Incidental Mutation 'IGL00225:Oraov1'
ID2323
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oraov1
Ensembl Gene ENSMUSG00000031072
Gene Nameoral cancer overexpressed 1
SynonymsTAOS1, 2210010N10Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.905) question?
Stock #IGL00225
Quality Score
Status
Chromosome7
Chromosomal Location144915100-144931701 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 144917668 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 86 (G86D)
Ref Sequence ENSEMBL: ENSMUSP00000115840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033388] [ENSMUST00000105895] [ENSMUST00000128057] [ENSMUST00000141737]
Predicted Effect probably benign
Transcript: ENSMUST00000033388
AA Change: G86D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000033388
Gene: ENSMUSG00000031072
AA Change: G86D

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 2.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000093964
Predicted Effect probably benign
Transcript: ENSMUST00000105895
AA Change: G86D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101515
Gene: ENSMUSG00000031072
AA Change: G86D

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 2e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000128057
AA Change: G86D

PolyPhen 2 Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000115840
Gene: ENSMUSG00000031072
AA Change: G86D

DomainStartEndE-ValueType
Pfam:Yae1_N 36 74 7.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000141737
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147460
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207094
Predicted Effect unknown
Transcript: ENSMUST00000207453
AA Change: G2D
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227063
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Flii T C 11: 60,723,415 N93D probably benign Het
Gm8356 T C 14: 6,537,141 K24E probably damaging Het
Hars G A 18: 36,768,172 T409M probably damaging Het
Ivns1abp A G 1: 151,351,112 probably null Het
Kcnq4 G A 4: 120,698,016 Q657* probably null Het
Kdm4c T G 4: 74,345,567 V696G probably benign Het
Klrb1f T A 6: 129,053,175 probably benign Het
Lrp4 G A 2: 91,495,026 V1399I probably benign Het
Mki67 A G 7: 135,690,120 V3168A probably benign Het
Nf1 T A 11: 79,395,905 I177K probably damaging Het
Nnt A T 13: 119,369,997 N371K probably damaging Het
Olfr472 C T 7: 107,903,104 P129L probably damaging Het
Olfr60 A G 7: 140,345,210 Y260H probably damaging Het
Prkdc G T 16: 15,809,644 V3389L possibly damaging Het
Prr16 T A 18: 51,303,120 Y224N possibly damaging Het
Ptgs1 G A 2: 36,237,219 C39Y probably damaging Het
Sla T C 15: 66,782,630 D269G possibly damaging Het
Stk38l T A 6: 146,758,473 M1K probably null Het
Trim24 T A 6: 37,903,648 N160K possibly damaging Het
Zfp451 A G 1: 33,786,540 probably benign Het
Other mutations in Oraov1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Oraov1 APN 7 144916483 missense probably damaging 0.99
IGL03130:Oraov1 APN 7 144916460 missense probably damaging 1.00
PIT4382001:Oraov1 UTSW 7 144916444 missense probably damaging 1.00
R0784:Oraov1 UTSW 7 144919277 missense probably benign 0.33
R1938:Oraov1 UTSW 7 144916468 missense probably damaging 0.99
R4115:Oraov1 UTSW 7 144919646 missense possibly damaging 0.78
R4695:Oraov1 UTSW 7 144928978 unclassified probably null
R6056:Oraov1 UTSW 7 144915286 missense possibly damaging 0.76
R6364:Oraov1 UTSW 7 144919268 missense probably benign 0.00
Posted On2011-12-09