Incidental Mutation 'R2148:Dennd3'
ID 234043
Institutional Source Beutler Lab
Gene Symbol Dennd3
Ensembl Gene ENSMUSG00000036661
Gene Name DENN domain containing 3
Synonyms E030003N15Rik
MMRRC Submission 040151-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.210) question?
Stock # R2148 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 73384409-73444091 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73426909 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 762 (H762L)
Ref Sequence ENSEMBL: ENSMUSP00000134002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043414] [ENSMUST00000160267] [ENSMUST00000173292]
AlphaFold A2RT67
Predicted Effect probably benign
Transcript: ENSMUST00000043414
AA Change: H762L

PolyPhen 2 Score 0.336 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: H762L

DomainStartEndE-ValueType
Blast:uDENN 12 161 3e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
WD40 1232 1272 1.1e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160267
SMART Domains Protein: ENSMUSP00000124538
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
Blast:WD40 51 90 2e-9 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162488
SMART Domains Protein: ENSMUSP00000125657
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Blast:DENN 33 104 5e-28 BLAST
DENN 116 302 1.54e-62 SMART
dDENN 312 376 5.63e-6 SMART
WD40 892 931 3.68e1 SMART
WD40 934 975 3.32e-5 SMART
WD40 1109 1149 1.1e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173292
AA Change: H762L

PolyPhen 2 Score 0.347 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: H762L

DomainStartEndE-ValueType
Blast:uDENN 12 161 2e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C A 1: 71,302,647 (GRCm39) V2191L probably benign Het
Abca13 A G 11: 9,565,764 (GRCm39) Y4796C probably damaging Het
Actn2 A T 13: 12,315,835 (GRCm39) M228K probably damaging Het
Agbl1 T G 7: 76,064,465 (GRCm39) probably null Het
Ahi1 T G 10: 20,846,875 (GRCm39) V435G possibly damaging Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Arfgef1 C T 1: 10,270,103 (GRCm39) A349T probably benign Het
Arhgap6 A G X: 167,579,496 (GRCm39) T94A probably benign Het
Atg4c C A 4: 99,109,463 (GRCm39) N143K possibly damaging Het
Bcor G A X: 11,923,862 (GRCm39) A578V possibly damaging Het
Bop1 A G 15: 76,339,487 (GRCm39) V286A probably damaging Het
C1qtnf12 A G 4: 156,050,922 (GRCm39) N297S probably benign Het
Cacna1a A T 8: 85,356,304 (GRCm39) Q1887L possibly damaging Het
Cadps2 G T 6: 23,838,998 (GRCm39) probably benign Het
Chl1 T C 6: 103,692,362 (GRCm39) probably null Het
Cnot2 A G 10: 116,342,185 (GRCm39) I173T probably benign Het
Cntnap5b T A 1: 100,311,199 (GRCm39) I564N probably benign Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Cyp2j11 G A 4: 96,204,595 (GRCm39) T317I probably damaging Het
Dcaf8l T C X: 88,449,883 (GRCm39) D82G possibly damaging Het
Dgkd T G 1: 87,809,643 (GRCm39) N110K probably damaging Het
Dhx8 A T 11: 101,629,203 (GRCm39) R198* probably null Het
Dnah8 A T 17: 30,956,232 (GRCm39) I2071F probably damaging Het
Dsc3 C T 18: 20,098,695 (GRCm39) R828Q probably damaging Het
Fbxl4 T C 4: 22,427,333 (GRCm39) F525L possibly damaging Het
Glb1 T C 9: 114,279,716 (GRCm39) Y375H probably damaging Het
Gpatch1 A G 7: 34,998,701 (GRCm39) V343A probably benign Het
Gpr139 A G 7: 118,744,192 (GRCm39) V131A probably benign Het
Hamp T C 7: 30,642,137 (GRCm39) T34A possibly damaging Het
Homer2 T G 7: 81,274,043 (GRCm39) D51A possibly damaging Het
Hspa1l C T 17: 35,196,366 (GRCm39) A135V probably damaging Het
Igsf10 A G 3: 59,243,998 (GRCm39) M112T possibly damaging Het
Ikbkb A T 8: 23,172,761 (GRCm39) L153Q probably damaging Het
Kif19a A T 11: 114,671,594 (GRCm39) I158F probably damaging Het
L1cam A T X: 72,904,747 (GRCm39) F536Y probably damaging Het
Lamb3 T C 1: 193,010,212 (GRCm39) V275A probably benign Het
Lhx1 A T 11: 84,410,647 (GRCm39) S226T probably benign Het
Llcfc1 G A 6: 41,662,155 (GRCm39) G53D possibly damaging Het
Loxl4 A G 19: 42,592,631 (GRCm39) probably null Het
Magee1 A T X: 104,166,564 (GRCm39) D783V probably damaging Het
Mak T C 13: 41,195,513 (GRCm39) K400R probably benign Het
Mgat4c T C 10: 102,224,790 (GRCm39) F335L probably benign Het
Mgat4f T A 1: 134,318,251 (GRCm39) M341K probably damaging Het
Mospd2 A G X: 163,739,473 (GRCm39) probably null Het
Mtor T C 4: 148,540,469 (GRCm39) F245L possibly damaging Het
Mycbp2 G A 14: 103,393,358 (GRCm39) H3068Y probably damaging Het
Myo5a T A 9: 75,087,429 (GRCm39) L1095H probably damaging Het
Nlrp1a T A 11: 71,013,733 (GRCm39) K506* probably null Het
Or5d18 C A 2: 87,864,943 (GRCm39) C180F probably damaging Het
Parvb A G 15: 84,116,369 (GRCm39) K33E possibly damaging Het
Phkb A G 8: 86,744,115 (GRCm39) D588G probably damaging Het
Pkd1l2 A T 8: 117,783,064 (GRCm39) I752N probably damaging Het
Pkhd1 C A 1: 20,484,444 (GRCm39) probably null Het
Plod3 C T 5: 137,016,627 (GRCm39) R30* probably null Het
Ppfia4 T C 1: 134,240,372 (GRCm39) I591V probably benign Het
Prickle2 A G 6: 92,402,652 (GRCm39) L112P probably damaging Het
Ptgs2 G T 1: 149,981,465 (GRCm39) A583S probably benign Het
Pycr2 T C 1: 180,734,413 (GRCm39) V231A probably damaging Het
Ralgapa2 T C 2: 146,273,807 (GRCm39) D540G probably benign Het
Rasal1 T A 5: 120,800,096 (GRCm39) I150N probably damaging Het
Rimkla T A 4: 119,331,779 (GRCm39) M140L possibly damaging Het
Sacs T C 14: 61,410,827 (GRCm39) L34P probably damaging Het
Sema3d A G 5: 12,534,926 (GRCm39) Y106C probably damaging Het
Serpinb8 T A 1: 107,533,657 (GRCm39) D237E probably benign Het
Slc19a2 T C 1: 164,089,657 (GRCm39) W158R probably damaging Het
Sorbs1 A T 19: 40,365,268 (GRCm39) F172I possibly damaging Het
Spaca7 A T 8: 12,636,447 (GRCm39) D91V probably damaging Het
Tead3 A G 17: 28,552,638 (GRCm39) F187L probably damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Tmem131 C A 1: 36,851,690 (GRCm39) V938L probably benign Het
Tmem132c T A 5: 127,540,026 (GRCm39) W351R probably damaging Het
Tmem178b A T 6: 40,184,435 (GRCm39) Q111L probably damaging Het
Trap1 T C 16: 3,878,624 (GRCm39) D236G probably damaging Het
Trim45 T A 3: 100,839,360 (GRCm39) L754* probably null Het
Tubgcp5 A G 7: 55,449,259 (GRCm39) E152G probably damaging Het
Uaca A T 9: 60,776,961 (GRCm39) L447F probably damaging Het
Vps51 A G 19: 6,118,164 (GRCm39) V777A probably benign Het
Wdr11 A G 7: 129,230,807 (GRCm39) probably null Het
Zfp462 T A 4: 55,013,670 (GRCm39) S1879T probably benign Het
Zfr2 T G 10: 81,077,950 (GRCm39) V259G probably benign Het
Other mutations in Dennd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Dennd3 APN 15 73,438,982 (GRCm39) missense probably benign 0.26
IGL00579:Dennd3 APN 15 73,412,691 (GRCm39) missense possibly damaging 0.63
IGL02101:Dennd3 APN 15 73,399,794 (GRCm39) missense possibly damaging 0.81
IGL02164:Dennd3 APN 15 73,416,297 (GRCm39) missense probably benign 0.26
IGL02389:Dennd3 APN 15 73,438,905 (GRCm39) missense probably damaging 1.00
IGL02604:Dennd3 APN 15 73,428,252 (GRCm39) missense probably damaging 1.00
IGL02697:Dennd3 APN 15 73,396,085 (GRCm39) missense possibly damaging 0.82
IGL02885:Dennd3 APN 15 73,440,545 (GRCm39) missense probably benign
IGL03356:Dennd3 APN 15 73,440,482 (GRCm39) missense probably benign 0.19
IGL03388:Dennd3 APN 15 73,416,208 (GRCm39) missense probably damaging 0.98
BB006:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
BB016:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R0118:Dennd3 UTSW 15 73,436,925 (GRCm39) missense probably damaging 1.00
R0925:Dennd3 UTSW 15 73,405,284 (GRCm39) missense probably damaging 1.00
R1076:Dennd3 UTSW 15 73,412,582 (GRCm39) missense probably damaging 1.00
R1355:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1370:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1480:Dennd3 UTSW 15 73,404,695 (GRCm39) missense probably benign 0.20
R1727:Dennd3 UTSW 15 73,436,977 (GRCm39) missense possibly damaging 0.95
R1732:Dennd3 UTSW 15 73,409,267 (GRCm39) splice site probably benign
R1771:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1776:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1779:Dennd3 UTSW 15 73,394,357 (GRCm39) critical splice donor site probably null
R1838:Dennd3 UTSW 15 73,436,949 (GRCm39) missense probably damaging 1.00
R2146:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2146:Dennd3 UTSW 15 73,395,345 (GRCm39) missense probably damaging 1.00
R2147:Dennd3 UTSW 15 73,395,336 (GRCm39) missense probably damaging 1.00
R2149:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2150:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2174:Dennd3 UTSW 15 73,427,154 (GRCm39) missense probably damaging 1.00
R2295:Dennd3 UTSW 15 73,395,404 (GRCm39) critical splice donor site probably null
R2905:Dennd3 UTSW 15 73,429,495 (GRCm39) missense probably damaging 1.00
R3106:Dennd3 UTSW 15 73,436,973 (GRCm39) nonsense probably null
R3757:Dennd3 UTSW 15 73,394,083 (GRCm39) missense probably benign 0.00
R3785:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3786:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3787:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3847:Dennd3 UTSW 15 73,414,581 (GRCm39) missense possibly damaging 0.64
R4369:Dennd3 UTSW 15 73,412,658 (GRCm39) missense probably damaging 0.98
R4601:Dennd3 UTSW 15 73,439,009 (GRCm39) missense probably damaging 0.99
R4666:Dennd3 UTSW 15 73,442,709 (GRCm39) missense probably damaging 1.00
R4680:Dennd3 UTSW 15 73,405,225 (GRCm39) missense possibly damaging 0.82
R4708:Dennd3 UTSW 15 73,395,344 (GRCm39) missense probably damaging 1.00
R4789:Dennd3 UTSW 15 73,394,131 (GRCm39) missense probably damaging 1.00
R4920:Dennd3 UTSW 15 73,412,574 (GRCm39) missense probably benign 0.13
R5043:Dennd3 UTSW 15 73,399,785 (GRCm39) missense probably benign 0.00
R5074:Dennd3 UTSW 15 73,419,144 (GRCm39) missense probably damaging 1.00
R5410:Dennd3 UTSW 15 73,419,297 (GRCm39) missense probably benign 0.02
R5421:Dennd3 UTSW 15 73,438,964 (GRCm39) missense probably benign
R5560:Dennd3 UTSW 15 73,404,744 (GRCm39) missense probably damaging 1.00
R6008:Dennd3 UTSW 15 73,438,929 (GRCm39) missense possibly damaging 0.88
R6357:Dennd3 UTSW 15 73,428,321 (GRCm39) missense possibly damaging 0.49
R6563:Dennd3 UTSW 15 73,416,229 (GRCm39) missense probably damaging 0.98
R6687:Dennd3 UTSW 15 73,428,215 (GRCm39) missense possibly damaging 0.64
R6837:Dennd3 UTSW 15 73,429,542 (GRCm39) missense probably damaging 1.00
R6910:Dennd3 UTSW 15 73,426,965 (GRCm39) missense probably benign 0.01
R7125:Dennd3 UTSW 15 73,405,140 (GRCm39) missense possibly damaging 0.50
R7297:Dennd3 UTSW 15 73,429,459 (GRCm39) missense probably damaging 1.00
R7524:Dennd3 UTSW 15 73,396,095 (GRCm39) nonsense probably null
R7580:Dennd3 UTSW 15 73,428,296 (GRCm39) missense possibly damaging 0.89
R7653:Dennd3 UTSW 15 73,434,275 (GRCm39) missense probably damaging 0.99
R7731:Dennd3 UTSW 15 73,434,216 (GRCm39) missense probably damaging 0.99
R7767:Dennd3 UTSW 15 73,394,079 (GRCm39) missense probably benign
R7806:Dennd3 UTSW 15 73,442,624 (GRCm39) missense possibly damaging 0.87
R7860:Dennd3 UTSW 15 73,412,657 (GRCm39) missense probably damaging 0.97
R7902:Dennd3 UTSW 15 73,439,964 (GRCm39) critical splice donor site probably benign
R7929:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R8218:Dennd3 UTSW 15 73,384,622 (GRCm39) missense probably benign 0.31
R8436:Dennd3 UTSW 15 73,434,198 (GRCm39) missense probably damaging 1.00
R8444:Dennd3 UTSW 15 73,442,672 (GRCm39) missense probably benign 0.09
R8698:Dennd3 UTSW 15 73,394,154 (GRCm39) missense possibly damaging 0.52
R8967:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R9147:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9148:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9194:Dennd3 UTSW 15 73,419,153 (GRCm39) missense probably benign 0.04
R9449:Dennd3 UTSW 15 73,429,477 (GRCm39) missense probably damaging 1.00
R9501:Dennd3 UTSW 15 73,419,041 (GRCm39) missense probably benign 0.01
R9616:Dennd3 UTSW 15 73,440,563 (GRCm39) missense probably benign
R9730:Dennd3 UTSW 15 73,426,959 (GRCm39) missense probably damaging 1.00
RF006:Dennd3 UTSW 15 73,419,441 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAGTAAGTCAGATTGCCCTCG -3'
(R):5'- AGCAAGAACAGGCGCTTCTG -3'

Sequencing Primer
(F):5'- AGATTGCCCTCGCTCTGAG -3'
(R):5'- ACAGGCGCTTCTGGGTCATG -3'
Posted On 2014-10-01