Incidental Mutation 'R2187:Fndc1'
ID 237900
Institutional Source Beutler Lab
Gene Symbol Fndc1
Ensembl Gene ENSMUSG00000071984
Gene Name fibronectin type III domain containing 1
Synonyms 1110027O12Rik
MMRRC Submission 040189-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R2187 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 7957401-8046134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 7960604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 1604 (I1604F)
Ref Sequence ENSEMBL: ENSMUSP00000095036 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097425]
AlphaFold A0A6I8MWX0
Predicted Effect noncoding transcript
Transcript: ENSMUST00000097424
Predicted Effect probably damaging
Transcript: ENSMUST00000097425
AA Change: I1604F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000095036
Gene: ENSMUSG00000071984
AA Change: I1604F

DomainStartEndE-ValueType
Blast:FN3 1 50 6e-25 BLAST
FN3 54 137 7.82e-4 SMART
FN3 156 240 1.48e-4 SMART
FN3 256 340 3.67e-9 SMART
low complexity region 377 388 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 646 676 N/A INTRINSIC
low complexity region 766 777 N/A INTRINSIC
low complexity region 868 884 N/A INTRINSIC
low complexity region 1021 1027 N/A INTRINSIC
low complexity region 1036 1050 N/A INTRINSIC
low complexity region 1076 1090 N/A INTRINSIC
Blast:FN3 1227 1276 2e-18 BLAST
low complexity region 1277 1354 N/A INTRINSIC
low complexity region 1395 1403 N/A INTRINSIC
low complexity region 1407 1423 N/A INTRINSIC
FN3 1494 1577 4.32e-6 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 T A 17: 31,324,491 (GRCm39) S245R probably damaging Het
AI597479 T A 1: 43,139,983 (GRCm39) W70R probably damaging Het
Ankrd55 A G 13: 112,520,039 (GRCm39) S575G probably benign Het
Bfsp2 T A 9: 103,303,976 (GRCm39) K343* probably null Het
Cant1 A T 11: 118,299,667 (GRCm39) Y227* probably null Het
Cd2bp2 T C 7: 126,793,963 (GRCm39) N109D probably benign Het
Chmp6 A G 11: 119,807,562 (GRCm39) E135G possibly damaging Het
Dsp T G 13: 38,360,383 (GRCm39) S329R probably damaging Het
Epha5 A T 5: 84,234,223 (GRCm39) F767L probably damaging Het
Epha7 A T 4: 28,942,648 (GRCm39) T566S possibly damaging Het
Erap1 A T 13: 74,810,524 (GRCm39) I288F probably damaging Het
Erich6 A G 3: 58,537,266 (GRCm39) probably null Het
Fbxo10 A G 4: 45,058,531 (GRCm39) V402A probably benign Het
Foxd4 T G 19: 24,877,219 (GRCm39) Q327P probably damaging Het
Fxn T A 19: 24,257,853 (GRCm39) N26I probably benign Het
Hsf5 G T 11: 87,529,010 (GRCm39) G582C possibly damaging Het
Itga8 A G 2: 12,199,231 (GRCm39) V522A possibly damaging Het
Kplce A G 3: 92,775,922 (GRCm39) S254P probably damaging Het
Lyst C T 13: 13,883,926 (GRCm39) T2938I possibly damaging Het
Mib2 T C 4: 155,739,390 (GRCm39) E863G possibly damaging Het
Mrgpra9 A G 7: 46,884,797 (GRCm39) F290S probably damaging Het
Mst1 T C 9: 107,961,539 (GRCm39) Y599H possibly damaging Het
Mylk4 T C 13: 32,905,996 (GRCm39) I165V probably damaging Het
Nipsnap2 T C 5: 129,823,537 (GRCm39) probably null Het
Nol8 T C 13: 49,815,475 (GRCm39) Y528H probably benign Het
Nup93 T A 8: 95,027,478 (GRCm39) S295R probably damaging Het
Nutm2 A T 13: 50,621,453 (GRCm39) Q6L probably benign Het
Or2b6 A T 13: 21,823,555 (GRCm39) I46N probably damaging Het
Or5ak20 T G 2: 85,184,259 (GRCm39) S4R probably benign Het
Or5b12b T A 19: 12,861,619 (GRCm39) C125S probably damaging Het
Or6c33 A G 10: 129,853,557 (GRCm39) E109G probably damaging Het
Pip5k1a A T 3: 94,979,229 (GRCm39) L189Q probably damaging Het
Plekha4 C T 7: 45,198,698 (GRCm39) R574C probably damaging Het
Ppp2cb A G 8: 34,100,705 (GRCm39) E42G possibly damaging Het
Prkd3 T A 17: 79,282,983 (GRCm39) Q244L probably benign Het
Ptpn14 C T 1: 189,595,425 (GRCm39) R1023* probably null Het
Ptpra A G 2: 130,346,219 (GRCm39) T127A probably benign Het
Rad54l2 ACCTCCTCCTCCTCCTCCTCCTCCTC ACCTCCTCCTCCTCCTCCTCCTC 9: 106,631,191 (GRCm39) probably benign Het
Rasgrf1 T C 9: 89,876,888 (GRCm39) I751T possibly damaging Het
Rbm27 A G 18: 42,459,022 (GRCm39) K697R probably damaging Het
Rhoa C T 9: 108,212,352 (GRCm39) T127M probably benign Het
Rnpepl1 A G 1: 92,844,617 (GRCm39) S370G probably null Het
Sdk1 C T 5: 142,100,329 (GRCm39) T1453I probably damaging Het
Sel1l2 A G 2: 140,072,793 (GRCm39) L614S probably damaging Het
Slc6a20b T A 9: 123,427,653 (GRCm39) I419F probably damaging Het
Slc8a1 C T 17: 81,955,982 (GRCm39) S352N possibly damaging Het
Spta1 A G 1: 174,020,532 (GRCm39) D547G probably damaging Het
Tc2n G A 12: 101,672,803 (GRCm39) T46I probably damaging Het
Terb1 T A 8: 105,199,516 (GRCm39) Y476F probably benign Het
Trim12a T A 7: 103,953,399 (GRCm39) E237D probably damaging Het
Usp47 T C 7: 111,666,398 (GRCm39) L309P probably damaging Het
Other mutations in Fndc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Fndc1 APN 17 7,984,086 (GRCm39) missense unknown
IGL00590:Fndc1 APN 17 7,983,933 (GRCm39) missense unknown
IGL00765:Fndc1 APN 17 7,991,525 (GRCm39) missense unknown
IGL00904:Fndc1 APN 17 7,975,195 (GRCm39) missense probably benign 0.35
IGL01153:Fndc1 APN 17 7,998,874 (GRCm39) critical splice donor site probably null
IGL01557:Fndc1 APN 17 7,975,221 (GRCm39) missense probably damaging 0.99
IGL02493:Fndc1 APN 17 7,994,377 (GRCm39) missense unknown
IGL02501:Fndc1 APN 17 7,984,230 (GRCm39) missense unknown
IGL02503:Fndc1 APN 17 7,990,348 (GRCm39) missense unknown
IGL02887:Fndc1 APN 17 7,992,470 (GRCm39) missense unknown
IGL03348:Fndc1 APN 17 7,991,479 (GRCm39) missense unknown
pinnacle UTSW 17 7,992,154 (GRCm39) missense unknown
spire UTSW 17 7,990,312 (GRCm39) missense unknown
IGL02988:Fndc1 UTSW 17 7,972,355 (GRCm39) missense possibly damaging 0.95
PIT4466001:Fndc1 UTSW 17 7,969,206 (GRCm39) missense probably damaging 1.00
R0336:Fndc1 UTSW 17 7,983,939 (GRCm39) missense unknown
R0403:Fndc1 UTSW 17 7,994,420 (GRCm39) splice site probably null
R0403:Fndc1 UTSW 17 7,972,555 (GRCm39) missense probably damaging 1.00
R0538:Fndc1 UTSW 17 8,003,173 (GRCm39) splice site probably benign
R0646:Fndc1 UTSW 17 7,960,505 (GRCm39) missense possibly damaging 0.92
R1140:Fndc1 UTSW 17 7,994,258 (GRCm39) missense unknown
R1523:Fndc1 UTSW 17 7,992,041 (GRCm39) missense unknown
R1609:Fndc1 UTSW 17 7,991,598 (GRCm39) missense unknown
R1632:Fndc1 UTSW 17 7,992,032 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R2004:Fndc1 UTSW 17 8,023,761 (GRCm39) missense probably damaging 1.00
R2007:Fndc1 UTSW 17 7,997,580 (GRCm39) unclassified probably benign
R2128:Fndc1 UTSW 17 7,997,497 (GRCm39) unclassified probably benign
R2251:Fndc1 UTSW 17 7,972,439 (GRCm39) missense probably damaging 1.00
R2322:Fndc1 UTSW 17 8,007,847 (GRCm39) missense probably damaging 0.98
R2425:Fndc1 UTSW 17 8,023,850 (GRCm39) missense probably damaging 1.00
R2921:Fndc1 UTSW 17 8,023,707 (GRCm39) missense probably damaging 0.98
R2985:Fndc1 UTSW 17 7,975,155 (GRCm39) missense possibly damaging 0.93
R3436:Fndc1 UTSW 17 7,969,189 (GRCm39) missense probably damaging 0.99
R3499:Fndc1 UTSW 17 7,972,416 (GRCm39) missense possibly damaging 0.70
R3508:Fndc1 UTSW 17 7,983,940 (GRCm39) nonsense probably null
R3766:Fndc1 UTSW 17 8,003,253 (GRCm39) missense probably damaging 1.00
R3813:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R3814:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R4031:Fndc1 UTSW 17 7,988,584 (GRCm39) nonsense probably null
R4544:Fndc1 UTSW 17 7,992,376 (GRCm39) missense unknown
R4583:Fndc1 UTSW 17 7,958,081 (GRCm39) missense probably damaging 1.00
R4619:Fndc1 UTSW 17 7,984,036 (GRCm39) missense unknown
R4700:Fndc1 UTSW 17 7,990,312 (GRCm39) missense unknown
R4743:Fndc1 UTSW 17 7,991,111 (GRCm39) nonsense probably null
R4803:Fndc1 UTSW 17 7,972,538 (GRCm39) missense probably damaging 0.98
R4862:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R4876:Fndc1 UTSW 17 7,990,471 (GRCm39) missense unknown
R5057:Fndc1 UTSW 17 7,990,802 (GRCm39) nonsense probably null
R5327:Fndc1 UTSW 17 7,991,540 (GRCm39) missense unknown
R5372:Fndc1 UTSW 17 7,984,042 (GRCm39) missense unknown
R5533:Fndc1 UTSW 17 7,991,608 (GRCm39) missense unknown
R5754:Fndc1 UTSW 17 7,988,585 (GRCm39) missense unknown
R5762:Fndc1 UTSW 17 7,990,366 (GRCm39) missense unknown
R5830:Fndc1 UTSW 17 8,007,918 (GRCm39) missense possibly damaging 0.87
R5924:Fndc1 UTSW 17 7,992,442 (GRCm39) missense unknown
R6147:Fndc1 UTSW 17 7,972,594 (GRCm39) splice site probably null
R6175:Fndc1 UTSW 17 7,991,479 (GRCm39) missense unknown
R6303:Fndc1 UTSW 17 7,977,317 (GRCm39) missense probably damaging 0.98
R6377:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R6704:Fndc1 UTSW 17 7,990,642 (GRCm39) missense unknown
R6857:Fndc1 UTSW 17 7,991,002 (GRCm39) missense unknown
R6865:Fndc1 UTSW 17 7,991,672 (GRCm39) missense unknown
R7069:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R7153:Fndc1 UTSW 17 8,020,477 (GRCm39) missense probably damaging 1.00
R7159:Fndc1 UTSW 17 8,019,763 (GRCm39) missense probably damaging 0.97
R7359:Fndc1 UTSW 17 8,032,318 (GRCm39) splice site probably null
R7731:Fndc1 UTSW 17 7,992,271 (GRCm39) missense unknown
R7743:Fndc1 UTSW 17 7,983,969 (GRCm39) missense unknown
R7884:Fndc1 UTSW 17 7,992,029 (GRCm39) missense unknown
R8071:Fndc1 UTSW 17 7,991,362 (GRCm39) missense unknown
R8100:Fndc1 UTSW 17 7,990,685 (GRCm39) missense unknown
R8317:Fndc1 UTSW 17 8,019,720 (GRCm39) nonsense probably null
R8362:Fndc1 UTSW 17 8,001,207 (GRCm39) missense unknown
R8835:Fndc1 UTSW 17 7,958,111 (GRCm39) missense probably damaging 1.00
R8841:Fndc1 UTSW 17 7,992,181 (GRCm39) missense unknown
R8912:Fndc1 UTSW 17 8,019,778 (GRCm39) missense probably null 0.26
R9236:Fndc1 UTSW 17 7,992,460 (GRCm39) missense unknown
R9392:Fndc1 UTSW 17 7,991,957 (GRCm39) missense unknown
R9412:Fndc1 UTSW 17 7,991,198 (GRCm39) missense unknown
R9618:Fndc1 UTSW 17 7,990,313 (GRCm39) missense unknown
R9632:Fndc1 UTSW 17 7,991,622 (GRCm39) missense unknown
R9748:Fndc1 UTSW 17 7,991,929 (GRCm39) missense unknown
Z1088:Fndc1 UTSW 17 8,001,311 (GRCm39) missense probably damaging 0.96
Z1176:Fndc1 UTSW 17 8,023,709 (GRCm39) missense possibly damaging 0.90
Z1176:Fndc1 UTSW 17 7,992,425 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCCATCCATGTGTAAGACTTACC -3'
(R):5'- GTTAACCCATGATTAAGTGAGAGC -3'

Sequencing Primer
(F):5'- GACTTACCTTTGAGATTGTCACTGAG -3'
(R):5'- AGGAAGGCAGTTGTCTGA -3'
Posted On 2014-10-02