Incidental Mutation 'R0200:Iars1'
| ID |
23592 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Iars1
|
| Ensembl Gene |
ENSMUSG00000037851 |
| Gene Name |
isoleucyl-tRNA synthetase 1 |
| Synonyms |
Iars, 2510016L12Rik, E430001P04Rik |
| MMRRC Submission |
038457-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0200 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
49835606-49887743 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 49879678 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 983
(D983V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047363]
[ENSMUST00000164260]
[ENSMUST00000165316]
|
| AlphaFold |
Q8BU30 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000047363
AA Change: D983V
PolyPhen 2
Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000048096
Gene: ENSMUSG00000037851
AA Change: D983V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
9.2e-242 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
197 |
3.7e-6 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
1.1e-23 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164260
AA Change: D983V
PolyPhen 2
Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000126806
Gene: ENSMUSG00000037851
AA Change: D983V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165270
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165316
AA Change: D983V
PolyPhen 2
Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000132082
Gene: ENSMUSG00000037851
AA Change: D983V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165656
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.7%
- 20x: 86.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatf |
T |
C |
11: 84,336,502 (GRCm39) |
K466E |
probably damaging |
Het |
| Abcc3 |
T |
C |
11: 94,245,900 (GRCm39) |
D1245G |
probably damaging |
Het |
| Adam12 |
T |
C |
7: 133,576,145 (GRCm39) |
|
probably null |
Het |
| Akap11 |
A |
G |
14: 78,748,193 (GRCm39) |
V1398A |
probably benign |
Het |
| Ank1 |
T |
G |
8: 23,586,828 (GRCm39) |
L461R |
probably damaging |
Het |
| Ankfn1 |
T |
C |
11: 89,332,792 (GRCm39) |
S402G |
possibly damaging |
Het |
| Arhgef40 |
A |
C |
14: 52,234,431 (GRCm39) |
E911D |
probably damaging |
Het |
| Atp2b1 |
C |
T |
10: 98,815,676 (GRCm39) |
Q107* |
probably null |
Het |
| Cacng3 |
T |
A |
7: 122,271,008 (GRCm39) |
C4* |
probably null |
Het |
| Cds1 |
G |
A |
5: 101,962,299 (GRCm39) |
V305M |
probably damaging |
Het |
| Cecr2 |
T |
G |
6: 120,738,758 (GRCm39) |
F1162V |
probably damaging |
Het |
| Cfap70 |
A |
T |
14: 20,498,631 (GRCm39) |
Y19N |
probably damaging |
Het |
| Chrm5 |
A |
G |
2: 112,311,065 (GRCm39) |
V17A |
probably benign |
Het |
| Col20a1 |
T |
C |
2: 180,642,231 (GRCm39) |
I714T |
probably damaging |
Het |
| Cpeb2 |
T |
A |
5: 43,419,119 (GRCm39) |
M156K |
possibly damaging |
Het |
| Cstdc6 |
T |
C |
16: 36,143,386 (GRCm39) |
|
probably null |
Het |
| Defb25 |
C |
A |
2: 152,464,332 (GRCm39) |
V71L |
probably benign |
Het |
| Dhx35 |
A |
T |
2: 158,671,543 (GRCm39) |
M325L |
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,558,902 (GRCm39) |
L1019H |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,046,403 (GRCm39) |
D3195V |
probably damaging |
Het |
| Dph5 |
A |
G |
3: 115,722,352 (GRCm39) |
S277G |
probably benign |
Het |
| Dpm1 |
C |
A |
2: 168,065,075 (GRCm39) |
|
probably null |
Het |
| Dsg1a |
A |
T |
18: 20,473,995 (GRCm39) |
M1023L |
probably benign |
Het |
| Egf |
A |
G |
3: 129,499,882 (GRCm39) |
Y252H |
probably benign |
Het |
| Egf |
A |
G |
3: 129,531,198 (GRCm39) |
S126P |
probably damaging |
Het |
| Enam |
T |
C |
5: 88,640,886 (GRCm39) |
W183R |
possibly damaging |
Het |
| Foxn1 |
T |
C |
