Mutagenetix > Incidental Mutation

Incidental Mutation 'R2126:Muc5ac'

229899

Institutional Source

Beutler Lab

Gene Symbol

Muc5ac

Ensembl Gene

ENSMUSG00000037974

Gene Name

mucin 5, subtypes A and C, tracheobronchial/gastric

Synonyms

MGM, 2210005L13Rik

MMRRC Submission

040129-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2126 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

141342709-141372968 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 141364479 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 2597 (S2597P)

Ref Sequence

ENSEMBL: ENSMUSP00000122353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041924] [ENSMUST00000155534] [ENSMUST00000163321]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041924
AA Change: S1893P

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000039699
Gene: ENSMUSG00000037974
AA Change: S1893P

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	1.6e-14	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	6.1e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1482	2.3e-25	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1692	2.2e-27	PFAM
Pfam:Mucin2_WxxW	1765	1857	8.6e-27	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000155534
AA Change: S2597P

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000122353
Gene: ENSMUSG00000037974
AA Change: S2597P

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	9.6e-15	PFAM
VWC	395	437	3.54e-1	SMART
VWD	422	586	2.35e-33	SMART
C8	623	697	8.42e-36	SMART
Pfam:TIL	703	760	3.6e-9	PFAM
VWC	762	826	6.75e-1	SMART
VWC	864	906	4.06e-1	SMART
VWD	891	1051	1.51e-45	SMART
C8	1087	1161	2.78e-36	SMART
low complexity region	1316	1331	N/A	INTRINSIC
low complexity region	1334	1367	N/A	INTRINSIC
low complexity region	1372	1388	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1395	1483	1.3e-25	PFAM
low complexity region	1522	1533	N/A	INTRINSIC
low complexity region	1537	1564	N/A	INTRINSIC
low complexity region	1579	1596	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1605	1693	1.3e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000163321
AA Change: S1893P

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131681
Gene: ENSMUSG00000037974
AA Change: S1893P

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	7.9e-15	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	1.9e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1481	1.1e-23	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1691	1.1e-25	PFAM
Pfam:Mucin2_WxxW	1765	1856	6.3e-24	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.8%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 116 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadac	A	G	3: 59,947,066 (GRCm39)	T255A	possibly damaging	Het
Acat3	C	T	17: 13,146,294 (GRCm39)	A230T	probably benign	Het
Acsl1	C	A	8: 46,986,663 (GRCm39)	P650Q	probably benign	Het
Adgrl3	T	A	5: 81,660,383 (GRCm39)	I316N	probably damaging	Het
Agrp	G	T	8: 106,293,467 (GRCm39)	T106K	probably damaging	Het
AI429214	T	A	8: 37,461,362 (GRCm39)	V170E	probably benign	Het
Akap13	G	A	7: 75,375,052 (GRCm39)	G1895S	possibly damaging	Het
Alpk2	G	A	18: 65,483,439 (GRCm39)	Q190*	probably null	Het
Aox3	C	A	1: 58,197,375 (GRCm39)	Q574K	probably benign	Het
Apeh	A	G	9: 107,962,866 (GRCm39)	Y702H	probably damaging	Het
Aqp11	A	G	7: 97,386,692 (GRCm39)	I151T	probably benign	Het
Arhgap28	A	G	17: 68,176,010 (GRCm39)	V363A	possibly damaging	Het
Arhgef18	A	G	8: 3,501,939 (GRCm39)	N699S	probably damaging	Het
Asnsd1	A	G	1: 53,386,476 (GRCm39)	S384P	probably benign	Het
Atl1	G	T	12: 69,978,431 (GRCm39)		probably null	Het
Atp13a2	A	T	4: 140,722,702 (GRCm39)	D203V	possibly damaging	Het
Axdnd1	A	T	1: 156,160,784 (GRCm39)	N164K	probably benign	Het
Bnipl	T	A	3: 95,152,994 (GRCm39)	I162F	probably damaging	Het
Cacna1d	A	T	14: 29,845,120 (GRCm39)	L655I	probably damaging	Het
Canx	T	C	11: 50,195,185 (GRCm39)	I294M	probably damaging	Het
Casz1	T	C	4: 149,030,521 (GRCm39)	F1180S	probably damaging	Het
Cav3	T	C	6: 112,449,344 (GRCm39)	Y121H	probably benign	Het
Cd4	A	C	6: 124,847,499 (GRCm39)	S222A	probably benign	Het
Cds1	T	C	5: 101,960,416 (GRCm39)	I289T	probably benign	Het
Cep112	T	C	11: 108,399,084 (GRCm39)	F328L	probably damaging	Het
Ces4a	G	A	8: 105,864,729 (GRCm39)	G69S	probably damaging	Het
Cfap44	A	T	16: 44,230,838 (GRCm39)	D273V	probably benign	Het
Cfap91	T	C	16: 38,162,124 (GRCm39)	T6A	probably benign	Het
Clec7a	C	T	6: 129,447,918 (GRCm39)	G49D	probably benign	Het
Col22a1	G	A	15: 71,729,102 (GRCm39)	Q599*	probably null	Het
Col6a5	T	A	9: 105,822,799 (GRCm39)	H186L	unknown	Het
Dclk2	C	T	3: 86,712,946 (GRCm39)	R503Q	possibly damaging	Het
Dnah12	A	T	14: 26,445,613 (GRCm39)	R725*	probably null	Het
Dnajc10	G	A	2: 80,181,078 (GRCm39)		probably null	Het
Edem3	A	T	1: 151,670,482 (GRCm39)	H337L	possibly damaging	Het
Eif2ak4	A	T	2: 118,252,604 (GRCm39)	H392L	probably benign	Het
Ercc6l2	G	A	13: 63,996,585 (GRCm39)	V365I	probably damaging	Het
Fan1	T	C	7: 63,996,636 (GRCm39)	E978G	probably damaging	Het
Fcrl6	C	T	1: 172,426,815 (GRCm39)	V44M	probably benign	Het
Gaa	G	A	11: 119,161,108 (GRCm39)	W50*	probably null	Het
Gm10032	T	C	14: 67,030,227 (GRCm39)		noncoding transcript	Het
Gm10985	CTCTAT	CT	3: 53,752,670 (GRCm39)		probably null	Het
Gprc5b	G	T	7: 118,583,398 (GRCm39)	P157Q	probably damaging	Het
Gsdmc3	G	A	15: 63,730,383 (GRCm39)	Q394*	probably null	Het
Gucd1	A	G	10: 75,347,922 (GRCm39)	S38P	probably damaging	Het
Higd1a	A	T	9: 121,679,313 (GRCm39)	I58N	probably damaging	Het
Hmx3	G	C	7: 131,146,278 (GRCm39)	V329L	possibly damaging	Het
Hnrnpul2	A	T	19: 8,801,802 (GRCm39)	R337*	probably null	Het
Idua	T	A	5: 108,829,304 (GRCm39)	H368Q	possibly damaging	Het
Ifih1	A	G	2: 62,453,811 (GRCm39)	V218A	probably benign	Het
Ip6k1	G	A	9: 107,918,195 (GRCm39)	E77K	possibly damaging	Het
Kif1b	G	A	4: 149,272,097 (GRCm39)	S1568L	possibly damaging	Het
Klhl30	T	A	1: 91,286,499 (GRCm39)		probably null	Het
Lasp1	T	A	11: 97,726,960 (GRCm39)	D227E	probably benign	Het
Lhx6	A	G	2: 35,981,336 (GRCm39)	I85T	possibly damaging	Het
Limch1	A	G	5: 67,187,103 (GRCm39)	D840G	probably damaging	Het
Loxl4	C	G	19: 42,592,402 (GRCm39)	E385D	probably damaging	Het
Lrrtm4	A	T	6: 79,998,722 (GRCm39)	I44F	probably damaging	Het
Ltbp2	T	C	12: 84,832,483 (GRCm39)		probably null	Het
Lyg1	T	C	1: 37,989,755 (GRCm39)	Y44C	probably damaging	Het
Map1a	A	G	2: 121,129,122 (GRCm39)	I129V	probably damaging	Het
Med27	C	T	2: 29,414,442 (GRCm39)	Q150*	probably null	Het
Ms4a5	A	T	19: 11,256,732 (GRCm39)	I55N	probably damaging	Het
Mxd1	A	C	6: 86,628,422 (GRCm39)		probably null	Het
Myo3a	A	G	2: 22,468,186 (GRCm39)	D480G	probably benign	Het
Neb	T	C	2: 52,200,650 (GRCm39)	Y343C	probably damaging	Het
Niban1	A	C	1: 151,571,886 (GRCm39)	E277A	probably damaging	Het
Niban1	A	G	1: 151,584,884 (GRCm39)	I494V	possibly damaging	Het
Nrn1	A	C	13: 36,914,180 (GRCm39)	V34G	probably damaging	Het
Or4k52	A	G	2: 111,610,841 (GRCm39)	M59V	probably damaging	Het
Or4n5	A	G	14: 50,132,524 (GRCm39)	I245T	probably benign	Het
Or52b1	C	T	7: 104,978,459 (GRCm39)	W313*	probably null	Het
Or56a3	A	G	7: 104,735,822 (GRCm39)	T300A	probably damaging	Het
Or8b39	G	T	9: 37,996,572 (GRCm39)	V147L	probably benign	Het
Or8h9	T	C	2: 86,789,442 (GRCm39)	Y120C	possibly damaging	Het
Or8k40	A	T	2: 86,584,796 (GRCm39)	N95K	probably benign	Het
Pdia4	A	T	6: 47,773,771 (GRCm39)	V526E	probably damaging	Het
Pdia6	T	C	12: 17,328,546 (GRCm39)	V167A	probably damaging	Het
Pgk2	A	G	17: 40,518,400 (GRCm39)	F343L	probably damaging	Het
Piwil1	T	C	5: 128,831,160 (GRCm39)	V827A	probably damaging	Het
Plag1	A	T	4: 3,904,169 (GRCm39)	Y341N	possibly damaging	Het
Plch2	T	C	4: 155,083,456 (GRCm39)	E393G	probably damaging	Het
Ptprg	T	A	14: 12,154,355 (GRCm38)	M692K	probably benign	Het
Rassf8	G	A	6: 145,760,908 (GRCm39)	R78H	probably benign	Het
Rif1	GCCACCA	GCCA	2: 52,000,336 (GRCm39)		probably benign	Het
Rnf213	A	G	11: 119,341,027 (GRCm39)	Q3556R	probably damaging	Het
Rpa2	T	C	4: 132,496,099 (GRCm39)		probably null	Het
Rpe	T	G	1: 66,755,139 (GRCm39)	F174V	possibly damaging	Het
Sbf2	T	C	7: 110,159,502 (GRCm39)	D36G	probably damaging	Het
Scn2a	T	A	2: 65,582,423 (GRCm39)	Y1590*	probably null	Het
Slc24a4	T	C	12: 102,189,018 (GRCm39)	V151A	probably damaging	Het
Slc30a8	A	T	15: 52,159,330 (GRCm39)	M17L	probably benign	Het
Slit3	T	C	11: 35,579,506 (GRCm39)	Y1228H	probably damaging	Het
Smad4	G	A	18: 73,795,815 (GRCm39)	T193M	probably benign	Het
Smtn	T	A	11: 3,480,045 (GRCm39)	H392L	probably benign	Het
St8sia3	A	G	18: 64,402,745 (GRCm39)	D128G	probably damaging	Het
Sucla2	A	T	14: 73,830,108 (GRCm39)	M382L	possibly damaging	Het
Tbx5	A	G	5: 119,974,988 (GRCm39)	T4A	probably benign	Het
Tdrd5	T	C	1: 156,104,143 (GRCm39)	R528G	probably damaging	Het
Tex44	T	C	1: 86,354,811 (GRCm39)	L240P	probably benign	Het
Tns4	A	T	11: 98,970,904 (GRCm39)		probably null	Het
Trappc10	A	T	10: 78,039,758 (GRCm39)	V731E	possibly damaging	Het
Ttf1	A	G	2: 28,961,357 (GRCm39)	K582E	probably damaging	Het
Ttf2	C	A	3: 100,855,509 (GRCm39)	Q895H	possibly damaging	Het
Ttll6	A	G	11: 96,038,358 (GRCm39)	E402G	probably damaging	Het
Ttn	A	T	2: 76,720,436 (GRCm39)		probably null	Het
Ugt8a	T	C	3: 125,669,195 (GRCm39)	D303G	probably damaging	Het
Ulk1	G	T	5: 110,940,302 (GRCm39)	A373D	probably benign	Het
Vmn2r13	A	G	5: 109,306,058 (GRCm39)	S507P	probably benign	Het
Vmn2r19	T	A	6: 123,293,033 (GRCm39)	D358E	possibly damaging	Het
Vmn2r88	T	C	14: 51,651,264 (GRCm39)	S201P	probably benign	Het
Zfp36l2	A	G	17: 84,494,403 (GRCm39)	F78S	probably damaging	Het
Zfp454	A	C	11: 50,764,822 (GRCm39)	S203R	probably benign	Het
Zfp616	C	A	11: 73,976,229 (GRCm39)	Q833K	probably benign	Het
Znhit2	A	G	19: 6,112,091 (GRCm39)	T279A	probably benign	Het
Zswim3	T	A	2: 164,661,913 (GRCm39)	I131N	probably benign	Het

