Incidental Mutation 'R2112:Arpc1b'
ID 232655
Institutional Source Beutler Lab
Gene Symbol Arpc1b
Ensembl Gene ENSMUSG00000029622
Gene Name actin related protein 2/3 complex, subunit 1B
Synonyms L72, p41-ARC, SOP2Hs
MMRRC Submission 040116-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2112 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 145051066-145064996 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145060579 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 124 (Y124H)
Ref Sequence ENSEMBL: ENSMUSP00000143438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031627] [ENSMUST00000085679] [ENSMUST00000136074] [ENSMUST00000196111] [ENSMUST00000141602]
AlphaFold Q9WV32
Predicted Effect probably benign
Transcript: ENSMUST00000031627
SMART Domains Protein: ENSMUSP00000031627
Gene: ENSMUSG00000029623

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
low complexity region 28 47 N/A INTRINSIC
low complexity region 52 69 N/A INTRINSIC
Pfam:PP28 84 163 3e-35 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000085679
AA Change: Y124H

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000082822
Gene: ENSMUSG00000029622
AA Change: Y124H

DomainStartEndE-ValueType
Blast:WD40 1 36 4e-14 BLAST
WD40 41 80 1.21e-7 SMART
WD40 85 124 1.54e0 SMART
WD40 130 170 1.56e-1 SMART
WD40 191 230 7.7e-1 SMART
Blast:WD40 233 271 9e-18 BLAST
WD40 317 358 3.55e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126343
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128229
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129033
Predicted Effect possibly damaging
Transcript: ENSMUST00000136074
AA Change: Y31H

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000115022
Gene: ENSMUSG00000029622
AA Change: Y31H

DomainStartEndE-ValueType
Pfam:WD40 3 29 2.5e-3 PFAM
WD40 77 121 1.79e-1 SMART
WD40 142 181 7.7e-1 SMART
Blast:WD40 184 222 1e-18 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138235
Predicted Effect probably damaging
Transcript: ENSMUST00000196111
AA Change: Y124H

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000143438
Gene: ENSMUSG00000029622
AA Change: Y124H

DomainStartEndE-ValueType
Blast:WD40 1 36 4e-14 BLAST
WD40 41 80 1.21e-7 SMART
WD40 85 124 1.54e0 SMART
WD40 130 170 1.56e-1 SMART
WD40 191 230 7.7e-1 SMART
Blast:WD40 237 275 2e-16 BLAST
WD40 321 362 3.55e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138900
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144375
Predicted Effect probably benign
Transcript: ENSMUST00000141602
SMART Domains Protein: ENSMUSP00000122340
Gene: ENSMUSG00000029622

DomainStartEndE-ValueType
Blast:WD40 1 36 2e-15 BLAST
PDB:2P9U|C 1 56 2e-33 PDB
SCOP:d1k8kc_ 9 56 2e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138922
SMART Domains Protein: ENSMUSP00000115515
Gene: ENSMUSG00000029622

