Mutagenetix > Incidental Mutation

Incidental Mutation 'R2182:Or13p3'

237226

Institutional Source

Beutler Lab

Gene Symbol

Or13p3

Ensembl Gene

ENSMUSG00000046790

Gene Name

olfactory receptor family 13 subfamily P member 3

Synonyms

GA_x6K02T2QD9B-18838170-18837232, MOR258-1, Olfr1341

MMRRC Submission

040184-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

R2182 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

118566606-118567544 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 118567542 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Arginine at position 313 (*313R)

Ref Sequence

ENSEMBL: ENSMUSP00000149466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061215] [ENSMUST00000214131] [ENSMUST00000215117]

AlphaFold

Q7TQV4

Predicted Effect

probably null
Transcript: ENSMUST00000061215
AA Change: *313R

SMART Domains

Protein: ENSMUSP00000095523
Gene: ENSMUSG00000046790
AA Change: *313R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	8.4e-54	PFAM
Pfam:7TM_GPCR_Srsx	35	304	1.5e-7	PFAM
Pfam:7tm_1	41	290	1.7e-24	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214131
AA Change: *313R

Predicted Effect

probably null
Transcript: ENSMUST00000215117
AA Change: *313R

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930550C14Rik	A	G	9: 53,334,243 (GRCm39)	H17R	probably damaging	Het
Abca15	G	A	7: 119,939,450 (GRCm39)	W281*	probably null	Het
Aloxe3	G	A	11: 69,020,426 (GRCm39)	V157M	possibly damaging	Het
Arhgap26	G	T	18: 39,490,862 (GRCm39)		probably benign	Het
Atp7b	T	C	8: 22,504,563 (GRCm39)	N698S	probably damaging	Het
Clec4a4	A	G	6: 122,990,716 (GRCm39)		probably null	Het
Clgn	C	T	8: 84,137,039 (GRCm39)	T252I	possibly damaging	Het
Cyp2a12	A	T	7: 26,730,571 (GRCm39)	N179Y	probably damaging	Het
D630045J12Rik	C	T	6: 38,151,082 (GRCm39)		probably null	Het
Dennd5a	G	T	7: 109,533,201 (GRCm39)	R190S	probably benign	Het
Dtx4	C	A	19: 12,460,471 (GRCm39)	G384V	probably null	Het
Dxo	T	C	17: 35,057,868 (GRCm39)	V191A	probably benign	Het
Eprs1	G	A	1: 185,111,939 (GRCm39)		probably null	Het
Fntb	A	G	12: 76,909,309 (GRCm39)	N99S	probably benign	Het
Gm5773	T	A	3: 93,680,820 (GRCm39)	I164K	probably benign	Het
Golm2	A	G	2: 121,697,909 (GRCm39)	D75G	probably damaging	Het
Hyal5	T	C	6: 24,877,879 (GRCm39)	I325T	probably damaging	Het
Igsf8	G	A	1: 172,118,295 (GRCm39)		probably null	Het
Lamc2	A	G	1: 153,002,612 (GRCm39)	V17A	possibly damaging	Het
Lpxn	T	C	19: 12,810,122 (GRCm39)		probably null	Het
Macf1	A	G	4: 123,386,464 (GRCm39)	V1296A	probably damaging	Het
Mpdz	A	T	4: 81,266,959 (GRCm39)	L318Q	probably damaging	Het
Mpl	T	A	4: 118,314,610 (GRCm39)	Q13L	probably benign	Het
Mpnd	A	G	17: 56,322,964 (GRCm39)	S399G	probably benign	Het
Mrps5	T	C	2: 127,444,407 (GRCm39)	L347P	probably damaging	Het
Naip1	T	A	13: 100,550,188 (GRCm39)	Q1217H	probably benign	Het
Nav2	G	A	7: 49,247,002 (GRCm39)	V2176I	probably benign	Het
Obi1	A	G	14: 104,743,612 (GRCm39)	S156P	possibly damaging	Het
Or7g33	T	C	9: 19,448,638 (GRCm39)	N196S	probably benign	Het
Or8b43	A	G	9: 38,360,420 (GRCm39)	N84S	probably benign	Het
Or8g36	A	T	9: 39,422,722 (GRCm39)	M98K	probably damaging	Het
Pbx2	C	A	17: 34,814,640 (GRCm39)	Y324*	probably null	Het
Pcsk7	T	A	9: 45,839,917 (GRCm39)	C702S	probably benign	Het
Pramel11	T	A	4: 143,623,760 (GRCm39)	H138L	possibly damaging	Het
Rictor	T	C	15: 6,801,685 (GRCm39)	S458P	probably damaging	Het
Scaf4	T	C	16: 90,027,028 (GRCm39)	M905V	probably benign	Het
Scarf2	T	C	16: 17,620,886 (GRCm39)	C185R	probably damaging	Het
Scd1	T	G	19: 44,391,732 (GRCm39)	I101L	probably benign	Het
Slc6a2	A	G	8: 93,687,876 (GRCm39)	M1V	probably null	Het
Sost	T	C	11: 101,854,676 (GRCm39)	Y211C	probably damaging	Het
Sphkap	A	G	1: 83,254,405 (GRCm39)	S828P	probably damaging	Het
Tnn	T	C	1: 159,968,170 (GRCm39)		probably null	Het
Tnrc18	T	C	5: 142,745,816 (GRCm39)	K1319R	unknown	Het
Vmn2r60	A	G	7: 41,844,931 (GRCm39)	T765A	probably benign	Het
Vmn2r91	C	A	17: 18,325,691 (GRCm39)	T103K	possibly damaging	Het
Zbtb44	T	C	9: 30,977,972 (GRCm39)	C429R	possibly damaging	Het
Zc3h4	G	A	7: 16,156,441 (GRCm39)	G327D	unknown	Het
Zfp292	A	G	4: 34,807,417 (GRCm39)	C1876R	probably damaging	Het
Zfp839	C	T	12: 110,834,772 (GRCm39)	L676F	probably damaging	Het
Zg16	A	G	7: 126,649,544 (GRCm39)	L139P	probably damaging	Het
Zscan12	A	G	13: 21,552,961 (GRCm39)	I262V	probably benign	Het

Other mutations in Or13p3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Or13p3	APN	4	118,567,119 (GRCm39)	missense	probably damaging	1.00
IGL02699:Or13p3	APN	4	118,567,395 (GRCm39)	missense	probably benign	0.36
IGL02798:Or13p3	APN	4	118,566,696 (GRCm39)	missense	probably damaging	0.97
IGL03271:Or13p3	APN	4	118,566,982 (GRCm39)	missense	probably damaging	0.99
R0085:Or13p3	UTSW	4	118,567,078 (GRCm39)	missense	probably benign	0.18
R0355:Or13p3	UTSW	4	118,566,808 (GRCm39)	missense	probably benign	0.06
R1134:Or13p3	UTSW	4	118,567,476 (GRCm39)	missense	probably damaging	0.97
R1561:Or13p3	UTSW	4	118,566,751 (GRCm39)	missense	probably damaging	0.99
R1574:Or13p3	UTSW	4	118,566,751 (GRCm39)	missense	probably damaging	0.99
R2167:Or13p3	UTSW	4	118,567,252 (GRCm39)	missense	probably benign	0.18
R2237:Or13p3	UTSW	4	118,567,192 (GRCm39)	missense	probably damaging	1.00
R3775:Or13p3	UTSW	4	118,567,351 (GRCm39)	missense	probably damaging	1.00
R6000:Or13p3	UTSW	4	118,567,441 (GRCm39)	missense	probably damaging	1.00
R6249:Or13p3	UTSW	4	118,566,910 (GRCm39)	missense	probably damaging	1.00
R6331:Or13p3	UTSW	4	118,567,144 (GRCm39)	missense	probably benign	0.34
R6527:Or13p3	UTSW	4	118,567,045 (GRCm39)	missense	possibly damaging	0.56
R7795:Or13p3	UTSW	4	118,566,855 (GRCm39)	missense	possibly damaging	0.94
R8752:Or13p3	UTSW	4	118,567,083 (GRCm39)	missense	probably damaging	1.00
R9281:Or13p3	UTSW	4	118,566,592 (GRCm39)	start gained	probably benign
R9366:Or13p3	UTSW	4	118,566,831 (GRCm39)	missense	probably damaging	0.98
R9389:Or13p3	UTSW	4	118,567,353 (GRCm39)	missense	probably benign	0.01
R9518:Or13p3	UTSW	4	118,567,120 (GRCm39)	missense	probably damaging	0.98
X0063:Or13p3	UTSW	4	118,566,952 (GRCm39)	missense	probably damaging	1.00
Z1088:Or13p3	UTSW	4	118,567,423 (GRCm39)	missense	probably benign	0.00
Z1177:Or13p3	UTSW	4	118,567,355 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AAAGCCTTCTCCACCTGTGC -3'
(R):5'- TGCCTGGGAGACAATTCACAG -3'

Sequencing Primer
(F):5'- ACATCACTGTGGTCACCATG -3'
(R):5'- TGGGAGACAATTCACAGTGCCC -3'

Posted On

2014-10-02