Incidental Mutation 'R2120:Vmn2r115'
ID 231415
Institutional Source Beutler Lab
Gene Symbol Vmn2r115
Ensembl Gene ENSMUSG00000091076
Gene Name vomeronasal 2, receptor 115
Synonyms V2Rp4, EG638102
MMRRC Submission 040124-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R2120 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 23562951-23579102 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 23578297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 590 (L590R)
Ref Sequence ENSEMBL: ENSMUSP00000131447 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168175]
AlphaFold E9Q0E7
Predicted Effect probably damaging
Transcript: ENSMUST00000168175
AA Change: L590R

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: L590R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 471 1.4e-28 PFAM
Pfam:NCD3G 512 565 2.9e-20 PFAM
Pfam:7tm_3 598 833 5e-55 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (86/86)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,259,013 (GRCm39) probably benign Het
Abcg5 T A 17: 84,978,575 (GRCm39) E294D probably benign Het
Actrt2 C T 4: 154,751,551 (GRCm39) R195Q probably benign Het
Adamts12 C T 15: 11,310,665 (GRCm39) T974I probably damaging Het
Ankrd65 A G 4: 155,876,530 (GRCm39) T239A probably benign Het
Ano7 G T 1: 93,329,855 (GRCm39) probably benign Het
Apc A T 18: 34,409,654 (GRCm39) E198V probably damaging Het
Arhgef10 A G 8: 14,984,820 (GRCm39) D200G probably damaging Het
Atp9a A T 2: 168,495,457 (GRCm39) V583E probably damaging Het
Bicral C T 17: 47,135,741 (GRCm39) A490T probably benign Het
C1rl C T 6: 124,485,672 (GRCm39) P348S probably damaging Het
Cog1 T C 11: 113,540,424 (GRCm39) L13P probably damaging Het
Cx3cr1 T A 9: 119,880,749 (GRCm39) T218S probably damaging Het
Cyp2a12 A G 7: 26,736,071 (GRCm39) *493W probably null Het
Dmd G C X: 83,356,089 (GRCm39) A2257P probably benign Het
E2f4 A G 8: 106,026,973 (GRCm39) Y179C probably damaging Het
Ecel1 A G 1: 87,075,997 (GRCm39) S727P probably damaging Het
Endod1 T C 9: 14,268,949 (GRCm39) N179D probably benign Het
Epc2 C T 2: 49,437,621 (GRCm39) probably benign Het
Ets2 G T 16: 95,519,977 (GRCm39) R401L probably benign Het
Fgd4 C T 16: 16,243,692 (GRCm39) C614Y probably benign Het
Fgf18 A C 11: 33,068,003 (GRCm39) F129C probably damaging Het
Frem3 A T 8: 81,342,086 (GRCm39) T1460S probably benign Het
H2-M1 T G 17: 36,980,929 (GRCm39) T336P possibly damaging Het
Ikbkb T C 8: 23,157,233 (GRCm39) probably benign Het
Ipo7 G T 7: 109,648,838 (GRCm39) D704Y probably damaging Het
Jaml T A 9: 45,012,362 (GRCm39) I283N probably damaging Het
Jarid2 G T 13: 45,059,812 (GRCm39) M681I probably benign Het
Kif4-ps T C 12: 101,113,956 (GRCm39) L695P probably damaging Het
Kmt2d A G 15: 98,737,410 (GRCm39) probably benign Het
Krt25 T C 11: 99,212,023 (GRCm39) T205A probably benign Het
Lif T C 11: 4,219,051 (GRCm39) V110A possibly damaging Het
Ltbp1 T A 17: 75,617,154 (GRCm39) V1031E possibly damaging Het
Ltbr A G 6: 125,286,440 (GRCm39) S249P probably benign Het
Man2b1 A G 8: 85,819,653 (GRCm39) probably benign Het
Med16 A T 10: 79,738,916 (GRCm39) M290K possibly damaging Het
Mov10l1 C A 15: 88,891,830 (GRCm39) Q562K probably benign Het
Msantd2 C T 9: 37,434,227 (GRCm39) R357W probably damaging Het
