Incidental Mutation 'R2212:Pla2g4f'
ID 239430
Institutional Source Beutler Lab
Gene Symbol Pla2g4f
Ensembl Gene ENSMUSG00000046971
Gene Name phospholipase A2, group IVF
Synonyms 4732472I07Rik, Pla2zeta
MMRRC Submission 040214-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R2212 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 120130438-120144646 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120133587 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 579 (S579G)
Ref Sequence ENSEMBL: ENSMUSP00000062607 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054651]
AlphaFold Q50L41
Predicted Effect probably benign
Transcript: ENSMUST00000054651
AA Change: S579G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000062607
Gene: ENSMUSG00000046971
AA Change: S579G

DomainStartEndE-ValueType
C2 45 144 7.51e-11 SMART
PLAc 285 797 1.6e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142183
Meta Mutation Damage Score 0.0934 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,603,977 (GRCm39) Y6C probably damaging Het
3425401B19Rik T A 14: 32,383,559 (GRCm39) Q802L probably benign Het
Adarb2 T C 13: 8,802,654 (GRCm39) F643S probably damaging Het
Angptl4 A G 17: 33,994,392 (GRCm39) I401T probably damaging Het
Ap2a2 T A 7: 141,178,689 (GRCm39) N105K probably benign Het
Atp8b4 C A 2: 126,217,677 (GRCm39) W613L probably damaging Het
Cibar1 A G 4: 12,171,696 (GRCm39) probably null Het
Coq10a A G 10: 128,200,998 (GRCm39) V93A possibly damaging Het
Cyp4f39 A T 17: 32,706,037 (GRCm39) E376V possibly damaging Het
Deup1 A T 9: 15,511,139 (GRCm39) D213E probably benign Het
Ehmt2 A G 17: 35,118,341 (GRCm39) S39G probably benign Het
Eya1 T A 1: 14,344,433 (GRCm39) probably null Het
Fcna G C 2: 25,517,505 (GRCm39) P49A probably damaging Het
Flnb AAGGAG AAG 14: 7,881,652 (GRCm38) probably benign Het
Fscn2 G T 11: 120,252,417 (GRCm39) probably benign Het
Gckr T A 5: 31,458,211 (GRCm39) probably null Het
Golgb1 A G 16: 36,707,709 (GRCm39) K68E probably damaging Het
H2-M11 G A 17: 36,859,822 (GRCm39) V272M probably damaging Het
Hace1 T A 10: 45,524,771 (GRCm39) D234E possibly damaging Het
Il18r1 A T 1: 40,530,227 (GRCm39) D318V probably damaging Het
Il4i1 T C 7: 44,486,082 (GRCm39) L22P probably damaging Het
Kcnq3 A T 15: 65,892,142 (GRCm39) F411Y probably benign Het
Kcnt2 A G 1: 140,458,538 (GRCm39) Y775C probably damaging Het
Krt84 A C 15: 101,440,973 (GRCm39) V73G probably benign Het
Lcp2 A C 11: 34,020,995 (GRCm39) D117A probably benign Het
Lemd1 C A 1: 132,156,024 (GRCm39) T22K probably benign Het
Mdm4 T C 1: 132,922,260 (GRCm39) D294G probably damaging Het
Mep1a G A 17: 43,788,154 (GRCm39) A634V probably benign Het
Myh15 A G 16: 48,959,095 (GRCm39) D989G probably benign Het
Myo1g G T 11: 6,467,870 (GRCm39) H188Q possibly damaging Het
Nsmaf C A 4: 6,396,732 (GRCm39) L918F probably damaging Het
Or10d4 T A 9: 39,580,524 (GRCm39) M57K probably damaging Het
Or2v2 C T 11: 49,004,043 (GRCm39) C170Y probably damaging Het
Or51f5 T C 7: 102,423,962 (GRCm39) L77P possibly damaging Het
Or51q1 T C 7: 103,628,609 (GRCm39) L76P probably damaging Het
Pfkfb2 A T 1: 130,635,269 (GRCm39) N97K probably damaging Het
Phlda1 A T 10: 111,343,029 (GRCm39) E255V probably damaging Het
Plcz1 C T 6: 139,947,807 (GRCm39) R525Q probably damaging Het
Ppargc1b G A 18: 61,444,291 (GRCm39) Q291* probably null Het
Ppef2 T G 5: 92,376,581 (GRCm39) S649R probably damaging Het
Ppp1r3b A G 8: 35,851,379 (GRCm39) T73A possibly damaging Het
Prss43 G C 9: 110,658,532 (GRCm39) Q277H probably damaging Het
Rusc2 T G 4: 43,415,935 (GRCm39) S414A probably damaging Het
Serpina3j G A 12: 104,280,985 (GRCm39) D53N probably damaging Het
Sez6l A G 5: 112,623,227 (GRCm39) L108P possibly damaging Het
Slc1a7 A G 4: 107,868,191 (GRCm39) E497G probably benign Het
Spag8 T A 4: 43,651,606 (GRCm39) S423C probably damaging Het
Spata13 A G 14: 60,944,172 (GRCm39) T522A probably benign Het
Spryd3 A G 15: 102,038,711 (GRCm39) probably null Het
Sry T A Y: 2,663,339 (GRCm39) N107I probably damaging Het
St6galnac1 A G 11: 116,656,682 (GRCm39) W486R probably damaging Het
Syt1 G T 10: 108,340,275 (GRCm39) P348T possibly damaging Het
Taok2 T C 7: 126,470,030 (GRCm39) I933V possibly damaging Het
Tex9 C A 9: 72,385,040 (GRCm39) Q265H possibly damaging Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Trim59 T C 3: 68,944,876 (GRCm39) T155A probably benign Het
Trim69 T C 2: 122,009,125 (GRCm39) V395A probably benign Het
Tusc1 C A 4: 93,223,173 (GRCm39) R162L probably damaging Het
Ubash3a A T 17: 31,437,008 (GRCm39) Q208H probably damaging Het
Ubn2 A G 6: 38,475,674 (GRCm39) T1211A probably benign Het
Vmn2r110 A T 17: 20,794,209 (GRCm39) probably null Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zfyve28 C T 5: 34,357,028 (GRCm39) M723I probably benign Het
Zmynd8 A T 2: 165,657,371 (GRCm39) M533K probably damaging Het
Other mutations in Pla2g4f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00539:Pla2g4f APN 2 120,133,219 (GRCm39) missense possibly damaging 0.53
IGL01652:Pla2g4f APN 2 120,132,716 (GRCm39) missense possibly damaging 0.86
IGL02792:Pla2g4f APN 2 120,133,850 (GRCm39) missense probably damaging 1.00
R0625:Pla2g4f UTSW 2 120,135,522 (GRCm39) missense probably damaging 1.00
R1760:Pla2g4f UTSW 2 120,144,547 (GRCm39) unclassified probably benign
R1799:Pla2g4f UTSW 2 120,141,549 (GRCm39) missense possibly damaging 0.49
R2351:Pla2g4f UTSW 2 120,130,923 (GRCm39) missense probably benign 0.01
R3412:Pla2g4f UTSW 2 120,133,587 (GRCm39) missense probably benign
R3414:Pla2g4f UTSW 2 120,133,587 (GRCm39) missense probably benign
R3906:Pla2g4f UTSW 2 120,130,980 (GRCm39) missense probably benign 0.28
R4084:Pla2g4f UTSW 2 120,142,806 (GRCm39) missense probably benign 0.36
R4477:Pla2g4f UTSW 2 120,134,153 (GRCm39) missense probably damaging 1.00
R4529:Pla2g4f UTSW 2 120,131,100 (GRCm39) missense probably damaging 0.99
R4606:Pla2g4f UTSW 2 120,144,467 (GRCm39) missense probably benign 0.00
R4685:Pla2g4f UTSW 2 120,135,496 (GRCm39) missense probably damaging 1.00
R4728:Pla2g4f UTSW 2 120,131,402 (GRCm39) missense probably benign 0.19
R4782:Pla2g4f UTSW 2 120,133,757 (GRCm39) missense probably damaging 1.00
R4957:Pla2g4f UTSW 2 120,130,980 (GRCm39) missense probably benign 0.28
R5781:Pla2g4f UTSW 2 120,135,504 (GRCm39) missense probably damaging 0.97
R6158:Pla2g4f UTSW 2 120,131,552 (GRCm39) missense probably benign 0.21
R6232:Pla2g4f UTSW 2 120,132,702 (GRCm39) missense possibly damaging 0.63
R6629:Pla2g4f UTSW 2 120,138,723 (GRCm39) missense probably damaging 1.00
R6894:Pla2g4f UTSW 2 120,134,077 (GRCm39) missense probably benign 0.44
R6939:Pla2g4f UTSW 2 120,137,782 (GRCm39) missense probably damaging 1.00
R7131:Pla2g4f UTSW 2 120,135,035 (GRCm39) missense probably null 0.01
R7221:Pla2g4f UTSW 2 120,131,476 (GRCm39) missense probably benign 0.06
R7421:Pla2g4f UTSW 2 120,137,737 (GRCm39) missense probably benign 0.07
R7767:Pla2g4f UTSW 2 120,135,490 (GRCm39) missense possibly damaging 0.87
R8466:Pla2g4f UTSW 2 120,130,963 (GRCm39) missense probably damaging 1.00
R9389:Pla2g4f UTSW 2 120,132,781 (GRCm39) missense probably damaging 1.00
R9425:Pla2g4f UTSW 2 120,133,264 (GRCm39) missense possibly damaging 0.75
R9500:Pla2g4f UTSW 2 120,142,713 (GRCm39) critical splice acceptor site probably null
R9657:Pla2g4f UTSW 2 120,135,138 (GRCm39) missense probably benign
R9714:Pla2g4f UTSW 2 120,142,900 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTTCCGTAACTTTGGCCAG -3'
(R):5'- GCTCTGAATTCTTCATGGGCC -3'

Sequencing Primer
(F):5'- AACTTTGGCCAGTCATCTAGG -3'
(R):5'- TGCATTTCTGGCCAGAGC -3'
Posted On 2014-10-15