DomainStartEndE-ValueType
PDB:2P9U|C 2 93 4e-43 PDB
SCOP:d1k8kc_ 35 93 2e-11 SMART
Blast:WD40 50 87 3e-20 BLAST
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1b A G 5: 121,638,777 (GRCm39) probably benign Het
Adprhl1 A G 8: 13,298,694 (GRCm39) Y79H probably damaging Het
Ambra1 T A 2: 91,706,132 (GRCm39) W746R probably damaging Het
Ankhd1 A T 18: 36,774,679 (GRCm39) K1420I probably damaging Het
Ap1b1 T C 11: 4,965,613 (GRCm39) F51L probably damaging Het
Arhgap24 A C 5: 103,040,366 (GRCm39) R434S probably damaging Het
Arhgap29 T C 3: 121,805,210 (GRCm39) L525P probably benign Het
Arr3 T A X: 99,658,247 (GRCm39) F269L possibly damaging Het
Atp11b G T 3: 35,891,677 (GRCm39) V830F probably damaging Het
Ccdc71l T A 12: 32,429,229 (GRCm39) F83I probably damaging Het
Cdh23 G T 10: 60,141,362 (GRCm39) F3127L probably damaging Het
Cfap251 G A 5: 123,392,438 (GRCm39) probably benign Het
Cldn15 T A 5: 136,997,016 (GRCm39) M19K possibly damaging Het
Cog4 A G 8: 111,585,214 (GRCm39) Y292C possibly damaging Het
Col12a1 A G 9: 79,551,181 (GRCm39) V2145A possibly damaging Het
Col5a3 T C 9: 20,721,073 (GRCm39) I110V unknown Het
Cps1 T A 1: 67,216,139 (GRCm39) D821E probably benign Het
Crnkl1 A T 2: 145,772,617 (GRCm39) Y153* probably null Het
Dock10 T A 1: 80,483,359 (GRCm39) K2082M probably damaging Het
Dock10 T C 1: 80,483,360 (GRCm39) K2083E probably damaging Het
Dst T C 1: 34,208,259 (GRCm39) S737P probably damaging Het
Dthd1 T C 5: 62,979,251 (GRCm39) Y304H probably damaging Het
Dthd1 T C 5: 63,000,222 (GRCm39) S515P probably damaging Het
Etf1 A T 18: 35,042,154 (GRCm39) probably null Het
Fmnl2 A G 2: 52,995,549 (GRCm39) E424G probably damaging Het
Galt A G 4: 41,758,245 (GRCm39) T337A probably benign Het
Gbp4 A G 5: 105,283,042 (GRCm39) L76P possibly damaging Het
Gcfc2 C A 6: 81,900,759 (GRCm39) D24E probably benign Het
Gigyf2 A G 1: 87,368,452 (GRCm39) H1044R probably damaging Het
Glg1 T C 8: 111,919,178 (GRCm39) D315G probably damaging Het
Gm4787 C T 12: 81,424,607 (GRCm39) C517Y probably damaging Het
Gnl3l A G X: 149,780,290 (GRCm39) S217P probably damaging Het
Gpr37 T C 6: 25,669,380 (GRCm39) Y488C possibly damaging Het
Hap1 T C 11: 100,244,825 (GRCm39) D240G probably benign Het
Hhla1 C G 15: 65,808,232 (GRCm39) W271S probably benign Het
Hmgxb3 T C 18: 61,288,458 (GRCm39) R470G possibly damaging Het
Inpp5a A G 7: 139,154,877 (GRCm39) D332G probably damaging Het
Insr A G 8: 3,219,748 (GRCm39) S925P probably benign Het
Isoc2b T A 7: 4,852,474 (GRCm39) D171V probably damaging Het
Kif20b T C 19: 34,909,132 (GRCm39) I223T probably benign Het
Krt6b T C 15: 101,586,999 (GRCm39) T258A possibly damaging Het
Lipo4 G A 19: 33,488,926 (GRCm39) P219L probably benign Het
Luc7l T C 17: 26,474,101 (GRCm39) probably null Het
Madd T C 2: 91,007,321 (GRCm39) K264E possibly damaging Het
Mcf2l A T 8: 13,051,867 (GRCm39) K433N probably damaging Het
Mob3b A T 4: 35,083,795 (GRCm39) N131K probably damaging Het
Mtus1 G T 8: 41,475,608 (GRCm39) P819T probably damaging Het
Myo15a T C 11: 60,384,994 (GRCm39) F1699L probably damaging Het
Nav1 C T 1: 135,376,742 (GRCm39) R1694Q probably damaging Het
Neb G C 2: 52,218,776 (GRCm39) T78S probably damaging Het
Nek2 T C 1: 191,559,320 (GRCm39) V275A probably benign Het
Nfatc1 A T 18: 80,678,879 (GRCm39) C836* probably null Het
Nos1 T C 5: 118,074,636 (GRCm39) V1060A probably benign Het
Notch3 T A 17: 32,363,584 (GRCm39) I1160F probably benign Het
Nox4 T C 7: 87,021,216 (GRCm39) L476P probably damaging Het
Npc1 A T 18: 12,346,529 (GRCm39) N222K possibly damaging Het
Nrn1l C A 8: 106,621,378 (GRCm39) H109Q possibly damaging Het
Or4c11 T C 2: 88,695,545 (GRCm39) S199P possibly damaging Het
Or4k15 G T 14: 50,364,080 (GRCm39) L15F probably damaging Het
Or6d13 T C 6: 116,517,611 (GRCm39) Y66H possibly damaging Het
Or7a41 T C 10: 78,871,248 (GRCm39) L206P probably damaging Het
Or8g27 T C 9: 39,129,075 (GRCm39) Y141H probably benign Het
Or8g33 C A 9: 39,337,966 (GRCm39) V134L probably benign Het
Pcnt T C 10: 76,256,360 (GRCm39) K627E probably damaging Het
Plch1 T A 3: 63,630,227 (GRCm39) T514S probably damaging Het
Ppargc1b G A 18: 61,444,321 (GRCm39) P297S probably benign Het
Ppig A G 2: 69,580,451 (GRCm39) T662A unknown Het
Prdm2 A C 4: 142,858,506 (GRCm39) S1595A probably benign Het
Ptpn5 T A 7: 46,732,890 (GRCm39) T318S probably benign Het
Ralgps2 A G 1: 156,660,278 (GRCm39) Y265H probably damaging Het
Seh1l T C 18: 67,920,249 (GRCm39) I182T probably damaging Het
Slc12a6 T C 2: 112,186,830 (GRCm39) I943T probably damaging Het
Slc5a5 A T 8: 71,342,395 (GRCm39) probably null Het
Sparcl1 T A 5: 104,236,289 (GRCm39) Q488L probably damaging Het
Sphkap T G 1: 83,253,602 (GRCm39) K1382N probably benign Het
Sybu T C 15: 44,536,731 (GRCm39) S532G probably benign Het
Syde2 G A 3: 145,704,241 (GRCm39) G131S possibly damaging Het
Taok1 C T 11: 77,462,472 (GRCm39) V206I probably benign Het
Tas1r2 G T 4: 139,382,666 (GRCm39) M101I probably benign Het
Trpc6 C T 9: 8,656,613 (GRCm39) T680I probably damaging Het
Trub1 T C 19: 57,473,646 (GRCm39) probably null Het
Tspan1 G T 4: 116,020,885 (GRCm39) probably null Het
Ttc28 G A 5: 111,424,139 (GRCm39) E1438K probably damaging Het
Ubr3 A G 2: 69,808,136 (GRCm39) T1206A possibly damaging Het
Ulbp3 C T 10: 3,076,459 (GRCm39) noncoding transcript Het
Usp40 A G 1: 87,877,936 (GRCm39) I1117T probably benign Het
Usp43 G T 11: 67,812,536 (GRCm39) N113K probably damaging Het
Vcan T A 13: 89,841,422 (GRCm39) D414V probably damaging Het
Vmn1r202 T A 13: 22,685,904 (GRCm39) Y171F possibly damaging Het
Zfp142 A G 1: 74,612,795 (GRCm39) S451P probably damaging Het
Zfp516 A G 18: 82,975,536 (GRCm39) D578G probably damaging Het
Zfp90 G A 8: 107,152,120 (GRCm39) C611Y probably damaging Het
Zfp954 A G 7: 7,118,609 (GRCm39) C312R probably damaging Het
Zmym3 A T X: 100,450,993 (GRCm39) V1208D probably damaging Het
Other mutations in Arpc1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Arpc1b APN 5 145,064,679 (GRCm39) utr 3 prime probably benign
IGL01625:Arpc1b APN 5 145,058,555 (GRCm39) splice site probably null
IGL01859:Arpc1b APN 5 145,060,540 (GRCm39) missense probably damaging 0.98
illusory UTSW 5 145,059,377 (GRCm39) missense probably damaging 1.00
FR4304:Arpc1b UTSW 5 145,063,601 (GRCm39) frame shift probably null
FR4340:Arpc1b UTSW 5 145,063,602 (GRCm39) frame shift probably null
FR4737:Arpc1b UTSW 5 145,063,597 (GRCm39) frame shift probably null
R0110:Arpc1b UTSW 5 145,064,525 (GRCm39) missense probably damaging 1.00
R0245:Arpc1b UTSW 5 145,063,670 (GRCm39) missense probably damaging 1.00
R0469:Arpc1b UTSW 5 145,064,525 (GRCm39) missense probably damaging 1.00
R0652:Arpc1b UTSW 5 145,063,670 (GRCm39) missense probably damaging 1.00
R0827:Arpc1b UTSW 5 145,062,566 (GRCm39) missense probably benign 0.34
R1117:Arpc1b UTSW 5 145,062,564 (GRCm39) missense possibly damaging 0.95
R1453:Arpc1b UTSW 5 145,062,555 (GRCm39) missense probably damaging 1.00
R1895:Arpc1b UTSW 5 145,059,443 (GRCm39) missense probably null 0.99
R1946:Arpc1b UTSW 5 145,059,443 (GRCm39) missense probably null 0.99
R2050:Arpc1b UTSW 5 145,062,729 (GRCm39) missense probably damaging 1.00
R4924:Arpc1b UTSW 5 145,063,625 (GRCm39) missense probably benign 0.02
R6534:Arpc1b UTSW 5 145,059,377 (GRCm39) missense probably damaging 1.00
R6883:Arpc1b UTSW 5 145,063,739 (GRCm39) missense probably benign 0.31
R8523:Arpc1b UTSW 5 145,061,492 (GRCm39) missense probably damaging 1.00
R8854:Arpc1b UTSW 5 145,060,405 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAGTAACCGCATTGTGACCTG -3'
(R):5'- CTCAGTGTAGTATCCCCGGAAG -3'

Sequencing Primer
(F):5'- ATTGTGACCTGCGGCAC -3'
(R):5'- TATCCCCGGAAGTCAGAGTTG -3'
Posted On 2014-09-18