Incidental Mutation 'R2141:Rev3l'
| ID |
236270 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rev3l
|
| Ensembl Gene |
ENSMUSG00000019841 |
| Gene Name |
REV3 like, DNA directed polymerase zeta catalytic subunit |
| Synonyms |
Sez4, Rev |
| MMRRC Submission |
040144-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2141 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
39608114-39751207 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 39724045 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 785
(V785A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115630
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019986]
[ENSMUST00000131186]
[ENSMUST00000139803]
[ENSMUST00000164763]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019986
AA Change: V2659A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000019986
Gene: ENSMUSG00000019841
AA Change: V2659A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DNA_pol_B_exo1
|
43 |
201 |
1.6e-10 |
PFAM |
|
low complexity region
|
494 |
506 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
969 |
N/A |
INTRINSIC |
|
low complexity region
|
1042 |
1057 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
low complexity region
|
1424 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1595 |
N/A |
INTRINSIC |
|
Blast:POLBc
|
1825 |
2243 |
1e-163 |
BLAST |
|
PDB:4GK5|D
|
1863 |
1895 |
4e-13 |
PDB |
|
POLBc
|
2308 |
2783 |
5.32e-105 |
SMART |
|
Blast:POLBc
|
2860 |
2926 |
2e-14 |
BLAST |
|
Pfam:zf-C4pol
|
3034 |
3103 |
8.2e-16 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131186
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139803
AA Change: V785A
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000115630
Gene: ENSMUSG00000019841
AA Change: V785A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:POLBc
|
1 |
369 |
1e-155 |
BLAST |
|
POLBc
|
434 |
805 |
4.77e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164763
AA Change: V2659A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000131519
Gene: ENSMUSG00000019841
AA Change: V2659A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DNA_pol_B_exo1
|
43 |
200 |
1.3e-11 |
PFAM |
|
low complexity region
|
494 |
506 |
N/A |
INTRINSIC |
|
Pfam:DUF4683
|
745 |
1132 |
1.7e-162 |
PFAM |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
low complexity region
|
1424 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1595 |
N/A |
INTRINSIC |
|
Blast:POLBc
|
1825 |
2243 |
1e-163 |
BLAST |
|
PDB:4GK5|D
|
1863 |
1895 |
4e-13 |
PDB |
|
POLBc
|
2308 |
2783 |
5.32e-105 |
SMART |
|
Blast:POLBc
|
2860 |
2926 |
2e-14 |
BLAST |
|
Pfam:zf-C4pol
|
3034 |
3102 |
6.1e-15 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
97% (107/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
PHENOTYPE: Nullizygous mice exhibit complete embryonic lethality and abnormal embryonic tissue morphology with widespread degeneration and cell death. Mice carrying the amino acid substitution of phenylalanine for leucine at position 2610 display alterations in somatic hypermutation frequency and specificity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810065E05Rik |
G |
T |
11: 58,314,752 (GRCm39) |
C150F |
probably damaging |
Het |
| Aagab |
T |
A |
9: 63,523,957 (GRCm39) |
|
probably null |
Het |
| Abca15 |
A |
C |
7: 120,006,697 (GRCm39) |
T1654P |
probably damaging |
Het |
| Abca17 |
T |
A |
17: 24,553,240 (GRCm39) |
Y157F |
probably benign |
Het |
| Aftph |
A |
T |
11: 20,648,318 (GRCm39) |
L813* |
probably null |
Het |
| Agap1 |
T |
C |
1: 89,765,477 (GRCm39) |
I615T |
probably damaging |
Het |
| Ak3 |
T |
G |
19: 29,000,247 (GRCm39) |
Q221H |
probably benign |
Het |
| Aldoa |
A |
G |
7: 126,396,814 (GRCm39) |
|
probably null |
Het |
| Anxa8 |
T |
C |
14: 33,813,873 (GRCm39) |
|
probably null |
Het |
| Atpsckmt |
T |
C |
15: 31,609,718 (GRCm39) |
F146L |
probably benign |
Het |
| Baz2a |
A |
G |
10: 127,959,481 (GRCm39) |
D1329G |
probably damaging |
Het |
| Calhm6 |
G |
T |
10: 34,003,691 (GRCm39) |
A72E |
probably damaging |
Het |
| Capn9 |
G |
A |
8: 125,332,450 (GRCm39) |
G430R |
possibly damaging |
Het |
| Cd55 |
C |
T |
1: 130,377,160 (GRCm39) |
V333I |
probably benign |
Het |
| Cep70 |
A |
G |
9: 99,178,438 (GRCm39) |
Y512C |
probably damaging |
Het |
| Cfhr2 |
T |
G |
1: 139,758,893 (GRCm39) |
R52S |
probably benign |
Het |
| Clcn6 |
A |
G |
4: 148,108,594 (GRCm39) |
F145S |
possibly damaging |
Het |
| Cnksr1 |
A |
G |
4: 133,956,939 (GRCm39) |
Y488H |
probably damaging |
Het |
| Diablo |
A |
G |
5: 123,661,424 (GRCm39) |
V24A |
probably benign |
Het |
| Dnah7b |
T |
A |
1: 46,307,830 (GRCm39) |
M3048K |
probably damaging |
Het |
| Dsel |
T |
C |
1: 111,787,187 (GRCm39) |
N1116S |
probably benign |
Het |
| Efnb1 |
A |
G |
X: 98,191,123 (GRCm39) |
Y343C |
probably damaging |
Het |
| Esco1 |
A |
G |
18: 10,574,873 (GRCm39) |
|
probably null |
Het |
| Fancd2 |
A |
G |
6: 113,526,282 (GRCm39) |
N335S |
probably benign |
Het |
| Flnc |
A |
G |
6: 29,448,674 (GRCm39) |
Y1304C |
probably damaging |
Het |
| Fubp3 |
A |
G |
2: 31,490,569 (GRCm39) |
|
probably benign |
Het |
| Gemin4 |
G |
C |
11: 76,101,876 (GRCm39) |
P962A |
probably damaging |
Het |
| Gjc3 |
A |
C |
5: 137,955,808 (GRCm39) |
L159R |
probably damaging |
Het |
| Gli1 |
A |
G |
10: 127,172,596 (GRCm39) |
L182P |
probably damaging |
Het |
| Gm21957 |
G |
T |
7: 124,818,625 (GRCm39) |
|
noncoding transcript |
Het |
| Gm28040 |
AGTG |
AGTGGCACCTTTGGTG |
1: 133,255,059 (GRCm39) |
|
probably benign |
Het |
| Gm5885 |
A |
G |
6: 133,506,238 (GRCm39) |
|
noncoding transcript |
Het |
| Gon4l |
A |
T |
3: 88,794,902 (GRCm39) |
T402S |
possibly damaging |
Het |
| Gprasp1 |
G |
A |
X: 134,702,791 (GRCm39) |
E995K |
possibly damaging |
Het |
| Gvin-ps5 |
T |
A |
7: 105,929,163 (GRCm39) |
T245S |
probably damaging |
Het |
| Helb |
A |
T |
10: 119,941,926 (GRCm39) |
M254K |
possibly damaging |
Het |
| Ift20 |
G |
A |
11: 78,430,860 (GRCm39) |
E68K |
probably damaging |
Het |
| Igfn1 |
AGGG |
AGG |
1: 135,902,590 (GRCm39) |
|
probably benign |
Het |
| Impdh2 |
A |
G |
9: 108,442,546 (GRCm39) |
E305G |
possibly damaging |
Het |
| Ints7 |
T |
A |
1: 191,336,972 (GRCm39) |
C351S |
possibly damaging |
Het |
| Ipo9 |
ATCCTCCTCCTCCTCCTC |
ATCCTCCTCCTCCTCCTCCTC |
1: 135,314,006 (GRCm39) |
|
probably benign |
Het |
| Ipo9 |
A |
G |
1: 135,329,988 (GRCm39) |
V484A |
probably benign |
Het |
| Kcnq3 |
T |
C |
15: 65,867,700 (GRCm39) |
M648V |
probably benign |
Het |
| Kctd16 |
A |
G |
18: 40,392,231 (GRCm39) |
E273G |
possibly damaging |
Het |
| Kif18a |
T |
A |
2: 109,163,848 (GRCm39) |
N732K |
probably benign |
Het |
| Kif21b |
C |
T |
1: 136,080,002 (GRCm39) |
R513W |
probably damaging |
Het |
| Klhl36 |
T |
C |
8: 120,603,511 (GRCm39) |
C589R |
possibly damaging |
Het |
| Lck |
A |
G |
4: 129,442,713 (GRCm39) |
Y481H |
probably damaging |
Het |
| Lmtk2 |
A |
G |
5: 144,084,433 (GRCm39) |
Y156C |
probably damaging |
Het |
| Mical3 |
A |
T |
6: 121,008,095 (GRCm39) |
|
probably null |
Het |
| Mki67 |
A |
G |
7: 135,297,321 (GRCm39) |
I2571T |
possibly damaging |
Het |
| Mx2 |
G |
A |
16: 97,339,903 (GRCm39) |
E20K |
probably benign |
Het |
| Myo10 |
A |
G |
15: 25,714,194 (GRCm39) |
E87G |
probably benign |
Het |
| Myo18b |
T |
C |
5: 113,021,892 (GRCm39) |
K500R |
probably benign |
Het |
| N4bp2l2 |
A |
T |
5: 150,571,001 (GRCm39) |
I458N |
probably damaging |
Het |
| Nat10 |
T |
C |
2: 103,561,648 (GRCm39) |
|
probably null |
Het |
| Nfasc |
G |
A |
1: 132,524,383 (GRCm39) |
P932L |
probably damaging |
Het |
| Nipa1 |
C |
A |
7: 55,647,259 (GRCm39) |
|
probably null |
Het |
| Nkpd1 |
A |
G |
7: 19,258,162 (GRCm39) |
Q647R |
probably damaging |
Het |
| Nlrc4 |
T |
A |
17: 74,754,946 (GRCm39) |
|
probably benign |
Het |
| Nmbr |
C |
A |
10: 14,646,186 (GRCm39) |
Y353* |
probably null |
Het |
| Nos1ap |
T |
A |
1: 170,156,735 (GRCm39) |
D241V |
probably damaging |
Het |
| Obsl1 |
G |
A |
1: 75,486,756 (GRCm38) |
T1764M |
probably benign |
Het |
| Optc |
A |
T |
1: 133,831,534 (GRCm39) |
|
probably null |
Het |
| Or4f4b |
A |
T |
2: 111,313,975 (GRCm39) |
T95S |
probably benign |
Het |
| Or5d43 |
A |
G |
2: 88,105,354 (GRCm39) |
V13A |
probably benign |
Het |
| Or5m13 |
A |
G |
2: 85,749,171 (GRCm39) |
I301V |
probably null |
Het |
| Or6c201 |
A |
G |
10: 128,968,875 (GRCm39) |
I254T |
probably benign |
Het |
| Pank1 |
G |
A |
19: 34,856,380 (GRCm39) |
R33C |
possibly damaging |
Het |
| Pcmtd1 |
C |
T |
1: 7,239,789 (GRCm39) |
R77C |
probably damaging |
Het |
| Phkg2 |
G |
A |
7: 127,181,386 (GRCm39) |
|
probably null |
Het |
| Plcb4 |
G |
A |
2: 135,818,019 (GRCm39) |
V762M |
probably damaging |
Het |
| Pramel7 |
T |
A |
2: 87,320,321 (GRCm39) |
H324L |
probably damaging |
Het |
| Prelp |
C |
T |
1: 133,842,869 (GRCm39) |
R92K |
probably benign |
Het |
| Ptgr3 |
T |
C |
18: 84,112,668 (GRCm39) |
Y115H |
probably benign |
Het |
| Rai1 |
C |
A |
11: 60,080,293 (GRCm39) |
S1452R |
possibly damaging |
Het |
| Ren1 |
C |
G |
1: 133,278,516 (GRCm39) |
|
probably null |
Het |
| Ro60 |
T |
C |
1: 143,635,772 (GRCm39) |
D458G |
probably benign |
Het |
| Rufy2 |
G |
T |
10: 62,826,773 (GRCm39) |
R104L |
probably damaging |
Het |
| Senp6 |
T |
A |
9: 80,031,102 (GRCm39) |
N8K |
probably damaging |
Het |
| Septin4 |
A |
T |
11: 87,474,262 (GRCm39) |
Q60L |
probably benign |
Het |
| Sipa1l2 |
G |
A |
8: 126,218,230 (GRCm39) |
P369L |
probably benign |
Het |
| Slc43a1 |
T |
C |
2: 84,671,305 (GRCm39) |
L37P |
probably damaging |
Het |
| Slf1 |
T |
A |
13: 77,197,338 (GRCm39) |
|
probably null |
Het |
| Ssr2 |
T |
A |
3: 88,483,949 (GRCm39) |
|
probably benign |
Het |
| Syt2 |
ACTCTCTCT |
ACTCTCTCTCT |
1: 134,674,479 (GRCm39) |
|
probably benign |
Het |
| Tas2r115 |
T |
C |
6: 132,714,321 (GRCm39) |
K210R |
probably benign |
Het |
| Tbx18 |
A |
G |
9: 87,597,706 (GRCm39) |
V276A |
probably damaging |
Het |
| Tesl1 |
T |
A |
X: 23,773,549 (GRCm39) |
V350E |
probably benign |
Het |
| Tie1 |
G |
A |
4: 118,330,008 (GRCm39) |
R1072* |
probably null |
Het |
| Tm2d2 |
C |
A |
8: 25,512,674 (GRCm39) |
T174K |
probably damaging |
Het |
| Tmem98 |
A |
G |
11: 80,705,158 (GRCm39) |
D82G |
possibly damaging |
Het |
| Tmub2 |
A |
G |
11: 102,178,379 (GRCm39) |
E94G |
possibly damaging |
Het |
| Tnnt2 |
TG |
TGG |
1: 135,774,499 (GRCm39) |
|
probably benign |
Het |
| Tonsl |
A |
T |
15: 76,516,861 (GRCm39) |
I923N |
probably damaging |
Het |
| Ttc21a |
G |
A |
9: 119,793,361 (GRCm39) |
V977M |
probably damaging |
Het |
| Ube2ql1 |
T |
C |
13: 69,886,783 (GRCm39) |
D226G |
probably damaging |
Het |
| Ubr4 |
C |
T |
4: 139,204,518 (GRCm39) |
T4810M |
probably damaging |
Het |
| Wdr87-ps |
T |
C |
7: 29,230,935 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp408 |
A |
G |
2: 91,478,194 (GRCm39) |
|
probably benign |
Het |
| Zfp473 |
T |
C |
7: 44,382,501 (GRCm39) |
T610A |
possibly damaging |
Het |
| Zfp804b |
A |
G |
5: 6,822,583 (GRCm39) |
V160A |
probably benign |
Het |
| Zfp960 |
A |
G |
17: 17,308,146 (GRCm39) |
T287A |
probably benign |
Het |
|
| Other mutations in Rev3l |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Rev3l
|
APN |
10 |
39,682,965 (GRCm39) |
missense |
probably benign |
|
|
IGL00815:Rev3l
|
APN |
10 |
39,735,149 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00964:Rev3l
|
APN |
10 |
39,740,802 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01765:Rev3l
|
APN |
10 |
39,704,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01792:Rev3l
|
APN |
10 |
39,699,336 (GRCm39) |
missense |
probably benign |
|
|
IGL01950:Rev3l
|
APN |
10 |
39,697,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01963:Rev3l
|
APN |
10 |
39,698,733 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02089:Rev3l
|
APN |
10 |
39,701,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02288:Rev3l
|
APN |
10 |
39,704,212 (GRCm39) |
missense |
probably benign |
|
|
IGL02381:Rev3l
|
APN |
10 |
39,697,342 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02409:Rev3l
|
APN |
10 |
39,697,144 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02434:Rev3l
|
APN |
10 |
39,698,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02570:Rev3l
|
APN |
10 |
39,724,009 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02581:Rev3l
|
APN |
10 |
39,697,277 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02654:Rev3l
|
APN |
10 |
39,738,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02720:Rev3l
|
APN |
10 |
39,698,391 (GRCm39) |
nonsense |
probably null |
|
|
IGL02746:Rev3l
|
APN |
10 |
39,700,585 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02829:Rev3l
|
APN |
10 |
39,701,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02961:Rev3l
|
APN |
10 |
39,703,941 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02974:Rev3l
|
APN |
10 |
39,738,743 (GRCm39) |
nonsense |
probably null |
|
|
IGL03029:Rev3l
|
APN |
10 |
39,704,482 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL03153:Rev3l
|
APN |
10 |
39,682,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Rev3l
|
APN |
10 |
39,700,786 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0068:Rev3l
|
UTSW |
10 |
39,700,827 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0068:Rev3l
|
UTSW |
10 |
39,700,827 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0153:Rev3l
|
UTSW |
10 |
39,750,124 (GRCm39) |
nonsense |
probably null |
|
|
R0308:Rev3l
|
UTSW |
10 |
39,700,890 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0355:Rev3l
|
UTSW |
10 |
39,693,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0513:Rev3l
|
UTSW |
10 |
39,704,139 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0523:Rev3l
|
UTSW |
10 |
39,724,045 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0559:Rev3l
|
UTSW |
10 |
39,700,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0761:Rev3l
|
UTSW |
10 |
39,750,191 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1023:Rev3l
|
UTSW |
10 |
39,708,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1159:Rev3l
|
UTSW |
10 |
39,727,921 (GRCm39) |
nonsense |
probably null |
|
|
R1398:Rev3l
|
UTSW |
10 |
39,697,579 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1478:Rev3l
|
UTSW |
10 |
39,659,329 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1517:Rev3l
|
UTSW |
10 |
39,714,439 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1527:Rev3l
|
UTSW |
10 |
39,698,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Rev3l
|
UTSW |
10 |
39,682,658 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1695:Rev3l
|
UTSW |
10 |
39,700,612 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1695:Rev3l
|
UTSW |
10 |
39,700,611 (GRCm39) |
nonsense |
probably null |
|
|
R1782:Rev3l
|
UTSW |
10 |
39,675,881 (GRCm39) |
missense |
probably benign |
|
|
R1815:Rev3l
|
UTSW |
10 |
39,698,867 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1818:Rev3l
|
UTSW |
10 |
39,704,420 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2039:Rev3l
|
UTSW |
10 |
39,700,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2071:Rev3l
|
UTSW |
10 |
39,700,349 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2101:Rev3l
|
UTSW |
10 |
39,704,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2883:Rev3l
|
UTSW |
10 |
39,701,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Rev3l
|
UTSW |
10 |
39,722,206 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3910:Rev3l
|
UTSW |
10 |
39,696,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Rev3l
|
UTSW |
10 |
39,696,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Rev3l
|
UTSW |
10 |
39,696,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4590:Rev3l
|
UTSW |
10 |
39,682,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4631:Rev3l
|
UTSW |
10 |
39,704,412 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4633:Rev3l
|
UTSW |
10 |
39,722,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Rev3l
|
UTSW |
10 |
39,699,393 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4724:Rev3l
|
UTSW |
10 |
39,722,802 (GRCm39) |
nonsense |
probably null |
|
|
R4810:Rev3l
|
UTSW |
10 |
39,699,721 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4857:Rev3l
|
UTSW |
10 |
39,714,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Rev3l
|
UTSW |
10 |
39,697,456 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4928:Rev3l
|
UTSW |
10 |
39,699,981 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4970:Rev3l
|
UTSW |
10 |
39,699,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4977:Rev3l
|
UTSW |
10 |
39,699,574 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5112:Rev3l
|
UTSW |
10 |
39,699,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5261:Rev3l
|
UTSW |
10 |
39,722,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Rev3l
|
UTSW |
10 |
39,700,927 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5570:Rev3l
|
UTSW |
10 |
39,728,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5628:Rev3l
|
UTSW |
10 |
39,698,963 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5689:Rev3l
|
UTSW |
10 |
39,670,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5781:Rev3l
|
UTSW |
10 |
39,699,089 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5829:Rev3l
|
UTSW |
10 |
39,682,902 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5984:Rev3l
|
UTSW |
10 |
39,618,685 (GRCm39) |
intron |
probably benign |
|
|
R5990:Rev3l
|
UTSW |
10 |
39,699,807 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6054:Rev3l
|
UTSW |
10 |
39,700,146 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6171:Rev3l
|
UTSW |
10 |
39,738,709 (GRCm39) |
nonsense |
probably null |
|
|
R6220:Rev3l
|
UTSW |
10 |
39,698,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6520:Rev3l
|
UTSW |
10 |
39,698,698 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6798:Rev3l
|
UTSW |
10 |
39,730,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Rev3l
|
UTSW |
10 |
39,706,917 (GRCm39) |
nonsense |
probably null |
|
|
R6812:Rev3l
|
UTSW |
10 |
39,699,544 (GRCm39) |
missense |
probably benign |
|
|
R6904:Rev3l
|
UTSW |
10 |
39,697,477 (GRCm39) |
missense |
probably benign |
|
|
R6905:Rev3l
|
UTSW |
10 |
39,693,323 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6938:Rev3l
|
UTSW |
10 |
39,738,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7037:Rev3l
|
UTSW |
10 |
39,727,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7124:Rev3l
|
UTSW |
10 |
39,698,163 (GRCm39) |
nonsense |
probably null |
|
|
R7286:Rev3l
|
UTSW |
10 |
39,699,601 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7385:Rev3l
|
UTSW |
10 |
39,699,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7575:Rev3l
|
UTSW |
10 |
39,697,441 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7596:Rev3l
|
UTSW |
10 |
39,697,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7597:Rev3l
|
UTSW |
10 |
39,698,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7670:Rev3l
|
UTSW |
10 |
39,712,718 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Rev3l
|
UTSW |
10 |
39,699,481 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7818:Rev3l
|
UTSW |
10 |
39,699,898 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7874:Rev3l
|
UTSW |
10 |
39,698,491 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7991:Rev3l
|
UTSW |
10 |
39,739,734 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8059:Rev3l
|
UTSW |
10 |
39,719,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8174:Rev3l
|
UTSW |
10 |
39,735,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8187:Rev3l
|
UTSW |
10 |
39,682,693 (GRCm39) |
missense |
probably benign |
|
|
R8299:Rev3l
|
UTSW |
10 |
39,697,537 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8352:Rev3l
|
UTSW |
10 |
39,698,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8452:Rev3l
|
UTSW |
10 |
39,698,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Rev3l
|
UTSW |
10 |
39,703,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8487:Rev3l
|
UTSW |
10 |
39,682,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8512:Rev3l
|
UTSW |
10 |
39,697,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8554:Rev3l
|
UTSW |
10 |
39,682,838 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8702:Rev3l
|
UTSW |
10 |
39,714,465 (GRCm39) |
nonsense |
probably null |
|
|
R8848:Rev3l
|
UTSW |
10 |
39,722,705 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8857:Rev3l
|
UTSW |
10 |
39,670,965 (GRCm39) |
nonsense |
probably null |
|
|
R8870:Rev3l
|
UTSW |
10 |
39,738,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Rev3l
|
UTSW |
10 |
39,700,809 (GRCm39) |
missense |
probably benign |
|
|
R9175:Rev3l
|
UTSW |
10 |
39,730,764 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9286:Rev3l
|
UTSW |
10 |
39,682,947 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9299:Rev3l
|
UTSW |
10 |
39,723,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Rev3l
|
UTSW |
10 |
39,693,149 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9337:Rev3l
|
UTSW |
10 |
39,698,850 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9342:Rev3l
|
UTSW |
10 |
39,697,458 (GRCm39) |
missense |
probably benign |
|
|
R9389:Rev3l
|
UTSW |
10 |
39,698,967 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9395:Rev3l
|
UTSW |
10 |
39,735,219 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9458:Rev3l
|
UTSW |
10 |
39,659,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9481:Rev3l
|
UTSW |
10 |
39,701,033 (GRCm39) |
missense |
probably benign |
|
|
R9646:Rev3l
|
UTSW |
10 |
39,698,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9686:Rev3l
|
UTSW |
10 |
39,743,384 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
X0022:Rev3l
|
UTSW |
10 |
39,704,603 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1088:Rev3l
|
UTSW |
10 |
39,700,314 (GRCm39) |
missense |
probably benign |
0.41 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACTTAGAAATGCTTGTTTGGTG -3'
(R):5'- TCCAAGTCTAACCAAAGCAAGATGG -3'
Sequencing Primer
(F):5'- GCCTTTAATCCTAGCACTTGAGAGG -3'
(R):5'- CAAAATTGTTTCCCAGAAGATTTTGG -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation