Incidental Mutation 'R2191:Flrt1'
ID 238160
Institutional Source Beutler Lab
Gene Symbol Flrt1
Ensembl Gene ENSMUSG00000047787
Gene Name fibronectin leucine rich transmembrane protein 1
Synonyms D630040I23Rik
MMRRC Submission 040193-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R2191 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 7069366-7083094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7073194 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 451 (I451T)
Ref Sequence ENSEMBL: ENSMUSP00000109010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040261
SMART Domains Protein: ENSMUSP00000039507
Gene: ENSMUSG00000036278

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 25 41 N/A INTRINSIC
low complexity region 59 74 N/A INTRINSIC
A1pp 151 281 7.67e-46 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000113383
AA Change: I451T

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000109010
Gene: ENSMUSG00000047787
AA Change: I451T

DomainStartEndE-ValueType
low complexity region 2 28 N/A INTRINSIC
LRRNT 53 85 4.11e-6 SMART
LRR 127 149 2.61e1 SMART
LRR 150 175 4.71e1 SMART
LRR 177 199 1.76e1 SMART
LRR 200 220 7.36e0 SMART
LRR 221 246 1.49e1 SMART
LRR 247 270 9.77e1 SMART
LRR 271 292 1.53e1 SMART
LRR_TYP 293 316 3.55e-6 SMART
LRRCT 328 379 5.19e-9 SMART
low complexity region 381 392 N/A INTRINSIC
FN3 434 515 1.49e0 SMART
transmembrane domain 556 578 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A G 6: 23,078,865 (GRCm39) S716P possibly damaging Het
Abcb5 A C 12: 118,831,691 (GRCm39) N1220K probably damaging Het
Acsl3 A T 1: 78,676,857 (GRCm39) E479D probably damaging Het
Actn1 A T 12: 80,218,576 (GRCm39) L736* probably null Het
Adcyap1 A G 17: 93,507,454 (GRCm39) S5G possibly damaging Het
Adgrv1 T C 13: 81,714,409 (GRCm39) N958S possibly damaging Het
Armc1 T A 3: 19,188,225 (GRCm39) N274Y probably damaging Het
Atp9b G A 18: 80,796,266 (GRCm39) R926W probably damaging Het
Cacna1e G T 1: 154,319,591 (GRCm39) Q1370K probably damaging Het
Cdip1 C T 16: 4,587,927 (GRCm39) S12N probably benign Het
Chrna3 T A 9: 54,923,329 (GRCm39) I160F probably damaging Het
Cnot1 A G 8: 96,488,054 (GRCm39) I534T probably damaging Het
Cr2 T A 1: 194,845,689 (GRCm39) I465F possibly damaging Het
Daw1 A G 1: 83,170,384 (GRCm39) D232G probably benign Het
Dcaf6 T C 1: 165,250,433 (GRCm39) T144A probably benign Het
Dhx30 A T 9: 109,915,186 (GRCm39) probably null Het
Dnah7a A G 1: 53,645,034 (GRCm39) S1001P possibly damaging Het
Dnajb9 T C 12: 44,253,856 (GRCm39) T184A probably benign Het
Dsg1b T C 18: 20,542,675 (GRCm39) *1061Q probably null Het
Dvl1 G A 4: 155,932,273 (GRCm39) V28I possibly damaging Het
Edem3 T A 1: 151,672,634 (GRCm39) V450D probably damaging Het
Ephb6 G T 6: 41,593,019 (GRCm39) R419L possibly damaging Het
Fbxo10 G C 4: 45,044,811 (GRCm39) P608R probably damaging Het
Gm6309 A T 5: 146,105,681 (GRCm39) V161E possibly damaging Het
Heatr5b A G 17: 79,081,106 (GRCm39) L1382P probably damaging Het
Igsf1 C A X: 48,872,027 (GRCm39) L714F probably damaging Het
Inpp4b C T 8: 82,723,931 (GRCm39) P488S probably damaging Het
Ints6l T A X: 55,550,110 (GRCm39) H678Q probably benign Het
Itprid1 A T 6: 55,944,704 (GRCm39) Q475L probably benign Het
Kdm2a A T 19: 4,406,959 (GRCm39) probably null Het
Khdrbs3 G T 15: 68,964,809 (GRCm39) V249F probably damaging Het
Kmt2d A T 15: 98,758,930 (GRCm39) probably null Het
Laptm4a T C 12: 8,972,296 (GRCm39) probably null Het
Lrp2bp C T 8: 46,466,206 (GRCm39) T105I probably benign Het
Lrrc37 A C 11: 103,509,793 (GRCm39) probably benign Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Mtmr3 A T 11: 4,449,032 (GRCm39) W244R probably damaging Het
Myo18a A G 11: 77,709,441 (GRCm39) D138G probably damaging Het
Nlrp9b A T 7: 19,757,587 (GRCm39) I275L probably benign Het
Nol6 C T 4: 41,118,720 (GRCm39) R719H probably benign Het
Omt2b G A 9: 78,235,457 (GRCm39) probably benign Het
Or2a54 T C 6: 43,092,999 (GRCm39) S108P probably benign Het
Or5h23 A T 16: 58,906,038 (GRCm39) D269E probably benign Het
Or8g23 A T 9: 38,971,701 (GRCm39) I87K probably benign Het
Pclo C T 5: 14,763,862 (GRCm39) L4112F unknown Het
Pglyrp2 T C 17: 32,634,931 (GRCm39) N477S probably benign Het
Phf20 T C 2: 156,118,574 (GRCm39) V426A probably benign Het
Pla2g4e CTT CTTT 2: 120,021,680 (GRCm39) probably null Het
Plagl1 A C 10: 13,004,685 (GRCm39) probably benign Het
Ppip5k2 A G 1: 97,671,835 (GRCm39) V479A probably damaging Het
Prkdc A C 16: 15,516,688 (GRCm39) T1021P probably damaging Het
Rdh7 C T 10: 127,724,467 (GRCm39) V6I probably benign Het
Rictor A T 15: 6,789,095 (GRCm39) H237L probably benign Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Rttn T C 18: 89,113,772 (GRCm39) probably null Het
Setd5 C T 6: 113,088,390 (GRCm39) Q173* probably null Het
Sipa1l1 T A 12: 82,443,465 (GRCm39) Y918* probably null Het
Slc13a1 T G 6: 24,134,396 (GRCm39) E162D possibly damaging Het
Slc39a9 G A 12: 80,709,301 (GRCm39) A52T probably damaging Het
Srebf1 T C 11: 60,111,365 (GRCm39) D2G probably damaging Het
Stab1 A T 14: 30,864,757 (GRCm39) M66K probably benign Het
Stab1 T C 14: 30,881,227 (GRCm39) N601S probably damaging Het
Sv2b C T 7: 74,773,836 (GRCm39) G545D probably damaging Het
Syt5 G A 7: 4,546,088 (GRCm39) Q101* probably null Het
Thada A G 17: 84,753,949 (GRCm39) F341L probably benign Het
Tln2 T G 9: 67,262,503 (GRCm39) I585L probably damaging Het
Tmem67 C G 4: 12,069,413 (GRCm39) probably null Het
Tonsl G T 15: 76,516,880 (GRCm39) L917M probably damaging Het
Ttk A G 9: 83,744,236 (GRCm39) K519E probably damaging Het
Ttn T C 2: 76,537,478 (GRCm39) T34817A probably benign Het
Ubr1 A T 2: 120,756,528 (GRCm39) S700T probably damaging Het
Unc13b C A 4: 43,245,566 (GRCm39) C1312* probably null Het
Usp36 A G 11: 118,175,849 (GRCm39) L104P possibly damaging Het
Vmn1r216 T C 13: 23,283,403 (GRCm39) F29L probably benign Het
Vmn1r225 T C 17: 20,723,147 (GRCm39) I196T probably damaging Het
Vmn1r50 T C 6: 90,085,121 (GRCm39) F289L probably benign Het
Ythdf3 T C 3: 16,257,375 (GRCm39) probably benign Het
Zfp507 T A 7: 35,494,268 (GRCm39) K258N probably damaging Het
Zscan5b A G 7: 6,234,442 (GRCm39) H156R possibly damaging Het
Other mutations in Flrt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Flrt1 APN 19 7,074,277 (GRCm39) missense probably damaging 1.00
IGL01082:Flrt1 APN 19 7,073,339 (GRCm39) missense probably benign
IGL02535:Flrt1 APN 19 7,074,098 (GRCm39) missense probably benign 0.00
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0403:Flrt1 UTSW 19 7,073,284 (GRCm39) missense probably benign 0.01
R0645:Flrt1 UTSW 19 7,074,508 (GRCm39) intron probably benign
R0677:Flrt1 UTSW 19 7,073,544 (GRCm39) nonsense probably null
R1818:Flrt1 UTSW 19 7,072,711 (GRCm39) missense probably damaging 1.00
R2228:Flrt1 UTSW 19 7,072,723 (GRCm39) missense probably damaging 1.00
R2471:Flrt1 UTSW 19 7,073,856 (GRCm39) missense probably damaging 1.00
R4978:Flrt1 UTSW 19 7,074,241 (GRCm39) missense probably damaging 1.00
R5460:Flrt1 UTSW 19 7,073,105 (GRCm39) missense probably damaging 0.99
R5630:Flrt1 UTSW 19 7,073,830 (GRCm39) missense probably damaging 1.00
R6326:Flrt1 UTSW 19 7,073,974 (GRCm39) missense probably damaging 1.00
R6734:Flrt1 UTSW 19 7,073,524 (GRCm39) missense possibly damaging 0.91
R6905:Flrt1 UTSW 19 7,072,757 (GRCm39) nonsense probably null
R7239:Flrt1 UTSW 19 7,073,329 (GRCm39) missense probably benign 0.12
R7799:Flrt1 UTSW 19 7,073,229 (GRCm39) missense possibly damaging 0.78
R8168:Flrt1 UTSW 19 7,074,002 (GRCm39) missense probably damaging 1.00
X0024:Flrt1 UTSW 19 7,073,114 (GRCm39) missense probably damaging 1.00
X0062:Flrt1 UTSW 19 7,074,244 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCCATGGTGACCATACAGATG -3'
(R):5'- TCACCAGCGAGATGGATGAG -3'

Sequencing Primer
(F):5'- ACAGATGATGTAGGTGGACTTG -3'
(R):5'- GCTAATGCAGCCGCCAAG -3'
Posted On 2014-10-02