Incidental Mutation 'IGL00231:Micall2'
| ID |
2396 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Micall2
|
| Ensembl Gene |
ENSMUSG00000036718 |
| Gene Name |
MICAL-like 2 |
| Synonyms |
MICAL-L2, Jrab, A930021H16Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.352)
|
| Stock # |
IGL00231
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
139692451-139722091 bp(-) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
T to A
at 139703311 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127937
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044642]
[ENSMUST00000170773]
|
| AlphaFold |
Q3TN34 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000044642
|
| SMART Domains |
Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
3 |
102 |
4.34e-20 |
SMART |
|
LIM
|
187 |
241 |
1.62e-5 |
SMART |
|
low complexity region
|
242 |
253 |
N/A |
INTRINSIC |
|
low complexity region
|
326 |
344 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
489 |
N/A |
INTRINSIC |
|
low complexity region
|
502 |
518 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
746 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
770 |
N/A |
INTRINSIC |
|
DUF3585
|
840 |
980 |
3.1e-63 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000170773
|
| SMART Domains |
Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkra_
|
1 |
25 |
9e-5 |
SMART |
|
Blast:DUF3585
|
1 |
45 |
2e-7 |
BLAST |
|
LIM
|
104 |
158 |
1.62e-5 |
SMART |
|
low complexity region
|
159 |
170 |
N/A |
INTRINSIC |
|
low complexity region
|
243 |
261 |
N/A |
INTRINSIC |
|
low complexity region
|
345 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
419 |
435 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
672 |
687 |
N/A |
INTRINSIC |
|
DUF3585
|
757 |
897 |
3.1e-63 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl1 |
A |
G |
4: 86,303,877 (GRCm39) |
T1346A |
probably benign |
Het |
| Ccdc102a |
T |
C |
8: 95,638,266 (GRCm39) |
|
probably null |
Het |
| Cgrrf1 |
T |
C |
14: 47,069,779 (GRCm39) |
F16S |
probably damaging |
Het |
| Clybl |
T |
C |
14: 122,616,610 (GRCm39) |
|
probably benign |
Het |
| Cubn |
T |
C |
2: 13,386,660 (GRCm39) |
E1535G |
possibly damaging |
Het |
| Dmrtc1b |
C |
A |
X: 101,757,233 (GRCm39) |
P226H |
probably benign |
Het |
| Dnah17 |
G |
A |
11: 117,979,040 (GRCm39) |
A1784V |
possibly damaging |
Het |
| Dnajc24 |
A |
G |
2: 105,832,348 (GRCm39) |
Y12H |
probably damaging |
Het |
| Drd1 |
T |
C |
13: 54,207,486 (GRCm39) |
T236A |
probably benign |
Het |
| Ep400 |
A |
T |
5: 110,835,707 (GRCm39) |
V1934D |
unknown |
Het |
| Flt1 |
A |
G |
5: 147,517,110 (GRCm39) |
|
probably null |
Het |
| Fut8 |
A |
G |
12: 77,495,262 (GRCm39) |
K284R |
probably benign |
Het |
| Hcn1 |
A |
G |
13: 118,112,529 (GRCm39) |
E831G |
probably damaging |
Het |
| Inpp5j |
A |
T |
11: 3,450,009 (GRCm39) |
|
probably benign |
Het |
| Insig2 |
A |
G |
1: 121,233,676 (GRCm39) |
Y213H |
probably damaging |
Het |
| Kcnh4 |
G |
A |
11: 100,647,821 (GRCm39) |
|
probably benign |
Het |
| Kifc2 |
T |
A |
15: 76,551,662 (GRCm39) |
|
probably benign |
Het |
| Krt75 |
T |
C |
15: 101,481,081 (GRCm39) |
E231G |
probably benign |
Het |
| Men1 |
G |
A |
19: 6,387,237 (GRCm39) |
|
probably null |
Het |
| Mfsd4b2 |
T |
A |
10: 39,801,057 (GRCm39) |
|
probably benign |
Het |
| Or10ag2 |
A |
G |
2: 87,248,910 (GRCm39) |
T173A |
possibly damaging |
Het |
| Or8s5 |
C |
T |
15: 98,238,054 (GRCm39) |
S256N |
possibly damaging |
Het |
| Osbp2 |
C |
T |
11: 3,676,561 (GRCm39) |
D287N |
possibly damaging |
Het |
| Plin1 |
A |
G |
7: 79,376,408 (GRCm39) |
|
probably benign |
Het |
| Ppl |
T |
C |
16: 4,907,409 (GRCm39) |
N962S |
probably benign |
Het |
| Psg25 |
C |
T |
7: 18,260,106 (GRCm39) |
|
probably benign |
Het |
| Ptprt |
A |
T |
2: 161,652,544 (GRCm39) |
D601E |
probably benign |
Het |
| S100a7l2 |
A |
G |
3: 90,995,665 (GRCm39) |
M79T |
probably benign |
Het |
| Sbno2 |
C |
A |
10: 79,900,340 (GRCm39) |
|
probably benign |
Het |
| Sntg2 |
T |
C |
12: 30,326,720 (GRCm39) |
D147G |
probably benign |
Het |
| Sox4 |
C |
A |
13: 29,136,956 (GRCm39) |
G17W |
probably damaging |
Het |
| Stam2 |
T |
A |
2: 52,596,418 (GRCm39) |
I307F |
possibly damaging |
Het |
| Tbx21 |
T |
G |
11: 96,989,749 (GRCm39) |
E481A |
probably damaging |
Het |
| Tsc2 |
G |
A |
17: 24,827,081 (GRCm39) |
T876I |
probably damaging |
Het |
| Wdfy4 |
T |
C |
14: 32,824,496 (GRCm39) |
I1308V |
possibly damaging |
Het |
| Wdr37 |
C |
T |
13: 8,870,541 (GRCm39) |
V143I |
probably damaging |
Het |
| Wdr43 |
T |
G |
17: 71,959,809 (GRCm39) |
Y550D |
probably damaging |
Het |
| Wnk4 |
A |
G |
11: 101,159,574 (GRCm39) |
D593G |
possibly damaging |
Het |
|
| Other mutations in Micall2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00496:Micall2
|
APN |
5 |
139,702,083 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02641:Micall2
|
APN |
5 |
139,705,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03245:Micall2
|
APN |
5 |
139,705,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03252:Micall2
|
APN |
5 |
139,702,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1214:Micall2
|
UTSW |
5 |
139,697,396 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1468:Micall2
|
UTSW |
5 |
139,705,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Micall2
|
UTSW |
5 |
139,705,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1831:Micall2
|
UTSW |
5 |
139,702,508 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1833:Micall2
|
UTSW |
5 |
139,702,508 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1969:Micall2
|
UTSW |
5 |
139,721,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2023:Micall2
|
UTSW |
5 |
139,703,266 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R2060:Micall2
|
UTSW |
5 |
139,697,317 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2330:Micall2
|
UTSW |
5 |
139,703,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3820:Micall2
|
UTSW |
5 |
139,701,611 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4299:Micall2
|
UTSW |
5 |
139,695,226 (GRCm39) |
intron |
probably benign |
|
|
R4334:Micall2
|
UTSW |
5 |
139,699,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4451:Micall2
|
UTSW |
5 |
139,692,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4769:Micall2
|
UTSW |
5 |
139,692,641 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4911:Micall2
|
UTSW |
5 |
139,702,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Micall2
|
UTSW |
5 |
139,696,344 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5118:Micall2
|
UTSW |
5 |
139,702,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5155:Micall2
|
UTSW |
5 |
139,695,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5475:Micall2
|
UTSW |
5 |
139,702,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5750:Micall2
|
UTSW |
5 |
139,701,456 (GRCm39) |
splice site |
probably null |
|
|
R5998:Micall2
|
UTSW |
5 |
139,692,666 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6181:Micall2
|
UTSW |
5 |
139,702,506 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6852:Micall2
|
UTSW |
5 |
139,701,548 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7046:Micall2
|
UTSW |
5 |
139,694,699 (GRCm39) |
unclassified |
probably benign |
|
|
R7395:Micall2
|
UTSW |
5 |
139,702,124 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8514:Micall2
|
UTSW |
5 |
139,701,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8889:Micall2
|
UTSW |
5 |
139,703,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8892:Micall2
|
UTSW |
5 |
139,703,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8960:Micall2
|
UTSW |
5 |
139,702,025 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9060:Micall2
|
UTSW |
5 |
139,705,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9209:Micall2
|
UTSW |
5 |
139,696,170 (GRCm39) |
missense |
unknown |
|
|
R9227:Micall2
|
UTSW |
5 |
139,701,827 (GRCm39) |
missense |
unknown |
|
|
R9230:Micall2
|
UTSW |
5 |
139,701,827 (GRCm39) |
missense |
unknown |
|
|
R9260:Micall2
|
UTSW |
5 |
139,695,453 (GRCm39) |
missense |
unknown |
|
|
R9452:Micall2
|
UTSW |
5 |
139,703,311 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1088:Micall2
|
UTSW |
5 |
139,702,050 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1088:Micall2
|
UTSW |
5 |
139,692,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Micall2
|
UTSW |
5 |
139,696,057 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2011-12-09 |
Incidental Mutation