense unknown
R6150:Tex2 UTSW 11 106,457,906 (GRCm39) missense probably benign 0.34
R6785:Tex2 UTSW 11 106,424,776 (GRCm39) missense probably damaging 1.00
R6879:Tex2 UTSW 11 106,424,836 (GRCm39) missense unknown
R7038:Tex2 UTSW 11 106,402,726 (GRCm39) critical splice donor site probably null
R7117:Tex2 UTSW 11 106,435,071 (GRCm39) missense unknown
R7336:Tex2 UTSW 11 106,439,685 (GRCm39) missense unknown
R7568:Tex2 UTSW 11 106,439,562 (GRCm39) missense unknown
R7622:Tex2 UTSW 11 106,437,721 (GRCm39) missense unknown
R8228:Tex2 UTSW 11 106,457,997 (GRCm39) missense probably benign 0.34
R8407:Tex2 UTSW 11 106,459,221 (GRCm39) missense probably damaging 1.00
R8807:Tex2 UTSW 11 106,458,414 (GRCm39) missense unknown
R8807:Tex2 UTSW 11 106,435,194 (GRCm39) missense unknown
R8882:Tex2 UTSW 11 106,435,062 (GRCm39) missense unknown
R8926:Tex2 UTSW 11 106,459,230 (GRCm39) missense
R8936:Tex2 UTSW 11 106,458,144 (GRCm39) nonsense probably null
R8988:Tex2 UTSW 11 106,402,731 (GRCm39) missense unknown
R9165:Tex2 UTSW 11 106,458,095 (GRCm39) missense unknown
R9294:Tex2 UTSW 11 106,459,361 (GRCm39) missense probably damaging 1.00
R9314:Tex2 UTSW 11 106,435,075 (GRCm39) missense unknown
R9405:Tex2 UTSW 11 106,435,214 (GRCm39) missense unknown
R9419:Tex2 UTSW 11 106,457,835 (GRCm39) nonsense probably null
R9477:Tex2 UTSW 11 106,410,706 (GRCm39) critical splice donor site probably null
R9626:Tex2 UTSW 11 106,437,579 (GRCm39) missense unknown
R9634:Tex2 UTSW 11 106,458,978 (GRCm39) missense unknown
T0970:Tex2 UTSW 11 106,437,772 (GRCm39) missense unknown
Z1177:Tex2 UTSW 11 106,424,834 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCTTTAAACACATCTGCTGGG -3'
(R):5'- ACTTAGTGATCAACCCTTGCC -3'

Sequencing Primer
(F):5'- ACACATCTGCTGGGTTTCTTTG -3'
(R):5'- CTCTGTGGTGCCAGTGCTC -3'
Posted On 2014-09-17