Mtcl2 T C 2: 156,875,245 (GRCm39) E835G probably damaging Het
Mtmr6 T C 14: 60,534,108 (GRCm39) F449L probably damaging Het
Myt1l A T 12: 29,833,618 (GRCm39) probably null Het
Neb A G 2: 52,154,076 (GRCm39) F2345S probably damaging Het
Nlrp6 T C 7: 140,506,357 (GRCm39) V766A probably benign Het
Or11g27 T C 14: 50,771,403 (GRCm39) I178T probably damaging Het
Or4k36 A G 2: 111,145,844 (GRCm39) T7A probably benign Het
Or6d13 A T 6: 116,517,416 (GRCm39) M1L probably null Het
Or8k22 G A 2: 86,163,689 (GRCm39) R4C probably benign Het
Patj T A 4: 98,344,462 (GRCm39) D591E probably benign Het
Pde6d A G 1: 86,473,524 (GRCm39) F91L probably benign Het
Pitpnm2 G A 5: 124,265,332 (GRCm39) P757L probably damaging Het
Plcd4 A G 1: 74,603,584 (GRCm39) T662A probably benign Het
Podn C T 4: 107,880,558 (GRCm39) A31T probably damaging Het
Prss37 G A 6: 40,492,294 (GRCm39) R186* probably null Het
Psg20 T A 7: 18,414,947 (GRCm39) Y316F probably benign Het
Psmd1 T A 1: 86,006,422 (GRCm39) S263T possibly damaging Het
Pum1 C A 4: 130,396,581 (GRCm39) T112K possibly damaging Het
Rab3gap2 A T 1: 184,993,564 (GRCm39) D782V possibly damaging Het
Rasgrp2 T A 19: 6,454,425 (GRCm39) M156K probably benign Het
Reln G A 5: 22,174,083 (GRCm39) H2007Y probably damaging Het
Rhbdl2 T A 4: 123,718,712 (GRCm39) I222K probably damaging Het
Rimbp2 A G 5: 128,865,582 (GRCm39) S582P probably damaging Het
Rpe T C 1: 66,754,387 (GRCm39) M153T probably damaging Het
Sars1 T C 3: 108,341,472 (GRCm39) I114V probably benign Het
Scamp5 C A 9: 57,354,508 (GRCm39) V49F possibly damaging Het
Sec14l1 C T 11: 117,039,358 (GRCm39) probably benign Het
Serpinb8 A G 1: 107,533,617 (GRCm39) E224G probably damaging Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Slco6c1 C T 1: 96,993,808 (GRCm39) R645H possibly damaging Het
Srgn T A 10: 62,343,413 (GRCm39) probably benign Het
Stk40 C T 4: 126,022,640 (GRCm39) T138I probably benign Het
Syt10 C T 15: 89,674,979 (GRCm39) D456N probably damaging Het
Tada3 T C 6: 113,347,976 (GRCm39) I263V possibly damaging Het
Tas2r106 A T 6: 131,655,317 (GRCm39) L178H probably damaging Het
Tas2r115 T A 6: 132,714,470 (GRCm39) R160S possibly damaging Het
Trak1 T A 9: 121,302,063 (GRCm39) *940R probably null Het
Trp53bp2 A G 1: 182,269,204 (GRCm39) M223V probably benign Het
Ttc21b C T 2: 66,057,098 (GRCm39) V625I probably benign Het
Txnrd1 T A 10: 82,723,067 (GRCm39) C421S possibly damaging Het
Unc45a T C 7: 79,989,846 (GRCm39) T8A probably benign Het
Usp6nl T A 2: 6,445,748 (GRCm39) V552E probably damaging Het
Vmn2r88 A T 14: 51,650,665 (GRCm39) H126L probably benign Het
Vps13c A G 9: 67,826,616 (GRCm39) D1419G possibly damaging Het
Vwa3a A G 7: 120,391,641 (GRCm39) T776A probably benign Het
Zfp580 T C 7: 5,056,008 (GRCm39) Y123H probably damaging Het
Other mutations in Vmn2r115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r115 APN 17 23,575,934 (GRCm39) missense probably benign 0.00
IGL00990:Vmn2r115 APN 17 23,565,345 (GRCm39) nonsense probably null
IGL00990:Vmn2r115 APN 17 23,578,371 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,565,135 (GRCm39) missense probably benign 0.03
IGL00990:Vmn2r115 APN 17 23,565,252 (GRCm39) missense probably benign 0.14
IGL00990:Vmn2r115 APN 17 23,565,313 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,578,323 (GRCm39) missense probably benign 0.22
IGL00990:Vmn2r115 APN 17 23,565,150 (GRCm39) missense probably benign 0.00
IGL00990:Vmn2r115 APN 17 23,565,180 (GRCm39) missense possibly damaging 0.90
IGL00990:Vmn2r115 APN 17 23,567,008 (GRCm39) nonsense probably null
IGL00990:Vmn2r115 APN 17 23,578,798 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,578,753 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r115 APN 17 23,565,238 (GRCm39) missense probably benign 0.19
IGL00990:Vmn2r115 APN 17 23,565,346 (GRCm39) missense probably benign 0.30
IGL01073:Vmn2r115 APN 17 23,564,971 (GRCm39) missense probably benign 0.12
IGL01101:Vmn2r115 APN 17 23,564,971 (GRCm39) missense probably benign 0.12
IGL01300:Vmn2r115 APN 17 23,578,755 (GRCm39) missense probably damaging 1.00
IGL01415:Vmn2r115 APN 17 23,578,755 (GRCm39) missense probably damaging 1.00
IGL02309:Vmn2r115 APN 17 23,564,113 (GRCm39) missense probably benign 0.01
IGL02863:Vmn2r115 APN 17 23,578,257 (GRCm39) missense probably damaging 0.97
R0023:Vmn2r115 UTSW 17 23,565,252 (GRCm39) missense probably benign 0.14
R0197:Vmn2r115 UTSW 17 23,578,755 (GRCm39) missense probably damaging 1.00
R0361:Vmn2r115 UTSW 17 23,564,196 (GRCm39) missense probably benign 0.11
R0601:Vmn2r115 UTSW 17 23,579,074 (GRCm39) missense probably null 0.51
R0676:Vmn2r115 UTSW 17 23,565,238 (GRCm39) missense probably benign 0.19
R0685:Vmn2r115 UTSW 17 23,578,249 (GRCm39) missense probably benign
R0865:Vmn2r115 UTSW 17 23,565,382 (GRCm39) missense possibly damaging 0.65
R1124:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1145:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1146:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1207:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1266:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1318:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1367:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1376:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1376:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1420:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1469:Vmn2r115 UTSW 17 23,564,992 (GRCm39) missense probably damaging 0.99
R1469:Vmn2r115 UTSW 17 23,564,992 (GRCm39) missense probably damaging 0.99
R1604:Vmn2r115 UTSW 17 23,564,245 (GRCm39) missense probably benign 0.12
R1645:Vmn2r115 UTSW 17 23,565,192 (GRCm39) missense possibly damaging 0.69
R1646:Vmn2r115 UTSW 17 23,578,513 (GRCm39) missense probably damaging 1.00
R1650:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1678:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1716:Vmn2r115 UTSW 17 23,566,795 (GRCm39) missense probably benign
R1846:Vmn2r115 UTSW 17 23,578,357 (GRCm39) missense probably damaging 1.00
R1847:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1885:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R1887:Vmn2r115 UTSW 17 23,565,007 (GRCm39) missense possibly damaging 0.91
R1937:Vmn2r115 UTSW 17 23,578,388 (GRCm39) missense probably damaging 1.00
R2007:Vmn2r115 UTSW 17 23,566,927 (GRCm39) missense possibly damaging 0.94
R3161:Vmn2r115 UTSW 17 23,575,998 (GRCm39) missense possibly damaging 0.82
R3780:Vmn2r115 UTSW 17 23,564,146 (GRCm39) missense probably damaging 1.00
R3806:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R3982:Vmn2r115 UTSW 17 23,578,948 (GRCm39) missense probably damaging 1.00
R4019:Vmn2r115 UTSW 17 23,579,017 (GRCm39) missense probably damaging 1.00
R4039:Vmn2r115 UTSW 17 23,564,077 (GRCm39) missense probably benign 0.26
R4087:Vmn2r115 UTSW 17 23,565,358 (GRCm39) missense probably benign 0.35
R4089:Vmn2r115 UTSW 17 23,565,358 (GRCm39) missense probably benign 0.35
R4379:Vmn2r115 UTSW 17 23,564,197 (GRCm39) missense possibly damaging 0.95
R4417:Vmn2r115 UTSW 17 23,564,854 (GRCm39) missense probably benign 0.02
R4601:Vmn2r115 UTSW 17 23,565,373 (GRCm39) missense probably benign 0.01
R4874:Vmn2r115 UTSW 17 23,578,825 (GRCm39) missense probably damaging 1.00
R5466:Vmn2r115 UTSW 17 23,579,030 (GRCm39) missense probably damaging 1.00
R5613:Vmn2r115 UTSW 17 23,564,307 (GRCm39) missense probably benign
R5821:Vmn2r115 UTSW 17 23,566,937 (GRCm39) missense probably damaging 0.99
R6120:Vmn2r115 UTSW 17 23,565,003 (GRCm39) missense probably damaging 1.00
R6193:Vmn2r115 UTSW 17 23,575,983 (GRCm39) missense probably benign 0.01
R6213:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R6290:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
R6319:Vmn2r115 UTSW 17 23,566,877 (GRCm39) missense possibly damaging 0.70
R6495:Vmn2r115 UTSW 17 23,578,572 (GRCm39) missense probably benign 0.02
R6599:Vmn2r115 UTSW 17 23,565,006 (GRCm39) missense probably benign 0.00
R6764:Vmn2r115 UTSW 17 23,565,046 (GRCm39) missense probably damaging 1.00
R6970:Vmn2r115 UTSW 17 23,564,989 (GRCm39) missense probably benign 0.23
R7023:Vmn2r115 UTSW 17 23,578,785 (GRCm39) missense probably damaging 1.00
R7236:Vmn2r115 UTSW 17 23,578,576 (GRCm39) missense probably benign 0.01
R7353:Vmn2r115 UTSW 17 23,564,887 (GRCm39) missense possibly damaging 0.65
R7483:Vmn2r115 UTSW 17 23,565,371 (GRCm39) missense possibly damaging 0.95
R7743:Vmn2r115 UTSW 17 23,564,772 (GRCm39) nonsense probably null
R8005:Vmn2r115 UTSW 17 23,563,124 (GRCm39) nonsense probably null
R8191:Vmn2r115 UTSW 17 23,578,530 (GRCm39) missense probably damaging 1.00
R8544:Vmn2r115 UTSW 17 23,564,773 (GRCm39) missense possibly damaging 0.88
R8890:Vmn2r115 UTSW 17 23,578,497 (GRCm39) missense probably damaging 0.98
R9098:Vmn2r115 UTSW 17 23,564,803 (GRCm39) missense probably benign
R9114:Vmn2r115 UTSW 17 23,564,307 (GRCm39) missense probably benign
R9189:Vmn2r115 UTSW 17 23,564,784 (GRCm39) missense probably damaging 1.00
R9351:Vmn2r115 UTSW 17 23,578,482 (GRCm39) missense probably benign 0.05
R9397:Vmn2r115 UTSW 17 23,564,152 (GRCm39) nonsense probably null
R9410:Vmn2r115 UTSW 17 23,578,915 (GRCm39) missense possibly damaging 0.67
R9593:Vmn2r115 UTSW 17 23,578,184 (GRCm39) missense probably damaging 0.99
V5622:Vmn2r115 UTSW 17 23,578,333 (GRCm39) missense probably benign
V5622:Vmn2r115 UTSW 17 23,565,201 (GRCm39) missense probably damaging 1.00
X0023:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
X0033:Vmn2r115 UTSW 17 23,578,962 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TGGTTAAGTGAAATATCCTGTCAGT -3'
(R):5'- TTTTAGCCAAGACAGTGGAAACA -3'

Sequencing Primer
(F):5'- CCTGTCAGTAAAATTGCTAAAGCTAC -3'
(R):5'- CCAAATGTGATTTGTTGTAGGATGC -3'
Posted On 2014-09-18