Incidental Mutation 'R2152:Slc2a5'
ID 234367
Institutional Source Beutler Lab
Gene Symbol Slc2a5
Ensembl Gene ENSMUSG00000028976
Gene Name solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms GLUT5
MMRRC Submission 040155-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R2152 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 150203801-150228625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 150210095 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 27 (S27A)
Ref Sequence ENSEMBL: ENSMUSP00000030826 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030826]
AlphaFold Q9WV38
Predicted Effect probably damaging
Transcript: ENSMUST00000030826
AA Change: S27A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030826
Gene: ENSMUSG00000028976
AA Change: S27A

DomainStartEndE-ValueType
Pfam:MFS_1 16 397 1e-19 PFAM
Pfam:Sugar_tr 19 474 2.1e-138 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136610
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 108 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr3 A T 1: 90,141,565 (GRCm39) Y8F probably benign Het
Acy1 T C 9: 106,312,816 (GRCm39) E175G probably damaging Het
Add2 T C 6: 86,075,580 (GRCm39) L243P probably damaging Het
Adsl A G 15: 80,851,863 (GRCm39) D407G probably damaging Het
Afg3l1 T G 8: 124,221,575 (GRCm39) I478S probably damaging Het
Aoc1l1 T A 6: 48,953,473 (GRCm39) I466N probably damaging Het
Arfrp1 T C 2: 181,001,487 (GRCm39) T108A probably benign Het
Art5 A G 7: 101,747,407 (GRCm39) L124P possibly damaging Het
Asap2 A T 12: 21,162,084 (GRCm39) T14S probably damaging Het
Atp2c2 A G 8: 120,482,841 (GRCm39) N901S probably benign Het
Bbs12 G T 3: 37,375,309 (GRCm39) E586* probably null Het
Bicd2 G T 13: 49,533,052 (GRCm39) C546F probably damaging Het
Bid A T 6: 120,877,215 (GRCm39) L42Q probably damaging Het
Bpifb9a A G 2: 154,102,055 (GRCm39) K51E probably benign Het
Calcr G T 6: 3,687,615 (GRCm39) T424K probably benign Het
Cd46 A G 1: 194,744,721 (GRCm39) I339T probably benign Het
Chek1 C A 9: 36,635,279 (GRCm39) V35F probably damaging Het
Cntn3 A G 6: 102,183,498 (GRCm39) I719T probably damaging Het
Cyb5r1 T C 1: 134,337,363 (GRCm39) I163T possibly damaging Het
Cyp2d26 A T 15: 82,676,907 (GRCm39) probably null Het
Dclk1 A G 3: 55,154,633 (GRCm39) Y21C probably damaging Het
Dgcr2 G A 16: 17,709,351 (GRCm39) probably null Het
Dhx38 T C 8: 110,287,306 (GRCm39) S221G probably benign Het
Dis3l T A 9: 64,214,545 (GRCm39) N981I probably benign Het
Dnah3 C T 7: 119,551,236 (GRCm39) V3028I probably benign Het
Dnah6 T C 6: 73,026,149 (GRCm39) Y3448C probably benign Het
Dok5 G A 2: 170,642,816 (GRCm39) G38D probably damaging Het
Epb41l1 A G 2: 156,356,048 (GRCm39) D528G probably damaging Het
Fat4 A T 3: 39,037,544 (GRCm39) Y3732F probably damaging Het
Fcsk T A 8: 111,615,704 (GRCm39) T542S probably benign Het
Fgfr4 A T 13: 55,314,777 (GRCm39) Y640F probably damaging Het
Foxo6 T A 4: 120,125,811 (GRCm39) D328V probably benign Het
Foxp1 A G 6: 98,993,502 (GRCm39) L134P probably damaging Het
Frem2 G A 3: 53,424,450 (GRCm39) R2996* probably null Het
Garem2 T C 5: 30,313,297 (GRCm39) S54P probably damaging Het
Gcn1 T A 5: 115,747,888 (GRCm39) I1765N probably benign Het
Gm4787 T A 12: 81,423,993 (GRCm39) I722F probably benign Het
Gpc6 G T 14: 117,163,504 (GRCm39) A53S probably benign Het
Gtpbp8 A G 16: 44,560,390 (GRCm39) probably null Het
H2-Q2 T C 17: 35,564,252 (GRCm39) probably null Het
Hapln2 C A 3: 87,930,920 (GRCm39) R157L probably benign Het
Hemgn C A 4: 46,396,607 (GRCm39) E210* probably null Het
Hpse T A 5: 100,839,269 (GRCm39) K360* probably null Het
Iqcj A T 3: 67,962,643 (GRCm39) E68V probably damaging Het
Kat2a T C 11: 100,603,172 (GRCm39) probably benign Het
Kat6b A T 14: 21,718,735 (GRCm39) H1138L probably benign Het
Kcnab1 A T 3: 65,278,861 (GRCm39) I371F probably damaging Het
Klhl30 C A 1: 91,285,546 (GRCm39) A356D probably benign Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Micu1 G T 10: 59,699,110 (GRCm39) M468I probably benign Het
Mrc1 A G 2: 14,332,675 (GRCm39) T1292A probably damaging Het
Myh8 G A 11: 67,185,295 (GRCm39) E849K probably damaging Het
Myom3 G T 4: 135,530,544 (GRCm39) R1152L probably benign Het
Nedd4l T A 18: 65,343,401 (GRCm39) H820Q probably damaging Het
Nlrp4g T A 9: 124,353,339 (GRCm38) noncoding transcript Het
Oga A T 19: 45,746,461 (GRCm39) Y779* probably null Het
Or13p5 C T 4: 118,592,446 (GRCm39) A240V possibly damaging Het
Or1m1 T C 9: 18,666,391 (GRCm39) D180G probably damaging Het
Or2a51 A G 6: 43,179,003 (GRCm39) I142V probably benign Het
Or51a39 G T 7: 102,362,788 (GRCm39) H277Q probably benign Het
Or52j3 A T 7: 102,835,847 (GRCm39) D13V probably benign Het
Or8b49 G T 9: 38,505,707 (GRCm39) L63F probably damaging Het
Or8g54 A T 9: 39,706,943 (GRCm39) I91F probably benign Het
Or9s23 T C 1: 92,501,630 (GRCm39) S246P probably damaging Het
Otop1 T A 5: 38,460,194 (GRCm39) M587K probably damaging Het
Pgm5 T A 19: 24,812,179 (GRCm39) I118F probably damaging Het
Phc2 A G 4: 128,638,859 (GRCm39) *41W probably null Het
Phf8-ps T A 17: 33,285,908 (GRCm39) D298V probably damaging Het
Piezo2 A T 18: 63,247,112 (GRCm39) M532K probably damaging Het
Pjvk A T 2: 76,488,713 (GRCm39) I295F probably benign Het
Popdc2 A G 16: 38,183,482 (GRCm39) N155S possibly damaging Het
Ppp4r3a G T 12: 101,008,826 (GRCm39) N684K probably damaging Het
Prpf4b T A 13: 35,084,402 (GRCm39) M930K probably benign Het
Ptpn12 C A 5: 21,207,466 (GRCm39) Q297H probably damaging Het
Ptprz1 C A 6: 23,030,670 (GRCm39) L1010I probably damaging Het
Rabepk A T 2: 34,674,562 (GRCm39) D232E possibly damaging Het
Rad51ap2 A G 12: 11,507,986 (GRCm39) H636R probably benign Het
Rb1 T C 14: 73,526,165 (GRCm39) T169A probably benign Het
Rcc2 T C 4: 140,444,428 (GRCm39) L373P probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rrbp1 A G 2: 143,796,118 (GRCm39) L1200P possibly damaging Het
Sdk1 A G 5: 141,778,699 (GRCm39) N226D probably damaging Het
Selenbp1 G A 3: 94,851,441 (GRCm39) R398H probably damaging Het
Selenoo A G 15: 88,983,485 (GRCm39) M509V probably benign Het
Sidt2 T C 9: 45,856,638 (GRCm39) D477G probably damaging Het
Slc30a5 A T 13: 100,940,457 (GRCm39) H619Q probably damaging Het
Slc5a9 A G 4: 111,750,420 (GRCm39) I146T possibly damaging Het
Slc6a1 G T 6: 114,284,731 (GRCm39) G263V probably damaging Het
Slmap A G 14: 26,139,402 (GRCm39) Y771H probably damaging Het
Snx29 A G 16: 11,218,707 (GRCm39) D181G possibly damaging Het
Spata31d1c G A 13: 65,181,779 (GRCm39) probably null Het
Stat5a C A 11: 100,764,916 (GRCm39) T213N probably benign Het
Stt3a A T 9: 36,659,292 (GRCm39) V349D probably damaging Het
Tcf20 A T 15: 82,739,803 (GRCm39) D549E probably damaging Het
Thbs2 T A 17: 14,893,471 (GRCm39) D903V probably damaging Het
Tln2 T C 9: 67,209,842 (GRCm39) T432A probably damaging Het
Tmc1 A T 19: 20,834,039 (GRCm39) N241K probably benign Het
Tmem260 G T 14: 48,715,066 (GRCm39) R240L possibly damaging Het
Tnfaip6 A T 2: 51,933,742 (GRCm39) E32D probably damaging Het
Trpa1 A T 1: 14,969,625 (GRCm39) H381Q probably damaging Het
Tsen2 T C 6: 115,524,936 (GRCm39) I45T possibly damaging Het
Ttc6 G A 12: 57,752,338 (GRCm39) V1415I probably damaging Het
Ttll7 G T 3: 146,635,944 (GRCm39) R426L probably damaging Het
Ttn A C 2: 76,570,482 (GRCm39) S26804A probably damaging Het
Ubqlnl A T 7: 103,797,890 (GRCm39) C536S probably benign Het
Vmn2r73 A G 7: 85,506,936 (GRCm39) V792A probably benign Het
Zfp345 T C 2: 150,314,578 (GRCm39) T320A probably benign Het
Zfp407 T C 18: 84,227,774 (GRCm39) D1945G possibly damaging Het
Other mutations in Slc2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00819:Slc2a5 APN 4 150,210,113 (GRCm39) missense probably damaging 1.00
IGL01071:Slc2a5 APN 4 150,205,190 (GRCm39) utr 5 prime probably benign
IGL01977:Slc2a5 APN 4 150,226,675 (GRCm39) missense probably damaging 0.97
IGL03271:Slc2a5 APN 4 150,220,040 (GRCm39) missense probably damaging 1.00
BB006:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
BB016:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R0760:Slc2a5 UTSW 4 150,224,124 (GRCm39) missense probably benign
R0906:Slc2a5 UTSW 4 150,227,287 (GRCm39) missense probably benign 0.21
R1099:Slc2a5 UTSW 4 150,226,636 (GRCm39) missense probably benign 0.01
R1809:Slc2a5 UTSW 4 150,227,514 (GRCm39) missense probably damaging 1.00
R2099:Slc2a5 UTSW 4 150,227,634 (GRCm39) nonsense probably null
R2253:Slc2a5 UTSW 4 150,224,447 (GRCm39) missense possibly damaging 0.78
R2696:Slc2a5 UTSW 4 150,205,203 (GRCm39) missense probably benign
R4835:Slc2a5 UTSW 4 150,224,462 (GRCm39) missense probably benign 0.06
R4926:Slc2a5 UTSW 4 150,205,199 (GRCm39) nonsense probably null
R5123:Slc2a5 UTSW 4 150,224,262 (GRCm39) nonsense probably null
R5397:Slc2a5 UTSW 4 150,224,280 (GRCm39) splice site probably null
R6209:Slc2a5 UTSW 4 150,227,557 (GRCm39) missense probably benign 0.00
R6342:Slc2a5 UTSW 4 150,223,983 (GRCm39) missense possibly damaging 0.93
R6547:Slc2a5 UTSW 4 150,220,076 (GRCm39) missense possibly damaging 0.94
R7340:Slc2a5 UTSW 4 150,224,439 (GRCm39) missense probably benign 0.44
R7507:Slc2a5 UTSW 4 150,210,107 (GRCm39) missense probably damaging 1.00
R7537:Slc2a5 UTSW 4 150,213,526 (GRCm39) missense possibly damaging 0.89
R7572:Slc2a5 UTSW 4 150,226,642 (GRCm39) missense probably benign 0.33
R7751:Slc2a5 UTSW 4 150,227,591 (GRCm39) missense probably damaging 1.00
R7929:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R8058:Slc2a5 UTSW 4 150,227,590 (GRCm39) missense probably damaging 1.00
R8318:Slc2a5 UTSW 4 150,224,115 (GRCm39) missense possibly damaging 0.90
R8477:Slc2a5 UTSW 4 150,210,119 (GRCm39) missense probably benign 0.09
R8498:Slc2a5 UTSW 4 150,210,590 (GRCm39) missense probably benign 0.01
R8975:Slc2a5 UTSW 4 150,224,270 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGAGAGCCTGTTGTCACC -3'
(R):5'- ACGTCCATGAGAAGCTGAAGTC -3'

Sequencing Primer
(F):5'- GAGAGCCTGTTGTCACCTCAATG -3'
(R):5'- AGGACTTGGTCATTCACATGGC -3'
Posted On 2014-10-01