Incidental Mutation 'R2177:Or14c45'
ID 236941
Institutional Source Beutler Lab
Gene Symbol Or14c45
Ensembl Gene ENSMUSG00000057067
Gene Name olfactory receptor family 14 subfamily C member 45
Synonyms Olfr297, GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
MMRRC Submission 040179-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R2177 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 86175967-86176899 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86176870 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 302 (V302I)
Ref Sequence ENSEMBL: ENSMUSP00000134371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071112] [ENSMUST00000172965]
AlphaFold Q7TS07
Predicted Effect probably benign
Transcript: ENSMUST00000071112
AA Change: V302I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000132942
Gene: ENSMUSG00000057067
AA Change: V302I

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.9e-45 PFAM
Pfam:7tm_1 39 288 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172965
AA Change: V302I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: V302I

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 97% (60/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik T A 5: 88,120,312 (GRCm39) N356K probably damaging Het
Acap2 C T 16: 30,952,346 (GRCm39) probably null Het
Adamts19 T C 18: 59,087,626 (GRCm39) L552P possibly damaging Het
Adamts2 T A 11: 50,668,055 (GRCm39) M539K probably damaging Het
Aplp1 A T 7: 30,141,946 (GRCm39) C210* probably null Het
Apoa1 A T 9: 46,141,371 (GRCm39) K156* probably null Het
AW551984 G A 9: 39,511,111 (GRCm39) R159C probably benign Het
Bok C T 1: 93,622,787 (GRCm39) Q112* probably null Het
Cemip2 T C 19: 21,789,149 (GRCm39) S528P possibly damaging Het
Cfap57 T G 4: 118,463,885 (GRCm39) I323L probably benign Het
Cfap69 T A 5: 5,675,803 (GRCm39) E270D probably damaging Het
Ch25h G T 19: 34,452,097 (GRCm39) L144M probably damaging Het
Clcn6 T A 4: 148,099,057 (GRCm39) I429F possibly damaging Het
Cpb1 T A 3: 20,320,611 (GRCm39) T115S probably benign Het
Csf1r T A 18: 61,248,015 (GRCm39) probably benign Het
Ddx6 A G 9: 44,539,028 (GRCm39) T279A probably damaging Het
Dnah8 A G 17: 30,872,367 (GRCm39) H452R probably benign Het
Dscam T A 16: 96,411,524 (GRCm39) D1784V probably damaging Het
Exo1 T A 1: 175,710,456 (GRCm39) probably null Het
Fcho1 A G 8: 72,164,905 (GRCm39) S459P probably damaging Het
Fxyd4 C T 6: 117,911,393 (GRCm39) A56T probably damaging Het
Gbf1 T C 19: 46,254,109 (GRCm39) S599P probably benign Het
Iqce T C 5: 140,677,348 (GRCm39) probably benign Het
Kat2a A G 11: 100,601,648 (GRCm39) F256L probably damaging Het
Klk1b1 G T 7: 43,618,695 (GRCm39) R24L possibly damaging Het
Krtap16-1 A G 11: 99,877,275 (GRCm39) V43A probably damaging Het
Maea C G 5: 33,529,034 (GRCm39) Q326E probably benign Het
Man1a2 A T 3: 100,539,847 (GRCm39) I308N probably damaging Het
Marf1 G T 16: 13,970,471 (GRCm39) R83S probably benign Het
Me3 A C 7: 89,282,278 (GRCm39) T54P probably benign Het
Mme A T 3: 63,208,426 (GRCm39) I63L probably benign Het
Mmel1 A G 4: 154,978,560 (GRCm39) N664S probably damaging Het
Mrgprb2 A G 7: 48,202,128 (GRCm39) V199A probably benign Het
Mrpl36 T A 13: 73,479,588 (GRCm39) F33I probably benign Het
Nlrp4e A T 7: 23,054,686 (GRCm39) T947S probably benign Het
Or4b1d T A 2: 89,968,808 (GRCm39) H225L possibly damaging Het
Or8b55 A T 9: 38,727,482 (GRCm39) I228F possibly damaging Het
Parp4 A T 14: 56,896,746 (GRCm39) R1923S unknown Het
Pcm1 T C 8: 41,729,002 (GRCm39) V658A probably benign Het
Pkhd1l1 A G 15: 44,322,791 (GRCm39) S26G probably benign Het
Prom1 A T 5: 44,184,081 (GRCm39) H433Q possibly damaging Het
Rab7 T C 6: 87,982,063 (GRCm39) D104G probably damaging Het
Rabgap1l A G 1: 160,551,632 (GRCm39) V282A possibly damaging Het
Rdh13 T C 7: 4,430,666 (GRCm39) E264G possibly damaging Het
Rock1 C G 18: 10,070,263 (GRCm39) R1270T probably benign Het
Sdhaf4 C T 1: 24,035,370 (GRCm39) G93R probably damaging Het
Sec24a T C 11: 51,595,228 (GRCm39) T910A probably benign Het
Sesn1 A G 10: 41,779,778 (GRCm39) H345R possibly damaging Het
Snx4 T A 16: 33,106,428 (GRCm39) probably null Het
Tchh A G 3: 93,351,439 (GRCm39) E293G unknown Het
Ulk2 T A 11: 61,682,335 (GRCm39) T727S probably benign Het
Usp53 T C 3: 122,729,706 (GRCm39) E756G probably damaging Het
Vmn2r68 G A 7: 84,871,123 (GRCm39) A720V probably benign Het
Vmn2r79 A G 7: 86,645,839 (GRCm39) N56S possibly damaging Het
Washc5 A T 15: 59,235,118 (GRCm39) Y263* probably null Het
Zfp119b A T 17: 56,245,639 (GRCm39) C516S probably damaging Het
Other mutations in Or14c45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Or14c45 APN 7 86,175,986 (GRCm39) missense probably benign 0.10
IGL01823:Or14c45 APN 7 86,176,249 (GRCm39) missense probably damaging 1.00
PIT4378001:Or14c45 UTSW 7 86,176,306 (GRCm39) missense possibly damaging 0.50
R0304:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R0737:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R2436:Or14c45 UTSW 7 86,176,591 (GRCm39) missense probably damaging 0.99
R4289:Or14c45 UTSW 7 86,176,262 (GRCm39) missense probably damaging 1.00
R4639:Or14c45 UTSW 7 86,175,969 (GRCm39) start codon destroyed probably null 1.00
R5202:Or14c45 UTSW 7 86,176,324 (GRCm39) missense probably damaging 1.00
R5782:Or14c45 UTSW 7 86,176,421 (GRCm39) missense probably damaging 0.98
R6446:Or14c45 UTSW 7 86,176,310 (GRCm39) missense possibly damaging 0.90
R6615:Or14c45 UTSW 7 86,176,120 (GRCm39) missense probably benign 0.06
R6920:Or14c45 UTSW 7 86,176,522 (GRCm39) missense probably benign 0.00
R7150:Or14c45 UTSW 7 86,176,322 (GRCm39) missense probably damaging 1.00
R7309:Or14c45 UTSW 7 86,176,349 (GRCm39) missense probably damaging 1.00
R7621:Or14c45 UTSW 7 86,176,280 (GRCm39) missense probably benign 0.37
R8257:Or14c45 UTSW 7 86,176,678 (GRCm39) missense possibly damaging 0.95
R9349:Or14c45 UTSW 7 86,176,373 (GRCm39) missense probably benign 0.01
R9466:Or14c45 UTSW 7 86,176,080 (GRCm39) missense probably benign
R9479:Or14c45 UTSW 7 86,176,285 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TGTCCCTCACATCATTGTAGCA -3'
(R):5'- TGGCATCAAGGCTTCTTCTT -3'

Sequencing Primer
(F):5'- CCCTCACATCATTGTAGCATATTTG -3'
(R):5'- CCATATGGGAGGACATGGATG -3'
Posted On 2014-10-02