Incidental Mutation 'R0193:Cadps2'
| ID |
23217 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
038452-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0193 (G1)
|
| Quality Score |
202 |
|
Status
|
Validated
(trace)
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23599439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 260
(K260R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125972
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115356]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018122
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069074
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115356
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000111013
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115358
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115361
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136279
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142913
AA Change: K260R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: K260R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163871
AA Change: K289R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: K289R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166458
AA Change: K260R
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: K260R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Meta Mutation Damage Score |
0.0594 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 94.7%
- 20x: 85.3%
|
| Validation Efficiency |
95% (186/196) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb1 |
T |
C |
15: 74,444,005 (GRCm39) |
S96P |
probably damaging |
Het |
| Akr1c20 |
A |
G |
13: 4,561,292 (GRCm39) |
|
probably benign |
Het |
| Atp2a3 |
G |
T |
11: 72,863,046 (GRCm39) |
V99L |
possibly damaging |
Het |
| Atp6v0a1 |
T |
A |
11: 100,939,308 (GRCm39) |
I691N |
possibly damaging |
Het |
| Atp8b1 |
C |
T |
18: 64,694,707 (GRCm39) |
R525Q |
probably benign |
Het |
| Aurkb |
A |
G |
11: 68,939,370 (GRCm39) |
D151G |
probably damaging |
Het |
| Bank1 |
A |
T |
3: 135,772,279 (GRCm39) |
|
probably benign |
Het |
| Bcl9l |
T |
C |
9: 44,418,703 (GRCm39) |
L847P |
probably damaging |
Het |
| Bscl2 |
T |
A |
19: 8,824,793 (GRCm39) |
M292K |
probably benign |
Het |
| Cacna1c |
C |
T |
6: 118,579,363 (GRCm39) |
|
probably benign |
Het |
| Cc2d2a |
T |
C |
5: 43,893,460 (GRCm39) |
S1419P |
probably damaging |
Het |
| Ccdc180 |
G |
A |
4: 45,914,803 (GRCm39) |
E145K |
probably benign |
Het |
| Ccno |
C |
T |
13: 113,125,418 (GRCm39) |
|
probably benign |
Het |
| Cd300a |
A |
G |
11: 114,784,202 (GRCm39) |
D70G |
probably benign |
Het |
| Cenpc1 |
T |
C |
5: 86,180,262 (GRCm39) |
D670G |
probably benign |
Het |
| Cenpl |
A |
G |
1: 160,913,558 (GRCm39) |
I323V |
probably damaging |
Het |
| Cfap44 |
A |
G |
16: 44,269,573 (GRCm39) |
|
probably null |
Het |
| Cfap74 |
C |
T |
4: 155,510,572 (GRCm39) |
R386C |
probably benign |
Het |
| Cic |
T |
A |
7: 24,986,565 (GRCm39) |
S1299T |
probably damaging |
Het |
| Cic |
C |
A |
7: 24,986,566 (GRCm39) |
S1299Y |
probably damaging |
Het |
| Clcnkb |
T |
C |
4: 141,139,627 (GRCm39) |
E125G |
possibly damaging |
Het |
| Clstn1 |
G |
A |
4: 149,719,253 (GRCm39) |
V361M |
probably damaging |
Het |
| Coro7 |
G |
A |
16: 4,445,368 (GRCm39) |
|
probably benign |
Het |
| Dchs1 |
C |
T |
7: 105,414,190 (GRCm39) |
R875H |
probably benign |
Het |
| Eif3j1 |
A |
C |
2: 121,882,508 (GRCm39) |
M239L |
probably benign |
Het |
| Eif4g3 |
G |
T |
4: 137,873,687 (GRCm39) |
|
probably benign |
Het |
| Elapor2 |
A |
T |
5: 9,472,359 (GRCm39) |
Q352L |
probably damaging |
Het |
| Erbb4 |
T |
C |
1: 68,083,119 (GRCm39) |
|
probably benign |
Het |
| Erlin2 |
T |
G |
8: 27,521,792 (GRCm39) |
V164G |
possibly damaging |
Het |
| Fbxo43 |
G |
T |
15: 36,162,029 (GRCm39) |
Q393K |
probably benign |
Het |
| Fcgr4 |
A |
T |
1: 170,853,329 (GRCm39) |
N178I |
possibly damaging |
Het |
| Grid2 |
A |
G |
6: 64,040,937 (GRCm39) |
N293S |
possibly damaging |
Het |
| H2-M1 |
C |
T |
17: 36,982,224 (GRCm39) |
V126I |
probably benign |
Het |
| Htr1f |
T |
A |
16: 64,747,112 (GRCm39) |
Y60F |
probably damaging |
Het |
| Ilf2 |
A |
G |
3: 90,388,646 (GRCm39) |
|
probably null |
Het |
| Impg2 |
A |
T |
16: 56,085,412 (GRCm39) |
K931* |
probably null |
Het |
| Ints1 |
T |
C |
5: 139,737,485 (GRCm39) |
E2176G |
probably damaging |
Het |
| Iqsec2 |
T |
C |
X: 151,006,399 (GRCm39) |
V1319A |
probably benign |
Het |
| Iqsec3 |
G |
T |
6: 121,387,683 (GRCm39) |
D685E |
probably damaging |
Het |
| Itgbl1 |
G |
A |
14: 124,083,958 (GRCm39) |
V279I |
probably benign |
Het |
| Kdm4b |
C |
T |
17: 56,700,952 (GRCm39) |
A541V |
probably benign |
Het |
| Kif14 |
A |
T |
1: 136,396,176 (GRCm39) |
T161S |
probably benign |
Het |
| Krt86 |
T |
C |
15: 101,377,244 (GRCm39) |
|
probably benign |
Het |
| Kyat1 |
C |
T |
2: 30,077,198 (GRCm39) |
|
probably null |
Het |
| Limch1 |
T |
C |
5: 67,184,882 (GRCm39) |
W791R |
probably damaging |
Het |
| Map3k11 |
T |
A |
19: 5,745,874 (GRCm39) |
M396K |
probably damaging |
Het |
| Mat2a |
A |
G |
6: 72,413,178 (GRCm39) |
|
probably null |
Het |
| Mbnl2 |
A |
G |
14: 120,616,649 (GRCm39) |
I88V |
possibly damaging |
Het |
| Mib2 |
T |
C |
4: 155,740,130 (GRCm39) |
T708A |
probably benign |
Het |
| Mix23 |
T |
C |
16: 35,903,184 (GRCm39) |
S59P |
probably damaging |
Het |
| Mkks |
T |
C |
2: 136,719,526 (GRCm39) |
|
probably null |
Het |
| Mtss1 |
T |
C |
15: 58,815,866 (GRCm39) |
M565V |
probably damaging |
Het |
| Myoc |
A |
G |
1: 162,476,604 (GRCm39) |
N436S |
probably damaging |
Het |
| Myod1 |
T |
A |
7: 46,026,536 (GRCm39) |
V147E |
probably damaging |
Het |
| Ngef |
A |
G |
1: 87,437,056 (GRCm39) |
L144P |
probably benign |
Het |
| Ngrn |
C |
T |
7: 79,911,678 (GRCm39) |
R92W |
probably damaging |
Het |
| Nup153 |
G |
A |
13: 46,863,130 (GRCm39) |
T349I |
probably benign |
Het |
| Or4c15 |
T |
A |
2: 88,760,627 (GRCm39) |
I11L |
probably benign |
Het |
| Or52ad1 |
G |
T |
7: 102,995,411 (GRCm39) |
S241R |
possibly damaging |
Het |
| Pigl |
A |
G |
11: 62,394,574 (GRCm39) |
I135M |
probably damaging |
Het |
| Pitpnm3 |
A |
G |
11: 71,961,318 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,429,141 (GRCm39) |
F2420I |
probably damaging |
Het |
| Polr2b |
C |
T |
5: 77,467,923 (GRCm39) |
T119M |
probably damaging |
Het |
| Prr29 |
A |
G |
11: 106,267,722 (GRCm39) |
Y130C |
probably damaging |
Het |
| Rab11fip3 |
T |
C |
17: 26,209,973 (GRCm39) |
I1048V |
probably damaging |
Het |
| Rab12 |
G |
A |
17: 66,807,357 (GRCm39) |
T124I |
probably damaging |
Het |
| Rab44 |
A |
G |
17: 29,359,281 (GRCm39) |
S490G |
probably benign |
Het |
| Rasa3 |
A |
G |
8: 13,620,233 (GRCm39) |
|
probably null |
Het |
| Rhbdl3 |
C |
T |
11: 80,244,400 (GRCm39) |
S369L |
possibly damaging |
Het |
| Rimbp2 |
A |
T |
5: 128,865,420 (GRCm39) |
S643T |
probably benign |
Het |
| Rin1 |
T |
G |
19: 5,102,680 (GRCm39) |
S396R |
probably damaging |
Het |
| Rpusd3 |
C |
T |
6: 113,396,198 (GRCm39) |
G28S |
probably damaging |
Het |
| Rtl9 |
T |
A |
X: 141,883,274 (GRCm39) |
S229T |
probably damaging |
Het |
| Rufy1 |
G |
T |
11: 50,280,679 (GRCm39) |
T701N |
probably benign |
Het |
| Scn4a |
A |
T |
11: 106,211,364 (GRCm39) |
L1551* |
probably null |
Het |
| Sec24b |
T |
C |
3: 129,782,633 (GRCm39) |
N1119S |
probably null |
Het |
| Serbp1 |
T |
A |
6: 67,249,868 (GRCm39) |
*75R |
probably null |
Het |
| Setx |
C |
T |
2: 29,069,685 (GRCm39) |
P2497S |
probably benign |
Het |
| Slc26a11 |
A |
T |
11: 119,250,140 (GRCm39) |
I132F |
probably damaging |
Het |
| Slc4a1 |
A |
G |
11: 102,243,510 (GRCm39) |
V707A |
possibly damaging |
Het |
| Slfn1 |
A |
G |
11: 83,012,669 (GRCm39) |
I262V |
probably damaging |
Het |
| Tmem168 |
T |
A |
6: 13,583,312 (GRCm39) |
D523V |
possibly damaging |
Het |
| Traf7 |
G |
T |
17: 24,729,525 (GRCm39) |
Q469K |
probably benign |
Het |
| Trdmt1 |
C |
A |
2: 13,549,428 (GRCm39) |
V6F |
probably damaging |
Het |
| Tsacc |
A |
T |
3: 88,194,395 (GRCm39) |
|
probably benign |
Het |
| Vmn2r5 |
A |
G |
3: 64,398,951 (GRCm39) |
I589T |
possibly damaging |
Het |
| Vmn2r7 |
T |
C |
3: 64,598,460 (GRCm39) |
D699G |
probably damaging |
Het |
| Vmn2r82 |
T |
C |
10: 79,217,129 (GRCm39) |
V487A |
probably damaging |
Het |
| Zbtb47 |
T |
C |
9: 121,596,732 (GRCm39) |
V696A |
probably damaging |
Het |
| Zfp287 |
A |
T |
11: 62,605,855 (GRCm39) |
S351T |
probably benign |
Het |
| Zfp654 |
T |
C |
16: 64,606,051 (GRCm39) |
H176R |
possibly damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,297 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,646 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGATGGCTAAGACACATCCAGGC -3'
(R):5'- TGGGGTATAGCAGAATCCAGCAGAC -3'
Sequencing Primer
(F):5'- AGGAAAGTCTTCTCCATGACTG -3'
(R):5'- AGACTTCCGAACCGTCTTTAATC -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation