Incidental Mutation 'R2107:Vps35l'
ID 232171
Institutional Source Beutler Lab
Gene Symbol Vps35l
Ensembl Gene ENSMUSG00000030982
Gene Name VPS35 endosomal protein sorting factor like
Synonyms 9030624J02Rik, Vsp35l
MMRRC Submission 040111-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R2107 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 118339401-118440712 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 118393762 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000033280] [ENSMUST00000059390] [ENSMUST00000106552] [ENSMUST00000106553]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000033280
Predicted Effect probably benign
Transcript: ENSMUST00000059390
SMART Domains Protein: ENSMUSP00000051263
Gene: ENSMUSG00000030982

DomainStartEndE-ValueType
low complexity region 71 100 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106552
SMART Domains Protein: ENSMUSP00000102162
Gene: ENSMUSG00000030982

DomainStartEndE-ValueType
low complexity region 47 76 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106553
SMART Domains Protein: ENSMUSP00000102163
Gene: ENSMUSG00000030982

DomainStartEndE-ValueType
low complexity region 47 76 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149749
SMART Domains Protein: ENSMUSP00000121323
Gene: ENSMUSG00000030982

DomainStartEndE-ValueType
Pfam:Vps35 2 198 7.3e-10 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001O22Rik A T 2: 30,685,744 (GRCm39) L364Q probably damaging Het
A2m C A 6: 121,631,571 (GRCm39) L623M probably benign Het
Ace2 A G X: 162,923,728 (GRCm39) N24S probably benign Het
Acp2 G A 2: 91,033,940 (GRCm39) probably benign Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Bcas3 G A 11: 85,348,704 (GRCm39) V199I probably damaging Het
Cblb T A 16: 51,973,079 (GRCm39) probably null Het
Ccdc88c G T 12: 100,887,808 (GRCm39) D1557E probably benign Het
Cdc20 T C 4: 118,290,710 (GRCm39) Y430C probably damaging Het
Cdk5rap1 C T 2: 154,195,166 (GRCm39) D350N probably benign Het
Cgrrf1 T A 14: 47,090,833 (GRCm39) probably benign Het
Chia1 T A 3: 106,036,156 (GRCm39) Y185* probably null Het
Cmtm8 A T 9: 114,625,176 (GRCm39) V85D possibly damaging Het
Cplx4 A G 18: 66,089,964 (GRCm39) S152P probably benign Het
Crmp1 G T 5: 37,399,838 (GRCm39) R117L probably benign Het
Csad G C 15: 102,087,469 (GRCm39) L365V probably null Het
Dyrk1a C T 16: 94,487,386 (GRCm39) T532M probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fan1 T G 7: 64,016,536 (GRCm39) R529S probably damaging Het
Fbln5 A G 12: 101,737,528 (GRCm39) W173R probably damaging Het
Gm9611 A T 14: 42,116,611 (GRCm39) N42K possibly damaging Het
Gnal T A 18: 67,346,649 (GRCm39) L257Q probably damaging Het
Hint3 A T 10: 30,494,252 (GRCm39) F33I probably damaging Het
Ipcef1 A G 10: 6,840,501 (GRCm39) S403P probably benign Het
Kmt2c T C 5: 25,514,822 (GRCm39) N3007S probably benign Het
Kpna3 T C 14: 61,607,933 (GRCm39) D424G possibly damaging Het
Krt90 A G 15: 101,471,064 (GRCm39) I66T probably benign Het
Lamc2 A G 1: 153,030,132 (GRCm39) probably benign Het
Lmtk3 G T 7: 45,443,393 (GRCm39) C692F possibly damaging Het
Lrguk T C 6: 34,039,296 (GRCm39) M269T probably benign Het
Lrrc19 T A 4: 94,527,531 (GRCm39) T227S probably benign Het
Lrrk1 C A 7: 65,929,030 (GRCm39) D1201Y probably damaging Het
Matn2 T A 15: 34,423,905 (GRCm39) Y588N probably damaging Het
Mmp1b A G 9: 7,369,310 (GRCm39) W346R probably damaging Het
Mpo T C 11: 87,686,901 (GRCm39) Y177H probably damaging Het
Mprip A G 11: 59,660,717 (GRCm39) K2166R probably damaging Het
Myo15a T C 11: 60,382,636 (GRCm39) Y1544H probably damaging Het
Nav1 C T 1: 135,376,742 (GRCm39) R1694Q probably damaging Het
Nedd9 A T 13: 41,492,455 (GRCm39) C12* probably null Het
Neu1 G A 17: 35,153,374 (GRCm39) R299Q probably benign Het
Nisch C T 14: 30,894,097 (GRCm39) V172I probably damaging Het
Npy2r A T 3: 82,448,436 (GRCm39) probably null Het
Ogg1 C A 6: 113,306,254 (GRCm39) N150K probably damaging Het
Or1j4 C A 2: 36,740,355 (GRCm39) A99E possibly damaging Het
Or1p1 T C 11: 74,180,216 (GRCm39) V248A probably damaging Het
Or6c219 A G 10: 129,781,581 (GRCm39) S2P probably damaging Het
Pck1 G C 2: 172,995,861 (GRCm39) E120Q probably benign Het
Pde11a A G 2: 76,168,266 (GRCm39) V229A probably damaging Het
Pias2 T C 18: 77,185,167 (GRCm39) F83L probably benign Het
Plagl1 A C 10: 13,004,391 (GRCm39) probably benign Het
Plin3 A T 17: 56,591,391 (GRCm39) S130T probably benign Het
Rcc2 A G 4: 140,448,496 (GRCm39) Y515C probably damaging Het
Rgs12 A G 5: 35,124,079 (GRCm39) K621E possibly damaging Het
Rnf6 G A 5: 146,148,091 (GRCm39) T309I probably damaging Het
Rpusd3 G T 6: 113,392,523 (GRCm39) T335N probably damaging Het
Scn8a A T 15: 100,916,244 (GRCm39) I1218F probably damaging Het
Slc23a1 T A 18: 35,758,879 (GRCm39) Q104L possibly damaging Het
Slc34a3 A T 2: 25,120,999 (GRCm39) V363D probably damaging Het
Smap1 A T 1: 23,887,535 (GRCm39) M248K possibly damaging Het
Sp1 A G 15: 102,318,113 (GRCm39) probably null Het
Tasor T A 14: 27,183,744 (GRCm39) probably null Het
Tbc1d1 T G 5: 64,442,048 (GRCm39) N689K probably benign Het
Tff2 T C 17: 31,361,256 (GRCm39) E99G possibly damaging Het
Tjp3 T C 10: 81,116,378 (GRCm39) N239D possibly damaging Het
Trim37 G A 11: 87,050,651 (GRCm39) R230Q probably benign Het
Ubr5 A G 15: 37,989,546 (GRCm39) M2090T probably benign Het
Unc13a T C 8: 72,108,895 (GRCm39) probably null Het
Usp43 GC G 11: 67,746,566 (GRCm39) probably null Het
Utrn C A 10: 12,312,108 (GRCm39) D616Y probably damaging Het
Vav2 T C 2: 27,157,315 (GRCm39) E829G probably damaging Het
Zfp26 A T 9: 20,353,533 (GRCm39) D85E probably benign Het
Zfp292 A T 4: 34,808,593 (GRCm39) F1484I possibly damaging Het
Other mutations in Vps35l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Vps35l APN 7 118,396,270 (GRCm39) critical splice donor site probably null
IGL00229:Vps35l APN 7 118,403,414 (GRCm39) splice site probably benign
IGL01066:Vps35l APN 7 118,372,234 (GRCm39) splice site probably null
IGL01433:Vps35l APN 7 118,373,274 (GRCm39) splice site probably null
IGL02381:Vps35l APN 7 118,374,598 (GRCm39) missense probably damaging 1.00
IGL02566:Vps35l APN 7 118,352,055 (GRCm39) missense probably benign 0.04
IGL03199:Vps35l APN 7 118,365,611 (GRCm39) missense probably benign 0.18
IGL03224:Vps35l APN 7 118,391,776 (GRCm39) unclassified probably benign
R0535:Vps35l UTSW 7 118,347,404 (GRCm39) missense possibly damaging 0.95
R1109:Vps35l UTSW 7 118,374,552 (GRCm39) missense probably damaging 0.97
R1378:Vps35l UTSW 7 118,393,796 (GRCm39) missense probably damaging 1.00
R1378:Vps35l UTSW 7 118,393,795 (GRCm39) nonsense probably null
R1412:Vps35l UTSW 7 118,409,194 (GRCm39) missense probably damaging 0.99
R1474:Vps35l UTSW 7 118,359,436 (GRCm39) missense probably damaging 1.00
R1586:Vps35l UTSW 7 118,409,195 (GRCm39) missense probably damaging 1.00
R1785:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R1786:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R1921:Vps35l UTSW 7 118,432,971 (GRCm39) missense probably damaging 0.98
R1971:Vps35l UTSW 7 118,374,557 (GRCm39) missense probably damaging 1.00
R2038:Vps35l UTSW 7 118,411,097 (GRCm39) missense probably damaging 0.98
R2130:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R2131:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R2132:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R2133:Vps35l UTSW 7 118,393,798 (GRCm39) missense probably damaging 1.00
R2405:Vps35l UTSW 7 118,391,818 (GRCm39) missense probably damaging 1.00
R2411:Vps35l UTSW 7 118,391,818 (GRCm39) missense probably damaging 1.00
R3910:Vps35l UTSW 7 118,345,613 (GRCm39) missense possibly damaging 0.86
R3911:Vps35l UTSW 7 118,345,613 (GRCm39) missense possibly damaging 0.86
R3912:Vps35l UTSW 7 118,345,613 (GRCm39) missense possibly damaging 0.86
R3971:Vps35l UTSW 7 118,433,022 (GRCm39) missense probably damaging 0.98
R4697:Vps35l UTSW 7 118,390,671 (GRCm39) missense probably damaging 1.00
R4964:Vps35l UTSW 7 118,379,491 (GRCm39) missense possibly damaging 0.84
R4980:Vps35l UTSW 7 118,406,232 (GRCm39) missense probably damaging 1.00
R5034:Vps35l UTSW 7 118,390,611 (GRCm39) missense probably damaging 0.99
R5309:Vps35l UTSW 7 118,412,799 (GRCm39) missense probably damaging 1.00
R5312:Vps35l UTSW 7 118,412,799 (GRCm39) missense probably damaging 1.00
R5743:Vps35l UTSW 7 118,396,234 (GRCm39) missense possibly damaging 0.89
R6017:Vps35l UTSW 7 118,409,144 (GRCm39) missense probably damaging 1.00
R6089:Vps35l UTSW 7 118,345,658 (GRCm39) missense possibly damaging 0.76
R6320:Vps35l UTSW 7 118,353,072 (GRCm39) missense probably benign 0.08
R6415:Vps35l UTSW 7 118,391,869 (GRCm39) missense probably damaging 1.00
R6861:Vps35l UTSW 7 118,342,898 (GRCm39) missense probably damaging 1.00
R7034:Vps35l UTSW 7 118,372,315 (GRCm39) missense probably damaging 1.00
R7036:Vps35l UTSW 7 118,372,315 (GRCm39) missense probably damaging 1.00
R7339:Vps35l UTSW 7 118,409,194 (GRCm39) missense probably damaging 0.99
R7456:Vps35l UTSW 7 118,403,340 (GRCm39) missense probably benign 0.01
R7493:Vps35l UTSW 7 118,393,800 (GRCm39) splice site probably null
R8064:Vps35l UTSW 7 118,353,147 (GRCm39) missense probably damaging 1.00
R8103:Vps35l UTSW 7 118,342,855 (GRCm39) missense probably benign 0.19
R8279:Vps35l UTSW 7 118,345,722 (GRCm39) missense probably benign
R8354:Vps35l UTSW 7 118,391,795 (GRCm39) missense probably benign 0.07
R8454:Vps35l UTSW 7 118,391,795 (GRCm39) missense probably benign 0.07
R8954:Vps35l UTSW 7 118,393,801 (GRCm39) missense possibly damaging 0.94
R9450:Vps35l UTSW 7 118,352,118 (GRCm39) critical splice donor site probably null
R9642:Vps35l UTSW 7 118,437,451 (GRCm39) missense probably benign 0.00
R9667:Vps35l UTSW 7 118,348,915 (GRCm39) critical splice donor site probably null
R9749:Vps35l UTSW 7 118,352,107 (GRCm39) missense probably benign 0.03
X0028:Vps35l UTSW 7 118,399,675 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GGGCTACGTGTTTCCTTTTATAAC -3'
(R):5'- TAAGGCCCCAGCTCAAGTAC -3'

Sequencing Primer
(F):5'- CAGTCAAGAGGATCCGACTGTC -3'
(R):5'- GTACCACTGCAGTATCCCTAAGTG -3'
Posted On 2014-09-18