Other mutations in Muc5ac

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Muc5ac	APN	7	141,366,440 (GRCm39)	missense	possibly damaging	0.93
IGL01064:Muc5ac	APN	7	141,361,210 (GRCm39)	missense	probably benign	0.12
IGL01155:Muc5ac	APN	7	141,360,680 (GRCm39)	splice site	probably benign
IGL01452:Muc5ac	APN	7	141,371,292 (GRCm39)	missense	probably benign	0.00
IGL01590:Muc5ac	APN	7	141,352,630 (GRCm39)	missense	probably benign	0.02
IGL02104:Muc5ac	APN	7	141,364,815 (GRCm39)	missense	probably damaging	0.98
IGL02152:Muc5ac	APN	7	141,353,914 (GRCm39)	missense	possibly damaging	0.86
IGL02153:Muc5ac	APN	7	141,372,537 (GRCm39)	nonsense	probably null
IGL02178:Muc5ac	APN	7	141,359,184 (GRCm39)	splice site	probably benign
IGL02403:Muc5ac	APN	7	141,357,187 (GRCm39)	missense	possibly damaging	0.71
IGL02576:Muc5ac	APN	7	141,370,781 (GRCm39)	missense	probably benign	0.01
IGL02665:Muc5ac	APN	7	141,344,823 (GRCm39)	missense	possibly damaging	0.71
IGL02704:Muc5ac	APN	7	141,349,000 (GRCm39)	missense	possibly damaging	0.71
IGL02808:Muc5ac	APN	7	141,359,512 (GRCm39)	missense	possibly damaging	0.72
IGL03283:Muc5ac	APN	7	141,367,518 (GRCm39)	missense	probably benign	0.34
IGL03384:Muc5ac	APN	7	141,366,140 (GRCm39)	missense	possibly damaging	0.71
IGL03046:Muc5ac	UTSW	7	141,348,950 (GRCm39)	missense	probably benign	0.27
PIT4515001:Muc5ac	UTSW	7	141,361,153 (GRCm39)	missense	probably damaging	0.99
R0092:Muc5ac	UTSW	7	141,372,367 (GRCm39)	missense	possibly damaging	0.72
R0145:Muc5ac	UTSW	7	141,349,012 (GRCm39)	missense	possibly damaging	0.71
R0147:Muc5ac	UTSW	7	141,364,776 (GRCm39)	missense	probably benign	0.08
R0363:Muc5ac	UTSW	7	141,354,697 (GRCm39)	missense	probably benign	0.01
R0384:Muc5ac	UTSW	7	141,365,988 (GRCm39)	missense	possibly damaging	0.71
R0440:Muc5ac	UTSW	7	141,345,771 (GRCm39)	nonsense	probably null
R0583:Muc5ac	UTSW	7	141,361,345 (GRCm39)	missense	probably damaging	0.99
R0616:Muc5ac	UTSW	7	141,349,981 (GRCm39)	missense	probably benign	0.02
R0682:Muc5ac	UTSW	7	141,359,406 (GRCm39)	missense	possibly damaging	0.53
R0685:Muc5ac	UTSW	7	141,361,446 (GRCm39)	missense	probably benign	0.03
R0883:Muc5ac	UTSW	7	141,350,002 (GRCm39)	missense	possibly damaging	0.71
R0924:Muc5ac	UTSW	7	141,361,252 (GRCm39)	missense	possibly damaging	0.68
R1300:Muc5ac	UTSW	7	141,370,666 (GRCm39)	missense	possibly damaging	0.73
R1315:Muc5ac	UTSW	7	141,361,060 (GRCm39)	missense	probably damaging	0.99
R1354:Muc5ac	UTSW	7	141,361,114 (GRCm39)	missense	probably damaging	0.99
R1484:Muc5ac	UTSW	7	141,367,629 (GRCm39)	splice site	probably null
R1599:Muc5ac	UTSW	7	141,352,640 (GRCm39)	missense	possibly damaging	0.52
R1758:Muc5ac	UTSW	7	141,355,268 (GRCm39)	missense	possibly damaging	0.86
R1837:Muc5ac	UTSW	7	141,360,823 (GRCm39)	missense	probably benign	0.00
R1911:Muc5ac	UTSW	7	141,350,041 (GRCm39)	missense	probably benign	0.18
R1922:Muc5ac	UTSW	7	141,347,426 (GRCm39)	missense	probably benign	0.03
R1966:Muc5ac	UTSW	7	141,357,113 (GRCm39)	missense	possibly damaging	0.92
R1994:Muc5ac	UTSW	7	141,366,889 (GRCm39)	missense	possibly damaging	0.93
R2056:Muc5ac	UTSW	7	141,345,772 (GRCm39)	missense	probably benign	0.01
R2170:Muc5ac	UTSW	7	141,366,084 (GRCm39)	missense	possibly damaging	0.93
R2258:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2259:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2293:Muc5ac	UTSW	7	141,360,936 (GRCm39)	missense	probably damaging	0.99
R2435:Muc5ac	UTSW	7	141,371,841 (GRCm39)	missense	possibly damaging	0.53
R2895:Muc5ac	UTSW	7	141,344,877 (GRCm39)	missense	possibly damaging	0.92
R2910:Muc5ac	UTSW	7	141,361,378 (GRCm39)	missense	probably damaging	0.99
R3154:Muc5ac	UTSW	7	141,346,473 (GRCm39)	splice site	probably null
R3762:Muc5ac	UTSW	7	141,361,212 (GRCm39)	missense	possibly damaging	0.53
R3791:Muc5ac	UTSW	7	141,352,238 (GRCm39)	missense	probably benign	0.32
R3806:Muc5ac	UTSW	7	141,367,471 (GRCm39)	missense	possibly damaging	0.91
R3825:Muc5ac	UTSW	7	141,368,460 (GRCm39)	missense	possibly damaging	0.92
R3888:Muc5ac	UTSW	7	141,344,961 (GRCm39)	missense	possibly damaging	0.51
R3929:Muc5ac	UTSW	7	141,356,629 (GRCm39)	missense	probably benign
R3981:Muc5ac	UTSW	7	141,367,512 (GRCm39)	missense	possibly damaging	0.86
R4034:Muc5ac	UTSW	7	141,353,581 (GRCm39)	critical splice donor site	probably null
R4043:Muc5ac	UTSW	7	141,361,215 (GRCm39)	missense	possibly damaging	0.53
R4061:Muc5ac	UTSW	7	141,364,867 (GRCm39)	missense	possibly damaging	0.85
R4106:Muc5ac	UTSW	7	141,356,572 (GRCm39)	missense	possibly damaging	0.86
R4206:Muc5ac	UTSW	7	141,370,847 (GRCm39)	missense	possibly damaging	0.73
R4613:Muc5ac	UTSW	7	141,344,840 (GRCm39)	missense	possibly damaging	0.93
R4719:Muc5ac	UTSW	7	141,343,500 (GRCm39)	missense	possibly damaging	0.83
R4751:Muc5ac	UTSW	7	141,371,338 (GRCm39)	missense	probably benign	0.00
R4789:Muc5ac	UTSW	7	141,352,619 (GRCm39)	missense	possibly damaging	0.86
R4928:Muc5ac	UTSW	7	141,371,639 (GRCm39)	nonsense	probably null
R4971:Muc5ac	UTSW	7	141,370,015 (GRCm39)	missense	possibly damaging	0.68
R4982:Muc5ac	UTSW	7	141,363,193 (GRCm39)	intron	probably benign
R5088:Muc5ac	UTSW	7	141,350,056 (GRCm39)	missense	possibly damaging	0.53
R5141:Muc5ac	UTSW	7	141,368,479 (GRCm39)	missense	possibly damaging	0.72
R5224:Muc5ac	UTSW	7	141,347,708 (GRCm39)	missense	probably benign	0.32
R5366:Muc5ac	UTSW	7	141,361,287 (GRCm39)	missense	probably benign	0.01
R5497:Muc5ac	UTSW	7	141,361,380 (GRCm39)	missense	probably damaging	0.99
R5507:Muc5ac	UTSW	7	141,361,569 (GRCm39)	missense	possibly damaging	0.72
R5643:Muc5ac	UTSW	7	141,347,452 (GRCm39)	critical splice donor site	probably null
R5811:Muc5ac	UTSW	7	141,352,721 (GRCm39)	missense	possibly damaging	0.51
R5946:Muc5ac	UTSW	7	141,371,644 (GRCm39)	missense	possibly damaging	0.73
R5970:Muc5ac	UTSW	7	141,344,406 (GRCm39)	nonsense	probably null
R5977:Muc5ac	UTSW	7	141,350,104 (GRCm39)	missense	possibly damaging	0.73
R6051:Muc5ac	UTSW	7	141,365,594 (GRCm39)	missense	possibly damaging	0.53
R6126:Muc5ac	UTSW	7	141,354,969 (GRCm39)	missense	possibly damaging	0.71
R6159:Muc5ac	UTSW	7	141,369,323 (GRCm39)	missense	possibly damaging	0.53
R6256:Muc5ac	UTSW	7	141,343,532 (GRCm39)	missense	possibly damaging	0.53
R6283:Muc5ac	UTSW	7	141,370,601 (GRCm39)	nonsense	probably null
R6341:Muc5ac	UTSW	7	141,355,229 (GRCm39)	missense	probably damaging	0.99
R6356:Muc5ac	UTSW	7	141,366,416 (GRCm39)	missense	probably benign	0.05
R6481:Muc5ac	UTSW	7	141,362,808 (GRCm39)	intron	probably benign
R6483:Muc5ac	UTSW	7	141,356,591 (GRCm39)	missense	probably benign	0.18
R6627:Muc5ac	UTSW	7	141,362,427 (GRCm39)	intron	probably benign
R6636:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6637:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6656:Muc5ac	UTSW	7	141,357,065 (GRCm39)	missense	probably damaging	0.98
R6721:Muc5ac	UTSW	7	141,352,729 (GRCm39)	missense	possibly damaging	0.71
R6794:Muc5ac	UTSW	7	141,363,289 (GRCm39)	intron	probably benign
R6844:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6847:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6852:Muc5ac	UTSW	7	141,370,644 (GRCm39)	missense	probably benign	0.03
R6862:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6863:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6864:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6865:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6874:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6875:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6876:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6877:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6889:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6920:Muc5ac	UTSW	7	141,347,035 (GRCm39)	missense	possibly damaging	0.86
R6998:Muc5ac	UTSW	7	141,372,451 (GRCm39)	missense	possibly damaging	0.92
R7017:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7091:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,385 (GRCm39)	intron	probably benign
R7110:Muc5ac	UTSW	7	141,353,559 (GRCm39)	missense	possibly damaging	0.95
R7117:Muc5ac	UTSW	7	141,367,559 (GRCm39)	nonsense	probably null
R7238:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7238:Muc5ac	UTSW	7	141,363,254 (GRCm39)	missense	unknown
R7396:Muc5ac	UTSW	7	141,362,152 (GRCm39)	missense	unknown
R7456:Muc5ac	UTSW	7	141,346,904 (GRCm39)	missense	probably benign	0.32
R7477:Muc5ac	UTSW	7	141,370,019 (GRCm39)	missense	possibly damaging	0.72
R7530:Muc5ac	UTSW	7	141,367,536 (GRCm39)	missense	possibly damaging	0.51
R7545:Muc5ac	UTSW	7	141,362,405 (GRCm39)	missense	unknown
R7604:Muc5ac	UTSW	7	141,363,446 (GRCm39)	missense	unknown
R7635:Muc5ac	UTSW	7	141,359,413 (GRCm39)	missense	probably damaging	0.98
R7635:Muc5ac	UTSW	7	141,359,490 (GRCm39)	missense	possibly damaging	0.53
R7650:Muc5ac	UTSW	7	141,363,159 (GRCm39)	missense	unknown
R7651:Muc5ac	UTSW	7	141,349,991 (GRCm39)	missense	possibly damaging	0.92
R7685:Muc5ac	UTSW	7	141,363,120 (GRCm39)	missense	unknown
R7720:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7749:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7750:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7751:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7754:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7798:Muc5ac	UTSW	7	141,347,778 (GRCm39)	critical splice donor site	probably null
R7835:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7837:Muc5ac	UTSW	7	141,369,700 (GRCm39)	missense	possibly damaging	0.53
R7858:Muc5ac	UTSW	7	141,357,166 (GRCm39)	missense	possibly damaging	0.51
R7866:Muc5ac	UTSW	7	141,349,589 (GRCm39)	missense	probably benign	0.00
R7874:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7876:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7877:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7881:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7884:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7921:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7976:Muc5ac	UTSW	7	141,363,528 (GRCm39)	missense	unknown
R8104:Muc5ac	UTSW	7	141,358,520 (GRCm39)	missense	possibly damaging	0.96
R8177:Muc5ac	UTSW	7	141,361,068 (GRCm39)	missense	probably damaging	1.00
R8214:Muc5ac	UTSW	7	141,356,685 (GRCm39)	missense	possibly damaging	0.53
R8292:Muc5ac	UTSW	7	141,363,000 (GRCm39)	missense	unknown
R8386:Muc5ac	UTSW	7	141,361,371 (GRCm39)	missense	possibly damaging	0.93
R8400:Muc5ac	UTSW	7	141,364,213 (GRCm39)	missense	probably damaging	0.99
R8504:Muc5ac	UTSW	7	141,360,892 (GRCm39)	missense	probably damaging	1.00
R8709:Muc5ac	UTSW	7	141,370,663 (GRCm39)	missense	possibly damaging	0.96
R8725:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8727:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8754:Muc5ac	UTSW	7	141,354,008 (GRCm39)	missense	possibly damaging	0.85
R8769:Muc5ac	UTSW	7	141,372,609 (GRCm39)	missense	probably damaging	1.00
R8933:Muc5ac	UTSW	7	141,343,493 (GRCm39)	missense	possibly damaging	0.59
R8939:Muc5ac	UTSW	7	141,347,091 (GRCm39)	missense	probably damaging	0.98
R9049:Muc5ac	UTSW	7	141,362,712 (GRCm39)	missense	unknown
R9124:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9131:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9132:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9135:Muc5ac	UTSW	7	141,352,218 (GRCm39)	missense	probably damaging	0.99
R9156:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9157:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9159:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9160:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9161:Muc5ac	UTSW	7	141,353,026 (GRCm39)	missense	possibly damaging	0.53
R9175:Muc5ac	UTSW	7	141,366,093 (GRCm39)	missense	possibly damaging	0.92
R9183:Muc5ac	UTSW	7	141,352,637 (GRCm39)	missense	possibly damaging	0.71
R9218:Muc5ac	UTSW	7	141,361,098 (GRCm39)	missense	probably damaging	0.99
R9219:Muc5ac	UTSW	7	141,370,800 (GRCm39)	nonsense	probably null
R9239:Muc5ac	UTSW	7	141,353,954 (GRCm39)	missense	probably damaging	0.99
R9246:Muc5ac	UTSW	7	141,364,215 (GRCm39)	missense	probably benign	0.11
R9287:Muc5ac	UTSW	7	141,361,626 (GRCm39)	missense	probably damaging	0.99
R9320:Muc5ac	UTSW	7	141,369,255 (GRCm39)	missense	probably benign	0.01
R9327:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
R9428:Muc5ac	UTSW	7	141,362,559 (GRCm39)	missense	unknown
R9430:Muc5ac	UTSW	7	141,362,569 (GRCm39)	missense	unknown
R9454:Muc5ac	UTSW	7	141,362,431 (GRCm39)	missense	unknown
R9483:Muc5ac	UTSW	7	141,365,465 (GRCm39)	nonsense	probably null
R9581:Muc5ac	UTSW	7	141,363,799 (GRCm39)	missense	unknown
R9610:Muc5ac	UTSW	7	141,350,078 (GRCm39)	missense	possibly damaging	0.86
R9642:Muc5ac	UTSW	7	141,349,601 (GRCm39)	missense	possibly damaging	0.71
R9684:Muc5ac	UTSW	7	141,364,798 (GRCm39)	missense	probably benign	0.41
R9760:Muc5ac	UTSW	7	141,360,985 (GRCm39)	missense	probably benign	0.05
R9778:Muc5ac	UTSW	7	141,349,021 (GRCm39)	nonsense	probably null
X0060:Muc5ac	UTSW	7	141,357,070 (GRCm39)	missense	possibly damaging	0.71
Z1088:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
Z1088:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
Z1177:Muc5ac	UTSW	7	141,371,777 (GRCm39)	missense	probably benign	0.33
Z1177:Muc5ac	UTSW	7	141,362,961 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TGTGCAACAACAGGGACCAG -3'
(R):5'- TCTGCTTCCAAGGCAGAAGG -3'

Sequencing Primer
(F):5'- CAGACTTCTCCTGTGACA -3'
(R):5'- CCTCAAGGCTTTCTACTTAATGAAAG -3'

Posted On

2014-09-17