Incidental Mutation 'R2143:Map1a'
| ID |
236455 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map1a
|
| Ensembl Gene |
ENSMUSG00000027254 |
| Gene Name |
microtubule-associated protein 1 A |
| Synonyms |
Mtap1a, Mtap-1, 6330416M19Rik, Mtap1 |
| MMRRC Submission |
040146-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.269)
|
| Stock # |
R2143 (G1)
|
| Quality Score |
178 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
121120081-121141313 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 121132426 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 843
(S843T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094639]
[ENSMUST00000110639]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094639
AA Change: S1081T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000092223
Gene: ENSMUSG00000027254
AA Change: S1081T
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:Lactamase_B
|
286 |
538 |
2e-54 |
BLAST |
|
SCOP:d1eq1a_
|
584 |
699 |
8e-5 |
SMART |
|
low complexity region
|
743 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
820 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
897 |
911 |
N/A |
INTRINSIC |
|
low complexity region
|
1228 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1334 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1540 |
1555 |
N/A |
INTRINSIC |
|
coiled coil region
|
1573 |
1602 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1616 |
1726 |
7.66e-6 |
PROSPERO |
|
coiled coil region
|
1747 |
1771 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1774 |
1888 |
7.66e-6 |
PROSPERO |
|
low complexity region
|
2060 |
2084 |
N/A |
INTRINSIC |
|
low complexity region
|
2121 |
2133 |
N/A |
INTRINSIC |
|
low complexity region
|
2156 |
2169 |
N/A |
INTRINSIC |
|
low complexity region
|
2383 |
2396 |
N/A |
INTRINSIC |
|
low complexity region
|
2436 |
2460 |
N/A |
INTRINSIC |
|
low complexity region
|
2517 |
2541 |
N/A |
INTRINSIC |
|
low complexity region
|
2589 |
2600 |
N/A |
INTRINSIC |
|
low complexity region
|
2662 |
2682 |
N/A |
INTRINSIC |
|
low complexity region
|
2685 |
2704 |
N/A |
INTRINSIC |
|
low complexity region
|
2716 |
2728 |
N/A |
INTRINSIC |
|
low complexity region
|
2766 |
2790 |
N/A |
INTRINSIC |
|
low complexity region
|
2980 |
2988 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110639
AA Change: S843T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000106269
Gene: ENSMUSG00000027254
AA Change: S843T
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:Lactamase_B
|
48 |
300 |
3e-54 |
BLAST |
|
SCOP:d1eq1a_
|
346 |
461 |
1e-4 |
SMART |
|
low complexity region
|
505 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
582 |
595 |
N/A |
INTRINSIC |
|
low complexity region
|
614 |
629 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
673 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1096 |
1106 |
N/A |
INTRINSIC |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
coiled coil region
|
1335 |
1364 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1378 |
1488 |
5.43e-6 |
PROSPERO |
|
coiled coil region
|
1509 |
1533 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1536 |
1650 |
5.43e-6 |
PROSPERO |
|
low complexity region
|
1822 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1883 |
1895 |
N/A |
INTRINSIC |
|
low complexity region
|
1918 |
1931 |
N/A |
INTRINSIC |
|
low complexity region
|
2145 |
2158 |
N/A |
INTRINSIC |
|
low complexity region
|
2198 |
2222 |
N/A |
INTRINSIC |
|
low complexity region
|
2279 |
2303 |
N/A |
INTRINSIC |
|
low complexity region
|
2351 |
2362 |
N/A |
INTRINSIC |
|
low complexity region
|
2424 |
2444 |
N/A |
INTRINSIC |
|
low complexity region
|
2447 |
2466 |
N/A |
INTRINSIC |
|
low complexity region
|
2478 |
2490 |
N/A |
INTRINSIC |
|
low complexity region
|
2528 |
2552 |
N/A |
INTRINSIC |
|
low complexity region
|
2742 |
2750 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133283
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit Purkinje cell degeneration. Mice homozygous for a spontaneous mutation exhibit mild ataxia and Purkinje cell degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 111 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310034C09Rik |
G |
C |
16: 88,556,053 (GRCm39) |
S89T |
probably benign |
Het |
| 4930522L14Rik |
C |
G |
5: 109,884,616 (GRCm39) |
C414S |
probably damaging |
Het |
| 4930553M12Rik |
G |
A |
4: 88,786,411 (GRCm39) |
T69I |
unknown |
Het |
| 4930553M12Rik |
T |
A |
4: 88,786,412 (GRCm39) |
T69S |
unknown |
Het |
| Apobr |
G |
A |
7: 126,186,288 (GRCm39) |
E600K |
probably benign |
Het |
| Armc8 |
C |
A |
9: 99,387,361 (GRCm39) |
R419L |
probably damaging |
Het |
| Ash1l |
T |
A |
3: 88,892,726 (GRCm39) |
M1535K |
probably benign |
Het |
| Atf7ip2 |
A |
G |
16: 10,058,509 (GRCm39) |
E316G |
probably null |
Het |
| Atp2a1 |
G |
A |
7: 126,047,897 (GRCm39) |
R638* |
probably null |
Het |
| Atp8b4 |
A |
T |
2: 126,216,430 (GRCm39) |
I672N |
probably damaging |
Het |
| Atrn |
T |
C |
2: 130,799,916 (GRCm39) |
V431A |
probably benign |
Het |
| Babam1 |
T |
C |
8: 71,851,084 (GRCm39) |
S116P |
probably damaging |
Het |
| Ccdc142 |
T |
C |
6: 83,079,203 (GRCm39) |
L180P |
probably damaging |
Het |
| Cd52 |
T |
C |
4: 133,821,048 (GRCm39) |
|
probably benign |
Het |
| Cdk17 |
T |
C |
10: 93,053,881 (GRCm39) |
L125P |
probably damaging |
Het |
| Ckap5 |
A |
G |
2: 91,396,090 (GRCm39) |
D531G |
probably benign |
Het |
| Cntn5 |
G |
T |
9: 9,748,420 (GRCm39) |
P487Q |
probably damaging |
Het |
| Crispld1 |
C |
T |
1: 17,819,860 (GRCm39) |
T286I |
probably benign |
Het |
| Crtap |
T |
C |
9: 114,209,036 (GRCm39) |
Y336C |
probably damaging |
Het |
| Ctu2 |
T |
A |
8: 123,205,891 (GRCm39) |
I213K |
probably benign |
Het |
| Dmac2l |
A |
G |
12: 69,787,828 (GRCm39) |
Q88R |
probably damaging |
Het |
| Dsc3 |
A |
G |
18: 20,113,743 (GRCm39) |
F393S |
possibly damaging |
Het |
| Dsg2 |
T |
A |
18: 20,712,218 (GRCm39) |
I118N |
probably damaging |
Het |
| Dstyk |
T |
A |
1: 132,391,113 (GRCm39) |
M838K |
probably damaging |
Het |
| Elmo3 |
T |
C |
8: 106,035,305 (GRCm39) |
V450A |
probably damaging |
Het |
| Eml5 |
A |
C |
12: 98,776,864 (GRCm39) |
F1417C |
probably damaging |
Het |
| Enam |
T |
A |
5: 88,640,779 (GRCm39) |
M147K |
probably benign |
Het |
| Entpd1 |
T |
C |
19: 40,725,227 (GRCm39) |
Y409H |
probably damaging |
Het |
| Extl1 |
C |
A |
4: 134,098,355 (GRCm39) |
E225D |
probably benign |
Het |
| Fbn2 |
A |
G |
18: 58,186,065 (GRCm39) |
V1761A |
possibly damaging |
Het |
| Fsip2 |
A |
T |
2: 82,820,615 (GRCm39) |
L5449F |
possibly damaging |
Het |
| Gabra5 |
G |
A |
7: 57,138,763 (GRCm39) |
T95I |
probably damaging |
Het |
| Gal3st2c |
C |
T |
1: 93,937,173 (GRCm39) |
Q373* |
probably null |
Het |
| Gbp5 |
A |
C |
3: 142,209,593 (GRCm39) |
T180P |
probably damaging |
Het |
| Glb1 |
T |
C |
9: 114,266,892 (GRCm39) |
L212P |
probably damaging |
Het |
| Gm11596 |
A |
T |
11: 99,683,789 (GRCm39) |
C110* |
probably null |
Het |
| Gpat2 |
T |
C |
2: 127,275,682 (GRCm39) |
F487L |
probably damaging |
Het |
| Hsph1 |
A |
T |
5: 149,554,951 (GRCm39) |
H110Q |
probably damaging |
Het |
| Ikbke |
C |
A |
1: 131,201,211 (GRCm39) |
V176L |
probably damaging |
Het |
| Ildr2 |
T |
C |
1: 166,096,895 (GRCm39) |
V38A |
probably damaging |
Het |
| Inpp4a |
G |
T |
1: 37,426,827 (GRCm39) |
C326F |
probably damaging |
Het |
| Irak2 |
T |
A |
6: 113,649,788 (GRCm39) |
V141D |
probably benign |
Het |
| Jade1 |
G |
A |
3: 41,559,143 (GRCm39) |
R408Q |
probably benign |
Het |
| Jmjd7 |
C |
A |
2: 119,860,601 (GRCm39) |
|
probably null |
Het |
| Kdm7a |
C |
T |
6: 39,145,884 (GRCm39) |
V348I |
possibly damaging |
Het |
| Kif20a |
A |
G |
18: 34,758,657 (GRCm39) |
D42G |
possibly damaging |
Het |
| Klhl7 |
A |
T |
5: 24,305,861 (GRCm39) |
M37L |
probably benign |
Het |
| Krt5 |
A |
G |
15: 101,620,794 (GRCm39) |
I151T |
probably damaging |
Het |
| Krtap1-5 |
T |
C |
11: 99,471,644 (GRCm39) |
I50V |
probably benign |
Het |
| Letm1 |
A |
AG |
5: 33,926,859 (GRCm39) |
|
probably null |
Het |
| Lrrc71 |
C |
T |
3: 87,652,828 (GRCm39) |
W148* |
probably null |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Map1s |
T |
A |
8: 71,363,608 (GRCm39) |
D48E |
probably damaging |
Het |
| Mast4 |
A |
G |
13: 102,871,983 (GRCm39) |
F2462L |
possibly damaging |
Het |
| Mettl21e |
T |
A |
1: 44,249,398 (GRCm39) |
Y86F |
probably benign |
Het |
| Myh6 |
A |
T |
14: 55,190,411 (GRCm39) |
D1035E |
probably damaging |
Het |
| Naip6 |
C |
T |
13: 100,436,367 (GRCm39) |
D719N |
probably damaging |
Het |
| Nat8f2 |
T |
G |
6: 85,845,239 (GRCm39) |
H41P |
probably benign |
Het |
| Ncam1 |
T |
A |
9: 49,454,319 (GRCm39) |
Q597L |
possibly damaging |
Het |
| Nek1 |
T |
A |
8: 61,481,730 (GRCm39) |
I215K |
probably damaging |
Het |
| Nol11 |
A |
T |
11: 107,071,881 (GRCm39) |
S237R |
probably benign |
Het |
| Npr2 |
T |
C |
4: 43,648,166 (GRCm39) |
F870S |
probably damaging |
Het |
| Nsd1 |
T |
C |
13: 55,408,210 (GRCm39) |
Y1285H |
probably damaging |
Het |
| Nup93 |
C |
T |
8: 95,023,108 (GRCm39) |
Q229* |
probably null |
Het |
| Or4a15 |
C |
T |
2: 89,193,447 (GRCm39) |
E109K |
probably damaging |
Het |
| Or7g12 |
G |
A |
9: 18,900,099 (GRCm39) |
A272T |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,099,186 (GRCm39) |
Y568* |
probably null |
Het |
| Parva |
A |
G |
7: 112,159,274 (GRCm39) |
D180G |
possibly damaging |
Het |
| Pask |
C |
T |
1: 93,249,019 (GRCm39) |
A794T |
probably benign |
Het |
| Pax1 |
T |
A |
2: 147,207,802 (GRCm39) |
C225S |
probably damaging |
Het |
| Pde4dip |
T |
A |
3: 97,795,835 (GRCm39) |
E51V |
possibly damaging |
Het |
| Pde6c |
A |
T |
19: 38,150,777 (GRCm39) |
H562L |
probably damaging |
Het |
| Pet100 |
T |
G |
8: 3,672,355 (GRCm39) |
L14R |
probably damaging |
Het |
| Pfkfb2 |
T |
C |
1: 130,626,460 (GRCm39) |
T438A |
probably benign |
Het |
| Pira2 |
A |
T |
7: 3,847,344 (GRCm39) |
L115Q |
probably damaging |
Het |
| Polr2d |
T |
A |
18: 31,929,132 (GRCm39) |
L127Q |
probably damaging |
Het |
| Prkd1 |
A |
G |
12: 50,536,694 (GRCm39) |
V130A |
possibly damaging |
Het |
| Psd3 |
T |
C |
8: 68,417,003 (GRCm39) |
D45G |
probably damaging |
Het |
| Ptpn13 |
A |
G |
5: 103,703,999 (GRCm39) |
T1344A |
probably benign |
Het |
| Ptpn6 |
T |
A |
6: 124,701,947 (GRCm39) |
H406L |
probably benign |
Het |
| Ric1 |
A |
T |
19: 29,510,652 (GRCm39) |
S78C |
probably damaging |
Het |
| Ric1 |
G |
A |
19: 29,510,653 (GRCm39) |
S78N |
probably damaging |
Het |
| Scgb1b2 |
G |
T |
7: 30,991,188 (GRCm39) |
|
probably benign |
Het |
| Senp7 |
A |
G |
16: 55,990,169 (GRCm39) |
H639R |
probably benign |
Het |
| Sgtb |
A |
T |
13: 104,260,767 (GRCm39) |
D72V |
probably damaging |
Het |
| Slc44a5 |
T |
C |
3: 153,964,086 (GRCm39) |
M484T |
probably benign |
Het |
| Slc5a1 |
A |
G |
5: 33,318,140 (GRCm39) |
K598E |
probably benign |
Het |
| Slit3 |
T |
A |
11: 35,503,088 (GRCm39) |
|
probably null |
Het |
| Smc1b |
T |
C |
15: 85,008,003 (GRCm39) |
H258R |
probably benign |
Het |
| Smu1 |
T |
C |
4: 40,744,073 (GRCm39) |
D318G |
probably damaging |
Het |
| Sned1 |
T |
A |
1: 93,199,406 (GRCm39) |
F495L |
probably damaging |
Het |
| Svs3a |
C |
A |
2: 164,131,804 (GRCm39) |
S124Y |
probably damaging |
Het |
| Syngr4 |
A |
G |
7: 45,536,464 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
G |
A |
7: 65,305,539 (GRCm39) |
M254I |
possibly damaging |
Het |
| Tdpoz1 |
T |
A |
3: 93,578,143 (GRCm39) |
R214* |
probably null |
Het |
| Tm2d3 |
A |
G |
7: 65,344,987 (GRCm39) |
D54G |
probably damaging |
Het |
| Trim66 |
A |
T |
7: 109,074,320 (GRCm39) |
I647N |
probably damaging |
Het |
| Triml2 |
T |
A |
8: 43,646,548 (GRCm39) |
W346R |
probably damaging |
Het |
| Trp53bp1 |
A |
T |
2: 121,046,545 (GRCm39) |
V1085D |
probably benign |
Het |
| Trpv2 |
T |
C |
11: 62,483,612 (GRCm39) |
V483A |
probably benign |
Het |
| Ugp2 |
G |
T |
11: 21,278,949 (GRCm39) |
N412K |
probably benign |
Het |
| Upf1 |
T |
C |
8: 70,792,004 (GRCm39) |
D418G |
probably null |
Het |
| Vmn2r77 |
C |
A |
7: 86,461,152 (GRCm39) |
P826Q |
probably damaging |
Het |
| Vrtn |
T |
C |
12: 84,696,936 (GRCm39) |
M562T |
probably benign |
Het |
| Wdr55 |
A |
G |
18: 36,895,419 (GRCm39) |
N132S |
possibly damaging |
Het |
| Wipf2 |
A |
T |
11: 98,787,040 (GRCm39) |
R356S |
possibly damaging |
Het |
| Zdhhc6 |
T |
C |
19: 55,287,228 (GRCm39) |
K411E |
probably benign |
Het |
| Zfp260 |
A |
G |
7: 29,804,765 (GRCm39) |
K222E |
probably damaging |
Het |
| Zfp280d |
A |
G |
9: 72,220,011 (GRCm39) |
N237S |
probably damaging |
Het |
| Zfp445 |
T |
G |
9: 122,682,547 (GRCm39) |
S465R |
possibly damaging |
Het |
| Zfp821 |
A |
G |
8: 110,450,979 (GRCm39) |
D324G |
probably damaging |
Het |
|
| Other mutations in Map1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00419:Map1a
|
APN |
2 |
121,129,508 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00826:Map1a
|
APN |
2 |
121,132,757 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01476:Map1a
|
APN |
2 |
121,135,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02029:Map1a
|
APN |
2 |
121,133,779 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL02100:Map1a
|
APN |
2 |
121,133,327 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02136:Map1a
|
APN |
2 |
121,130,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02146:Map1a
|
APN |
2 |
121,129,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Map1a
|
APN |
2 |
121,137,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02456:Map1a
|
APN |
2 |
121,129,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02485:Map1a
|
APN |
2 |
121,129,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02535:Map1a
|
APN |
2 |
121,132,658 (GRCm39) |
nonsense |
probably null |
|
|
IGL02628:Map1a
|
APN |
2 |
121,130,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02721:Map1a
|
APN |
2 |
121,134,518 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL03273:Map1a
|
APN |
2 |
121,130,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Map1a
|
APN |
2 |
121,135,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Map1a
|
UTSW |
2 |
121,132,091 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0096:Map1a
|
UTSW |
2 |
121,131,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Map1a
|
UTSW |
2 |
121,131,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0218:Map1a
|
UTSW |
2 |
121,135,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0363:Map1a
|
UTSW |
2 |
121,132,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0450:Map1a
|
UTSW |
2 |
121,136,255 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0469:Map1a
|
UTSW |
2 |
121,136,255 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0477:Map1a
|
UTSW |
2 |
121,132,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0504:Map1a
|
UTSW |
2 |
121,133,422 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0510:Map1a
|
UTSW |
2 |
121,136,255 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0521:Map1a
|
UTSW |
2 |
121,136,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Map1a
|
UTSW |
2 |
121,129,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0619:Map1a
|
UTSW |
2 |
121,135,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0633:Map1a
|
UTSW |
2 |
121,138,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Map1a
|
UTSW |
2 |
121,133,264 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0893:Map1a
|
UTSW |
2 |
121,131,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0960:Map1a
|
UTSW |
2 |
121,132,124 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1115:Map1a
|
UTSW |
2 |
121,137,859 (GRCm39) |
splice site |
probably null |
|
|
R1166:Map1a
|
UTSW |
2 |
121,130,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1326:Map1a
|
UTSW |
2 |
121,136,671 (GRCm39) |
nonsense |
probably null |
|
|
R1331:Map1a
|
UTSW |
2 |
121,136,701 (GRCm39) |
nonsense |
probably null |
|
|
R1395:Map1a
|
UTSW |
2 |
121,134,406 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1489:Map1a
|
UTSW |
2 |
121,130,918 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1573:Map1a
|
UTSW |
2 |
121,134,607 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1596:Map1a
|
UTSW |
2 |
121,120,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1662:Map1a
|
UTSW |
2 |
121,136,889 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1675:Map1a
|
UTSW |
2 |
121,133,136 (GRCm39) |
nonsense |
probably null |
|
|
R1919:Map1a
|
UTSW |
2 |
121,137,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Map1a
|
UTSW |
2 |
121,129,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2126:Map1a
|
UTSW |
2 |
121,129,122 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2172:Map1a
|
UTSW |
2 |
121,138,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2249:Map1a
|
UTSW |
2 |
121,130,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2254:Map1a
|
UTSW |
2 |
121,134,272 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2255:Map1a
|
UTSW |
2 |
121,134,272 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3834:Map1a
|
UTSW |
2 |
121,137,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4011:Map1a
|
UTSW |
2 |
121,130,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4346:Map1a
|
UTSW |
2 |
121,131,806 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4842:Map1a
|
UTSW |
2 |
121,132,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4933:Map1a
|
UTSW |
2 |
121,136,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4978:Map1a
|
UTSW |
2 |
121,131,623 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4988:Map1a
|
UTSW |
2 |
121,133,531 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5026:Map1a
|
UTSW |
2 |
121,138,019 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5086:Map1a
|
UTSW |
2 |
121,134,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5155:Map1a
|
UTSW |
2 |
121,132,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5232:Map1a
|
UTSW |
2 |
121,132,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Map1a
|
UTSW |
2 |
121,132,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Map1a
|
UTSW |
2 |
121,130,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5465:Map1a
|
UTSW |
2 |
121,136,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5526:Map1a
|
UTSW |
2 |
121,136,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Map1a
|
UTSW |
2 |
121,136,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Map1a
|
UTSW |
2 |
121,135,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5817:Map1a
|
UTSW |
2 |
121,129,391 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5855:Map1a
|
UTSW |
2 |
121,134,155 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5917:Map1a
|
UTSW |
2 |
121,135,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5974:Map1a
|
UTSW |
2 |
121,134,857 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5987:Map1a
|
UTSW |
2 |
121,134,776 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6151:Map1a
|
UTSW |
2 |
121,120,304 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6406:Map1a
|
UTSW |
2 |
121,131,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Map1a
|
UTSW |
2 |
121,130,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7099:Map1a
|
UTSW |
2 |
121,130,998 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7211:Map1a
|
UTSW |
2 |
121,135,124 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7230:Map1a
|
UTSW |
2 |
121,131,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7305:Map1a
|
UTSW |
2 |
121,129,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7382:Map1a
|
UTSW |
2 |
121,121,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Map1a
|
UTSW |
2 |
121,120,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Map1a
|
UTSW |
2 |
121,130,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7767:Map1a
|
UTSW |
2 |
121,132,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Map1a
|
UTSW |
2 |
121,135,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7896:Map1a
|
UTSW |
2 |
121,135,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7993:Map1a
|
UTSW |
2 |
121,135,057 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8270:Map1a
|
UTSW |
2 |
121,129,501 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8365:Map1a
|
UTSW |
2 |
121,138,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8428:Map1a
|
UTSW |
2 |
121,135,418 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8490:Map1a
|
UTSW |
2 |
121,135,045 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8678:Map1a
|
UTSW |
2 |
121,137,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8798:Map1a
|
UTSW |
2 |
121,132,768 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8857:Map1a
|
UTSW |
2 |
121,138,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8878:Map1a
|
UTSW |
2 |
121,138,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8909:Map1a
|
UTSW |
2 |
121,129,391 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8917:Map1a
|
UTSW |
2 |
121,131,791 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8947:Map1a
|
UTSW |
2 |
121,135,450 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9069:Map1a
|
UTSW |
2 |
121,134,145 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9198:Map1a
|
UTSW |
2 |
121,133,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Map1a
|
UTSW |
2 |
121,132,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9290:Map1a
|
UTSW |
2 |
121,131,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Map1a
|
UTSW |
2 |
121,133,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Map1a
|
UTSW |
2 |
121,136,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9680:Map1a
|
UTSW |
2 |
121,132,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9792:Map1a
|
UTSW |
2 |
121,121,304 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9793:Map1a
|
UTSW |
2 |
121,121,304 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9795:Map1a
|
UTSW |
2 |
121,121,304 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF003:Map1a
|
UTSW |
2 |
121,136,777 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Map1a
|
UTSW |
2 |
121,136,789 (GRCm39) |
small insertion |
probably benign |
|
|
RF009:Map1a
|
UTSW |
2 |
121,136,782 (GRCm39) |
small insertion |
probably benign |
|
|
RF010:Map1a
|
UTSW |
2 |
121,136,799 (GRCm39) |
small insertion |
probably benign |
|
|
RF014:Map1a
|
UTSW |
2 |
121,136,776 (GRCm39) |
small insertion |
probably benign |
|
|
RF017:Map1a
|
UTSW |
2 |
121,136,789 (GRCm39) |
small insertion |
probably benign |
|
|
RF024:Map1a
|
UTSW |
2 |
121,136,788 (GRCm39) |
small insertion |
probably benign |
|
|
RF025:Map1a
|
UTSW |
2 |
121,136,775 (GRCm39) |
small insertion |
probably benign |
|
|
RF030:Map1a
|
UTSW |
2 |
121,136,798 (GRCm39) |
small insertion |
probably benign |
|
|
RF030:Map1a
|
UTSW |
2 |
121,136,792 (GRCm39) |
small insertion |
probably benign |
|
|
RF033:Map1a
|
UTSW |
2 |
121,136,780 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Map1a
|
UTSW |
2 |
121,136,788 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Map1a
|
UTSW |
2 |
121,136,785 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Map1a
|
UTSW |
2 |
121,136,782 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Map1a
|
UTSW |
2 |
121,136,775 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Map1a
|
UTSW |
2 |
121,136,785 (GRCm39) |
small insertion |
probably benign |
|
|
RF042:Map1a
|
UTSW |
2 |
121,136,768 (GRCm39) |
small insertion |
probably benign |
|
|
RF044:Map1a
|
UTSW |
2 |
121,136,774 (GRCm39) |
small insertion |
probably benign |
|
|
RF045:Map1a
|
UTSW |
2 |
121,136,774 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Map1a
|
UTSW |
2 |
121,136,777 (GRCm39) |
small insertion |
probably benign |
|
|
RF052:Map1a
|
UTSW |
2 |
121,136,776 (GRCm39) |
small insertion |
probably benign |
|
|
RF053:Map1a
|
UTSW |
2 |
121,136,771 (GRCm39) |
small insertion |
probably benign |
|
|
RF060:Map1a
|
UTSW |
2 |
121,136,799 (GRCm39) |
small insertion |
probably benign |
|
|
RF061:Map1a
|
UTSW |
2 |
121,136,768 (GRCm39) |
small insertion |
probably benign |
|
|
Z1176:Map1a
|
UTSW |
2 |
121,133,719 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Map1a
|
UTSW |
2 |
121,135,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGAAGCCAGCCAGTCTGC -3'
(R):5'- CAGAGAAATCCTCACAGGGC -3'
Sequencing Primer
(F):5'- CAGCCAGTCTGCAGAGAGTG -3'
(R):5'- CGGTGACTTGAAGCCCTTGTC -3'
|
| Posted On |
2014-10-01 |
Incidental Mutation