Incidental Mutation 'R2166:Cmklr2'
ID 235476
Institutional Source Beutler Lab
Gene Symbol Cmklr2
Ensembl Gene ENSMUSG00000046856
Gene Name chemerin chemokine-like receptor 2
Synonyms Gpr1
MMRRC Submission 040169-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2166 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 63221850-63253702 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 63223107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 43 (F43L)
Ref Sequence ENSEMBL: ENSMUSP00000051417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027108] [ENSMUST00000050536] [ENSMUST00000129339] [ENSMUST00000135877] [ENSMUST00000142062] [ENSMUST00000188524]
AlphaFold Q8K087
Predicted Effect probably benign
Transcript: ENSMUST00000027108
Predicted Effect probably benign
Transcript: ENSMUST00000050536
AA Change: F43L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000051417
Gene: ENSMUSG00000046856
AA Change: F43L

DomainStartEndE-ValueType
Pfam:7tm_1 55 302 3.9e-40 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082668
Predicted Effect probably benign
Transcript: ENSMUST00000129339
SMART Domains Protein: ENSMUSP00000116492
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
EF-1_beta_acid 103 130 2.53e-4 SMART
EF1_GNE 139 225 3.86e-44 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000135877
SMART Domains Protein: ENSMUSP00000137671
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
transmembrane domain 38 57 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000142062
Predicted Effect probably benign
Transcript: ENSMUST00000188524
SMART Domains Protein: ENSMUSP00000140895
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
EF-1_beta_acid 62 89 1.2e-8 SMART
EF1_GNE 98 184 2.9e-48 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,716,762 (GRCm39) F779I probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Birc6 A T 17: 74,942,790 (GRCm39) T2761S probably benign Het
Cav1 A T 6: 17,339,430 (GRCm39) I141F possibly damaging Het
Gm973 A G 1: 59,565,898 (GRCm39) D39G possibly damaging Het
Gucy1a2 T A 9: 3,579,513 (GRCm39) probably null Het
Il1b A T 2: 129,206,968 (GRCm39) M264K probably damaging Het
Itpr1 A G 6: 108,365,186 (GRCm39) Y38C probably damaging Het
Kcnb2 A C 1: 15,781,540 (GRCm39) D804A possibly damaging Het
Kcnt1 T A 2: 25,781,195 (GRCm39) probably benign Het
Krt6b T C 15: 101,587,050 (GRCm39) probably null Het
Mef2a A G 7: 66,915,870 (GRCm39) V144A probably damaging Het
Mroh3 A G 1: 136,113,791 (GRCm39) M666T probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Nalcn T A 14: 123,607,363 (GRCm39) Y702F probably benign Het
Napepld T A 5: 21,888,230 (GRCm39) K73I possibly damaging Het
Or5h23 T A 16: 58,905,949 (GRCm39) K299I probably benign Het
Or8g21 G A 9: 38,906,513 (GRCm39) Q73* probably null Het
Pappa A C 4: 65,074,682 (GRCm39) D412A probably damaging Het
Plbd1 A G 6: 136,590,788 (GRCm39) probably null Het
Ppp1r10 G T 17: 36,241,481 (GRCm39) R752L unknown Het
Prep T C 10: 44,968,751 (GRCm39) probably benign Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptprz1 A G 6: 23,045,632 (GRCm39) N2134S possibly damaging Het
Rhbdl3 A G 11: 80,210,523 (GRCm39) Y92C probably damaging Het
Rtkn2 T C 10: 67,877,526 (GRCm39) S532P possibly damaging Het
Rtl1 T A 12: 109,556,988 (GRCm39) H1617L probably damaging Het
Skint6 T A 4: 112,711,649 (GRCm39) N956I probably benign Het
Slc13a2 A G 11: 78,293,901 (GRCm39) V287A probably benign Het
Slc9a2 A G 1: 40,781,928 (GRCm39) K386E probably damaging Het
Spata20 G A 11: 94,369,930 (GRCm39) H789Y probably benign Het
Stk19 A G 17: 35,051,486 (GRCm39) I23T possibly damaging Het
Tonsl A G 15: 76,521,513 (GRCm39) I293T probably benign Het
Topbp1 A G 9: 103,190,128 (GRCm39) probably null Het
Trappc2l T A 8: 123,339,901 (GRCm39) S44T probably benign Het
Tsr1 A G 11: 74,798,280 (GRCm39) probably null Het
Ugdh A G 5: 65,574,357 (GRCm39) probably benign Het
Unc119 A G 11: 78,238,161 (GRCm39) probably null Het
Zkscan14 G A 5: 145,132,944 (GRCm39) P196S probably benign Het
Zmat4 T C 8: 24,392,152 (GRCm39) L36P probably damaging Het
Other mutations in Cmklr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Cmklr2 APN 1 63,222,497 (GRCm39) missense probably damaging 0.99
IGL01086:Cmklr2 APN 1 63,222,650 (GRCm39) missense probably benign 0.01
IGL01490:Cmklr2 APN 1 63,222,455 (GRCm39) missense probably damaging 0.99
IGL02409:Cmklr2 APN 1 63,222,875 (GRCm39) missense probably damaging 1.00
IGL02426:Cmklr2 APN 1 63,222,827 (GRCm39) missense probably damaging 0.97
R0218:Cmklr2 UTSW 1 63,222,690 (GRCm39) missense probably benign 0.25
R2088:Cmklr2 UTSW 1 63,222,811 (GRCm39) splice site probably null
R2895:Cmklr2 UTSW 1 63,222,321 (GRCm39) missense probably benign 0.24
R2896:Cmklr2 UTSW 1 63,222,321 (GRCm39) missense probably benign 0.24
R5102:Cmklr2 UTSW 1 63,222,326 (GRCm39) missense probably damaging 0.99
R5131:Cmklr2 UTSW 1 63,222,840 (GRCm39) missense probably damaging 1.00
R5471:Cmklr2 UTSW 1 63,223,058 (GRCm39) missense probably damaging 1.00
R5652:Cmklr2 UTSW 1 63,222,626 (GRCm39) missense probably benign 0.00
R6187:Cmklr2 UTSW 1 63,222,434 (GRCm39) missense probably damaging 1.00
R7956:Cmklr2 UTSW 1 63,222,665 (GRCm39) missense probably damaging 0.99
R8953:Cmklr2 UTSW 1 63,222,272 (GRCm39) missense probably damaging 1.00
R9031:Cmklr2 UTSW 1 63,223,145 (GRCm39) missense probably benign 0.03
X0060:Cmklr2 UTSW 1 63,222,218 (GRCm39) missense probably benign 0.02
Z1177:Cmklr2 UTSW 1 63,222,798 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAAGGCCACGTAGGAAATGTAC -3'
(R):5'- GCAAGCCCTTCTAAAATCGTC -3'

Sequencing Primer
(F):5'- CCACGTAGGAAATGTACAGGGG -3'
(R):5'- GCCCTTCTAAAATCGTCATAAAATGG -3'
Posted On 2014-10-01