Incidental Mutation 'R2154:Vmn2r97'
| ID |
234658 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
040157-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R2154 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 19167584 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 613
(R613*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000168710
AA Change: R613*
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: R613*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
A |
G |
8: 73,208,959 (GRCm39) |
E363G |
probably benign |
Het |
| Abca3 |
A |
G |
17: 24,596,693 (GRCm39) |
Y382C |
probably damaging |
Het |
| Abca5 |
A |
G |
11: 110,183,000 (GRCm39) |
I1019T |
probably benign |
Het |
| Acox3 |
A |
T |
5: 35,762,568 (GRCm39) |
S481C |
probably damaging |
Het |
| Ankrd7 |
T |
A |
6: 18,870,030 (GRCm39) |
M261K |
probably benign |
Het |
| Aqr |
A |
C |
2: 113,967,485 (GRCm39) |
M510R |
probably damaging |
Het |
| Arpc1a |
A |
T |
5: 145,029,369 (GRCm39) |
T56S |
probably benign |
Het |
| Asap2 |
A |
T |
12: 21,162,084 (GRCm39) |
T14S |
probably damaging |
Het |
| Aspg |
A |
G |
12: 112,087,408 (GRCm39) |
E288G |
probably benign |
Het |
| Atp2c2 |
A |
G |
8: 120,482,841 (GRCm39) |
N901S |
probably benign |
Het |
| Cabcoco1 |
A |
G |
10: 68,267,092 (GRCm39) |
L205P |
probably damaging |
Het |
| Cant1 |
A |
G |
11: 118,302,263 (GRCm39) |
L18P |
probably damaging |
Het |
| Cdca2 |
G |
A |
14: 67,914,425 (GRCm39) |
P945S |
probably damaging |
Het |
| Cfap74 |
A |
G |
4: 155,513,753 (GRCm39) |
K522E |
possibly damaging |
Het |
| Chek1 |
C |
A |
9: 36,635,279 (GRCm39) |
V35F |
probably damaging |
Het |
| Cpa6 |
A |
T |
1: 10,407,547 (GRCm39) |
M330K |
probably damaging |
Het |
| Creb3l4 |
G |
T |
3: 90,145,792 (GRCm39) |
N246K |
probably damaging |
Het |
| Cyp2c55 |
T |
A |
19: 39,022,819 (GRCm39) |
V319D |
probably damaging |
Het |
| Dapk1 |
T |
A |
13: 60,877,317 (GRCm39) |
S519T |
probably benign |
Het |
| Dhx38 |
T |
C |
8: 110,287,306 (GRCm39) |
S221G |
probably benign |
Het |
| Dis3l |
T |
A |
9: 64,214,545 (GRCm39) |
N981I |
probably benign |
Het |
| Dock4 |
T |
A |
12: 40,870,661 (GRCm39) |
V1467E |
probably damaging |
Het |
| Dock4 |
ACCTGCTCTGCC |
ACCTGCTCTGCCTGCTCTGCC |
12: 40,894,547 (GRCm39) |
|
probably benign |
Het |
| Dok5 |
G |
A |
2: 170,642,816 (GRCm39) |
G38D |
probably damaging |
Het |
| Ercc6l2 |
T |
C |
13: 64,013,821 (GRCm39) |
S631P |
probably damaging |
Het |
| Fat4 |
A |
T |
3: 38,941,688 (GRCm39) |
S194C |
probably damaging |
Het |
| Fcsk |
T |
A |
8: 111,615,704 (GRCm39) |
T542S |
probably benign |
Het |
| Garem2 |
T |
C |
5: 30,313,297 (GRCm39) |
S54P |
probably damaging |
Het |
| Gdf10 |
T |
C |
14: 33,656,346 (GRCm39) |
I436T |
probably damaging |
Het |
| Gfod1 |
T |
C |
13: 43,456,946 (GRCm39) |
T10A |
possibly damaging |
Het |
| Gucy1a1 |
A |
G |
3: 82,018,458 (GRCm39) |
|
probably null |
Het |
| Heatr5b |
G |
T |
17: 79,138,873 (GRCm39) |
Q90K |
probably benign |
Het |
| Ikzf3 |
T |
A |
11: 98,376,475 (GRCm39) |
K211* |
probably null |
Het |
| Itgam |
A |
C |
7: 127,684,749 (GRCm39) |
D373A |
probably damaging |
Het |
| Itpripl2 |
A |
G |
7: 118,089,107 (GRCm39) |
F484S |
probably damaging |
Het |
| Kat6b |
A |
T |
14: 21,718,735 (GRCm39) |
H1138L |
probably benign |
Het |
| Kif16b |
T |
C |
2: 142,532,500 (GRCm39) |
K1213R |
probably damaging |
Het |
| Klra3 |
G |
C |
6: 130,310,107 (GRCm39) |
R138G |
probably benign |
Het |
| Mmp25 |
T |
A |
17: 23,850,048 (GRCm39) |
Y504F |
probably damaging |
Het |
| Mtf2 |
A |
G |
5: 108,228,797 (GRCm39) |
K38E |
possibly damaging |
Het |
| Myh14 |
A |
C |
7: 44,301,853 (GRCm39) |
|
probably null |
Het |
| Nedd4l |
T |
A |
18: 65,343,401 (GRCm39) |
H820Q |
probably damaging |
Het |
| Nfkb1 |
T |
C |
3: 135,307,240 (GRCm39) |
T562A |
probably benign |
Het |
| Or8b49 |
G |
T |
9: 38,505,707 (GRCm39) |
L63F |
probably damaging |
Het |
| Pds5a |
A |
T |
5: 65,807,841 (GRCm39) |
V464E |
probably damaging |
Het |
| Peak1 |
C |
T |
9: 56,114,496 (GRCm39) |
V452M |
probably damaging |
Het |
| Phf2 |
T |
C |
13: 48,973,549 (GRCm39) |
Y372C |
unknown |
Het |
| Poc1a |
T |
A |
9: 106,162,773 (GRCm39) |
|
probably null |
Het |
| Prss33 |
C |
T |
17: 24,053,817 (GRCm39) |
V87M |
probably damaging |
Het |
| Psmc2 |
C |
G |
5: 22,008,127 (GRCm39) |
L344V |
possibly damaging |
Het |
| Ptpn12 |
C |
A |
5: 21,207,466 (GRCm39) |
Q297H |
probably damaging |
Het |
| Rabgap1 |
T |
C |
2: 37,365,453 (GRCm39) |
V242A |
probably damaging |
Het |
| Rad1 |
C |
A |
15: 10,486,721 (GRCm39) |
H39Q |
possibly damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,507,986 (GRCm39) |
H636R |
probably benign |
Het |
| Samd9l |
C |
T |
6: 3,372,945 (GRCm39) |
D1439N |
possibly damaging |
Het |
| Sbno1 |
A |
T |
5: 124,516,574 (GRCm39) |
D1266E |
probably benign |
Het |
| Sidt2 |
T |
C |
9: 45,856,638 (GRCm39) |
D477G |
probably damaging |
Het |
| Slc22a13 |
T |
C |
9: 119,037,753 (GRCm39) |
K125R |
probably benign |
Het |
| Slc6a1 |
G |
T |
6: 114,284,731 (GRCm39) |
G263V |
probably damaging |
Het |
| Slmap |
A |
G |
14: 26,139,402 (GRCm39) |
Y771H |
probably damaging |
Het |
| Smg1 |
A |
T |
7: 117,757,299 (GRCm39) |
|
probably benign |
Het |
| Spinkl |
A |
T |
18: 44,302,194 (GRCm39) |
N32K |
probably benign |
Het |
| Stxbp1 |
T |
A |
2: 32,692,868 (GRCm39) |
I383F |
probably damaging |
Het |
| Taf3 |
C |
T |
2: 9,956,377 (GRCm39) |
E597K |
possibly damaging |
Het |
| Tln2 |
T |
C |
9: 67,209,842 (GRCm39) |
T432A |
probably damaging |
Het |
| Tmco6 |
T |
C |
18: 36,874,740 (GRCm39) |
V409A |
probably benign |
Het |
| Tstd2 |
T |
C |
4: 46,129,235 (GRCm39) |
T198A |
probably damaging |
Het |
| Vmn1r230 |
T |
A |
17: 21,067,063 (GRCm39) |
M84K |
probably damaging |
Het |
| Vmn1r45 |
T |
A |
6: 89,910,965 (GRCm39) |
S2C |
possibly damaging |
Het |
| Vmn2r25 |
T |
A |
6: 123,816,805 (GRCm39) |
T259S |
probably benign |
Het |
| Vmn2r70 |
A |
G |
7: 85,212,923 (GRCm39) |
S495P |
possibly damaging |
Het |
| Yme1l1 |
T |
C |
2: 23,052,520 (GRCm39) |
L58P |
probably damaging |
Het |
| Zan |
G |
A |
5: 137,412,511 (GRCm39) |
|
probably benign |
Het |
| Zfhx4 |
A |
G |
3: 5,466,801 (GRCm39) |
T2320A |
possibly damaging |
Het |
| Zfp407 |
T |
C |
18: 84,227,774 (GRCm39) |
D1945G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGACCAGATGTAGACAAGTGTG -3'
(R):5'- TGACCTTAAAGGCAAGGACC -3'
Sequencing Primer
(F):5'- ATGTAGACAAGTGTGTGAAGTGTC -3'
(R):5'- ACCACAGTGATAGCTTTGGC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation