Incidental Mutation 'R2164:Vmn2r25'
ID 235346
Institutional Source Beutler Lab
Gene Symbol Vmn2r25
Ensembl Gene ENSMUSG00000094672
Gene Name vomeronasal 2, receptor 25
Synonyms EG545874
MMRRC Submission 040167-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R2164 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 123799773-123830149 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 123816518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 354 (D354E)
Ref Sequence ENSEMBL: ENSMUSP00000124342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162046]
AlphaFold W4VSP2
Predicted Effect possibly damaging
Transcript: ENSMUST00000162046
AA Change: D354E

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: D354E

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 473 6e-31 PFAM
Pfam:NCD3G 519 572 5.8e-25 PFAM
Pfam:7tm_3 603 840 4.8e-55 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 CTGTAGGAAATCTTCAATGT CTGT 11: 110,101,019 (GRCm39) probably null Het
Adcy8 C T 15: 64,792,783 (GRCm39) G58S probably benign Het
Adgra2 T A 8: 27,604,232 (GRCm39) L24* probably null Het
Ampd2 C A 3: 107,992,685 (GRCm39) probably benign Het
Ankrd26 T G 6: 118,502,752 (GRCm39) E806A probably damaging Het
Apol9b A G 15: 77,619,639 (GRCm39) D145G probably benign Het
Ash1l T A 3: 88,892,726 (GRCm39) M1535K probably benign Het
Atf6 A G 1: 170,622,304 (GRCm39) M439T probably damaging Het
B3glct A T 5: 149,677,621 (GRCm39) M417L probably damaging Het
Cep192 A T 18: 67,953,431 (GRCm39) T483S probably damaging Het
Cep290 G A 10: 100,354,657 (GRCm39) E914K probably damaging Het
Chst15 C T 7: 131,872,114 (GRCm39) A56T probably damaging Het
Col27a1 A T 4: 63,143,661 (GRCm39) T450S probably benign Het
Cpsf2 A G 12: 101,951,594 (GRCm39) N177S probably damaging Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Ctc1 C T 11: 68,926,441 (GRCm39) A859V possibly damaging Het
Dcakd A G 11: 102,888,183 (GRCm39) Y134H possibly damaging Het
Dctn3 G T 4: 41,723,065 (GRCm39) Y22* probably null Het
Dync2h1 T A 9: 7,124,797 (GRCm39) D2025V probably damaging Het
Dync2li1 T C 17: 84,943,702 (GRCm39) S92P probably damaging Het
Eml5 A G 12: 98,853,356 (GRCm39) V81A probably damaging Het
Espl1 C T 15: 102,228,023 (GRCm39) R1625C probably damaging Het
Fam181a T C 12: 103,282,785 (GRCm39) V230A probably benign Het
Fanci T A 7: 79,045,743 (GRCm39) D28E probably benign Het
Fmn1 A G 2: 113,195,962 (GRCm39) N554S unknown Het
Frem2 T C 3: 53,444,751 (GRCm39) Y2460C probably damaging Het
Fscb G A 12: 64,520,567 (GRCm39) P300S probably damaging Het
Gm28042 A G 2: 119,867,229 (GRCm39) D438G probably benign Het
Ldaf1 A G 7: 119,719,462 (GRCm39) E157G possibly damaging Het
Map1b C T 13: 99,565,846 (GRCm39) V2292M unknown Het
Nbas A G 12: 13,380,647 (GRCm39) D635G possibly damaging Het
Ncapg2 A G 12: 116,414,095 (GRCm39) probably null Het
Nrp2 A T 1: 62,783,514 (GRCm39) E205V probably damaging Het
Pcdhb3 A T 18: 37,435,239 (GRCm39) T402S possibly damaging Het
Phc1 T C 6: 122,299,296 (GRCm39) N638D possibly damaging Het
Plcb1 A G 2: 135,188,250 (GRCm39) N781S possibly damaging Het
Prkdc T A 16: 15,523,071 (GRCm39) D1164E probably damaging Het
Proser2 T A 2: 6,105,506 (GRCm39) R353W possibly damaging Het
Prxl2b T G 4: 154,982,606 (GRCm39) Y56S probably damaging Het
Ptges T A 2: 30,782,708 (GRCm39) T115S probably benign Het
Ptprk A T 10: 28,436,138 (GRCm39) D833V probably damaging Het
Pum1 T A 4: 130,455,394 (GRCm39) L173* probably null Het
Pum1 G T 4: 130,455,395 (GRCm39) L269F probably damaging Het
Rasgrp4 A G 7: 28,838,470 (GRCm39) Y106C probably damaging Het
Rbbp6 T A 7: 122,598,697 (GRCm39) probably benign Het
Rdh1 A G 10: 127,596,041 (GRCm39) T79A possibly damaging Het
Relb A C 7: 19,347,686 (GRCm39) probably null Het
Rnf122 G A 8: 31,602,192 (GRCm39) W6* probably null Het
Rnf31 A G 14: 55,829,994 (GRCm39) E138G possibly damaging Het
Scaf8 G A 17: 3,247,485 (GRCm39) R936Q probably damaging Het
Scube3 T A 17: 28,385,108 (GRCm39) V686D possibly damaging Het
Snrnp27 A T 6: 86,653,196 (GRCm39) C141S probably benign Het
Spns2 C T 11: 72,349,497 (GRCm39) V252M possibly damaging Het
Tomm40l C T 1: 171,047,703 (GRCm39) S220N probably damaging Het
Trim17 A G 11: 58,862,237 (GRCm39) D423G probably damaging Het
Trpc6 A AT 9: 8,610,466 (GRCm39) probably null Het
Tut4 G A 4: 108,360,226 (GRCm39) R481Q possibly damaging Het
Uba5 A T 9: 103,937,442 (GRCm39) M89K probably damaging Het
Vav2 T C 2: 27,163,718 (GRCm39) D628G probably damaging Het
Vmn2r107 T C 17: 20,595,904 (GRCm39) L819P probably damaging Het
Xrn1 A G 9: 95,888,873 (GRCm39) E984G possibly damaging Het
Zbtb17 T C 4: 141,191,557 (GRCm39) V223A probably benign Het
Zfp592 T C 7: 80,691,186 (GRCm39) S1122P possibly damaging Het
Other mutations in Vmn2r25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Vmn2r25 APN 6 123,830,130 (GRCm39) missense probably benign 0.25
IGL01781:Vmn2r25 APN 6 123,816,324 (GRCm39) missense possibly damaging 0.48
IGL01843:Vmn2r25 APN 6 123,829,962 (GRCm39) missense possibly damaging 0.67
IGL02023:Vmn2r25 APN 6 123,816,388 (GRCm39) missense probably damaging 0.96
IGL02502:Vmn2r25 APN 6 123,816,392 (GRCm39) missense probably damaging 0.96
IGL02709:Vmn2r25 APN 6 123,816,723 (GRCm39) missense possibly damaging 0.50
IGL03053:Vmn2r25 APN 6 123,800,077 (GRCm39) missense probably damaging 1.00
PIT4468001:Vmn2r25 UTSW 6 123,816,557 (GRCm39) missense probably benign 0.00
PIT4812001:Vmn2r25 UTSW 6 123,800,447 (GRCm39) missense probably damaging 1.00
R0054:Vmn2r25 UTSW 6 123,829,984 (GRCm39) missense probably benign 0.00
R0312:Vmn2r25 UTSW 6 123,805,539 (GRCm39) splice site probably benign
R0366:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R0390:Vmn2r25 UTSW 6 123,800,140 (GRCm39) missense probably damaging 1.00
R0466:Vmn2r25 UTSW 6 123,829,008 (GRCm39) missense probably benign 0.16
R0541:Vmn2r25 UTSW 6 123,816,786 (GRCm39) missense probably damaging 0.97
R0612:Vmn2r25 UTSW 6 123,816,481 (GRCm39) missense probably damaging 1.00
R0865:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R1219:Vmn2r25 UTSW 6 123,816,282 (GRCm39) missense probably benign 0.00
R1240:Vmn2r25 UTSW 6 123,828,864 (GRCm39) missense probably damaging 0.98
R1701:Vmn2r25 UTSW 6 123,828,754 (GRCm39) splice site probably null
R1780:Vmn2r25 UTSW 6 123,805,424 (GRCm39) missense probably damaging 1.00
R1809:Vmn2r25 UTSW 6 123,802,337 (GRCm39) missense probably benign 0.00
R1833:Vmn2r25 UTSW 6 123,816,643 (GRCm39) missense probably benign 0.01
R1964:Vmn2r25 UTSW 6 123,800,254 (GRCm39) missense possibly damaging 0.94
R2154:Vmn2r25 UTSW 6 123,816,805 (GRCm39) missense probably benign 0.01
R3799:Vmn2r25 UTSW 6 123,830,143 (GRCm39) missense probably benign 0.12
R3836:Vmn2r25 UTSW 6 123,830,044 (GRCm39) missense probably damaging 1.00
R3946:Vmn2r25 UTSW 6 123,817,057 (GRCm39) missense probably damaging 0.97
R4282:Vmn2r25 UTSW 6 123,800,606 (GRCm39) missense probably damaging 1.00
R4367:Vmn2r25 UTSW 6 123,805,496 (GRCm39) missense probably damaging 1.00
R4438:Vmn2r25 UTSW 6 123,816,756 (GRCm39) missense probably benign 0.03
R4488:Vmn2r25 UTSW 6 123,799,819 (GRCm39) missense probably damaging 1.00
R4580:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.46
R4631:Vmn2r25 UTSW 6 123,829,962 (GRCm39) missense possibly damaging 0.94
R4765:Vmn2r25 UTSW 6 123,800,182 (GRCm39) missense probably damaging 1.00
R4908:Vmn2r25 UTSW 6 123,805,406 (GRCm39) missense probably benign
R5207:Vmn2r25 UTSW 6 123,817,062 (GRCm39) missense probably damaging 1.00
R5254:Vmn2r25 UTSW 6 123,802,277 (GRCm39) missense probably damaging 1.00
R5444:Vmn2r25 UTSW 6 123,805,451 (GRCm39) missense probably benign 0.00
R5586:Vmn2r25 UTSW 6 123,802,255 (GRCm39) missense probably damaging 1.00
R5607:Vmn2r25 UTSW 6 123,805,318 (GRCm39) missense possibly damaging 0.49
R5985:Vmn2r25 UTSW 6 123,800,587 (GRCm39) missense probably benign
R6046:Vmn2r25 UTSW 6 123,799,876 (GRCm39) missense probably damaging 1.00
R6057:Vmn2r25 UTSW 6 123,799,900 (GRCm39) missense possibly damaging 0.69
R6569:Vmn2r25 UTSW 6 123,828,941 (GRCm39) missense probably benign 0.01
R6826:Vmn2r25 UTSW 6 123,800,071 (GRCm39) missense probably damaging 1.00
R7054:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R7120:Vmn2r25 UTSW 6 123,805,394 (GRCm39) missense possibly damaging 0.51
R7177:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7287:Vmn2r25 UTSW 6 123,829,040 (GRCm39) missense possibly damaging 0.49
R7397:Vmn2r25 UTSW 6 123,800,498 (GRCm39) missense probably damaging 0.96
R7486:Vmn2r25 UTSW 6 123,800,101 (GRCm39) missense probably damaging 1.00
R7699:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7700:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7759:Vmn2r25 UTSW 6 123,800,339 (GRCm39) missense probably damaging 0.99
R7802:Vmn2r25 UTSW 6 123,828,791 (GRCm39) missense possibly damaging 0.88
R7850:Vmn2r25 UTSW 6 123,805,431 (GRCm39) missense probably damaging 1.00
R8064:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R8170:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R8340:Vmn2r25 UTSW 6 123,829,972 (GRCm39) missense probably benign 0.01
R8346:Vmn2r25 UTSW 6 123,802,350 (GRCm39) missense probably benign 0.00
R8395:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.81
R8889:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R9094:Vmn2r25 UTSW 6 123,805,391 (GRCm39) missense probably benign 0.44
R9204:Vmn2r25 UTSW 6 123,830,092 (GRCm39) missense probably benign 0.00
R9253:Vmn2r25 UTSW 6 123,816,960 (GRCm39) missense probably damaging 0.98
R9392:Vmn2r25 UTSW 6 123,816,937 (GRCm39) missense probably benign
R9520:Vmn2r25 UTSW 6 123,830,066 (GRCm39) nonsense probably null
R9525:Vmn2r25 UTSW 6 123,800,164 (GRCm39) missense probably damaging 1.00
R9622:Vmn2r25 UTSW 6 123,816,579 (GRCm39) missense probably damaging 0.99
X0020:Vmn2r25 UTSW 6 123,816,359 (GRCm39) missense possibly damaging 0.95
Z1176:Vmn2r25 UTSW 6 123,799,856 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATACACAGCAGCATGGACTTTG -3'
(R):5'- TGGAGACACACATTCTCTTCTG -3'

Sequencing Primer
(F):5'- CAGCAGCATGGACTTTGTAGCTC -3'
(R):5'- AGACACACATTCTCTTCTGCGAATTG -3'
Posted On 2014-10-01