Incidental Mutation 'R2090:Zfp652'
ID 231727
Institutional Source Beutler Lab
Gene Symbol Zfp652
Ensembl Gene ENSMUSG00000075595
Gene Name zinc finger protein 652
Synonyms 9530033F24Rik
MMRRC Submission 040095-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.796) question?
Stock # R2090 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 95639893-95655541 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 95644834 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 240 (D240G)
Ref Sequence ENSEMBL: ENSMUSP00000115393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091565] [ENSMUST00000107717] [ENSMUST00000133070] [ENSMUST00000148945]
AlphaFold Q5DU09
Predicted Effect probably benign
Transcript: ENSMUST00000091565
AA Change: D420G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000089153
Gene: ENSMUSG00000075595
AA Change: D420G

DomainStartEndE-ValueType
low complexity region 95 108 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
low complexity region 173 213 N/A INTRINSIC
low complexity region 220 231 N/A INTRINSIC
ZnF_C2H2 244 267 7.9e-4 SMART
ZnF_C2H2 271 291 6.15e1 SMART
ZnF_C2H2 298 321 1.76e-1 SMART
ZnF_C2H2 328 350 2.53e-2 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.95e-3 SMART
ZnF_C2H2 412 434 1.95e-3 SMART
ZnF_C2H2 440 462 1.15e-5 SMART
ZnF_C2H2 468 488 6.15e1 SMART
low complexity region 508 529 N/A INTRINSIC
low complexity region 544 576 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107717
AA Change: D420G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000103345
Gene: ENSMUSG00000075595
AA Change: D420G

DomainStartEndE-ValueType
low complexity region 95 108 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
low complexity region 173 213 N/A INTRINSIC
low complexity region 220 231 N/A INTRINSIC
ZnF_C2H2 244 267 7.9e-4 SMART
ZnF_C2H2 271 291 6.15e1 SMART
ZnF_C2H2 298 321 1.76e-1 SMART
ZnF_C2H2 328 350 2.53e-2 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.95e-3 SMART
ZnF_C2H2 412 434 1.95e-3 SMART
ZnF_C2H2 440 462 1.15e-5 SMART
ZnF_C2H2 468 488 6.15e1 SMART
low complexity region 508 529 N/A INTRINSIC
low complexity region 544 576 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133070
AA Change: D420G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122280
Gene: ENSMUSG00000075595
AA Change: D420G

DomainStartEndE-ValueType
low complexity region 95 108 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
low complexity region 173 213 N/A INTRINSIC
low complexity region 220 231 N/A INTRINSIC
ZnF_C2H2 244 267 7.9e-4 SMART
ZnF_C2H2 271 291 6.15e1 SMART
ZnF_C2H2 298 321 1.76e-1 SMART
ZnF_C2H2 328 350 2.53e-2 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.95e-3 SMART
ZnF_C2H2 412 434 1.95e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148945
AA Change: D240G

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000115393
Gene: ENSMUSG00000075595
AA Change: D240G

DomainStartEndE-ValueType
low complexity region 95 108 N/A INTRINSIC
ZnF_C2H2 118 141 4.34e-1 SMART
ZnF_C2H2 148 170 2.53e-2 SMART
ZnF_C2H2 176 198 6.78e-3 SMART
ZnF_C2H2 204 226 2.95e-3 SMART
ZnF_C2H2 232 254 1.95e-3 SMART
ZnF_C2H2 260 282 1.15e-5 SMART
ZnF_C2H2 288 308 6.15e1 SMART
low complexity region 328 349 N/A INTRINSIC
low complexity region 364 396 N/A INTRINSIC
Meta Mutation Damage Score 0.1253 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (67/67)
Allele List at MGI

All alleles(23) : Targeted(1) Gene trapped(22)

Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A G 8: 25,391,456 (GRCm39) probably null Het
Adcy7 A T 8: 89,042,485 (GRCm39) T451S probably damaging Het
Adgrg3 A T 8: 95,766,558 (GRCm39) T410S possibly damaging Het
Alg11 G T 8: 22,555,646 (GRCm39) L302F possibly damaging Het
Ankrd17 A G 5: 90,445,905 (GRCm39) V310A possibly damaging Het
Atg16l2 C T 7: 100,942,575 (GRCm39) probably null Het
B3gnt2 A G 11: 22,786,291 (GRCm39) V299A probably benign Het
Birc6 A G 17: 74,969,791 (GRCm39) N4258S probably benign Het
C2cd4d A G 3: 94,271,321 (GRCm39) K196E probably benign Het
Calhm6 A G 10: 34,002,358 (GRCm39) S242P probably damaging Het
Cdr2l A G 11: 115,281,827 (GRCm39) K111E probably damaging Het
Crtam T C 9: 40,895,612 (GRCm39) Q41R possibly damaging Het
Cspp1 A G 1: 10,160,493 (GRCm39) K560R possibly damaging Het
Dcaf15 A T 8: 84,824,400 (GRCm39) Y571* probably null Het
Defa39 A T 8: 22,192,805 (GRCm39) W64R possibly damaging Het
Dpy19l4 T C 4: 11,304,344 (GRCm39) Y99C probably benign Het
Edem3 C T 1: 151,680,577 (GRCm39) probably benign Het
Enpp6 A T 8: 47,518,405 (GRCm39) probably null Het
Foxf2 T A 13: 31,810,824 (GRCm39) D254E probably benign Het
Gjb5 T C 4: 127,249,794 (GRCm39) N117D probably benign Het
Glmn G A 5: 107,709,794 (GRCm39) L337F probably damaging Het
Gsdmc2 T A 15: 63,698,675 (GRCm39) Y307F probably benign Het
Gsdmc3 T A 15: 63,738,631 (GRCm39) M144L probably benign Het
Ibtk A G 9: 85,603,046 (GRCm39) I653T probably benign Het
Il24 T G 1: 130,812,574 (GRCm39) D99A possibly damaging Het
Intu A G 3: 40,637,966 (GRCm39) Q484R probably benign Het
Iqca1l A G 5: 24,755,674 (GRCm39) S283P probably benign Het
Lsp1 T C 7: 142,045,544 (GRCm39) probably benign Het
Mad1l1 A G 5: 139,995,011 (GRCm39) S672P probably benign Het
Man2a2 A T 7: 80,013,858 (GRCm39) probably benign Het
Morc3 C A 16: 93,663,341 (GRCm39) H515N probably benign Het
Nav1 T C 1: 135,534,903 (GRCm39) probably benign Het
Ndor1 A G 2: 25,139,230 (GRCm39) L247P probably damaging Het
Nfkbiz A T 16: 55,636,818 (GRCm39) F494L probably benign Het
Nr1d1 G A 11: 98,661,436 (GRCm39) P277S probably damaging Het
Nrg2 T C 18: 36,151,496 (GRCm39) D682G probably benign Het
Nrros C T 16: 31,962,975 (GRCm39) W311* probably null Het
Oasl1 G A 5: 115,073,993 (GRCm39) D301N probably damaging Het
Or10ag56 A T 2: 87,139,762 (GRCm39) I230F probably benign Het
Or14a258 A T 7: 86,035,289 (GRCm39) I193N probably benign Het
Or5h26 A G 16: 58,988,503 (GRCm39) M1T probably null Het
Palmd A G 3: 116,721,083 (GRCm39) S123P probably damaging Het
Patj A G 4: 98,325,560 (GRCm39) probably benign Het
Pcsk4 T C 10: 80,161,655 (GRCm39) D162G probably benign Het
Plppr5 A G 3: 117,369,520 (GRCm39) D59G possibly damaging Het
Pmvk A C 3: 89,369,189 (GRCm39) R11S possibly damaging Het
Pnliprp1 A G 19: 58,728,901 (GRCm39) T363A probably benign Het
Poll A T 19: 45,547,277 (GRCm39) I65N probably benign Het
Prox1 T A 1: 189,893,009 (GRCm39) S479C probably damaging Het
Prss50 A T 9: 110,691,361 (GRCm39) S222C probably damaging Het
Rasa3 A C 8: 13,632,381 (GRCm39) probably benign Het
Sec14l3 T C 11: 4,025,481 (GRCm39) V335A probably benign Het
Setbp1 C T 18: 78,899,935 (GRCm39) S1244N probably benign Het
Sgcg A T 14: 61,483,213 (GRCm39) F63I probably damaging Het
Skp2 C A 15: 9,113,786 (GRCm39) G376C probably damaging Het
Slc2a13 T A 15: 91,400,695 (GRCm39) I176F probably benign Het
Smc6 A G 12: 11,339,987 (GRCm39) T432A probably benign Het
Snx25 G A 8: 46,509,150 (GRCm39) P478L probably damaging Het
Taf2 A T 15: 54,879,882 (GRCm39) H1151Q probably damaging Het
Thsd1 A G 8: 22,749,673 (GRCm39) K795R possibly damaging Het
Tmem108 G A 9: 103,361,976 (GRCm39) L537F possibly damaging Het
Ubr3 T C 2: 69,766,361 (GRCm39) Y410H probably damaging Het
Vav3 T C 3: 109,555,055 (GRCm39) probably null Het
Vmn1r224 T C 17: 20,639,524 (GRCm39) Y34H probably benign Het
Zeb1 T C 18: 5,766,458 (GRCm39) V323A possibly damaging Het
Zfp963 A T 8: 70,195,996 (GRCm39) C152* probably null Het
Other mutations in Zfp652
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0023:Zfp652 UTSW 11 95,644,295 (GRCm39) nonsense probably null
R0023:Zfp652 UTSW 11 95,644,295 (GRCm39) nonsense probably null
R0432:Zfp652 UTSW 11 95,654,565 (GRCm39) missense possibly damaging 0.50
R0464:Zfp652 UTSW 11 95,654,475 (GRCm39) missense probably damaging 0.99
R1146:Zfp652 UTSW 11 95,640,608 (GRCm39) missense possibly damaging 0.86
R1146:Zfp652 UTSW 11 95,640,608 (GRCm39) missense possibly damaging 0.86
R1920:Zfp652 UTSW 11 95,654,851 (GRCm39) missense possibly damaging 0.73
R1922:Zfp652 UTSW 11 95,654,851 (GRCm39) missense possibly damaging 0.73
R2290:Zfp652 UTSW 11 95,640,849 (GRCm39) missense possibly damaging 0.58
R2656:Zfp652 UTSW 11 95,640,155 (GRCm39) missense probably damaging 0.98
R4790:Zfp652 UTSW 11 95,640,435 (GRCm39) missense probably damaging 0.99
R5073:Zfp652 UTSW 11 95,640,890 (GRCm39) missense possibly damaging 0.65
R5098:Zfp652 UTSW 11 95,643,762 (GRCm39) missense probably damaging 1.00
R5209:Zfp652 UTSW 11 95,654,491 (GRCm39) missense possibly damaging 0.66
R5569:Zfp652 UTSW 11 95,640,116 (GRCm39) missense probably benign
R5905:Zfp652 UTSW 11 95,640,689 (GRCm39) missense probably benign
R6026:Zfp652 UTSW 11 95,640,788 (GRCm39) missense possibly damaging 0.95
R6054:Zfp652 UTSW 11 95,640,689 (GRCm39) missense probably benign
R6629:Zfp652 UTSW 11 95,654,616 (GRCm39) missense probably damaging 0.96
R6815:Zfp652 UTSW 11 95,640,230 (GRCm39) nonsense probably null
R6932:Zfp652 UTSW 11 95,654,667 (GRCm39) missense probably benign
R7384:Zfp652 UTSW 11 95,643,830 (GRCm39) missense probably damaging 1.00
R7644:Zfp652 UTSW 11 95,640,914 (GRCm39) missense probably damaging 1.00
R7667:Zfp652 UTSW 11 95,640,544 (GRCm39) missense probably benign 0.00
R7881:Zfp652 UTSW 11 95,640,935 (GRCm39) missense possibly damaging 0.83
R8045:Zfp652 UTSW 11 95,640,483 (GRCm39) missense possibly damaging 0.94
R8093:Zfp652 UTSW 11 95,640,288 (GRCm39) missense probably damaging 0.99
R8482:Zfp652 UTSW 11 95,643,719 (GRCm39) missense probably damaging 1.00
R8876:Zfp652 UTSW 11 95,639,921 (GRCm39) start gained probably benign
R9366:Zfp652 UTSW 11 95,643,833 (GRCm39) nonsense probably null
Z1177:Zfp652 UTSW 11 95,640,761 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AACCTGTAAGCTGCTGAGG -3'
(R):5'- GCCTACAGAGATACCATGTCTC -3'

Sequencing Primer
(F):5'- AAGCTGCTGAGGGTGGGC -3'
(R):5'- TGCAAATGTGTGCCAGTCAC -3'
Posted On 2014-09-18