Incidental Mutation 'R0201:Gria2'
| ID |
23612 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gria2
|
| Ensembl Gene |
ENSMUSG00000033981 |
| Gene Name |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
| Synonyms |
Glur-2, GluA2, GluR2, GluR-B, Glur2 |
| MMRRC Submission |
038458-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.274)
|
| Stock # |
R0201 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
80588757-80710142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 80615145 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 445
(Y445C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075316]
[ENSMUST00000107745]
[ENSMUST00000192463]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075316
AA Change: Y445C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000074787
Gene: ENSMUSG00000033981
AA Change: Y445C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
49 |
379 |
2.7e-58 |
PFAM |
|
PBPe
|
415 |
790 |
3.75e-132 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107745
AA Change: Y445C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000103374
Gene: ENSMUSG00000033981
AA Change: Y445C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
47 |
379 |
4.8e-53 |
PFAM |
|
PBPe
|
415 |
790 |
8.16e-133 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000192463
AA Change: Y445C
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000141447
Gene: ENSMUSG00000033981
AA Change: Y445C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
47 |
379 |
1.7e-51 |
PFAM |
|
PBPe
|
415 |
770 |
1.2e-105 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.2e-35 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193645
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194383
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194523
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195062
|
| Meta Mutation Damage Score |
0.8620 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.2%
|
| Validation Efficiency |
97% (91/94) |
| MGI Phenotype |
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamdec1 |
A |
G |
14: 68,819,406 (GRCm39) |
|
probably null |
Het |
| Adamts16 |
T |
A |
13: 70,927,763 (GRCm39) |
Q492L |
possibly damaging |
Het |
| Aplnr |
A |
G |
2: 84,967,521 (GRCm39) |
D182G |
probably damaging |
Het |
| Arnt2 |
G |
T |
7: 84,010,867 (GRCm39) |
S3* |
probably null |
Het |
| Asxl3 |
T |
C |
18: 22,656,211 (GRCm39) |
V1407A |
probably benign |
Het |
| Atg13 |
A |
T |
2: 91,515,107 (GRCm39) |
|
probably null |
Het |
| Atm |
A |
T |
9: 53,365,579 (GRCm39) |
|
probably benign |
Het |
| Birc6 |
T |
G |
17: 74,916,322 (GRCm39) |
V1746G |
possibly damaging |
Het |
| Cbln1 |
G |
T |
8: 88,198,741 (GRCm39) |
T43K |
probably benign |
Het |
| Cbx5 |
T |
C |
15: 103,108,127 (GRCm39) |
T173A |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,894,854 (GRCm39) |
Y1437C |
probably damaging |
Het |
| Ccdc78 |
C |
A |
17: 26,008,210 (GRCm39) |
|
probably benign |
Het |
| Cd2bp2 |
A |
G |
7: 126,793,000 (GRCm39) |
Y341H |
probably damaging |
Het |
| Cdhr5 |
T |
A |
7: 140,856,291 (GRCm39) |
D88V |
probably damaging |
Het |
| Ces1f |
T |
A |
8: 93,993,957 (GRCm39) |
T275S |
probably null |
Het |
| Cimip4 |
T |
A |
15: 78,263,028 (GRCm39) |
M209L |
probably damaging |
Het |
| Clca4a |
T |
C |
3: 144,666,478 (GRCm39) |
N458S |
probably benign |
Het |
| Cog5 |
A |
G |
12: 31,889,840 (GRCm39) |
K521R |
probably damaging |
Het |
| Csf2ra |
T |
A |
19: 61,214,006 (GRCm39) |
T305S |
probably benign |
Het |
| Csmd3 |
T |
A |
15: 47,483,125 (GRCm39) |
|
probably benign |
Het |
| Cts6 |
T |
A |
13: 61,349,313 (GRCm39) |
R132* |
probably null |
Het |
| D5Ertd579e |
G |
T |
5: 36,773,809 (GRCm39) |
N195K |
probably damaging |
Het |
| Ddx1 |
A |
G |
12: 13,273,809 (GRCm39) |
V606A |
probably damaging |
Het |
| Dip2b |
G |
A |
15: 100,084,028 (GRCm39) |
D884N |
probably damaging |
Het |
| Ehhadh |
A |
G |
16: 21,592,243 (GRCm39) |
|
probably null |
Het |
| Enpp1 |
T |
A |
10: 24,529,815 (GRCm39) |
T608S |
probably benign |
Het |
| Fancm |
T |
C |
12: 65,148,406 (GRCm39) |
Y674H |
probably damaging |
Het |
| Fat4 |
T |
A |
3: 38,945,745 (GRCm39) |
V1546D |
probably damaging |
Het |
| Fsd1 |
G |
A |
17: 56,297,522 (GRCm39) |
A158T |
probably benign |
Het |
| Fzd2 |
T |
A |
11: 102,496,948 (GRCm39) |
M464K |
probably damaging |
Het |
| Gjc2 |
A |
G |
11: 59,068,416 (GRCm39) |
F22S |
possibly damaging |
Het |
| Hsdl1 |
T |
A |
8: 120,292,995 (GRCm39) |
I147F |
possibly damaging |
Het |
| Ifi44 |
T |
C |
3: 151,451,273 (GRCm39) |
Y226C |
probably damaging |
Het |
| Il16 |
A |
G |
7: 83,371,516 (GRCm39) |
C97R |
probably damaging |
Het |
| Impg1 |
A |
T |
9: 80,252,843 (GRCm39) |
S369T |
probably damaging |
Het |
| Jmjd1c |
A |
G |
10: 67,054,888 (GRCm39) |
T390A |
unknown |
Het |
| Lgi1 |
A |
G |
19: 38,289,741 (GRCm39) |
E269G |
possibly damaging |
Het |
| Lrp6 |
G |
T |
6: 134,427,860 (GRCm39) |
Y1577* |
probably null |
Het |
| Lrrc74a |
G |
T |
12: 86,808,547 (GRCm39) |
|
probably benign |
Het |
| Man1c1 |
A |
T |
4: 134,367,709 (GRCm39) |
|
probably null |
Het |
| Map1lc3b |
A |
C |
8: 122,317,289 (GRCm39) |
Q9P |
possibly damaging |
Het |
| Mboat1 |
G |
A |
13: 30,386,358 (GRCm39) |
R124H |
probably benign |
Het |
| Mcu |
A |
G |
10: 59,292,499 (GRCm39) |
L60P |
probably damaging |
Het |
| Mrs2 |
G |
T |
13: 25,202,517 (GRCm39) |
Q75K |
probably benign |
Het |
| Muc2 |
CGTG |
CGTGTG |
7: 141,699,185 (GRCm38) |
|
probably null |
Het |
| Neb |
G |
A |
2: 52,096,890 (GRCm39) |
|
probably benign |
Het |
| Nlrp2 |
C |
T |
7: 5,331,328 (GRCm39) |
G356D |
probably benign |
Het |
| Notch3 |
A |
G |
17: 32,375,122 (GRCm39) |
|
probably benign |
Het |
| Npr2 |
A |
C |
4: 43,641,617 (GRCm39) |
S474R |
probably damaging |
Het |
| Nup58 |
A |
G |
14: 60,482,065 (GRCm39) |
F100L |
probably benign |
Het |
| Osbpl6 |
A |
C |
2: 76,376,386 (GRCm39) |
D87A |
possibly damaging |
Het |
| Pabpc2 |
A |
T |
18: 39,908,360 (GRCm39) |
M542L |
probably benign |
Het |
| Papln |
A |
G |
12: 83,829,801 (GRCm39) |
|
probably benign |
Het |
| Parpbp |
T |
C |
10: 87,928,758 (GRCm39) |
I561V |
possibly damaging |
Het |
| Pcdhb13 |
C |
T |
18: 37,575,634 (GRCm39) |
A4V |
probably benign |
Het |
| Pelp1 |
T |
C |
11: 70,286,530 (GRCm39) |
T533A |
possibly damaging |
Het |
| Poldip3 |
T |
A |
15: 83,019,497 (GRCm39) |
M182L |
probably benign |
Het |
| Por |
T |
C |
5: 135,760,032 (GRCm39) |
S240P |
possibly damaging |
Het |
| Pramel15 |
A |
T |
4: 144,103,843 (GRCm39) |
|
probably benign |
Het |
| Pramel28 |
T |
C |
4: 143,691,460 (GRCm39) |
E421G |
probably damaging |
Het |
| Prss22 |
A |
T |
17: 24,215,275 (GRCm39) |
V167D |
probably damaging |
Het |
| Prss37 |
A |
C |
6: 40,493,283 (GRCm39) |
L61R |
probably damaging |
Het |
| Psmd1 |
C |
T |
1: 86,046,338 (GRCm39) |
T702M |
probably benign |
Het |
| Pxdn |
G |
T |
12: 30,052,430 (GRCm39) |
G869V |
possibly damaging |
Het |
| Rabgap1l |
A |
G |
1: 160,281,315 (GRCm39) |
|
probably benign |
Het |
| Rapgef6 |
T |
C |
11: 54,510,767 (GRCm39) |
V228A |
probably damaging |
Het |
| Rnf169 |
T |
C |
7: 99,575,210 (GRCm39) |
R462G |
possibly damaging |
Het |
| Rnft2 |
A |
G |
5: 118,332,745 (GRCm39) |
|
probably benign |
Het |
| Sgo2b |
T |
C |
8: 64,379,670 (GRCm39) |
D1054G |
probably benign |
Het |
| Sh3bgr |
T |
C |
16: 96,029,717 (GRCm39) |
|
probably benign |
Het |
| Slc12a4 |
A |
G |
8: 106,671,982 (GRCm39) |
V910A |
possibly damaging |
Het |
| Slc6a12 |
A |
T |
6: 121,332,331 (GRCm39) |
I222F |
probably benign |
Het |
| Spty2d1 |
G |
A |
7: 46,647,649 (GRCm39) |
R427* |
probably null |
Het |
| Ssc5d |
A |
G |
7: 4,947,662 (GRCm39) |
T1339A |
probably benign |
Het |
| Sspo |
A |
C |
6: 48,432,686 (GRCm39) |
E854A |
possibly damaging |
Het |
| Stx7 |
A |
G |
10: 24,060,977 (GRCm39) |
|
probably benign |
Het |
| Styk1 |
A |
T |
6: 131,278,693 (GRCm39) |
|
probably benign |
Het |
| Tmem163 |
T |
G |
1: 127,596,374 (GRCm39) |
|
probably benign |
Het |
| Tmppe |
C |
CT |
9: 114,233,707 (GRCm39) |
|
probably null |
Het |
| Tmx2 |
A |
G |
2: 84,503,426 (GRCm39) |
V229A |
probably benign |
Het |
| Top2b |
T |
C |
14: 16,383,174 (GRCm38) |
L54P |
probably damaging |
Het |
| Trim62 |
A |
T |
4: 128,796,343 (GRCm39) |
Y280F |
probably benign |
Het |
| Tssk4 |
A |
T |
14: 55,889,016 (GRCm39) |
K181* |
probably null |
Het |
| Tssk4 |
A |
T |
14: 55,889,017 (GRCm39) |
K181M |
probably damaging |
Het |
| Ubn1 |
A |
G |
16: 4,882,478 (GRCm39) |
D313G |
probably damaging |
Het |
| Ugt1a10 |
C |
T |
1: 88,142,845 (GRCm39) |
P113L |
probably damaging |
Het |
| Ugt1a10 |
C |
T |
1: 88,145,971 (GRCm39) |
P473L |
probably damaging |
Het |
|
| Other mutations in Gria2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00796:Gria2
|
APN |
3 |
80,618,097 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL00832:Gria2
|
APN |
3 |
80,614,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Gria2
|
APN |
3 |
80,599,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Gria2
|
APN |
3 |
80,615,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01924:Gria2
|
APN |
3 |
80,617,638 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01999:Gria2
|
APN |
3 |
80,639,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02362:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02389:Gria2
|
APN |
3 |
80,616,729 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02444:Gria2
|
APN |
3 |
80,609,860 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02532:Gria2
|
APN |
3 |
80,614,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Gria2
|
UTSW |
3 |
80,615,116 (GRCm39) |
nonsense |
probably null |
|
|
R0015:Gria2
|
UTSW |
3 |
80,615,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Gria2
|
UTSW |
3 |
80,615,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Gria2
|
UTSW |
3 |
80,618,165 (GRCm39) |
splice site |
probably benign |
|
|
R0551:Gria2
|
UTSW |
3 |
80,639,333 (GRCm39) |
splice site |
probably benign |
|
|
R0655:Gria2
|
UTSW |
3 |
80,639,377 (GRCm39) |
nonsense |
probably null |
|
|
R0866:Gria2
|
UTSW |
3 |
80,629,331 (GRCm39) |
splice site |
probably benign |
|
|
R1393:Gria2
|
UTSW |
3 |
80,614,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Gria2
|
UTSW |
3 |
80,639,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1563:Gria2
|
UTSW |
3 |
80,598,704 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1771:Gria2
|
UTSW |
3 |
80,599,608 (GRCm39) |
nonsense |
probably null |
|
|
R1775:Gria2
|
UTSW |
3 |
80,598,645 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Gria2
|
UTSW |
3 |
80,629,415 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1994:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1995:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R2001:Gria2
|
UTSW |
3 |
80,618,112 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2389:Gria2
|
UTSW |
3 |
80,609,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Gria2
|
UTSW |
3 |
80,614,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Gria2
|
UTSW |
3 |
80,648,260 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3967:Gria2
|
UTSW |
3 |
80,618,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4285:Gria2
|
UTSW |
3 |
80,614,969 (GRCm39) |
intron |
probably benign |
|
|
R4611:Gria2
|
UTSW |
3 |
80,599,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4612:Gria2
|
UTSW |
3 |
80,639,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4616:Gria2
|
UTSW |
3 |
80,614,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4706:Gria2
|
UTSW |
3 |
80,648,297 (GRCm39) |
missense |
probably benign |
|
|
R4996:Gria2
|
UTSW |
3 |
80,614,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5502:Gria2
|
UTSW |
3 |
80,614,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5930:Gria2
|
UTSW |
3 |
80,614,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6142:Gria2
|
UTSW |
3 |
80,709,024 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6233:Gria2
|
UTSW |
3 |
80,614,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6317:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6453:Gria2
|
UTSW |
3 |
80,648,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6526:Gria2
|
UTSW |
3 |
80,599,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Gria2
|
UTSW |
3 |
80,648,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6574:Gria2
|
UTSW |
3 |
80,596,603 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6720:Gria2
|
UTSW |
3 |
80,709,611 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7009:Gria2
|
UTSW |
3 |
80,614,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Gria2
|
UTSW |
3 |
80,596,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7191:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7225:Gria2
|
UTSW |
3 |
80,709,938 (GRCm39) |
unclassified |
probably benign |
|
|
R7374:Gria2
|
UTSW |
3 |
80,648,383 (GRCm39) |
missense |
probably benign |
|
|
R7837:Gria2
|
UTSW |
3 |
80,618,095 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8034:Gria2
|
UTSW |
3 |
80,709,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8125:Gria2
|
UTSW |
3 |
80,614,550 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8189:Gria2
|
UTSW |
3 |
80,629,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8209:Gria2
|
UTSW |
3 |
80,616,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8362:Gria2
|
UTSW |
3 |
80,615,197 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8481:Gria2
|
UTSW |
3 |
80,708,998 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8500:Gria2
|
UTSW |
3 |
80,599,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Gria2
|
UTSW |
3 |
80,614,294 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8918:Gria2
|
UTSW |
3 |
80,599,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Gria2
|
UTSW |
3 |
80,618,170 (GRCm39) |
intron |
probably benign |
|
|
R8971:Gria2
|
UTSW |
3 |
80,615,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Gria2
|
UTSW |
3 |
80,709,689 (GRCm39) |
start codon destroyed |
probably null |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTGCTTGAAGACAAGTGAAATGC -3'
(R):5'- TGAGGAGTCATGCTAACAGCTTTTGG -3'
Sequencing Primer
(F):5'- GTCAACAATCTTAGATGTGGGC -3'
(R):5'- GCTAACAGCTTTTGGGTATCTTAC -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation