Mutagenetix > Incidental Mutation

Incidental Mutation 'R2181:Vmn2r76'

237187

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r76

Ensembl Gene

ENSMUSG00000091239

Gene Name

vomeronasal 2, receptor 76

Synonyms

MMRRC Submission

040183-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R2181 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85874414-85895409 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85874743 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 745 (I745V)

Ref Sequence

ENSEMBL: ENSMUSP00000127309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165771]

AlphaFold

E9Q3F5

Predicted Effect

probably benign
Transcript: ENSMUST00000165771
AA Change: I745V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000127309
Gene: ENSMUSG00000091239
AA Change: I745V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	78	470	1.2e-29	PFAM
low complexity region	476	489	N/A	INTRINSIC
Pfam:NCD3G	513	565	3.7e-22	PFAM
Pfam:7tm_3	598	833	1.4e-52	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700037C18Rik	C	T	16: 3,724,950 (GRCm39)	S43N	possibly damaging	Het
Abcb5	T	G	12: 118,831,681 (GRCm39)	I1224L	possibly damaging	Het
Adgra2	G	A	8: 27,611,701 (GRCm39)	G1002S	probably damaging	Het
Arhgap28	T	C	17: 68,203,112 (GRCm39)	T114A	probably damaging	Het
Colec12	T	A	18: 9,846,828 (GRCm39)	S75T	probably damaging	Het
Cyp2c67	A	G	19: 39,597,541 (GRCm39)	C486R	possibly damaging	Het
Ecm2	T	A	13: 49,683,765 (GRCm39)	L581Q	probably damaging	Het
Faxc	T	A	4: 21,931,591 (GRCm39)	S10T	probably benign	Het
Frem2	A	G	3: 53,482,008 (GRCm39)	I1893T	possibly damaging	Het
Gabrr3	T	A	16: 59,268,372 (GRCm39)	D328E	probably damaging	Het
Gbp7	A	G	3: 142,249,791 (GRCm39)	I421V	possibly damaging	Het
Gorasp1	A	G	9: 119,757,422 (GRCm39)	S317P	probably damaging	Het
Htr6	A	G	4: 138,801,736 (GRCm39)	S113P	probably damaging	Het
Ift74	A	G	4: 94,520,951 (GRCm39)	E168G	probably damaging	Het
Kdm6b	A	T	11: 69,291,952 (GRCm39)	Y1443*	probably null	Het
Mmp28	A	C	11: 83,333,543 (GRCm39)	V466G	possibly damaging	Het
Nbea	A	T	3: 55,937,360 (GRCm39)	S750R	possibly damaging	Het
Nbeal1	T	C	1: 60,317,939 (GRCm39)	F1959L	probably damaging	Het
Nelfa	T	C	5: 34,057,853 (GRCm39)	N314D	probably benign	Het
Numbl	T	A	7: 26,968,346 (GRCm39)		probably null	Het
Or13c25	T	A	4: 52,911,524 (GRCm39)	K90M	probably damaging	Het
Or1j17	G	A	2: 36,578,346 (GRCm39)	D111N	probably damaging	Het
Or2p2	G	T	13: 21,257,394 (GRCm39)	P26T	probably damaging	Het
Or52e5	T	C	7: 104,719,418 (GRCm39)	V248A	possibly damaging	Het
Or5b113	G	T	19: 13,342,438 (GRCm39)	V149F	probably benign	Het
Penk	T	C	4: 4,134,041 (GRCm39)		probably null	Het
Pglyrp2	A	G	17: 32,637,936 (GRCm39)	S31P	probably damaging	Het
Pigg	T	C	5: 108,484,366 (GRCm39)	S538P	probably damaging	Het
Pld2	A	G	11: 70,433,815 (GRCm39)	T252A	possibly damaging	Het
Ppp2r5e	T	C	12: 75,509,098 (GRCm39)	I394V	probably benign	Het
Sh3rf1	G	T	8: 61,816,272 (GRCm39)	V510F	probably damaging	Het
Slc4a2	A	G	5: 24,640,651 (GRCm39)	H677R	possibly damaging	Het
Stam2	A	T	2: 52,593,156 (GRCm39)	H345Q	probably benign	Het
Tmtc3	T	C	10: 100,284,835 (GRCm39)	N600S	probably benign	Het
Trappc8	A	G	18: 20,952,279 (GRCm39)		probably null	Het
Vmn1r72	A	T	7: 11,403,595 (GRCm39)	C284*	probably null	Het
Zfhx4	A	C	3: 5,468,392 (GRCm39)	D2850A	probably damaging	Het
Zfp764	A	G	7: 127,005,671 (GRCm39)	W36R	probably damaging	Het
Zfp804b	G	A	5: 6,821,674 (GRCm39)	T463I	probably damaging	Het
Zfp811	T	G	17: 33,016,695 (GRCm39)	K448N	probably damaging	Het

Other mutations in Vmn2r76

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Vmn2r76	APN	7	85,877,925 (GRCm39)	missense	probably benign
IGL01374:Vmn2r76	APN	7	85,874,857 (GRCm39)	missense	probably benign	0.02
IGL01419:Vmn2r76	APN	7	85,874,910 (GRCm39)	missense	probably benign	0.32
IGL01627:Vmn2r76	APN	7	85,874,871 (GRCm39)	missense	probably damaging	1.00
IGL01730:Vmn2r76	APN	7	85,879,406 (GRCm39)	missense	probably benign	0.02
IGL01957:Vmn2r76	APN	7	85,877,925 (GRCm39)	missense	probably benign
IGL02214:Vmn2r76	APN	7	85,879,138 (GRCm39)	missense	probably benign	0.07
IGL02489:Vmn2r76	APN	7	85,878,071 (GRCm39)	missense	probably benign	0.41
IGL02543:Vmn2r76	APN	7	85,879,356 (GRCm39)	missense	probably benign	0.06
IGL02579:Vmn2r76	APN	7	85,877,961 (GRCm39)	nonsense	probably null
IGL02598:Vmn2r76	APN	7	85,877,879 (GRCm39)	missense	probably benign	0.05
IGL02720:Vmn2r76	APN	7	85,874,914 (GRCm39)	missense	probably benign	0.35
IGL02745:Vmn2r76	APN	7	85,879,495 (GRCm39)	missense	probably benign	0.06
IGL03393:Vmn2r76	APN	7	85,879,034 (GRCm39)	missense	probably benign	0.01
R0483:Vmn2r76	UTSW	7	85,874,959 (GRCm39)	missense	probably damaging	1.00
R0513:Vmn2r76	UTSW	7	85,877,987 (GRCm39)	missense	probably benign	0.01
R0528:Vmn2r76	UTSW	7	85,879,506 (GRCm39)	missense	possibly damaging	0.80
R0601:Vmn2r76	UTSW	7	85,875,323 (GRCm39)	critical splice acceptor site	probably null
R0662:Vmn2r76	UTSW	7	85,879,578 (GRCm39)	missense	probably benign	0.39
R0883:Vmn2r76	UTSW	7	85,877,904 (GRCm39)	missense	probably benign	0.00
R1532:Vmn2r76	UTSW	7	85,879,454 (GRCm39)	missense	probably benign	0.02
R1694:Vmn2r76	UTSW	7	85,879,356 (GRCm39)	missense	probably benign	0.06
R1696:Vmn2r76	UTSW	7	85,880,464 (GRCm39)	missense	possibly damaging	0.56
R2135:Vmn2r76	UTSW	7	85,880,219 (GRCm39)	missense	probably benign	0.02
R2151:Vmn2r76	UTSW	7	85,879,692 (GRCm39)	missense	probably benign
R2268:Vmn2r76	UTSW	7	85,879,707 (GRCm39)	missense	probably benign	0.03
R2877:Vmn2r76	UTSW	7	85,875,201 (GRCm39)	missense	probably benign	0.00
R3155:Vmn2r76	UTSW	7	85,874,959 (GRCm39)	missense	probably damaging	1.00
R3746:Vmn2r76	UTSW	7	85,874,763 (GRCm39)	missense	probably benign	0.11
R3799:Vmn2r76	UTSW	7	85,875,244 (GRCm39)	missense	probably benign	0.00
R3825:Vmn2r76	UTSW	7	85,880,415 (GRCm39)	missense	probably benign	0.10
R4058:Vmn2r76	UTSW	7	85,879,508 (GRCm39)	missense	probably benign	0.00
R4237:Vmn2r76	UTSW	7	85,879,740 (GRCm39)	missense	probably benign	0.00
R4404:Vmn2r76	UTSW	7	85,877,511 (GRCm39)	missense	probably benign	0.16
R4796:Vmn2r76	UTSW	7	85,879,652 (GRCm39)	missense	possibly damaging	0.95
R4838:Vmn2r76	UTSW	7	85,874,733 (GRCm39)	missense	probably damaging	1.00
R5175:Vmn2r76	UTSW	7	85,877,915 (GRCm39)	missense	probably benign	0.00
R5268:Vmn2r76	UTSW	7	85,875,267 (GRCm39)	missense	probably damaging	1.00
R5381:Vmn2r76	UTSW	7	85,874,496 (GRCm39)	missense	probably damaging	1.00
R5531:Vmn2r76	UTSW	7	85,874,657 (GRCm39)	missense	probably damaging	1.00
R5566:Vmn2r76	UTSW	7	85,875,286 (GRCm39)	missense	probably damaging	1.00
R5646:Vmn2r76	UTSW	7	85,875,261 (GRCm39)	missense	probably damaging	0.98
R5664:Vmn2r76	UTSW	7	85,895,202 (GRCm39)	critical splice donor site	probably null
R5818:Vmn2r76	UTSW	7	85,879,142 (GRCm39)	missense	probably benign	0.00
R6093:Vmn2r76	UTSW	7	85,877,469 (GRCm39)	nonsense	probably null
R6651:Vmn2r76	UTSW	7	85,878,059 (GRCm39)	missense	possibly damaging	0.64
R6741:Vmn2r76	UTSW	7	85,879,560 (GRCm39)	missense	probably benign
R6750:Vmn2r76	UTSW	7	85,875,114 (GRCm39)	missense	probably damaging	1.00
R7082:Vmn2r76	UTSW	7	85,874,440 (GRCm39)	missense	probably benign	0.01
R7136:Vmn2r76	UTSW	7	85,877,975 (GRCm39)	missense	probably benign	0.06
R7524:Vmn2r76	UTSW	7	85,879,374 (GRCm39)	missense	probably benign	0.00
R7524:Vmn2r76	UTSW	7	85,874,577 (GRCm39)	missense	probably benign	0.22
R7611:Vmn2r76	UTSW	7	85,879,388 (GRCm39)	missense	probably benign	0.04
R7833:Vmn2r76	UTSW	7	85,877,892 (GRCm39)	missense	probably benign
R8002:Vmn2r76	UTSW	7	85,879,271 (GRCm39)	missense	probably benign	0.05
R8021:Vmn2r76	UTSW	7	85,874,958 (GRCm39)	missense	probably damaging	1.00
R8023:Vmn2r76	UTSW	7	85,879,028 (GRCm39)	missense	probably benign	0.00
R8250:Vmn2r76	UTSW	7	85,875,231 (GRCm39)	missense	possibly damaging	0.82
R8428:Vmn2r76	UTSW	7	85,874,479 (GRCm39)	missense	possibly damaging	0.63
R8874:Vmn2r76	UTSW	7	85,877,999 (GRCm39)	missense	probably damaging	1.00
R9139:Vmn2r76	UTSW	7	85,879,170 (GRCm39)	missense	probably benign	0.02
R9357:Vmn2r76	UTSW	7	85,880,428 (GRCm39)	missense	probably benign	0.43
Z1176:Vmn2r76	UTSW	7	85,895,271 (GRCm39)	missense	probably benign	0.39

Predicted Primers

PCR Primer
(F):5'- TAAGGCCTTTCCATTGGTGC -3'
(R):5'- ACAATTACTGTAGTACTGGCCTTCAG -3'

Sequencing Primer
(F):5'- CCATTGGTGCTATGATAGACAGG -3'
(R):5'- CAGGTTCACTCTTCCTAGTAAAAGG -3'

Posted On

2014-10-02