11: 78,251,866 (GRCm39) |
Y455C |
probably damaging |
Het |
| Ikzf4 |
C |
A |
10: 128,470,545 (GRCm39) |
G325V |
probably damaging |
Het |
| Il1rl1 |
T |
A |
1: 40,480,463 (GRCm39) |
W31R |
possibly damaging |
Het |
| Ip6k3 |
C |
T |
17: 27,363,999 (GRCm39) |
D350N |
probably damaging |
Het |
| Irgc |
T |
C |
7: 24,131,431 (GRCm39) |
D462G |
probably benign |
Het |
| Itprid1 |
T |
C |
6: 55,874,941 (GRCm39) |
L297P |
probably benign |
Het |
| Jph3 |
A |
G |
8: 122,511,572 (GRCm39) |
E520G |
probably benign |
Het |
| Kcna2 |
T |
A |
3: 107,012,476 (GRCm39) |
D352E |
probably benign |
Het |
| Klk4 |
T |
A |
7: 43,534,785 (GRCm39) |
I248N |
probably damaging |
Het |
| Krtap16-1 |
T |
C |
11: 99,876,123 (GRCm39) |
Y427C |
probably damaging |
Het |
| Lgr4 |
A |
G |
2: 109,801,035 (GRCm39) |
|
probably null |
Het |
| Lhpp |
C |
T |
7: 132,212,406 (GRCm39) |
|
probably benign |
Het |
| Lypd3 |
T |
A |
7: 24,339,656 (GRCm39) |
V241D |
probably damaging |
Het |
| Lyz2 |
T |
A |
10: 117,116,678 (GRCm39) |
N57Y |
possibly damaging |
Het |
| Man1a |
A |
G |
10: 53,950,594 (GRCm39) |
V176A |
probably damaging |
Het |
| Mcm4 |
G |
A |
16: 15,447,503 (GRCm39) |
T487I |
probably benign |
Het |
| Mettl21c |
T |
A |
1: 44,052,814 (GRCm39) |
I68F |
probably damaging |
Het |
| Miip |
T |
A |
4: 147,946,720 (GRCm39) |
T313S |
probably damaging |
Het |
| Minar2 |
A |
G |
18: 59,195,531 (GRCm39) |
|
probably null |
Het |
| Mog |
A |
T |
17: 37,323,311 (GRCm39) |
I209K |
probably damaging |
Het |
| Myo1c |
C |
A |
11: 75,563,008 (GRCm39) |
D997E |
probably benign |
Het |
| Npc1 |
T |
C |
18: 12,352,261 (GRCm39) |
Y146C |
probably damaging |
Het |
| Nploc4 |
A |
G |
11: 120,304,507 (GRCm39) |
L238P |
probably damaging |
Het |
| Opa1 |
A |
G |
16: 29,432,947 (GRCm39) |
N544S |
probably benign |
Het |
| Or2j6 |
T |
C |
7: 139,980,788 (GRCm39) |
Y57C |
probably damaging |
Het |
| Or2v1 |
T |
A |
11: 49,025,874 (GRCm39) |
M285K |
probably damaging |
Het |
| Or6k6 |
T |
C |
1: 173,945,078 (GRCm39) |
H168R |
probably benign |
Het |
| Pam |
C |
T |
1: 97,822,126 (GRCm39) |
|
probably null |
Het |
| Pdgfra |
T |
C |
5: 75,324,438 (GRCm39) |
Y98H |
probably damaging |
Het |
| Plcz1 |
C |
T |
6: 139,936,459 (GRCm39) |
R590H |
probably damaging |
Het |
| Plxdc1 |
T |
C |
11: 97,824,838 (GRCm39) |
Y339C |
probably damaging |
Het |
| Plxna1 |
T |
C |
6: 89,300,575 (GRCm39) |
N1583S |
probably damaging |
Het |
| Plxna4 |
C |
T |
6: 32,174,023 (GRCm39) |
V1191M |
probably damaging |
Het |
| Polk |
T |
A |
13: 96,633,330 (GRCm39) |
N238Y |
probably benign |
Het |
| Ptprq |
T |
C |
10: 107,521,018 (GRCm39) |
N718S |
probably benign |
Het |
| Rsrc1 |
A |
T |
3: 67,088,194 (GRCm39) |
H176L |
probably damaging |
Het |
| Sbno1 |
T |
C |
5: 124,522,604 (GRCm39) |
D1072G |
probably damaging |
Het |
| Scmh1 |
A |
G |
4: 120,341,028 (GRCm39) |
K238R |
probably damaging |
Het |
| Senp7 |
A |
G |
16: 55,944,236 (GRCm39) |
T187A |
possibly damaging |
Het |
| Slc12a4 |
T |
C |
8: 106,678,249 (GRCm39) |
R315G |
probably benign |
Het |
| Slc16a10 |
A |
G |
10: 39,916,612 (GRCm39) |
V430A |
probably benign |
Het |
| Slc26a7 |
T |
C |
4: 14,621,317 (GRCm39) |
D23G |
probably benign |
Het |
| Slc28a2b |
T |
A |
2: 122,357,928 (GRCm39) |
*661R |
probably null |
Het |
| Slc7a7 |
A |
G |
14: 54,615,259 (GRCm39) |
L246P |
probably damaging |
Het |
| Spata7 |
T |
A |
12: 98,629,428 (GRCm39) |
S332T |
probably benign |
Het |
| Spsb1 |
A |
G |
4: 149,982,673 (GRCm39) |
*274R |
probably null |
Het |
| Sspo |
T |
G |
6: 48,463,349 (GRCm39) |
V3767G |
probably null |
Het |
| Syt10 |
C |
A |
15: 89,711,144 (GRCm39) |
A130S |
probably benign |
Het |
| Tgm6 |
T |
A |
2: 129,994,865 (GRCm39) |
|
probably null |
Het |
| Them7 |
A |
C |
2: 105,128,262 (GRCm39) |
N81T |
probably damaging |
Het |
| Tinag |
C |
A |
9: 76,859,217 (GRCm39) |
A464S |
probably damaging |
Het |
| Tmem217 |
T |
G |
17: 29,745,284 (GRCm39) |
I149L |
probably benign |
Het |
| Trp53rkb |
T |
G |
2: 166,637,603 (GRCm39) |
D186E |
probably damaging |
Het |
| Vmn1r20 |
T |
C |
6: 57,409,084 (GRCm39) |
Y137H |
probably damaging |
Het |
| Vmn1r60 |
T |
A |
7: 5,547,379 (GRCm39) |
L240F |
probably benign |
Het |
| Vmn1r64 |
A |
G |
7: 5,886,817 (GRCm39) |
M242T |
probably benign |
Het |
| Xkr4 |
T |
C |
1: 3,740,886 (GRCm39) |
N229S |
probably benign |
Het |
| Zcchc2 |
T |
A |
1: 105,931,853 (GRCm39) |
L352M |
probably damaging |
Het |
| Zfp217 |
C |
T |
2: 169,957,382 (GRCm39) |
A539T |
probably benign |
Het |
| Zfp638 |
T |
C |
6: 83,944,336 (GRCm39) |
L1018P |
probably damaging |
Het |
|
| Other mutations in Iars1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00697:Iars1
|
APN |
13 |
49,863,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00764:Iars1
|
APN |
13 |
49,865,303 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01153:Iars1
|
APN |
13 |
49,865,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01481:Iars1
|
APN |
13 |
49,882,174 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01596:Iars1
|
APN |
13 |
49,856,652 (GRCm39) |
missense |
probably benign |
|
|
IGL01682:Iars1
|
APN |
13 |
49,863,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01885:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01907:Iars1
|
APN |
13 |
49,863,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02023:Iars1
|
APN |
13 |
49,841,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Iars1
|
APN |
13 |
49,878,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02365:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02704:Iars1
|
APN |
13 |
49,874,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02838:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02975:Iars1
|
APN |
13 |
49,858,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02982:Iars1
|
APN |
13 |
49,863,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03034:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03060:Iars1
|
APN |
13 |
49,843,923 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL03156:Iars1
|
APN |
13 |
49,856,655 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03206:Iars1
|
APN |
13 |
49,846,546 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03343:Iars1
|
APN |
13 |
49,878,223 (GRCm39) |
missense |
probably benign |
0.12 |
|
gannett_peak
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
missouri
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
spacex
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
wind_river
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Iars1
|
UTSW |
13 |
49,875,688 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0356:Iars1
|
UTSW |
13 |
49,856,709 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0383:Iars1
|
UTSW |
13 |
49,885,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0657:Iars1
|
UTSW |
13 |
49,855,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1005:Iars1
|
UTSW |
13 |
49,840,921 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1427:Iars1
|
UTSW |
13 |
49,857,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1449:Iars1
|
UTSW |
13 |
49,887,186 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1647:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1648:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1664:Iars1
|
UTSW |
13 |
49,865,251 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1763:Iars1
|
UTSW |
13 |
49,876,553 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2192:Iars1
|
UTSW |
13 |
49,841,605 (GRCm39) |
splice site |
probably null |
|
|
R2203:Iars1
|
UTSW |
13 |
49,876,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2357:Iars1
|
UTSW |
13 |
49,841,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3724:Iars1
|
UTSW |
13 |
49,840,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4785:Iars1
|
UTSW |
13 |
49,878,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4934:Iars1
|
UTSW |
13 |
49,871,460 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4999:Iars1
|
UTSW |
13 |
49,863,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Iars1
|
UTSW |
13 |
49,841,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5268:Iars1
|
UTSW |
13 |
49,843,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Iars1
|
UTSW |
13 |
49,875,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Iars1
|
UTSW |
13 |
49,863,049 (GRCm39) |
splice site |
probably null |
|
|
R5960:Iars1
|
UTSW |
13 |
49,878,113 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5972:Iars1
|
UTSW |
13 |
49,863,108 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5978:Iars1
|
UTSW |
13 |
49,876,469 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6092:Iars1
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6167:Iars1
|
UTSW |
13 |
49,876,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Iars1
|
UTSW |
13 |
49,861,921 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6358:Iars1
|
UTSW |
13 |
49,880,619 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6385:Iars1
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6403:Iars1
|
UTSW |
13 |
49,840,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Iars1
|
UTSW |
13 |
49,878,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Iars1
|
UTSW |
13 |
49,873,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6957:Iars1
|
UTSW |
13 |
49,875,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7207:Iars1
|
UTSW |
13 |
49,841,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7254:Iars1
|
UTSW |
13 |
49,876,554 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7354:Iars1
|
UTSW |
13 |
49,857,796 (GRCm39) |
missense |
probably benign |
|
|
R7397:Iars1
|
UTSW |
13 |
49,882,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Iars1
|
UTSW |
13 |
49,860,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7799:Iars1
|
UTSW |
13 |
49,876,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7828:Iars1
|
UTSW |
13 |
49,878,748 (GRCm39) |
missense |
probably benign |
|
|
R8679:Iars1
|
UTSW |
13 |
49,856,675 (GRCm39) |
unclassified |
probably benign |
|
|
R8768:Iars1
|
UTSW |
13 |
49,878,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8797:Iars1
|
UTSW |
13 |
49,841,738 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8906:Iars1
|
UTSW |
13 |
49,882,177 (GRCm39) |
missense |
probably benign |
|
|
R8990:Iars1
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9134:Iars1
|
UTSW |
13 |
49,855,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Iars1
|
UTSW |
13 |
49,855,350 (GRCm39) |
missense |
probably benign |
|
|
R9394:Iars1
|
UTSW |
13 |
49,883,536 (GRCm39) |
missense |
probably benign |
|
|
R9668:Iars1
|
UTSW |
13 |
49,840,885 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9741:Iars1
|
UTSW |
13 |
49,844,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Iars1
|
UTSW |
13 |
49,874,564 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAATCTGTAGGCCGCCTGTCTC -3'
(R):5'- TTCTGTAGCAGCCTTGTGGAAGC -3'
Sequencing Primer
(F):5'- TCTGTCCCACCTGCCAG -3'
(R):5'- CTTCCCTGCGGAGTATAATCAGAG -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation