Incidental Mutation 'R2199:Il20'
ID 238535
Institutional Source Beutler Lab
Gene Symbol Il20
Ensembl Gene ENSMUSG00000026416
Gene Name interleukin 20
Synonyms Zcyto10
MMRRC Submission 040201-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2199 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 130834722-130839033 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 130838476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 74 (I74L)
Ref Sequence ENSEMBL: ENSMUSP00000027673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027673] [ENSMUST00000188581]
AlphaFold Q9JKV9
Predicted Effect probably benign
Transcript: ENSMUST00000027673
AA Change: I74L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000027673
Gene: ENSMUSG00000026416
AA Change: I74L

DomainStartEndE-ValueType
IL10 35 176 3.89e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188581
SMART Domains Protein: ENSMUSP00000141088
Gene: ENSMUSG00000026416

DomainStartEndE-ValueType
Pfam:IL10 35 154 1.9e-8 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice show an increased inflammatory response in contact hypersensitivity assays. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,554,598 (GRCm39) I119V probably benign Het
Arfgap2 T A 2: 91,096,037 (GRCm39) probably null Het
Ccm2 T C 11: 6,540,790 (GRCm39) V216A probably damaging Het
Ctdspl2 T C 2: 121,817,510 (GRCm39) probably null Het
Dmxl2 T C 9: 54,283,527 (GRCm39) T2769A probably benign Het
Dnah3 C T 7: 119,550,792 (GRCm39) V3165M possibly damaging Het
Dnajc1 A C 2: 18,313,710 (GRCm39) F137C probably damaging Het
Gli2 A T 1: 118,765,378 (GRCm39) D924E possibly damaging Het
Gnrhr T C 5: 86,345,677 (GRCm39) N3S probably benign Het
Grhl1 G T 12: 24,662,169 (GRCm39) R536L probably damaging Het
Hormad1 T C 3: 95,475,033 (GRCm39) probably null Het
Ints11 A G 4: 155,959,738 (GRCm39) K115R probably benign Het
Irx4 A T 13: 73,413,720 (GRCm39) E63D probably benign Het
Itch A C 2: 155,044,141 (GRCm39) Q482P probably benign Het
Kctd8 C A 5: 69,498,588 (GRCm39) M19I probably benign Het
Klhl31 T C 9: 77,557,383 (GRCm39) L33P probably damaging Het
Lrp1 A T 10: 127,382,709 (GRCm39) C3691S probably damaging Het
Lrrc39 A G 3: 116,364,610 (GRCm39) D167G probably damaging Het
Lrrd1 A T 5: 3,916,478 (GRCm39) I832L possibly damaging Het
Lrriq1 A G 10: 102,904,774 (GRCm39) V1620A probably damaging Het
Ltbr T C 6: 125,289,024 (GRCm39) K213E probably benign Het
Megf8 T A 7: 25,039,039 (GRCm39) D883E possibly damaging Het
Nherf2 T C 17: 24,859,570 (GRCm39) E174G probably null Het
Nmt1 T A 11: 102,954,682 (GRCm39) S405T probably damaging Het
Nsd3 G T 8: 26,156,073 (GRCm39) V547F probably damaging Het
Or4c110 A G 2: 88,831,894 (GRCm39) V246A probably damaging Het
Or7g16 C A 9: 18,727,219 (GRCm39) V124F probably damaging Het
Otud7a A G 7: 63,407,404 (GRCm39) K569R possibly damaging Het
Otud7b A G 3: 96,063,089 (GRCm39) Y776C probably damaging Het
Pcdh15 T C 10: 74,006,341 (GRCm39) I73T probably damaging Het
Rnf213 A T 11: 119,350,835 (GRCm39) H3890L probably benign Het
Sall3 T C 18: 81,015,085 (GRCm39) T948A probably benign Het
Slc44a3 T C 3: 121,307,393 (GRCm39) I198V probably benign Het
Smg7 C A 1: 152,730,079 (GRCm39) D405Y probably damaging Het
Synpo2l A G 14: 20,711,987 (GRCm39) L211S probably benign Het
Thsd7b A G 1: 130,145,895 (GRCm39) Y1601C probably benign Het
Traf4 T C 11: 78,050,806 (GRCm39) Y450C probably damaging Het
Trpv1 A G 11: 73,131,077 (GRCm39) K239E probably damaging Het
Ttn C T 2: 76,585,150 (GRCm39) G20302S probably damaging Het
Ube2o A G 11: 116,435,571 (GRCm39) S406P probably benign Het
Xrn2 C T 2: 146,866,670 (GRCm39) A80V probably damaging Het
Zfp616 C T 11: 73,975,456 (GRCm39) T575I possibly damaging Het
Other mutations in Il20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01979:Il20 APN 1 130,838,839 (GRCm39) missense probably damaging 0.98
IGL02297:Il20 APN 1 130,836,145 (GRCm39) missense probably damaging 0.99
IGL02322:Il20 APN 1 130,837,313 (GRCm39) missense probably damaging 1.00
R0627:Il20 UTSW 1 130,837,476 (GRCm39) splice site probably benign
R0885:Il20 UTSW 1 130,838,518 (GRCm39) missense probably benign 0.21
R1659:Il20 UTSW 1 130,836,086 (GRCm39) splice site probably null
R2037:Il20 UTSW 1 130,836,115 (GRCm39) missense probably damaging 0.99
R5632:Il20 UTSW 1 130,835,165 (GRCm39) missense probably benign 0.19
R6039:Il20 UTSW 1 130,838,478 (GRCm39) missense possibly damaging 0.65
R6039:Il20 UTSW 1 130,838,478 (GRCm39) missense possibly damaging 0.65
R6155:Il20 UTSW 1 130,838,477 (GRCm39) missense probably damaging 0.98
R6340:Il20 UTSW 1 130,836,118 (GRCm39) missense probably benign 0.30
R8675:Il20 UTSW 1 130,835,172 (GRCm39) missense probably damaging 1.00
Z1177:Il20 UTSW 1 130,839,124 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GACCAGACCAGGCTGTGAAG -3'
(R):5'- AGTCCTGGACAGTGCATTTCC -3'

Sequencing Primer
(F):5'- CAGGAGACAAGACCAGGTTGTG -3'
(R):5'- GTGCATTTCCAAGAGATGCC -3'
Posted On 2014-10-02