|Institutional Source||Beutler Lab|
|Gene Name||interleukin 1 family, member 8|
|Is this an essential gene?||Probably non essential (E-score: 0.022)|
|Stock #||R2137 (G1)|
|Chromosomal Location||24153161-24160519 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 24154660 bp|
|Amino Acid Change||Asparagine to Serine at position 24 (N24S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000028363 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000028363]|
|Predicted Effect||probably benign
AA Change: N24S
PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
AA Change: N24S
|Meta Mutation Damage Score||0.1452|
|Coding Region Coverage||
|Validation Efficiency||97% (60/62)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il1f8||
(F):5'- GGGGTAAGGACTTAGAGAAACTCTC -3'
(R):5'- CACTTGCCAGTTCTTATGGAGTTATC -3'
(F):5'- ATGATGGCTTTCCCTCCA -3'
(R):5'- GCAAGAGCTAAGTGACTTCACATTTC -3'