Incidental Mutation 'R2171:Smg6'
ID |
237500 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Smg6
|
Ensembl Gene |
ENSMUSG00000038290 |
Gene Name |
SMG6 nonsense mediated mRNA decay factor |
Synonyms |
Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) |
MMRRC Submission |
040173-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R2171 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
74816665-75055274 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 74929472 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Leucine
at position 967
(Q967L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000043555
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045281]
[ENSMUST00000140197]
|
AlphaFold |
P61406 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000045281
AA Change: Q967L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000043555 Gene: ENSMUSG00000038290 AA Change: Q967L
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
42 |
99 |
7.68e-6 |
PROSPERO |
internal_repeat_1
|
135 |
188 |
7.68e-6 |
PROSPERO |
low complexity region
|
212 |
227 |
N/A |
INTRINSIC |
low complexity region
|
257 |
271 |
N/A |
INTRINSIC |
low complexity region
|
376 |
390 |
N/A |
INTRINSIC |
low complexity region
|
417 |
426 |
N/A |
INTRINSIC |
low complexity region
|
436 |
453 |
N/A |
INTRINSIC |
low complexity region
|
538 |
549 |
N/A |
INTRINSIC |
coiled coil region
|
574 |
600 |
N/A |
INTRINSIC |
Pfam:EST1
|
637 |
742 |
1.8e-18 |
PFAM |
Pfam:EST1_DNA_bind
|
750 |
1106 |
1.6e-78 |
PFAM |
coiled coil region
|
1197 |
1234 |
N/A |
INTRINSIC |
PINc
|
1245 |
1396 |
2.85e-25 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000130145
|
SMART Domains |
Protein: ENSMUSP00000120229 Gene: ENSMUSG00000038290
Domain | Start | End | E-Value | Type |
coiled coil region
|
35 |
61 |
N/A |
INTRINSIC |
Pfam:EST1
|
99 |
204 |
1.3e-19 |
PFAM |
Pfam:EST1_DNA_bind
|
212 |
339 |
7.3e-37 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000140197
AA Change: Q28L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000120060 Gene: ENSMUSG00000038290 AA Change: Q28L
Domain | Start | End | E-Value | Type |
Pfam:EST1_DNA_bind
|
2 |
167 |
4.9e-25 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155508
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014] PHENOTYPE: Homozygosity for insertion of a transgene into intron 6 of the gene results in embryonic lethality. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice homozygous for a conditional allele activated in embryonic stem cells exhibit defective telomere maintenance and NMD. [provided by MGI curators]
|
Allele List at MGI |
All alleles(52) : Gene trapped(52)
|
Other mutations in this stock |
Total: 56 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abt1 |
A |
G |
13: 23,606,387 (GRCm39) |
L189P |
probably damaging |
Het |
Adgrl3 |
C |
A |
5: 81,660,362 (GRCm39) |
S377* |
probably null |
Het |
Adgrv1 |
A |
G |
13: 81,419,037 (GRCm39) |
V5986A |
probably damaging |
Het |
Arv1 |
T |
G |
8: 125,455,094 (GRCm39) |
C102W |
probably damaging |
Het |
Asb18 |
T |
C |
1: 89,896,419 (GRCm39) |
H207R |
probably benign |
Het |
Bach2 |
T |
C |
4: 32,501,662 (GRCm39) |
V13A |
probably damaging |
Het |
Bccip |
T |
C |
7: 133,320,843 (GRCm39) |
S206P |
probably benign |
Het |
Cdhr4 |
T |
C |
9: 107,870,117 (GRCm39) |
S41P |
probably benign |
Het |
Chd7 |
A |
G |
4: 8,752,424 (GRCm39) |
Y307C |
probably damaging |
Het |
Clec4f |
A |
T |
6: 83,629,846 (GRCm39) |
S237R |
possibly damaging |
Het |
Cntnap5a |
A |
G |
1: 116,116,132 (GRCm39) |
D538G |
possibly damaging |
Het |
Col9a2 |
T |
A |
4: 120,902,198 (GRCm39) |
C173* |
probably null |
Het |
Ctr9 |
T |
A |
7: 110,646,117 (GRCm39) |
M703K |
possibly damaging |
Het |
Cyp2a12 |
A |
G |
7: 26,729,057 (GRCm39) |
Y83C |
probably damaging |
Het |
Eef1akmt3 |
A |
C |
10: 126,868,843 (GRCm39) |
D210E |
probably benign |
Het |
Erbin |
A |
G |
13: 103,971,466 (GRCm39) |
F717L |
probably benign |
Het |
Gtf3a |
A |
G |
5: 146,892,272 (GRCm39) |
N341S |
probably benign |
Het |
Hltf |
T |
C |
3: 20,113,245 (GRCm39) |
V6A |
probably damaging |
Het |
Itga6 |
T |
A |
2: 71,650,358 (GRCm39) |
Y135N |
probably damaging |
Het |
Krt73 |
T |
C |
15: 101,709,345 (GRCm39) |
Q154R |
possibly damaging |
Het |
Lce1a1 |
C |
T |
3: 92,554,048 (GRCm39) |
C142Y |
unknown |
Het |
Lcorl |
A |
T |
5: 45,904,493 (GRCm39) |
I112N |
probably damaging |
Het |
Ltbp1 |
C |
T |
17: 75,598,312 (GRCm39) |
H916Y |
probably damaging |
Het |
Lypla2 |
T |
C |
4: 135,697,915 (GRCm39) |
|
probably null |
Het |
Man1c1 |
G |
C |
4: 134,430,749 (GRCm39) |
P11R |
probably damaging |
Het |
Mmp1a |
T |
A |
9: 7,475,357 (GRCm39) |
D375E |
probably damaging |
Het |
Nlrp14 |
T |
G |
7: 106,781,709 (GRCm39) |
L302R |
probably damaging |
Het |
Npy2r |
T |
G |
3: 82,447,708 (GRCm39) |
T243P |
possibly damaging |
Het |
Or11h4 |
A |
T |
14: 50,973,876 (GRCm39) |
S248T |
probably benign |
Het |
Or51k2 |
T |
C |
7: 103,595,992 (GRCm39) |
V73A |
probably damaging |
Het |
Paqr9 |
A |
T |
9: 95,442,931 (GRCm39) |
H307L |
probably damaging |
Het |
Phc3 |
T |
C |
3: 31,005,078 (GRCm39) |
T172A |
probably damaging |
Het |
Pigs |
A |
G |
11: 78,219,638 (GRCm39) |
T39A |
probably damaging |
Het |
Pik3c2g |
C |
T |
6: 139,801,012 (GRCm39) |
Q386* |
probably null |
Het |
Pira2 |
T |
C |
7: 3,847,417 (GRCm39) |
S91G |
probably benign |
Het |
Plxna2 |
T |
A |
1: 194,482,925 (GRCm39) |
N1539K |
probably damaging |
Het |
Poc5 |
C |
T |
13: 96,547,257 (GRCm39) |
H507Y |
probably damaging |
Het |
Pou2f1 |
A |
T |
1: 165,707,925 (GRCm39) |
|
probably benign |
Het |
Pthlh |
T |
G |
6: 147,158,694 (GRCm39) |
K89Q |
probably damaging |
Het |
Rims4 |
A |
T |
2: 163,706,046 (GRCm39) |
|
probably null |
Het |
Rnf138 |
A |
G |
18: 21,159,143 (GRCm39) |
N188D |
probably damaging |
Het |
Rreb1 |
A |
G |
13: 38,114,822 (GRCm39) |
D727G |
probably benign |
Het |
Sc5d |
T |
G |
9: 42,166,682 (GRCm39) |
K286Q |
probably benign |
Het |
Slc10a5 |
C |
T |
3: 10,400,342 (GRCm39) |
G106D |
possibly damaging |
Het |
Spty2d1 |
C |
T |
7: 46,644,361 (GRCm39) |
R636H |
probably damaging |
Het |
Srms |
A |
T |
2: 180,850,573 (GRCm39) |
Y195* |
probably null |
Het |
Susd4 |
A |
G |
1: 182,719,759 (GRCm39) |
D458G |
probably benign |
Het |
Tecta |
T |
C |
9: 42,270,220 (GRCm39) |
R1363G |
probably damaging |
Het |
Thbs1 |
G |
A |
2: 117,953,060 (GRCm39) |
G890D |
probably damaging |
Het |
Tpp2 |
T |
C |
1: 43,996,606 (GRCm39) |
V317A |
probably benign |
Het |
Ttpa |
T |
C |
4: 20,021,357 (GRCm39) |
V175A |
probably damaging |
Het |
Vps13b |
G |
T |
15: 35,887,343 (GRCm39) |
D3251Y |
probably benign |
Het |
Vps54 |
A |
G |
11: 21,248,810 (GRCm39) |
D441G |
probably benign |
Het |
Zfp738 |
A |
T |
13: 67,819,096 (GRCm39) |
Y298* |
probably null |
Het |
Zfp804a |
G |
A |
2: 82,087,527 (GRCm39) |
C452Y |
possibly damaging |
Het |
Zxdc |
A |
G |
6: 90,359,461 (GRCm39) |
K698E |
possibly damaging |
Het |
|
Other mutations in Smg6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00952:Smg6
|
APN |
11 |
74,819,974 (GRCm39) |
missense |
probably benign |
|
IGL01146:Smg6
|
APN |
11 |
74,821,254 (GRCm39) |
nonsense |
probably null |
|
IGL01505:Smg6
|
APN |
11 |
75,047,117 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01541:Smg6
|
APN |
11 |
74,816,770 (GRCm39) |
missense |
probably benign |
0.43 |
IGL01636:Smg6
|
APN |
11 |
74,825,929 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02379:Smg6
|
APN |
11 |
74,944,751 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02794:Smg6
|
APN |
11 |
74,944,760 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02964:Smg6
|
APN |
11 |
74,821,576 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03057:Smg6
|
APN |
11 |
74,826,260 (GRCm39) |
nonsense |
probably null |
|
1mM(1):Smg6
|
UTSW |
11 |
74,825,815 (GRCm39) |
splice site |
probably benign |
|
IGL03097:Smg6
|
UTSW |
11 |
74,823,252 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4802001:Smg6
|
UTSW |
11 |
75,046,991 (GRCm39) |
missense |
probably damaging |
0.96 |
R0269:Smg6
|
UTSW |
11 |
75,053,757 (GRCm39) |
missense |
probably benign |
|
R0344:Smg6
|
UTSW |
11 |
74,820,647 (GRCm39) |
missense |
probably damaging |
1.00 |
R0437:Smg6
|
UTSW |
11 |
74,820,527 (GRCm39) |
missense |
probably damaging |
1.00 |
R0452:Smg6
|
UTSW |
11 |
74,821,039 (GRCm39) |
missense |
probably benign |
|
R0511:Smg6
|
UTSW |
11 |
74,819,884 (GRCm39) |
missense |
probably damaging |
1.00 |
R0617:Smg6
|
UTSW |
11 |
75,053,757 (GRCm39) |
missense |
probably benign |
|
R0737:Smg6
|
UTSW |
11 |
75,050,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R1715:Smg6
|
UTSW |
11 |
74,820,256 (GRCm39) |
missense |
probably benign |
|
R1780:Smg6
|
UTSW |
11 |
74,836,942 (GRCm39) |
missense |
probably damaging |
1.00 |
R1927:Smg6
|
UTSW |
11 |
75,033,674 (GRCm39) |
missense |
probably damaging |
1.00 |
R2073:Smg6
|
UTSW |
11 |
74,821,120 (GRCm39) |
missense |
probably damaging |
1.00 |
R2513:Smg6
|
UTSW |
11 |
74,820,502 (GRCm39) |
missense |
probably damaging |
1.00 |
R3943:Smg6
|
UTSW |
11 |
74,820,367 (GRCm39) |
missense |
probably damaging |
1.00 |
R3944:Smg6
|
UTSW |
11 |
74,820,367 (GRCm39) |
missense |
probably damaging |
1.00 |
R4275:Smg6
|
UTSW |
11 |
74,884,700 (GRCm39) |
intron |
probably benign |
|
R4369:Smg6
|
UTSW |
11 |
74,823,269 (GRCm39) |
nonsense |
probably null |
|
R4452:Smg6
|
UTSW |
11 |
74,880,967 (GRCm39) |
missense |
probably benign |
0.14 |
R4864:Smg6
|
UTSW |
11 |
74,820,988 (GRCm39) |
missense |
possibly damaging |
0.89 |
R4885:Smg6
|
UTSW |
11 |
74,932,744 (GRCm39) |
missense |
probably damaging |
1.00 |
R5043:Smg6
|
UTSW |
11 |
74,820,721 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5189:Smg6
|
UTSW |
11 |
74,932,822 (GRCm39) |
missense |
probably damaging |
1.00 |
R5378:Smg6
|
UTSW |
11 |
74,932,820 (GRCm39) |
missense |
possibly damaging |
0.61 |
R5518:Smg6
|
UTSW |
11 |
74,944,724 (GRCm39) |
missense |
probably damaging |
0.99 |
R5725:Smg6
|
UTSW |
11 |
74,821,439 (GRCm39) |
missense |
probably benign |
0.45 |
R5746:Smg6
|
UTSW |
11 |
75,030,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Smg6
|
UTSW |
11 |
75,047,033 (GRCm39) |
missense |
probably damaging |
0.96 |
R6319:Smg6
|
UTSW |
11 |
75,047,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R6349:Smg6
|
UTSW |
11 |
74,944,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6500:Smg6
|
UTSW |
11 |
74,821,331 (GRCm39) |
missense |
possibly damaging |
0.74 |
R6619:Smg6
|
UTSW |
11 |
74,823,279 (GRCm39) |
critical splice donor site |
probably null |
|
R6820:Smg6
|
UTSW |
11 |
74,932,790 (GRCm39) |
missense |
probably damaging |
0.99 |
R6923:Smg6
|
UTSW |
11 |
74,820,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
R7361:Smg6
|
UTSW |
11 |
74,820,979 (GRCm39) |
missense |
probably benign |
0.00 |
R7494:Smg6
|
UTSW |
11 |
74,820,449 (GRCm39) |
missense |
probably benign |
|
R7498:Smg6
|
UTSW |
11 |
74,819,932 (GRCm39) |
missense |
probably benign |
0.01 |
R7681:Smg6
|
UTSW |
11 |
74,822,531 (GRCm39) |
missense |
probably damaging |
1.00 |
R7710:Smg6
|
UTSW |
11 |
74,821,445 (GRCm39) |
missense |
probably benign |
0.26 |
R7770:Smg6
|
UTSW |
11 |
74,884,687 (GRCm39) |
missense |
unknown |
|
R8159:Smg6
|
UTSW |
11 |
74,929,465 (GRCm39) |
missense |
probably damaging |
1.00 |
R8381:Smg6
|
UTSW |
11 |
74,822,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R8463:Smg6
|
UTSW |
11 |
74,820,886 (GRCm39) |
missense |
probably benign |
0.14 |
R8509:Smg6
|
UTSW |
11 |
74,932,702 (GRCm39) |
missense |
probably benign |
0.04 |
R8557:Smg6
|
UTSW |
11 |
75,047,064 (GRCm39) |
missense |
probably damaging |
0.98 |
R8743:Smg6
|
UTSW |
11 |
74,820,859 (GRCm39) |
missense |
probably benign |
|
R9240:Smg6
|
UTSW |
11 |
74,825,884 (GRCm39) |
missense |
probably damaging |
1.00 |
R9312:Smg6
|
UTSW |
11 |
74,820,877 (GRCm39) |
missense |
probably benign |
0.27 |
X0018:Smg6
|
UTSW |
11 |
74,820,812 (GRCm39) |
missense |
possibly damaging |
0.76 |
Z1186:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1187:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1188:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1189:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1190:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1191:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
Z1192:Smg6
|
UTSW |
11 |
75,047,092 (GRCm39) |
missense |
probably benign |
0.06 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCATCCTTCTGTGTGCAG -3'
(R):5'- CTGAGAGAAGACTGAGCACC -3'
Sequencing Primer
(F):5'- CAGGGCATGCTGGCAAGTG -3'
(R):5'- CAGCACTCTAAGGTTCATCTGGAC -3'
|
Posted On |
2014-10-02 |